肠道菌群调节与2型糖尿病相关性研究进展
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摘要
糖尿病是全球面临的最普遍、最严重的公共健康问题之一,患病率急剧上升。糖尿病引发的心血管、眼、肾及神经系统等并发症增加了患者致残或致命的风险。共生细菌对人类健康具有重要意义,越来越多的研究表明肠道菌群与糖尿病的发生、发展密切相关。宿主基因、免疫系统、饮食与肠道菌群之间的关系不断被揭示,肠道菌群调节成为糖尿病治疗的有效措施。文章就2型糖尿病人群肠道菌群变化、诱发2型糖尿病的机制以及肠道菌群调节对2型糖尿病治疗进展进行综述。
Diabetes is one of the most prevalent and critical public health problems in the world,with a sharp rise in its incidence,and a significant increase in its complications as cardiovascular,ocular,renal and neurological diseases,resulting in risks for being cripple or fatal.Symbiotic bacteria are of great significance to human health,and more and more studies show that intestinal flora is closely related to the occurrence and development of diabetes.The relationship between host gene,immune system,diet and intestinal flora has been constantly revealed,and the regulation of intestinal flora is an effective measure for diabetes treatment.This article reviews the changes of intestinal flora in type 2 diabetes mellitus,the mechanism of inducing type 2 diabetes and the latest development of the effect of intestinal flora regulation on type 2 diabetes.
Diabetes is one of the most prevalent and critical public health problems in the world,with a sharp rise in its incidence,and a significant increase in its complications as cardiovascular,ocular,renal and neurological diseases,resulting in risks for being cripple or fatal.Symbiotic bacteria are of great significance to human health,and more and more studies show that intestinal flora is closely related to the occurrence and development of diabetes.The relationship between host gene,immune system,diet and intestinal flora has been constantly revealed,and the regulation of intestinal flora is an effective measure for diabetes treatment.This article reviews the changes of intestinal flora in type 2 diabetes mellitus,the mechanism of inducing type 2 diabetes and the latest development of the effect of intestinal flora regulation on type 2 diabetes.
引文
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[26]TABUCHI M,OZAKI M,TAMURA A,et al.Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats[J].Biosci,Biotechnol,Biochem,2003,67(6):1421-1424.
[27]FORSLUND K,HILDEBRAND F,NIELSEN T,et al.Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota[J].Nature,2015,528(7581):262-266.
[28]KOH A,DE VADDER F,KOVATCHEVA-DATCHARY P,et al.From dietary fiber to host physiology:short-chain fatty acids as key bacterial metabolites[J].Cell,2016,165(6):1332-1345.
[29]WU H,ESTEVE E,TREMAROLI V,et al.Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes,contributing to the therapeutic effects of the drug[J].Nat Med,2017,23(7):850-858.
[30]PLOVIER H,EVERARD A,DRUART C,et al.A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice[J].Nat Med,2016,23(1):107-113.
[31]PANIGRAHI P,PARIDA S,NANDA N C,et al.A randomized synbiotic trial to prevent sepsis among infants in rural India[J].Nature,2017,548(7668):407-412.
[2]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中国糖尿病杂志,2014,22(8):2-42.
[3]SEKIROV I,RUSSELL S L,ANTUNES L C,et al.Gut microbiota in health and disease[J].Physiol Rev,2010,90(3):859-904.
[4]QIN J,LI R,RAES J,et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
[5]SOMMER F,B?CKHED F.The gut microbiota-masters of host development and physiology[J].Nat Rev Microbiol,2013,11(4):227-238.
[6]NICHOLSON J K,HOLMES E,KINROSS J,et al.Host-gut microbiota metabolic interactions[J].Science,2012,336(6086):1262-1267.
[7]DOMINGUEZ-BELLO M G,DE JESUS-LABOY K M,SHEN N,et al.Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer[J].Nat Med,2016,22(3):250-253.
[8]B?CKHED F,DING H,WANG T,et al.The gut microbiota as an environmental factor that regulates fat storage[J].Proc Natl Acad Sci USA,2004,101(44):15718-15723.
[9]QUIGLEY E M.Gut bacteria in health and disease[J].Gastroenterol Hepatol,2013,9(9):560-569.
[10]ZHAO L.The tale of our other genome[J].Nature,2010,465(7300):879-880.
[11]FURET JP,KONG L C,TAP J,et al.Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss links with metabolic and low-grade inflammation markers[J].Diabetes,2010,59(12):3049-3057.
[12]KARLSSON F H,TREMAROLI V,NOOKAEW I,et al.Gut metagenome in European women with normal,impaired and diabetic glucose control[J].Nature,2013,498(7452):99-103.
[13]QIN J,LI Y,CAI Z,et al.A metagenome-wide association study of gut microbiota in type 2 diabetes[J].Nature,2012,490(7418):55-60.
[14]HARTSTRA A V,BOUTER K E,B?CKHED F,et al.Insights into the role of the microbiome in obesity and type 2 diabetes[J].Diabetes Care,2014,38(1):159-165.
[15]MCLEAN M H,DIEGUEZ JR D,MILLER L M,et al.Does the microbiota play a role in the pathogenesis of autoimmune diseases?[J].Gut,2015,64(2):332-341.
[16]KREZNAR J H,KELLER M P,TRAEGER L L,et al.Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes[J].Cell Rep,2017,18(7):1739-1750.
[17]TILG H,MOSCHEN A R.Microbiota and diabetes:an evolving relationship[J].Gut,2014,63(9):1513-1521.
[18]COHEN L J,ESTERHAZY D,KIM S H,et al.Commensal bacteria make GPCR ligands that mimic human signalling molecules[J].Nature,2017,549(7670):48-53.
[19]PEDERSEN H K,GUDMUNDSDOTTIR V,NIELSEN H B,et al.Human gut microbes impact host serum metabolome and insulin sensitivity[J].Nature,2016,535(7612):376-381.
[20]GREER R L,DONG X,MORAES A C,et al.Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism[J].Nat Commun,2016,7:13329.
[21]陈露萍.个性化饮食干预结合运动指导在2型糖尿病治疗中的应用[J].上海预防医学,2015,27(4):188-189.
[22]ZHERNAKOVA A,KURILSHIKOV A,BONDER M J,et al.Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity[J].Science,2016,352(6285):565-569.
[23]刘琳,叶苗凉,韩雪.2014年上海市杨浦区社区老年2型糖尿病患者营养干预效果研究[J].上海预防医学,2015,27(11):665-668.
[24]MEMBREZ M,BLANCHER F,JAQUET M,et al.Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice[J].FASEB J,2008,22(7):2416-2426.
[25]CANI P D,BIBILONI R,KNAUF C,et al.Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice[J].Diabetes,2008,57(6):1470-1481.
[26]TABUCHI M,OZAKI M,TAMURA A,et al.Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats[J].Biosci,Biotechnol,Biochem,2003,67(6):1421-1424.
[27]FORSLUND K,HILDEBRAND F,NIELSEN T,et al.Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota[J].Nature,2015,528(7581):262-266.
[28]KOH A,DE VADDER F,KOVATCHEVA-DATCHARY P,et al.From dietary fiber to host physiology:short-chain fatty acids as key bacterial metabolites[J].Cell,2016,165(6):1332-1345.
[29]WU H,ESTEVE E,TREMAROLI V,et al.Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes,contributing to the therapeutic effects of the drug[J].Nat Med,2017,23(7):850-858.
[30]PLOVIER H,EVERARD A,DRUART C,et al.A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice[J].Nat Med,2016,23(1):107-113.
[31]PANIGRAHI P,PARIDA S,NANDA N C,et al.A randomized synbiotic trial to prevent sepsis among infants in rural India[J].Nature,2017,548(7668):407-412.