鲍曼不动杆菌噬菌体的研究进展
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摘要
鲍曼不动杆菌能引起严重的院内感染,近年来鲍曼不动杆菌的耐药性越来越强,给治疗和控制感染带来极大困难。噬菌体可在宿主菌内复制并可破坏宿主菌,而对动植物没有毒性。因此,噬菌体以其特有的自然特征有望成为较好的抗菌制剂,作为一种新兴的治疗方法,已经越来越受到人们的关注,对噬菌体展开广泛和深入的研究具有重要的基础意义和潜在的临床应用价值。
Acinetobacter baumannii can cause serious nosocomial infection. The drug resistance of Acinetobacter baumannii in recent years is becoming more and more strong,resulting in enormous difficulties to the treatment and control of the infection. Phages can reproduce in the hosts and destroy the host bacteria while having no toxicity to animals and plants. Therefore,phages with their unique natural features are expected to become better antimicrobial agents. They have drawn increasingly more attention as an emerging treatment method. Extensive and in-depth researches are of important significance and potential clinical application value.
Acinetobacter baumannii can cause serious nosocomial infection. The drug resistance of Acinetobacter baumannii in recent years is becoming more and more strong,resulting in enormous difficulties to the treatment and control of the infection. Phages can reproduce in the hosts and destroy the host bacteria while having no toxicity to animals and plants. Therefore,phages with their unique natural features are expected to become better antimicrobial agents. They have drawn increasingly more attention as an emerging treatment method. Extensive and in-depth researches are of important significance and potential clinical application value.
引文
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[15]Yang H,Liang L,Lin S,et al.Isolation and characterization of a virulent bacteriophage AB 1 of Acinetobacter baumannii[J].BMC Microbiol,2010,10(4):131-141.
[16]YU Long,WANG Jie,ZHAO Jian-Jun.Isolation of Escherichia coli phages and their biological characteristics[J].Bulletin Acad Milit Med Sci,2008,32(5):432-435.(in Chinese)于龙,王洁,赵建军.两株大肠杆菌烈性噬菌体的分离与生物学特征研究[J].军事医学科学院院刊,2008,32(5):432-435.
[17]PENG Fan,TONG Yi-gang,BAI Chang-qing.Isolation,biological characteristics and preservation methods of multidrug-resistant Acinetobacter baumannii bacteriophage IME-AB6[J].Lett Biotechnol,2013,0(5):641-644.(in Chinese)彭帆,童贻刚,柏长青.多耐药鲍曼不动杆菌噬菌体IME-AB6的分离、生物特性[J].生物技术通讯,2013,24(5):641-643.
[18]ZHANG Na,LI Shu-guang,CHEN Jin-long,et al.Advance of bacteriophages as therapeutic agents in bacterial infection[J].Chin Animal Husbandry&Veterin Med,2011,38(9):221-224.
[19]YE Dao-cheng,ZHU Cheng-gang,SHI Feng.Advances about the studies of phage lysins[J].Chin Biotechnol,2005,25(10):78-82.(in Chinese)叶道成,朱成钢,史锋.噬菌体溶壁酶研究进展[J].中国生物工程杂志,2005,25(10):78-82.
[20]Lin NT,Chiou PY,Chang LK,et al.Isolation and characterization ofФAB2:a novel bacteriophage of Acinetobacter baumannii[J].Res Microbiol,2010,161(4):308-314.
[21]LIANG Li,YANG Hong-jiang,JIN Xin.Purification of Acinetobacter baumannii bacteriophage[J].J Biol,2010,27(4):88-90,93.(in Chinese)梁莉,杨洪江,金鑫.鲍曼不动杆菌烈性噬菌体的分离与纯化[J].生物学杂志,2010,27(4):88-93.
[22]YU Jing-dan,SHI Hong-yan,WANG Dan,et al.Biologic characteristics of bacteriophages specific to Acinetobacter baumannii[J].J Microbiol,2013,33(2):17-23.(in Chinese)余静丹,史红艳,王丹,等.鲍曼不动杆菌噬菌体生物学特性的研究[J].微生物学杂志,2013,33(2):17-23.
[23]XU Yan,XIONG Hong-yan,SONG Jiang-yong,et al.Biological properties of an E.coli bacteriophage with broad host range[J].Acta Acad Med Milit Tertiae,2003,25(23):2106-2108.(in Chinese)徐焰,熊鸿燕,宋建勇,等.1株宽宿主谱大肠杆菌噬菌体的生物学特性观察[J].第三军医大学学报,2003,25(23):2106-2108.
[24]LIU Xiao-fei,REN Hui-ying,LIU Wen-hua,et al.Morphological observation on lytic cycle of bacteriophag Bp7[J].J Chin Electron Microscopy Society,2010,29(2):182-184.(in Chinese)刘霄飞,任慧英,刘文华,等.大肠杆菌噬菌体Bp7溶菌周期的电镜观察[J].电子显微学报,2010,29(2):182-184.
[25]HUANG Zhi-cheng,WANG Shi-wen,LI Ke-mei,et al.Isolation and lysis spectrum analysis of Acinetobacter bacteriophages[J].Chin J Nosocomiol,2009,19(3):268-270.(in Chinese)黄至澄,王世文,李恪梅,等.不动杆菌属噬菌体分离及其裂解谱分析[J].中华医院感染学杂志,2009,19(3):268-270.
[26]ZHANG Jie,LUO Yong-ai.Isolation and biological characteristics of phages of carbapenem-resistant Acinetobacter baumannii[J].J Shanghai Jiaotong Univ:Med Sci,2012,32(5):589-593.(in Chinese)张劼,罗永艾.耐碳青霉烯类鲍曼不动杆菌噬菌体的分离鉴定及其生物学特性[J].上海交通大学学报(医学版),2012,32(5):589-593.
[27]Merabishvili M,Pirnay JP,Verbeken G,et al.Quality-con trolled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trials[J].PLo S One,2009,4(3):e4944.
[28]Carvalho CM,Gannon BW,Halfhide DE,et al.The in vivo efficacy of two administration routes of a phage cocktail to reduce numbers of Campylobacter coli and Campylobacter jejuni in chickens[J].BMC Microbiol,2010,1(10):232.
[29]GAO Cheng-xiu,YAN Ya-xian.Advance in bacteriophages as therapeutic agents[J].Chin J Veterin Sci Technol,2007,37(7):641-644.(in Chinese)高成秀,严亚贤.噬菌体治疗制剂的研究进展[J].中国兽医科技,2007,37(7):641-644.
[30]SHI Yan-hong,YU Jing-dan,WAN Dan,et al.Purification of Acinetobacter baumannii bacteriophages by ultra filtration combined with density gradient centrifugation[J].Chin J Microecol,2013,25(3):350-352.(in Chinese)史艳红,余静丹,王丹,等.超滤过结合密度梯度离心纯化鲍曼不动杆菌噬菌体方法的建立[J].中国微生态学杂志,2013,25(3):350-352.
[2]GUO Xiao-kui.How to conquer bacteria in post-antibiotic era?[J].J Shanghai Jiaotong Univ(Med Sci),2012,32(11):1401-1403.(in Chinese)郭晓奎.后抗生素时代我们如何征服细菌?[J].上海交通大学学报(医学版),2012,32(11):1401-1403.
[3]WANG Jing,WANG Jin,SUN Yun-feng,et al.Recent advance in therapeutic Bacteriophage preparation[J].Food&Drug,2011,13(9):66-70.(in Chinese)王静,王劲,孙运峰,等.治疗性噬菌体制剂的研究进展[J].食品与药品,2011,13(9):66-70.
[4]JING Tao,WU Yi-mou.Pathogen biology[M].Beijing:People's Medical Publishing House,2013:150-152.(in Chinese)景涛,吴移谋.病原生物学[M].北京:人民卫生出版社,2013:150-152.
[5]Bukhari SZ,Hussain WM,Banjar AA,et al.Application of ventilator care bundle and its impact on ventilator associated pneumonia incidence rate in the adult intensive care unit[J].Saudi Med J,2012,33(3):278-283.
[6]ZHU Feng-jiao.Distribution of acinetobacter baumannii infection and surveillance of drug resistance[J].Chinese Journal of Nosocomiology,2011,21(5):1010-1012.(in Chinese)朱凤娇.鲍氏不动杆菌医院感染分布及耐药性监测[J].中华医院感染学杂志,2011,21(5):1010-1012.
[7]Dijkshoorn L,Nemec A,Seifert H.An increasing threat in hospitals:multidrug-resistant Acinetobacter baumannii[J].Nat Rev Microbiol,2007,5(12):939-951.
[8]Yuan Z,Tam VH.Polymyxin B:a naw strategy for multidrug-resistant Gram-negative organisims[J].Epert Opin Investing Drugs,2008,17(5):661-668.
[9]LINGing Bao-dong.Multidrug resistance in Acinetobacter baumanni:Mechanisms and anti-infective therapy[J].Chinese Journal of Antibiotics,2010,35(4)):241-254.(in Chinese)凌保东.鲍曼不动杆菌抗生素多重耐药性:耐药机制与感染治疗对策[J].中国抗生素杂志,2010,35(4):241-254.
[10]HUANG Wei,LI Xu-tingz,LIU Xing-fu.The research progress of bacterial biofilm and drug resistance[J].Inner Mongolian J Animal Sci Product,2012(8):81-83.(in Chinese)黄伟,李旭廷,刘兴福.细菌生物膜与细菌耐药性研究进展[J].内蒙古畜牧科学,2012(8):81-83.
[11]CHEN Tie-zhu,LI Xiao-sheng,ZENG Wen-kui,et al.Research and progress of drug-resistant mechanism of bacterial biofilm[J].J Clin Rehabilitat Tissue Engin Res,2010,14(12):2205-2208.(in Chinese)陈铁柱,李晓声,曾文魁,等.细菌生物膜耐药机制的研究与进展[J].中国组织工程研究与临床康复,2010,14(12):2205-2208.
[12]Carlton RM,Noordman WH,Biswas B,et al.Bacteriophage P100 for control of Listeria monocytogenes in foods:genome sequence,bioinformatic analyses,oral toxicity study,and application[J].Regul Toxicol Pharmacol,2005,43(3):301-312.
[13]CHEN Xiao-chun,WANG Ji-wen,CAO Yong-chang,et al.Advances in bacteriophage therapy against bacterial disease[J].Prog Veterin Med,2005,26(1):32-35.(in Chinese)陈晓春,王继文,曹永长,等.噬菌体在疾病治疗方面的应用与研究[J].动物医学进展,2005,26(1):32-35.
[14]WANG Sheng,TONG Yi-gang.Recent advance in bacteriophage therapy[J].Microbiol Chin,2009,36(7):1019-1024.(in Chinese)王盛,童贻刚.噬菌体治疗研究进展[J].微生物学通报,2009,36(7):1019-1024.
[15]Yang H,Liang L,Lin S,et al.Isolation and characterization of a virulent bacteriophage AB 1 of Acinetobacter baumannii[J].BMC Microbiol,2010,10(4):131-141.
[16]YU Long,WANG Jie,ZHAO Jian-Jun.Isolation of Escherichia coli phages and their biological characteristics[J].Bulletin Acad Milit Med Sci,2008,32(5):432-435.(in Chinese)于龙,王洁,赵建军.两株大肠杆菌烈性噬菌体的分离与生物学特征研究[J].军事医学科学院院刊,2008,32(5):432-435.
[17]PENG Fan,TONG Yi-gang,BAI Chang-qing.Isolation,biological characteristics and preservation methods of multidrug-resistant Acinetobacter baumannii bacteriophage IME-AB6[J].Lett Biotechnol,2013,0(5):641-644.(in Chinese)彭帆,童贻刚,柏长青.多耐药鲍曼不动杆菌噬菌体IME-AB6的分离、生物特性[J].生物技术通讯,2013,24(5):641-643.
[18]ZHANG Na,LI Shu-guang,CHEN Jin-long,et al.Advance of bacteriophages as therapeutic agents in bacterial infection[J].Chin Animal Husbandry&Veterin Med,2011,38(9):221-224.
[19]YE Dao-cheng,ZHU Cheng-gang,SHI Feng.Advances about the studies of phage lysins[J].Chin Biotechnol,2005,25(10):78-82.(in Chinese)叶道成,朱成钢,史锋.噬菌体溶壁酶研究进展[J].中国生物工程杂志,2005,25(10):78-82.
[20]Lin NT,Chiou PY,Chang LK,et al.Isolation and characterization ofФAB2:a novel bacteriophage of Acinetobacter baumannii[J].Res Microbiol,2010,161(4):308-314.
[21]LIANG Li,YANG Hong-jiang,JIN Xin.Purification of Acinetobacter baumannii bacteriophage[J].J Biol,2010,27(4):88-90,93.(in Chinese)梁莉,杨洪江,金鑫.鲍曼不动杆菌烈性噬菌体的分离与纯化[J].生物学杂志,2010,27(4):88-93.
[22]YU Jing-dan,SHI Hong-yan,WANG Dan,et al.Biologic characteristics of bacteriophages specific to Acinetobacter baumannii[J].J Microbiol,2013,33(2):17-23.(in Chinese)余静丹,史红艳,王丹,等.鲍曼不动杆菌噬菌体生物学特性的研究[J].微生物学杂志,2013,33(2):17-23.
[23]XU Yan,XIONG Hong-yan,SONG Jiang-yong,et al.Biological properties of an E.coli bacteriophage with broad host range[J].Acta Acad Med Milit Tertiae,2003,25(23):2106-2108.(in Chinese)徐焰,熊鸿燕,宋建勇,等.1株宽宿主谱大肠杆菌噬菌体的生物学特性观察[J].第三军医大学学报,2003,25(23):2106-2108.
[24]LIU Xiao-fei,REN Hui-ying,LIU Wen-hua,et al.Morphological observation on lytic cycle of bacteriophag Bp7[J].J Chin Electron Microscopy Society,2010,29(2):182-184.(in Chinese)刘霄飞,任慧英,刘文华,等.大肠杆菌噬菌体Bp7溶菌周期的电镜观察[J].电子显微学报,2010,29(2):182-184.
[25]HUANG Zhi-cheng,WANG Shi-wen,LI Ke-mei,et al.Isolation and lysis spectrum analysis of Acinetobacter bacteriophages[J].Chin J Nosocomiol,2009,19(3):268-270.(in Chinese)黄至澄,王世文,李恪梅,等.不动杆菌属噬菌体分离及其裂解谱分析[J].中华医院感染学杂志,2009,19(3):268-270.
[26]ZHANG Jie,LUO Yong-ai.Isolation and biological characteristics of phages of carbapenem-resistant Acinetobacter baumannii[J].J Shanghai Jiaotong Univ:Med Sci,2012,32(5):589-593.(in Chinese)张劼,罗永艾.耐碳青霉烯类鲍曼不动杆菌噬菌体的分离鉴定及其生物学特性[J].上海交通大学学报(医学版),2012,32(5):589-593.
[27]Merabishvili M,Pirnay JP,Verbeken G,et al.Quality-con trolled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trials[J].PLo S One,2009,4(3):e4944.
[28]Carvalho CM,Gannon BW,Halfhide DE,et al.The in vivo efficacy of two administration routes of a phage cocktail to reduce numbers of Campylobacter coli and Campylobacter jejuni in chickens[J].BMC Microbiol,2010,1(10):232.
[29]GAO Cheng-xiu,YAN Ya-xian.Advance in bacteriophages as therapeutic agents[J].Chin J Veterin Sci Technol,2007,37(7):641-644.(in Chinese)高成秀,严亚贤.噬菌体治疗制剂的研究进展[J].中国兽医科技,2007,37(7):641-644.
[30]SHI Yan-hong,YU Jing-dan,WAN Dan,et al.Purification of Acinetobacter baumannii bacteriophages by ultra filtration combined with density gradient centrifugation[J].Chin J Microecol,2013,25(3):350-352.(in Chinese)史艳红,余静丹,王丹,等.超滤过结合密度梯度离心纯化鲍曼不动杆菌噬菌体方法的建立[J].中国微生态学杂志,2013,25(3):350-352.