乌梅颗粒制备工艺研究
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摘要
为确定乌梅颗粒的最佳制备工艺,采用正交试验的方法,对乌梅颗粒的提取工艺进行研究、通过颗粒的成型率、流动性和有效成分的检测等条件对制备成型工艺进行摸索,结果表明,称取处方量乌梅、柿饼和诃子经提取浓缩后得浸膏相对密度为1.30～1.35,黄连和姜黄采用混合粉碎,以3000 r/min转速混合30 min。颗粒剂辅料选用蔗糖和糊精,其浸膏+药粉∶蔗糖∶糊精最佳比例为1∶0.3∶1。乌梅颗粒的制备工艺简单,质量可控,可作为最佳制备工艺。
To determine the best preparation technology of ebony particles,using the method of orthogonal test,the extraction process of ebony particles are studied,through particles forming rate,liquidity and effective components of detection conditions on the preparation for molding process,the results showed that the said take prescriptions of plum,dried persimmon and myrobalan after extraction enrichment to extract the relative density of1.30 ～ 1.35,rhizoma coptidis and turmeric with mixed shattered,30 min to 3000 r/min speed mixed.The granule excipients were sucrose and dextrin,and the best proportion of the extract+powder: sucrose: dextrin was 1 ∶ 0.3 ∶ 1.The preparation process of wumei granules is simple and controllable.
To determine the best preparation technology of ebony particles,using the method of orthogonal test,the extraction process of ebony particles are studied,through particles forming rate,liquidity and effective components of detection conditions on the preparation for molding process,the results showed that the said take prescriptions of plum,dried persimmon and myrobalan after extraction enrichment to extract the relative density of1.30 ～ 1.35,rhizoma coptidis and turmeric with mixed shattered,30 min to 3000 r/min speed mixed.The granule excipients were sucrose and dextrin,and the best proportion of the extract+powder: sucrose: dextrin was 1 ∶ 0.3 ∶ 1.The preparation process of wumei granules is simple and controllable.
引文
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[16]张华月,李琦,付晓伶.乌梅化学成分及药理作用研究进展[J].上海中医药杂志,2017,51(S1):296-300.Zhang H Y,Li Q,Fu X L.Research progress on chemical components and pharmacological effects of wumei[J].Shanghai journal of traditional Chinese medicine Tzu chi,2017 ploidy(S1):296-300.
[17]曹光中.中药浸提物生产工艺学[M].北京:化学工业出版社,2009.Cao G Z.Technology of production of traditional Chinese medicine extract[M].Beijing:chemical industry press,2009.
[2]王智云,孙玉刚,马正云,等.乌梅散颗粒的质量标准研究[J].中国煤炭工业医学杂志,2014,17(04):638-641.Wang Z Y,Sun Y G,Ma Z Y,el al.study on quality standards of wumei powder[J].China Journal of Coal Industry Medicine,2014,17(04):638-641.
[3]殷修城.兽药中药颗粒剂的临床应用[J].养殖技术顾问,2010(05):170.Yin X C.Clinical application of veterinary Chinese medicine granules[J].Breeding Technology Consultant,2010(05):170.
[4]李天.枸芪复肾颗粒的制备工艺及质量标准研究[D].吉林:吉林大学,2015.Li Tian.Study on the preparation technology and quality standards of cotonchi fushen granules[D].Jilin:jilin university,2015.
[5]徐莲英,候世祥,中药制药工艺技术解析[M].北京:人民卫生出版社,2003.Xu L Y,Hou S X,analysis of traditional Chinese medicine pharmaceutical technology[M].Beijing:people's medical publishing house,2003.
[6]黄晓东,葛晓陵,胡坪.中药黄连超细粉碎工艺研究[J].中国粉体技术,2011,17(04):68-70.Huang X D,Ge X L,Hu P.Research on the ultra-fine crushing process of Chinese herb coptis[J].China Powder Technology,2011,17(04):68-70.
[7]谭莹,邱丽颖,茅海亚,等.益元抑瘤汤颗粒剂的成型工艺研究[J].中成药,2013,35(09):2050-2053.Tan Y,Qiu L Y,Mao H Y,el al.Study on molding process of yiyuan antuotang granules[J].Chinese Patent Medicine,2013,35(09):2050-2053.
[8]徐新.正交试验法优选柴胡醇沉工艺[J].中国药业,2006,15(20):37.Xu X.Optimization of chaihu alcohol precipitation process by orthogonal experimental method[J].China Pharmaceutical,2006,15(20):37.
[9]唐勇琛,梁学政,陈惠红,等.正交试验优选五子补肾胶囊水提醇沉工艺[J].中医药院药学杂志,2013,33(23):2002-2004.Tang Y C,Liang X Z,Chen H H,el al.Orthogonal test for the optimization of the water extraction and alcohol precipitation process of wuzi bushen capsule[J].Journal of Traditional Chinese Medicine,2013,33(23):2002-2004.
[10]姜艳玲,张小华,张宏武,等.正交试验法优选健胃清肠合剂的水提醇沉工艺[J].中国实验方剂学杂志,2013,19(17):35-37.Jiang Y L,Zhang X H,Zhang H W,el al.The process of water extraction and alcohol precipitation for jianwei qingchang mixture by orthogonal experimental method[J].Chinese Journal of Experimental Formulation,2013,19(17):35-37.
[11]易艳东,马威,林世和,等.清脉颗粒醇沉工艺的正交优选[J].中国药师,2013,17(4):571-573.Yi Y D,Ma W,Lin S H,el al.Orthogonal optimization of qingmai granule alcohol precipitation process[J].Chinese Pharmacist,2013,17(4):571-573.
[12]侯世祥.中药新制剂成型性研究思路与方法[J].中国中药杂志,2000,25(1):4.Hou S X.Ideas and methods for the study of new formulation of TCM[J].Chinese Journal of Traditional Chinese Medicine,2000,25(1):4.
[13]王北婴,李仪奎.中药新药研制开发技术与方法[M].上海:上海科学技术出版社,2001.Wang B Y,Li Y K.Research and development technology and method of traditional Chinese medicine new drug[M].Shanghai:Shanghai Science and Technology Press,2001.
[14]GB 11986-1989.表面活性剂粉体和颗粒休止角的测量[S].GB 11986-1989.Measurement of resting Angle of surfactant powders and particles[S].
[15]孙宏冉,杨海明,陈志强,等.芩红奶牛乳房灌注液提取工艺研究[J].中国兽药杂志,2016,50(09):26-33.Sun H R,Yang H M,Chen Z Q,el al.Study on extraction technology of breast perfusion liquid in qinqin red cow[J].Chinese Veterinary Drug,2016,50(09):26-33.
[16]张华月,李琦,付晓伶.乌梅化学成分及药理作用研究进展[J].上海中医药杂志,2017,51(S1):296-300.Zhang H Y,Li Q,Fu X L.Research progress on chemical components and pharmacological effects of wumei[J].Shanghai journal of traditional Chinese medicine Tzu chi,2017 ploidy(S1):296-300.
[17]曹光中.中药浸提物生产工艺学[M].北京:化学工业出版社,2009.Cao G Z.Technology of production of traditional Chinese medicine extract[M].Beijing:chemical industry press,2009.