甲状腺功能减退症对妊娠晚期孕妇妊娠结局的影响研究
摘要
目的研究甲状腺功能减退症对妊娠晚期孕妇妊娠结局的影响。方法随机抽取70例甲状腺功能减退症妊娠晚期孕妇和70例甲状腺功能正常妊娠晚期孕妇作为研究对象,根据甲状腺功能状态分为参照组(甲状腺功能正常)和实验组(甲状腺功能减退)。给予实验组患者药物治疗,观察记录两组孕妇妊娠结局,后采用统计学软件SPSS 20.0对组间数据进行对比分析。结果①实验组妊娠不良结局发生率(11.43%),参照组妊娠不良结局发生率(1.43%),有统计学意义(P<0.05)。②实验组患者治疗后血脂及血压水平与治疗前明显要低,有统计学意义(P<0.05)。结论甲状腺功能减退症对妊娠晚期孕妇妊娠结局有重要影响,可引起早产、妊娠期高血压疾病、胎儿生长受限等不良妊娠结局发生,而及时给予其治疗则能够改善其血压及血脂指标,改善妊娠结局。
引文
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[2]Jabbar A,Ingoe L,Pearce S,et al.Thyroxine in acute myocardialinfarction(ThyrAMI)-levothyroxine in subclinical hypothyroidism post-acutemyocardial infarction:study protocol for a randomised controlled trial[J].Trials,2015(25)16:115.
[3]司晓宁.碳酸钙配伍小剂量阿司匹林对妊娠期高血压疾病高危孕产妇血压及胎盘和血清中T-bet、GATA-3的影响[J].中国妇幼保健,2017,32(11):2347-2349.
[4]魏雯,刘萍,郭海荣.妊娠期甲状腺功能减退症对母婴的影响及L-T4治疗后妊娠结局的分析[J].中国冶金工业医学杂志,2017,34(3):262-264.
[5]Busto-Mesa A,Cabrera-Rego JO,Carrero-Fernández L,et al.Changes in arterial stiffness,carotidintimamedia thickness,and epicardial fat after L-thyroxine replacement therapy in hypothyroidism[J].Endocrinol Nutr,2015,62(6):270-276.
[6]Cao J,Zhang J,Wang Z,et al.Hypothyroidism as a potential biomarker of efficacy of famitinib,a novel VEGFR-2 inhibitor in metastatic breast cancer[J].Cancer Chemother Pharmacol,2014,74(2):389-398.
[7]Irdem A,Ayd?n Sahin D,Kervancioglu M,et al.Evaluation of P-Wave Dispersion,Diastolic Function,and AtrialElectromechanical Conduction in Pediatric Patients with SubclinicalHypothyroidism[J].Echocardiography,2016,33(9):1397-1401.
[8]Chen LM,Chen QS,Jin GX,Si GX,et al.Effect of gestational subclinical hypothyroidism onearly neurodevelopment of offspring[J].J Perinatol,2015,35(9):678-682.