马钱子风湿丸结合针刀整体松解术对腰椎间盘突出症患者血清T细胞亚群的影响
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摘要
目的:观察马钱子风湿丸结合针刀整体松解术治疗腰椎间盘突出症对患者血清T细胞亚群的影响。方法:120例随机分为观察组与对照组各60例。观察组给予马钱子风湿丸结合针刀松解术治疗,对照组采用电针治疗,检测治疗前后T细胞亚群。结果:观察组治疗后CD4~+、CD4~+/CD8~+均较治疗前显著升高(P<0.05),治疗后CD8~+观察组明显低于对照组(P<0.05),治疗后CD4~+/CD8~+两组比较差异有统计学意义(P<0.01)。结论:马钱子风湿丸配合针刀松解术治疗腰椎间盘突出症能增强血清中T淋巴细胞亚群的活性,改善机体免疫功能,缓解临床症状。
Objective:To observe the effect on Serum T cell subsets in patients with lumbar disc herniation treated by Maqianzi Fengshi pills combined with acupotomy lysis. Method:120 cases of lumbar disc herniation were randomly divided into the observation group and the control group,60 cases in each group. The observation group were treated with Maqianzi Fengshi pills combined with acupotomy lysis while the control group were treated electroacupuncture. T cell subsets of the patients were detected before and after treatment. Result:CD4~+ and CD4~+/CD8~+ of the observation group after the treatment was significantly higher than that before the treatment(P<0.05). CD8~+ of the observation group after the treatment was significantly lower than that before the treatment(P<0.05).There was statistic significance in CD4~+/CD8~+ between the two groups after the treatment(P<0.01)Conclusion:Maqianzi Fengshi pills combined with acupotomy lysis could enhance the activity of T lymphocyte subsets in patients serum, effectively improve the body's immune function in patients and relieve the clinical symptoms in the treatment of lumbar disc herniation.
Objective:To observe the effect on Serum T cell subsets in patients with lumbar disc herniation treated by Maqianzi Fengshi pills combined with acupotomy lysis. Method:120 cases of lumbar disc herniation were randomly divided into the observation group and the control group,60 cases in each group. The observation group were treated with Maqianzi Fengshi pills combined with acupotomy lysis while the control group were treated electroacupuncture. T cell subsets of the patients were detected before and after treatment. Result:CD4~+ and CD4~+/CD8~+ of the observation group after the treatment was significantly higher than that before the treatment(P<0.05). CD8~+ of the observation group after the treatment was significantly lower than that before the treatment(P<0.05).There was statistic significance in CD4~+/CD8~+ between the two groups after the treatment(P<0.01)Conclusion:Maqianzi Fengshi pills combined with acupotomy lysis could enhance the activity of T lymphocyte subsets in patients serum, effectively improve the body's immune function in patients and relieve the clinical symptoms in the treatment of lumbar disc herniation.
引文
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[2]RONCAROLO MG,Levings MK.The role of different subsets of T regulatory cells in controlling autoimmunity.Curr Opin Immunol.2000;12:676-683.
[3]何维.医学免疫学[M].北京:人民卫生出版社,2010:189.
[4]李先辉,程传国,周永芹,等.外周血T淋巴细胞及TNF-α与颈椎病神经根性痛的相关性研究[J].免疫学杂志,2006,22(6):705.
[5]STOCKINGER B,BOURGEOIS C,KASSIOTIS G.CD4+memory T cells:functional differentiation and homeosta-sis.Immunol Rev.2006,211:39-48.
[6]田鹏,马信龙.外周血T淋巴细胞与腰椎间盘突出类型及直腿抬高试验的相关性[J].中国组织工程研究与临床康复2010,14(2):347-349.
[7]王葵光,胡有谷.腰椎间盘突出症的自身免疫状态[J].中华骨科杂志,1994,14(5):258-262.
[8]BOBECHKO,W.P.HIRSCH.C.Autoimmunerespouse to ncleus pulposus in the rabbit.IBIS,1965.47-B:574.
[9]GEHA.R.S.et al.Cellular abnormalities in patients with elevated serum Ig E levels.J Allery Clin Immunol.1986.78:995.