儿童生长贴对特发性矮小儿童IGF-1和IGFBP-3水平影响
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摘要
目的探讨儿童生长贴对特发性身材矮小儿童血液类胰岛素生长因子-1(IGF-1)和胰岛素生长因子结合蛋白-3(IGFBP-3)水平影响。方法选择2016年1~12月儿科因儿童特发性身材矮小就诊的患儿60例,按是否使用生长贴分为对照组和观察组各30例,对照组为仅采用饮食加运动治疗,观察组在对照组基础上给予自制儿童生长贴,疗程均为12个月。比较两组治疗前后身高增长值及IGF-1和IGFBP-3水平。结果两组治疗12个月后身高增长值比较,观察组显著高于对照组(t=6.40,P<0.01);两组治疗前IGF-1与IGFBP-3水平比较,差异无显著(t=0.61、1.05,P>0.05);治疗12个月后血清IGF-1与IGFBP-3水平比较,观察组显著高于对照组(t=2.83、3.55,P<0.01)。结论儿童生长贴可显著提高特发性身材矮小儿童身高增长值,可增高血液IGF-1和IGFBP-3水平。
Objective To explore the effect of children's growth pasteon the serum levels of insulin-like growth factor-1(IGF-1) and insulin-likegrowth factor binding protein-3(IGFBP-3) in children with idiopathic short stature(ISS).Methods Sixty children with ISS were selected from department of pediatrics from January to December 2016. They were divided into control group and observation group by the use of children's growth paste with 30 patients in each group. Children in control group were treated with diet and exercise therapy, while the observation group added self-made children's growth paste in the foundation of the therapy of the control group and both courses took 12 months.We compared the increment of height and the serum levels of IGF-1 and IGFBP-3 of the two groups before and after treatment. Results After 12-month treatment, the increment of height of the observation group was significantly higher than that of the control group(t=6.40, P<0.01). There was no significant difference in the serum levels of IGF-1 and IGFBP-3 between the two groups before treatment(t=0.61, 1.05, P>0.05). After 12-month treatment, the serum levels of IGF-1 and IGFBP-3 of the observation group were significantly higher than those of the control group(t=2.83, 3.55, P<0.01). Conclusion The use of children's growth paste can significantly improve the increment of height of children with ISS as well as the serum levels of IGF-1 and IGFBP-3.
Objective To explore the effect of children's growth pasteon the serum levels of insulin-like growth factor-1(IGF-1) and insulin-likegrowth factor binding protein-3(IGFBP-3) in children with idiopathic short stature(ISS).Methods Sixty children with ISS were selected from department of pediatrics from January to December 2016. They were divided into control group and observation group by the use of children's growth paste with 30 patients in each group. Children in control group were treated with diet and exercise therapy, while the observation group added self-made children's growth paste in the foundation of the therapy of the control group and both courses took 12 months.We compared the increment of height and the serum levels of IGF-1 and IGFBP-3 of the two groups before and after treatment. Results After 12-month treatment, the increment of height of the observation group was significantly higher than that of the control group(t=6.40, P<0.01). There was no significant difference in the serum levels of IGF-1 and IGFBP-3 between the two groups before treatment(t=0.61, 1.05, P>0.05). After 12-month treatment, the serum levels of IGF-1 and IGFBP-3 of the observation group were significantly higher than those of the control group(t=2.83, 3.55, P<0.01). Conclusion The use of children's growth paste can significantly improve the increment of height of children with ISS as well as the serum levels of IGF-1 and IGFBP-3.
引文
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[2]黄爱娣,李金华,吴潜珍,等.特发性矮小患儿的心理状态及护理对策[J].中国医药导报,2015,12(20):137-140.
[3]葛青玮,朱志颖.IGF-1、IGFBP3及其比值与生长激素缺乏型矮小症的相关性研究[J].临床和实验医学杂志,2017,16(3):255-257.
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[9]张宇,李温慈,应克伟,等.IGF-1与IGFBP-3在未青春发育特发性矮小儿童生长激素治疗中的意义[J].中国现代医生,2013,51(33):50-52.
[10]刘思思,班博,潘慧,等.济宁地区6~16岁儿童青少年矮小症患病现况研究[J].中华诊断学电子杂志,2017,5(3):188-191.
[11]陈显军,杨琍琦,刘德云,等.安徽省三个城市儿童矮小症患病率分析[J].中国儿童保健杂志,2017,25(4):401-405.
[12]赵强,李志洁.重组人生长激素治疗儿童生长激素缺乏症和特发性矮小症45例疗效观察[J].中国妇幼保健,2016,31(6):1300-1302.
[13]许乔雯,叶进.特发性矮小症中西医治疗进展[J].山东中医药大学学报,2015,39(6):569-572.
[14]琚玮,王素亭,巩治华.中医治未病思想在矮小症防治中的运用[J].中医研究,2014,27(12):9-10.
[15]毕美芬,张雪锋,沈立飚.针刺四缝穴合消积理脾法对30例矮小症患儿胰岛素样生长因子和身高的影响[J].新中医,2015,47(2):183-185.
[16]朱玉芳,潘革.GH-IGF-1轴与儿童生长发育[J].医学综述,2008,(3):321-323.
[17]刘小惠,吴小华.胰岛素样生长因子-1与促排卵结局及抑制素B、血管内皮生长因子的相关研究[J].生殖医学杂志,2018,(2):123-129.
[18]张腊红,陈兆军,林艳,等.检测血清IGF-1和IGFBP-3对儿童生长激素缺乏症的诊断价值[J].放射免疫学杂志,2004,(2):99-100.
[19]覃月和,潘革,李惠玲,等.6个月内婴儿血清生长激素、胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3变化与体格发育的关系[J].临床儿科杂志,2010,28(8):729-732.
[20]应小明,赵蓓,赵佳佳.IGF-1/IGFBP-3对生长激素缺乏型矮小症患儿诊断和疗效评估的价值[J].中国农村卫生事业管理,2013,33(1):68-70.
[2]黄爱娣,李金华,吴潜珍,等.特发性矮小患儿的心理状态及护理对策[J].中国医药导报,2015,12(20):137-140.
[3]葛青玮,朱志颖.IGF-1、IGFBP3及其比值与生长激素缺乏型矮小症的相关性研究[J].临床和实验医学杂志,2017,16(3):255-257.
[4]颜惠萍,周利,彭榕,等.重组人生长激素联合心理干预治疗矮小症患儿的临床研究[J].中国现代医生,2017,55(9):82-84.
[5]俞建,时毓民.矮小症的中医临床研究与展望[J].中国中西医结合儿科学,2015,7(3):193-195.
[6]中华医学会儿科学会内分泌遗传代谢学组.矮身材儿童诊治指南[J].中华儿科杂志,2008,46(6):428-430.
[7]孟令哲,辛颖.儿童身材矮小的病因探讨[J].中国中西医结合儿科学,2015,7(3):203-207.
[8]孙海玲,班博,潘慧,等.生长激素激发试验在矮小儿童临床诊断中的价值[J].中华诊断学电子杂志,2014,2(2):21-24.
[9]张宇,李温慈,应克伟,等.IGF-1与IGFBP-3在未青春发育特发性矮小儿童生长激素治疗中的意义[J].中国现代医生,2013,51(33):50-52.
[10]刘思思,班博,潘慧,等.济宁地区6~16岁儿童青少年矮小症患病现况研究[J].中华诊断学电子杂志,2017,5(3):188-191.
[11]陈显军,杨琍琦,刘德云,等.安徽省三个城市儿童矮小症患病率分析[J].中国儿童保健杂志,2017,25(4):401-405.
[12]赵强,李志洁.重组人生长激素治疗儿童生长激素缺乏症和特发性矮小症45例疗效观察[J].中国妇幼保健,2016,31(6):1300-1302.
[13]许乔雯,叶进.特发性矮小症中西医治疗进展[J].山东中医药大学学报,2015,39(6):569-572.
[14]琚玮,王素亭,巩治华.中医治未病思想在矮小症防治中的运用[J].中医研究,2014,27(12):9-10.
[15]毕美芬,张雪锋,沈立飚.针刺四缝穴合消积理脾法对30例矮小症患儿胰岛素样生长因子和身高的影响[J].新中医,2015,47(2):183-185.
[16]朱玉芳,潘革.GH-IGF-1轴与儿童生长发育[J].医学综述,2008,(3):321-323.
[17]刘小惠,吴小华.胰岛素样生长因子-1与促排卵结局及抑制素B、血管内皮生长因子的相关研究[J].生殖医学杂志,2018,(2):123-129.
[18]张腊红,陈兆军,林艳,等.检测血清IGF-1和IGFBP-3对儿童生长激素缺乏症的诊断价值[J].放射免疫学杂志,2004,(2):99-100.
[19]覃月和,潘革,李惠玲,等.6个月内婴儿血清生长激素、胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3变化与体格发育的关系[J].临床儿科杂志,2010,28(8):729-732.
[20]应小明,赵蓓,赵佳佳.IGF-1/IGFBP-3对生长激素缺乏型矮小症患儿诊断和疗效评估的价值[J].中国农村卫生事业管理,2013,33(1):68-70.