口服骨化三醇、钙剂治疗小儿佝偻病的临床效果分析
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摘要
目的探讨口服骨化三醇、钙剂治疗小儿佝偻病的临床效果。方法选取2017年6月～2018年6月在我院儿科治疗的小儿佝偻病患儿84例,随机分为两组,对照组常规口服维生素D滴剂及醋酸钙治疗,观察组口服骨化三醇联合醋酸钙治疗,比较两组临床疗效、各项血生化指标变化、骨密度指标变化、身高及体质量变化。结果观察组治疗有效率为97.62%,明显高于对照组的78.57%,差异有统计学意义(P<0.05);观察组治疗后血钙、血磷、25-(OH)D3明显高于对照组,而BALP明显低于对照组,差异有统计学意义(P<0.05);观察组治疗后桡骨及尺骨盐水平、骨密度明显高于对照组,差异有统计学意义(P<0.05);观察组治疗后身高增长、体质量增长明显高于对照组,夜惊、多汗、枕秃等发生率明显低于对照组,差异有统计学意义(P<0.05)。结论口服骨化三醇、钙剂治疗小儿佝偻病临床效果显著,有效提升血钙水平和骨密度,促进患儿生长发育,降低临床症状的发生率,具有积极的临床意义。
Objective To investigate the clinical effect of oral calcitriol and calcium in the treatment of infantile rickets. Methods A total of 84 children with pediatric rickets treated in the department of pediatrics of our hospital from June 2017 to June 2018 were randomly divided into two groups. The control group received conventional oral vitamin D drops and calcium acetate. The observation group received oral calcitriol combined with calcium acetate. The clinical efficacy, blood biochemical changes, bone mineral density changes, height and body weight changes were compared between the two groups. Results The effective rate of the observation group was 97.62%, which was significantly higher than that of the control group(78.57%), and the difference was statistically significant(P<0.05). The blood calcium, blood phosphorus and 25-(OH)D3 in the observation group after treatment were significantly higher those in the control group.The BALP in the observation group was significantly lower than that of the control group, and the difference was statistically significant(P<0.05). The tibia, ulnar salt level and bone mineral density were significantly higher in the observation group than those in the control group(P<0.05). The height growth and body mass growth of the observation group after treat ment were significantly higher than those of the control group. The incidences of night terror, sweating, and baldness were significantly lower than those of the control group, and the difference was statistically significant(P<0.05).Conclusion Oral calcitriol and calcium are effective in treating children with rickets, which effectively improve blood calcium level and bone density, promote growth and development of children, reduce the incidence of clinical symptoms, and have positive clinical significance.
Objective To investigate the clinical effect of oral calcitriol and calcium in the treatment of infantile rickets. Methods A total of 84 children with pediatric rickets treated in the department of pediatrics of our hospital from June 2017 to June 2018 were randomly divided into two groups. The control group received conventional oral vitamin D drops and calcium acetate. The observation group received oral calcitriol combined with calcium acetate. The clinical efficacy, blood biochemical changes, bone mineral density changes, height and body weight changes were compared between the two groups. Results The effective rate of the observation group was 97.62%, which was significantly higher than that of the control group(78.57%), and the difference was statistically significant(P<0.05). The blood calcium, blood phosphorus and 25-(OH)D3 in the observation group after treatment were significantly higher those in the control group.The BALP in the observation group was significantly lower than that of the control group, and the difference was statistically significant(P<0.05). The tibia, ulnar salt level and bone mineral density were significantly higher in the observation group than those in the control group(P<0.05). The height growth and body mass growth of the observation group after treat ment were significantly higher than those of the control group. The incidences of night terror, sweating, and baldness were significantly lower than those of the control group, and the difference was statistically significant(P<0.05).Conclusion Oral calcitriol and calcium are effective in treating children with rickets, which effectively improve blood calcium level and bone density, promote growth and development of children, reduce the incidence of clinical symptoms, and have positive clinical significance.
引文
[1]王华芳,赵飞.口服骨化三醇、钙剂治疗小儿佝偻病的疗效观察[J].中外医学研究,2015,13(15):123-124.
[2]陈虾,邓晓燕,叶郁辉,等.维生素AD波浪式剂量给药方法对预防婴儿维生素D缺乏病的效果与意义[J].中国全科医学,2015,18(12):1425.
[3]冯海霞,万燕萍.维生素D缺乏与儿童代谢综合征关系的研究现状[J].中华实用儿科临床杂志,2013,28(19):1514-1545.
[4]胡亚美,江载芳.诸福棠实用儿科学[M].第7版.北京:人民卫生出版社,2002:536-537.
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[6]居星耀,盛红斌,沈健.锌、维生素D、钙联用对婴幼儿佝偻病疗效及对生化指标和骨密度的影响[J].儿科药学杂志,2015,21(5):21-24.
[7]于立君,杜秋影,姚笠.骨化三醇治疗佝偻病的疗效[J].实用儿科临床杂志,2011,26(23):1829-1830.
[8]孙志贤.骨化三醇在治疗维生素D缺乏性佝偻病中的研究[J].黑龙江医药,2017,30(5):1031-1033.
[9]游诚,钟燕,赵莎,等.大剂量口服维生素D3治疗婴幼儿维生素D缺乏性佝偻病的临床疗效观察[J].中国医师杂志,2015,17(7):1088-1091.
[10]郭敬民,欧萍,邱君,等.锌钙维生素D3联用对佝偻病疗效及血微量元素影响的临床研究[J].现代预防医学,2013,40(15):2799-2801.
[11]郭伟,何淑旺,刘长涛,等.维生素AD滴剂联合用药的研究进展[J].临床合理用药杂志,2017,10(1):169-170.
[12]沙业霞. 671例婴幼儿佝偻病调查分析[J].现代医院,2014,14(5):153-154,156.
[13]谢荣.骨化三醇治疗小儿佝偻病疗效观察[J].吉林医学,2014,35(33):7369-7370.
[14]袁帅.试析醋酸钙加维生素AD治疗小儿佝偻病的临床疗效[J].当代医学,2018,24(1):35-36.
[15]刘红梅,李秀丽,周晓梅,等.骨化三醇治疗小儿佝偻病疗效对比观察[J].人民军医,2015,58(8):907-908.
[2]陈虾,邓晓燕,叶郁辉,等.维生素AD波浪式剂量给药方法对预防婴儿维生素D缺乏病的效果与意义[J].中国全科医学,2015,18(12):1425.
[3]冯海霞,万燕萍.维生素D缺乏与儿童代谢综合征关系的研究现状[J].中华实用儿科临床杂志,2013,28(19):1514-1545.
[4]胡亚美,江载芳.诸福棠实用儿科学[M].第7版.北京:人民卫生出版社,2002:536-537.
[5]刘玉静.骨化三醇联合维生素D对佝偻病患儿骨骼生长发育的影响[J].实用中西医结合临床,2017,17(11):87-88.
[6]居星耀,盛红斌,沈健.锌、维生素D、钙联用对婴幼儿佝偻病疗效及对生化指标和骨密度的影响[J].儿科药学杂志,2015,21(5):21-24.
[7]于立君,杜秋影,姚笠.骨化三醇治疗佝偻病的疗效[J].实用儿科临床杂志,2011,26(23):1829-1830.
[8]孙志贤.骨化三醇在治疗维生素D缺乏性佝偻病中的研究[J].黑龙江医药,2017,30(5):1031-1033.
[9]游诚,钟燕,赵莎,等.大剂量口服维生素D3治疗婴幼儿维生素D缺乏性佝偻病的临床疗效观察[J].中国医师杂志,2015,17(7):1088-1091.
[10]郭敬民,欧萍,邱君,等.锌钙维生素D3联用对佝偻病疗效及血微量元素影响的临床研究[J].现代预防医学,2013,40(15):2799-2801.
[11]郭伟,何淑旺,刘长涛,等.维生素AD滴剂联合用药的研究进展[J].临床合理用药杂志,2017,10(1):169-170.
[12]沙业霞. 671例婴幼儿佝偻病调查分析[J].现代医院,2014,14(5):153-154,156.
[13]谢荣.骨化三醇治疗小儿佝偻病疗效观察[J].吉林医学,2014,35(33):7369-7370.
[14]袁帅.试析醋酸钙加维生素AD治疗小儿佝偻病的临床疗效[J].当代医学,2018,24(1):35-36.
[15]刘红梅,李秀丽,周晓梅,等.骨化三醇治疗小儿佝偻病疗效对比观察[J].人民军医,2015,58(8):907-908.