银杏酮酯滴丸口服的皮肤美白效果观察
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摘要
目的:探讨银杏酮酯在皮肤美白应用中的效果。方法:选取2017年1月-2018年2月笔者医院皮肤科招募的志愿者50例,采用随机数字表法,将其分为观察组(n=26)和对照组(n=24),其中对照组仅给予面部清洁保湿及熏蒸;观察组在对照组基础上给予银杏酮酯,口服银杏酮酯滴丸5粒/次,3次/d,连续用3个月,在熏蒸上加入银杏酮酯滴丸5粒。观察两组美白效果、皮肤干燥改善情况等。结果:观察组美白效果明显优于对照组(P<0.05),总有效率达到84.62%;观察组干预后皮肤干燥评分为(1.10±0.23)分,明显低于对照组(P<0.05);观察组干预后皮肤pH值和黑色素值分别为(4.52±0.31)和(32.54±9.54),明显低于对照组(P<0.05),而皮肤含水量为(39.54±8.11)%,明显高于对照组(P<0.05);两组治疗期间未发现有丘疹、剧烈瘙痒等不良反应。结论:银杏酮酯滴丸口服有较好皮肤美白效果,值得推广使用。
Objective To investigate effect of Ginkgo ketone ester on skin whitening. Methods 50 volunteers recruited from the Department of Dermatology in our hospital from January 2017 to February 2018 were selected and randomly divided into observation group(n =26) and control group(n= 24) by random number table method, the observation group was given Ginkgo biloba ketone ester on the basis of the control group, Ginkgo Ketone Ester Dropping Pills were taken orally 5 tablets/time, 3 times/day for 3 months, and 5 tablets were added to the fumigated Ginkgo Ketone Ester Dropping Pills. while the control group was only given facial cleansing and moisturizing fumigating, and the whitening effect and the improvement of skin dryness and so on were observed. Results The whitening effect of the observation group was significantly better than that of the control group(P<0.05), and the total effective rate was 84.62%; The dry skin score of the observation group was 1.10±0.23, which was significantly lower than that of the control group(P<0.05); The skin pH value and melanin value of the observation group after intervention were 4.52±0.31 and 32.54±9.54, which were significantly lower than those of the control group(P<0.05),and the skin moisture content was(39.54±8.11)%, which was significantly higher than that of the control group(P<0.05). No adverse reactions such as papules and severe itching and so on were found in the two groups during treatment. Conclusion Ginkgo ketone ester has good effect in skin whitening and is worthy of promotion.
Objective To investigate effect of Ginkgo ketone ester on skin whitening. Methods 50 volunteers recruited from the Department of Dermatology in our hospital from January 2017 to February 2018 were selected and randomly divided into observation group(n =26) and control group(n= 24) by random number table method, the observation group was given Ginkgo biloba ketone ester on the basis of the control group, Ginkgo Ketone Ester Dropping Pills were taken orally 5 tablets/time, 3 times/day for 3 months, and 5 tablets were added to the fumigated Ginkgo Ketone Ester Dropping Pills. while the control group was only given facial cleansing and moisturizing fumigating, and the whitening effect and the improvement of skin dryness and so on were observed. Results The whitening effect of the observation group was significantly better than that of the control group(P<0.05), and the total effective rate was 84.62%; The dry skin score of the observation group was 1.10±0.23, which was significantly lower than that of the control group(P<0.05); The skin pH value and melanin value of the observation group after intervention were 4.52±0.31 and 32.54±9.54, which were significantly lower than those of the control group(P<0.05),and the skin moisture content was(39.54±8.11)%, which was significantly higher than that of the control group(P<0.05). No adverse reactions such as papules and severe itching and so on were found in the two groups during treatment. Conclusion Ginkgo ketone ester has good effect in skin whitening and is worthy of promotion.
引文
[1]张云莎,杨琳,庞赓,等.银杏内酯和银杏黄酮干预β-淀粉样蛋白跨血脑屏障低氧模型转运的体外研究[J].广东医学,2016,37(16):2389-2392.
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[5]姜丽,杨子平,包怡敏.银杏酮酯对急性血瘀证大鼠血流动力学及心肌组织肿瘤坏死因子-α通路的影响[J].中国中医药信息杂志,2017,24(11):34-38.
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[7]盖晓红,刘素香,任涛,等.银杏化学成分、制剂种类和不良反应的研究进展[J].药物评价研究,2017,40(6):742-751.
[8]Pawlosky RJ,Kemper MF,Kashiwaya Y,et al.Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease[J].J Neurochem,2017,141(2):195-207.
[9]Abdelzaher AO,Farghaly H,Elrefaiy A,et al.Protective effect of the standardized extract of ginkgo biloba(EGb761)against hypertension with hypercholesterolemia-induced renal injury in rats:Insights in the underlying mechanisms[J].J Biomedicine Pharmacotherapy,2017,95(10):944-955.
[10]Kim YJ,Bostami ABMR,Islam MM,et al.Effect of Fermented Ginkgo biloba and Camelia sinensis-Based Probiotics on Growth Performance,Immunity and Caecal Microbiology in Broilers[J].Int JPoultry Science,2016,15(2):62-71.
[11]Puchowicz MA,Seyfried TN.Novel ketone body therapy for managing Alzheimer's disease:An Editorial Highlight for Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease[J].J Neurochem,2017,141(2):162-164.
[12]李霄,张银华.银杏酮酯滴丸联合氯吡格雷在非心源性脑梗死二级预防中的疗效分析[J].国际中医中药杂志,2017,39(10):883-886.
[13]唐超园,祝丽欣,陈芝,等.血脑同步微透析研究大鼠口服银杏酮酯后内酯类成分的血脑分布[J].中草药,2017,48(2):272-277.
[14]程弘禹,张新江,李姗姗,等.银杏酮酯对缺血性卒中患者血浆促炎因子及认知功能的作用研究[J].中国卒中杂志,2016,11(11):947-953.
[2]郭吉安,余丕军,王露萍,等.脂肪干细胞旁分泌功能在面部抗衰老领域的研究应用与进展[J].中国组织工程研究,2017,38(5):789-794.
[3]石成方,刘畅,杨蓉娅.云苓在色素沉着性皮肤病中的应用研究[J].中国现代中药,2017,19(1):60-63.
[4]孔雪,赵华,唐颖.皮肤模型在化妆品功效评价中的应用研究进展[J].日用化学工业,2017,47(4):228-231.
[5]姜丽,杨子平,包怡敏.银杏酮酯对急性血瘀证大鼠血流动力学及心肌组织肿瘤坏死因子-α通路的影响[J].中国中医药信息杂志,2017,24(11):34-38.
[6]邵婷婷.银杏酮酯的提取分离技术研究进展[J].中国现代中药,2016,18(3):396-400.
[7]盖晓红,刘素香,任涛,等.银杏化学成分、制剂种类和不良反应的研究进展[J].药物评价研究,2017,40(6):742-751.
[8]Pawlosky RJ,Kemper MF,Kashiwaya Y,et al.Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease[J].J Neurochem,2017,141(2):195-207.
[9]Abdelzaher AO,Farghaly H,Elrefaiy A,et al.Protective effect of the standardized extract of ginkgo biloba(EGb761)against hypertension with hypercholesterolemia-induced renal injury in rats:Insights in the underlying mechanisms[J].J Biomedicine Pharmacotherapy,2017,95(10):944-955.
[10]Kim YJ,Bostami ABMR,Islam MM,et al.Effect of Fermented Ginkgo biloba and Camelia sinensis-Based Probiotics on Growth Performance,Immunity and Caecal Microbiology in Broilers[J].Int JPoultry Science,2016,15(2):62-71.
[11]Puchowicz MA,Seyfried TN.Novel ketone body therapy for managing Alzheimer's disease:An Editorial Highlight for Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease[J].J Neurochem,2017,141(2):162-164.
[12]李霄,张银华.银杏酮酯滴丸联合氯吡格雷在非心源性脑梗死二级预防中的疗效分析[J].国际中医中药杂志,2017,39(10):883-886.
[13]唐超园,祝丽欣,陈芝,等.血脑同步微透析研究大鼠口服银杏酮酯后内酯类成分的血脑分布[J].中草药,2017,48(2):272-277.
[14]程弘禹,张新江,李姗姗,等.银杏酮酯对缺血性卒中患者血浆促炎因子及认知功能的作用研究[J].中国卒中杂志,2016,11(11):947-953.