黏附斑激酶及其信号通路在胚胎早期发育中的作用研究进展
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摘要
黏附斑激酶(focal adhesion kinase,FAK)是胞内外信号转导的中枢分子,可以接受胞外的刺激、细胞黏着等各方面的信息以调控细胞的生长、代谢等。现有研究表明,FAK介导的信号传导在胚胎早期发育过程中具有重要作用。本文将介绍FAK信号通路最新的实验和理论进展,对其与胚胎早期发育过程的关系研究进展进行综述,为后续研究提供参考。
Focal adhesion kinase(FAK) is the central molecule of intracellular and extracellular signal transduction, which can accept extracellular stimuli, cell adhesion and other aspects of information to regulate cell growth, metabolism and so on. Existing studies have shown that FAK-mediated signal transduction plays an important role in early embryonic development. This paper introduces the latest experimental and theoretical advances in FAK signaling pathways, and reviews its relationship with early embryonic development and provides a convenient knowledge for subsequent studies.
Focal adhesion kinase(FAK) is the central molecule of intracellular and extracellular signal transduction, which can accept extracellular stimuli, cell adhesion and other aspects of information to regulate cell growth, metabolism and so on. Existing studies have shown that FAK-mediated signal transduction plays an important role in early embryonic development. This paper introduces the latest experimental and theoretical advances in FAK signaling pathways, and reviews its relationship with early embryonic development and provides a convenient knowledge for subsequent studies.
引文
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[14]黄俊.micro RNA-7/FAK在大肠癌的表达及意义[D].南昌:南昌大学,2013.
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[17]王伟.FAK在小鼠早期胚胎发育中的定位表达及功能研究[D].济南:山东师范大学,2014.
[18]Kokkinos MI,Brown HJ,de Iongh RU.Focal adhesion kinase(FAK)expression and activation during lens development[J].Mol Vis,2007,13:418-430.
[19]Zhu J,Luo J,Li Y,et al.HMGB1 induces human non-small cell lung cancer cell motility by activating integrinαvβ3/FAK through TLR4/NF-κB signaling pathway[J].Biochem Biophys Res Commun,2016,480(4):522-527.
[20]Petridou NI,Stylianou P,Christodoulou N,et al.Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos[J].PLo S One,2012,7(8):e42577.
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[22]Uonzalez-Fernandez L,Macias Iarcia B,Loux S,et al.Focal adhesion kinases and calcium/calmodulin-dependent protein kinases regulate protein tyrosine phosphorylation in stallion sperml[J].Biol Reprod,2013,88(6):138.
[23]Pelech S,Jelinkova I,Susor A,et al.Antibody microarray analyses of signal transduction protein expression and phosphory lation during porcine maturation[J].J Proteome Res,2008,7(7):2860-2871.
[24]Fonar Y,Uutkovich YE,Root H,et al.Focal adhesion ki-nase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate[J].Mol Biol Cell,2011,22(13):2409-2421.
[25]Petridou NI,Stylianou P,Skourides PA.A dominant-negative insights to FAK regulation and function in early embryonic morphogenesis[J].Development,2013,140(20):4266-4276.
[2]Alanko J,Ivaska J.Endosomes:Emerging Platforms for Integrin-Mediated FAK Signalling[J].Trends Cell Biol,2016,26(6):22-37.
[3]Béraud C,Dormoy V,Danilin S,et al.Targeting FAK scaffold functions inhibits human renal cell carcinoma growth[J].Int J Cancer,2015,137(7):34-48.
[4]Fonar Y,Frank D.FAK and WNT signaling:the meeting of two pathways in cancer and development[J].Anticancer Agents Med Chem,2011,11(7):600-606.
[5]Zhao X,Peng X,Sun S,et al.Role of kinase-independent and-dependent functions of FAK in endothelial cell survival and barrier function during embryonic development[J].J Cell Biol,2010,189(6):955-965.
[6]Peng X,Wu X,Druso JE,et al.Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase(FAK)conditional knockout mice[J].Proc Nati Acad Sci U S A,2008,105(18):25-31.
[7]张坤.CTGF/整合素/FAK信号通路在肝纤维化中的表达变化以及肝复康的调节作用[D].大连:大连医科大学,2013.
[8]Sanchez AM,Shortrede JE,Laura María Vargas-Roig LM,et al.Retinoic acid induces nuclear FAK translocation and reduces breast cancer cell adhesion through Moesin,FAK,and Paxillin[J].Mol Cell Endocrinol,2016,430:1-11.
[9]Alanko J,Ivaska J.Endosomes:Emerging Platforms for Integrin-Mediated FAK Signalling[J].Trends Cell Biol,2016,277(1):129-141.
[10]Mcinnis LK,Carroll DJ,Kinsey WH.Protein tyrosine kinase signaling during Oocyte maturation and fertilization[J].Mol Reprod Dev,2011,78(11):831-841.
[11]陈玉英,陈克力,潘凤,等.结直肠癌中FAK、FAK p Y397、Akt、NF-κB表达及相关性研究[J].临床肿瘤学杂志,2009,14(3):199-202.
[12]潘宁,章蔼然,牟茂森,等.FAK基因表达对人结直肠癌细胞增殖及运动的影响[J].细胞与分子免疫学杂志,2009,25(9):783-786.
[13]韩少山,刘青光,周振宇,等.FAK在肝细胞癌中的表达及临床病理意义[J].西安交通大学学报(医学版),2013,34(1):81-84,127.
[14]黄俊.micro RNA-7/FAK在大肠癌的表达及意义[D].南昌:南昌大学,2013.
[15]周琼.肺腺癌组织中FAK、CEA、DKK1的表达及FAK可能作用[D].衡阳:南华大学,2014.
[16]Hadjimichael C,Chanoumidou K,Papadopoulou N,et al.Common stemness regulators of embryonic and cancer stem cells[J].World J Stem Cells,2015,7(9):1150-1184.
[17]王伟.FAK在小鼠早期胚胎发育中的定位表达及功能研究[D].济南:山东师范大学,2014.
[18]Kokkinos MI,Brown HJ,de Iongh RU.Focal adhesion kinase(FAK)expression and activation during lens development[J].Mol Vis,2007,13:418-430.
[19]Zhu J,Luo J,Li Y,et al.HMGB1 induces human non-small cell lung cancer cell motility by activating integrinαvβ3/FAK through TLR4/NF-κB signaling pathway[J].Biochem Biophys Res Commun,2016,480(4):522-527.
[20]Petridou NI,Stylianou P,Christodoulou N,et al.Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos[J].PLo S One,2012,7(8):e42577.
[21]Corsi JM,Houbron C,Billuart P,et al.Autophosphorylationindependent and-dependent functions of focal adhesion kinase during development[J].J Biol Chem,2009,284(50):34769-34776.
[22]Uonzalez-Fernandez L,Macias Iarcia B,Loux S,et al.Focal adhesion kinases and calcium/calmodulin-dependent protein kinases regulate protein tyrosine phosphorylation in stallion sperml[J].Biol Reprod,2013,88(6):138.
[23]Pelech S,Jelinkova I,Susor A,et al.Antibody microarray analyses of signal transduction protein expression and phosphory lation during porcine maturation[J].J Proteome Res,2008,7(7):2860-2871.
[24]Fonar Y,Uutkovich YE,Root H,et al.Focal adhesion ki-nase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate[J].Mol Biol Cell,2011,22(13):2409-2421.
[25]Petridou NI,Stylianou P,Skourides PA.A dominant-negative insights to FAK regulation and function in early embryonic morphogenesis[J].Development,2013,140(20):4266-4276.