2005-2017年浙江省乙型肝炎流行病学特征
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摘要
目的分析浙江省2005-2017年乙型肝炎(乙肝)流行病学特征。方法通过中国疾病预防控制信息系统收集2005-2017年乙肝病例报告数据,进行描述流行病学分析。结果 2005-2017年浙江省共报告361714例乙肝病例,平均发病率(/10万)为52.71,其中2005-2011年、2012-2017年分别为76.73、26.88;急性、慢性、未分类乙肝分别为5.79、34.00、12.92;0-14岁、15-29岁、30-44岁、45-59岁、≥60岁分别为5.37、70.28、76.69、52.37、34.93;男、女性分别为72.11、32.35;各地市在13.41(杭州)-99.95(丽水)之间。结论浙江省2005-2017年乙肝报告发病率呈下降趋势,以<15岁儿童乙肝控制效果显著。需加强成人乙肝防控工作,提高乙肝病例报告质量。
Objective To analyze epidemiological characteristics of hepatitis B in Zhejiang province during 2005-2017.Methods We collected data on hepatitis B cases that had been reported to the Chinese Disease Control and Prevention Information System during 2005-2017 and conducted a descriptive analysis. Results A total of 361 714 hepatitis B cases were reported in Zhejiang during 2005-2017, for an average incidence of 52.71 per 100 000 population. Average annual incidences per 100 000 were 76.73 in 2005-2011 and 26.88 in 2012-2017. Incidences for acute, chronic, and unclassified hepatitis B were 5.79, 34.00, and 12.92, respectively. Incidences by age group for 0-14, 15-29, 30-44, 45-59, and ≥60 year olds were 5.37, 70.28, 76.69, 52.37, and 34.93, respectively; for males and female, incidences were 72.11 and 32.35;and by prefecture, incidences ranged f rom 13.41(Hangzhou) to 99.95(Lishui). Conclusions The incidence of hepatitis B decreased f rom 2005 to 2017 in Zhejiang, with remarkable achievements in hepatitis B control for children under 15 years old. We should enhance hepatitis B control for adults, and improve hepatitis B case reporting.
Objective To analyze epidemiological characteristics of hepatitis B in Zhejiang province during 2005-2017.Methods We collected data on hepatitis B cases that had been reported to the Chinese Disease Control and Prevention Information System during 2005-2017 and conducted a descriptive analysis. Results A total of 361 714 hepatitis B cases were reported in Zhejiang during 2005-2017, for an average incidence of 52.71 per 100 000 population. Average annual incidences per 100 000 were 76.73 in 2005-2011 and 26.88 in 2012-2017. Incidences for acute, chronic, and unclassified hepatitis B were 5.79, 34.00, and 12.92, respectively. Incidences by age group for 0-14, 15-29, 30-44, 45-59, and ≥60 year olds were 5.37, 70.28, 76.69, 52.37, and 34.93, respectively; for males and female, incidences were 72.11 and 32.35;and by prefecture, incidences ranged f rom 13.41(Hangzhou) to 99.95(Lishui). Conclusions The incidence of hepatitis B decreased f rom 2005 to 2017 in Zhejiang, with remarkable achievements in hepatitis B control for children under 15 years old. We should enhance hepatitis B control for adults, and improve hepatitis B case reporting.
引文
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[11]高建华,苏宁,黄若刚,等.北京市2010-2015年病毒性肝炎流行特征分析[J].国际病毒学杂志, 2016, 23(5):308-310.GAO Jianhua, SU Ning, HUANG Ruogang, et al.Epidemiological analysis of viral hepatitis in Beijing from 2010 to 2015[J]. International Journal of Virology, 2016,23(5):308-310.
[12]孙翔,刘元宝,许燕,等. 2006-2015年江苏省急性乙型病毒性肝炎发病率趋势分析[J].现代预防医学, 2017, 44(12):2279-2282.SUN Xiang, LIU Yuanbao, XU Yan, et al. Trend analysis of the incidence of acute hepatitis B in Jiangsu province between 2006 to 2015[J]. Modern Preventive Medicine,2017, 44(12):2279-2282.
[13]许盛楠,许琳,康文玉,等. 2007-2016年云南省急性乙型病毒性肝炎流行特征[J].中国疫苗和免疫, 2017, 23(6):647-652.XU Shengnan, XU Lin, KANG Wenyu, et al. Epidemiology of acute hepatitis B in Yunnan province, 2007-2016[J].Chinese Journal of Vaccines and Immunization, 2017,23(6):647-652.
[14] HE Hanqing, ZHOU Yang, XIE Shuyun. Assessment of the duplicate notif iable reporting of hepatitis B infection in Zhejiang province, China, 2005-2015[J]. Vaccine, 2017,35(36):4702-4706.
[15]尚晓鹏,吴晨,吴昊澄,等.浙江省医疗机构传染病报告质量调查[J].浙江预防医学, 2015, 27(6):635-637.SHANG Xiaopeng, WU Chen, WU Haocheng, et al.Investigation on the quality of infectious disease reporting in medical institutions of Zhejiang province[J]. Zhejiang Journal of Preventive Medicine, 2015, 27(6):635-637.
[16]中华人民共和国国家卫生和计划生育委员会.中国病毒性肝炎防治规划(2017-2020年)[J].中国病毒病杂志, 2018, 8(1):1-5.National Health and Family Planning Commission. Action plan for the prevention and treatment of viral hepatitis in China(2017-2020)[J]. Chinese Journal of Viral Diseases,2018, 8(1):1-5.
[17]周洋,何寒青,邓璇,等.浙江省乙型病毒性肝炎监测报告质量分析[J].预防医学, 2017, 29(9):865-868+873.ZHOU Yang, HE Hanqing, DENG Xuan, et al. An analysis on the hepatitis B report data from a pilot surveillance in Zhejiang province[J]. Preventive Medicine, 2017, 29(9):865-868+873.
[18]姚军,韩晓军,周绍聪,等.浙江省病毒性肝炎流行病学特点及对策[J].浙江预防医学, 1995, 7(1):13-15+26.YAO Jun, HAN Xiaojun, ZHOU Shaocong, et al.Epidemiological characteristics and countermeasures of viral hepatitis in Zhejiang province[J]. Zhejiang Journal of Preventive Medicine, 1995:7(1):13-15+26.
[19] ZHOU Y, HE H, DENG X, et al. Significant reduction in notification and seroprevalence rates of hepatitis B virus infection among the population of Zhejiang province,China, aged between 1 and 29 years from 2006 to 2014[J].Vaccine, 2017, 35(34):4355-4361.
[20]徐爱强,张丽.中国成年人乙型肝炎疫苗免疫策略的循证与思考[J].中华预防医学杂志, 2016, 50(6):473-477.XU Aiqiang, ZHANG Li. Immunization strategy of hepatitis B vaccines among adults in China:evidence based-medicine and consideration[J]. Chinese Journal of Preventive Medicine, 2016, 50(6):473-477.
[21] WANG F, ZHANG G, ZHENG H, et al. Post-vaccination serologic testing of inf ants born to hepatitis B surf ace antigen positive mothers in 4 provinces of China[J].Vaccine, 2017, 35(33):4229-4235.
[22]宋姝娟,黄春萍,刘牧文.杭州市2005-2012年乙型病毒性肝炎发病特征和报告质量分析[J].中国预防医学杂志, 2015,16(1):52-56.SONG Shujuan, HUANG Chunping, LIU Muwen.Epidemiological characteristics and report quality analysis for acute hepatitis B in Hangzhou, 2005-2012[J]. Chinese Preventive Medicine, 2015, 16(1):52-56.
[23]徐爱强,张丽.中国病毒性肝炎血清流行病学调查的回顾与意义[J].中华预防医学杂志, 2017, 51(6):457-460.XU Aiqiang, ZHANG Li. The review and significance of national seroepidemiological surveys on viral hepatitis in China[J]. Chinese Journal of Preventive Medicine, 2017,51(6):457-460.
[2]王宇.中国乙型肝炎疫苗接种及其成效[J].中国疫苗和免疫,2014, 20(2):97-99+131.WANG Yu. Hepatitis B vaccinat ion in China and its effect iveness[J]. Chinese Journal of Vaccines and Immunization, 2014, 20(2):97-99+131.
[3]崔富强,卢永,王富珍,等.中国2006年乙型肝炎报告病例构成分析[J].中华流行病学杂志, 2007, 28(9):872-874.CUI Fuqiang, LU Yong, WANG Fuzhen, et al. Analysis on the proportion of reported hepatitis B cases through pilot surveillance in China during 2006[J]. Chinese Journal of Epidemiology, 2007, 28(9):872-874.
[4]徐旭卿,林霞,曾蓓蓓,等. 1991-2007年浙江省乙型病毒性肝炎报告发病特征分析[J].疾病监测, 2010, 25(4):263-266.XU Xuqing, LIN Xia, ZENG Beibei, et al. Epidemiological analysis of viral hepatitis B in Zhejiang, 1991-2007[J].Disease Surveillance, 2010, 25(4):263-266.
[5] WANG Z, CHEN Y, PAN J. Trends of acute hepatitis B notif ication rates in eastern China f rom 2005 to 2013[J].PloS One, 2014, 9(12):e114645.
[6]陈永弟,姚军,陈恩富,等.浙江省1990-2006年疫苗时代乙型病毒性肝炎流行病学特征分析[J].中国农村卫生事业管理, 2010, 30(10):848-850.CHEN Yongdi, YAO Jun, CHEN Enfu, et al.Epidemiological analysis on hepatitis B in Zhejiang province during 1990-2006[J]. Chinese Rural Health Service Administration, 2010, 30(10):848-850.
[7]国家卫生和计划生育委员会.乙型病毒性肝炎诊断标准及处理原则(GB 15990-1995)[S]. 1995.Nat ional Heal th and Family Planning Commission.Diagnostic criteria and principles of management of viral hepatitis B(GB 15990-1995)[S]. 1995.
[8]国家卫生和计划生育委员会.乙型病毒性肝炎诊断标准(WS299-2008)[S]. 2008.Nat ional Heal th and Family Planning Commission.Diagnostic criteria for viral hepatitis B(WS299-2008)[S].2008.
[9]姚军.浙江省疫苗针对性疾病流行病学[M].杭州:浙江科学技术出版社, 2018.YAO Jun. Epidemiology of vaccine targeted diseases in Zhejiang[M]. Hangzhou:Zhejiang Science and Technology Press, 2018.
[10]吴伟慎,何海艳,李超,等.天津市2005-2014年不同类别乙型病毒性肝炎流行特征分析[J].公共卫生与预防医学,2015, 26(4):7-9.WU Weishen, HE Haiyan, LI Chao, et al. Epidemiological analysis of different types of hepatitis B in Tianjin(2005-2014)[J]. Journal of Public Health and Preventive Medicine, 2015, 26(4):7-9.
[11]高建华,苏宁,黄若刚,等.北京市2010-2015年病毒性肝炎流行特征分析[J].国际病毒学杂志, 2016, 23(5):308-310.GAO Jianhua, SU Ning, HUANG Ruogang, et al.Epidemiological analysis of viral hepatitis in Beijing from 2010 to 2015[J]. International Journal of Virology, 2016,23(5):308-310.
[12]孙翔,刘元宝,许燕,等. 2006-2015年江苏省急性乙型病毒性肝炎发病率趋势分析[J].现代预防医学, 2017, 44(12):2279-2282.SUN Xiang, LIU Yuanbao, XU Yan, et al. Trend analysis of the incidence of acute hepatitis B in Jiangsu province between 2006 to 2015[J]. Modern Preventive Medicine,2017, 44(12):2279-2282.
[13]许盛楠,许琳,康文玉,等. 2007-2016年云南省急性乙型病毒性肝炎流行特征[J].中国疫苗和免疫, 2017, 23(6):647-652.XU Shengnan, XU Lin, KANG Wenyu, et al. Epidemiology of acute hepatitis B in Yunnan province, 2007-2016[J].Chinese Journal of Vaccines and Immunization, 2017,23(6):647-652.
[14] HE Hanqing, ZHOU Yang, XIE Shuyun. Assessment of the duplicate notif iable reporting of hepatitis B infection in Zhejiang province, China, 2005-2015[J]. Vaccine, 2017,35(36):4702-4706.
[15]尚晓鹏,吴晨,吴昊澄,等.浙江省医疗机构传染病报告质量调查[J].浙江预防医学, 2015, 27(6):635-637.SHANG Xiaopeng, WU Chen, WU Haocheng, et al.Investigation on the quality of infectious disease reporting in medical institutions of Zhejiang province[J]. Zhejiang Journal of Preventive Medicine, 2015, 27(6):635-637.
[16]中华人民共和国国家卫生和计划生育委员会.中国病毒性肝炎防治规划(2017-2020年)[J].中国病毒病杂志, 2018, 8(1):1-5.National Health and Family Planning Commission. Action plan for the prevention and treatment of viral hepatitis in China(2017-2020)[J]. Chinese Journal of Viral Diseases,2018, 8(1):1-5.
[17]周洋,何寒青,邓璇,等.浙江省乙型病毒性肝炎监测报告质量分析[J].预防医学, 2017, 29(9):865-868+873.ZHOU Yang, HE Hanqing, DENG Xuan, et al. An analysis on the hepatitis B report data from a pilot surveillance in Zhejiang province[J]. Preventive Medicine, 2017, 29(9):865-868+873.
[18]姚军,韩晓军,周绍聪,等.浙江省病毒性肝炎流行病学特点及对策[J].浙江预防医学, 1995, 7(1):13-15+26.YAO Jun, HAN Xiaojun, ZHOU Shaocong, et al.Epidemiological characteristics and countermeasures of viral hepatitis in Zhejiang province[J]. Zhejiang Journal of Preventive Medicine, 1995:7(1):13-15+26.
[19] ZHOU Y, HE H, DENG X, et al. Significant reduction in notification and seroprevalence rates of hepatitis B virus infection among the population of Zhejiang province,China, aged between 1 and 29 years from 2006 to 2014[J].Vaccine, 2017, 35(34):4355-4361.
[20]徐爱强,张丽.中国成年人乙型肝炎疫苗免疫策略的循证与思考[J].中华预防医学杂志, 2016, 50(6):473-477.XU Aiqiang, ZHANG Li. Immunization strategy of hepatitis B vaccines among adults in China:evidence based-medicine and consideration[J]. Chinese Journal of Preventive Medicine, 2016, 50(6):473-477.
[21] WANG F, ZHANG G, ZHENG H, et al. Post-vaccination serologic testing of inf ants born to hepatitis B surf ace antigen positive mothers in 4 provinces of China[J].Vaccine, 2017, 35(33):4229-4235.
[22]宋姝娟,黄春萍,刘牧文.杭州市2005-2012年乙型病毒性肝炎发病特征和报告质量分析[J].中国预防医学杂志, 2015,16(1):52-56.SONG Shujuan, HUANG Chunping, LIU Muwen.Epidemiological characteristics and report quality analysis for acute hepatitis B in Hangzhou, 2005-2012[J]. Chinese Preventive Medicine, 2015, 16(1):52-56.
[23]徐爱强,张丽.中国病毒性肝炎血清流行病学调查的回顾与意义[J].中华预防医学杂志, 2017, 51(6):457-460.XU Aiqiang, ZHANG Li. The review and significance of national seroepidemiological surveys on viral hepatitis in China[J]. Chinese Journal of Preventive Medicine, 2017,51(6):457-460.