摘要
目的探讨功能性内镜鼻窦手术(FESS)联合鼻窦炎合剂冲洗对慢性鼻-鼻窦炎(CRS)患者鼻黏膜纤毛功能及生活质量的影响。方法选取90例接受FESS手术的CRS患者,随机分为观察组(n=45)和对照组(n=45)。观察组术后采用鼻窦炎合剂进行术腔冲洗,对照组采用复方氯化钠注射液。比较2组临床疗效、术后术腔清洁时间、术腔上皮化时间及治疗前后纤毛细胞数目/杯状细胞数目比值、鼻腔黏膜纤维传输速率(MTR)、鼻内镜Lund-Kennedy评分、鼻部症状视觉模拟(VAS)评分及鼻腔鼻窦结局测试-20量表(SNOT-20)评分。结果观察组总有效率显著高于对照组(P <0. 05)。观察组术后术腔清洁时间、术腔上皮化时间均显著短于对照组(P <0. 05)。术后6个月,观察组纤毛细胞数目/杯状细胞数目比值、MTR均显著高于对照组(P <0. 05),鼻内镜Lund-Kennedy评分、鼻部症状VAS评分及SNOT-20评分均显著低于对照组(P <0. 05)。结论鼻窦炎合剂能够改善FESS术后患者鼻黏膜纤毛功能,促进患者症状缓解,提高生活质量。
Objective To explore the influence of functional endoscopic sinus surgery( FESS) combined with sinusitis flushing on nasal mucociliary function and quality of life in patients with chronic rhinosinusitis( CRS). Methods A total of 90 CRS patients with FESS were randomly divided into observation group( n = 45) and control group( n = 45). The sinusitis mixture was used in the observation group,while the recurrent sodium chloride was used in the control group. The clinical efficacy,postoperative cavity cleaning time,intra-operative epithelialization time,the ratio of the number of ciliated cells to goblet cell number before and after treatment,nasal mucosal fiber transmission rate( MTR),nasal endoscopic Lund-Kennedy score,nasal symptom visual simulation score( VAS) and nasal sinus outcome test-20 scale( SNOT-20) score were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group( P < 0. 05). The postoperative cavity cleaning time and intra-operative epithelialization time in the observation group were significantly shorter than those in the control group( P <0. 05). At 6 months after operation,the ratio of the number of ciliated cells to the number of goblet cells and MTR in the observation group were significantly higher than those in the control group( P <0. 05),and the endoscopic Lund-Kennedy score,nasal symptom VAS score and SNOT-20 score were significantly lower than those in the control group( P < 0. 05). Conclusion Sinusitis mixture can improve the nasal mucociliary function of patients with FESS relieue symptoms and improve the quality of life.
引文
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