D-ribose increases triglyceride via upregulation of DGAT in the liver
|
摘要
<正>Dear Editor,Fatty liver disease or hepatic steatosis, recognized as the hepatic component of metabolic syndrome, can progress to cirrhosis and hepatocellular carcinoma (Youngwanichsetha,2018). Triglyceride, one of the most important lipid molecules, is involved in fatty liver (Kawano and Cohen, 2013)and other diseases such as hyperlipidaemia, coronary heart disease (Yin and Tang, 2011) and diabetes mellitus (Beshara et al., 2016). The liver is the main organ for triglyceride metabolism. Hepatocytes utilize non-esterified fatty acids and de novo lipogenesis to synthesize triglyceride, and the
引文
Adolph,T.E.,Grander,C.,Grabherr,F.,and Tilg,H.(2017).Adipokines and non-alcoholic fatty liver disease:Multiple interactions.Int J Mol Sci 18,1649.
Basaranoglu,M.,Basaranoglu,G.,Sabuncu,T.,and Sentürk,H.(2013).Fructose as a key player in the development of fatty liver disease.World J Gastroenterol 19,1166.
Beshara,A.,Cohen,E.,Goldberg,E.,Lilos,P.,Garty,M.,and Krause,I.(2016).Triglyceride levels and risk of type 2 diabetes mellitus:Alongitudinal large study.J Investig Med 64,383-387.
Chen,H.C.,Smith,S.J.,Ladha,Z.,Jensen,D.R.,Ferreira,L.D.,Pulawa,L.K.,McGuire,J.G.,Pitas,R.E.,Eckel,R.H.,and Farese Jr.,R.V.(2002).Increased insulin and leptin sensitivity in mice lacking acyl CoA:Diacylglycerol acyltransferase 1.J Clin Invest 109,1049-1055.
Chen,X.,Su,T.,Chen,Y.,He,Y.,Liu,Y.,Xu,Y.,Wei,Y.,Li,J.,and He,R.(2017).D-Ribose as a contributor to glycated haemoglobin.Ebiomedicine 25,143-153.
Kawano,Y.,and Cohen,D.E.(2013).Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease.J Gastroenterol 48,434-441.
Kazumi,T.,Kawaguchi,A.,Hirano,T.,and Yoshino,G.(2004).Serum adiponectin is associated with high-density lipoprotein cholesterol,triglycerides,and low-density lipoprotein particle size in young healthy men.Metabolism 53,589-593.
Sáinz,N.,Barrenetxe,J.,Moreno-Aliaga,M.J.,and Martínez,J.A.(2015).Leptin resistance and diet-induced obesity:Central and peripheral actions of leptin.Metabolism 64,35-46.
Seghieri,M.,Tricò,D.,and Natali,A.(2017).The impact of triglycerides on glucose tolerance:Lipotoxicity revisited.Diabetes Metab 43,314-322.
Su T.,and He R.Q.(2015)An insight of D-ribose metabolic imbalance in type 2 diabetes mellitus.Prog Biochem Biophys 42:390-392.
Su,T.,Xin,L.,He,Y.G.,Wei,Y.,Song,Y.X.,Li,W.W.,Wang,X.M.,and He,R.Q.(2013).The abnormally high level of uric D-ribose for type-2diabetics.Prog Biochem Biophys 40,816-825.
Yen,C.L.E.,Stone,S.J.,Koliwad,S.,Harris,C.,and Farese Jr.,R.V.(2008).Thematic review series:Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis.J Lipid Res 49,2283-2301.
Yin,K.,and Tang,C.K.(2011).Inflammation,lipid metabolism dysfunction,and hypertension:Active research fields in atherosclerosis-related cardiovascular disease in China.Sci China Life Sci 54,976-979.
Youngwanichsetha,S.(2018).Fatty liver:Risk factors and prevention.JNutr Food Sci 8,e145.
Yu,J.,and Li,P.(2017).The size matters:Regulation of lipid storage by lipid droplet dynamics.Sci China Life Sci 60,46-56.
Zhou,Y.,Wang,X.,Fan,S.,and He,R.(2018).A lumbrokinase isozyme targets hepatitis B e-antigen.Sci China Life Sci 61,1596-1598.
Basaranoglu,M.,Basaranoglu,G.,Sabuncu,T.,and Sentürk,H.(2013).Fructose as a key player in the development of fatty liver disease.World J Gastroenterol 19,1166.
Beshara,A.,Cohen,E.,Goldberg,E.,Lilos,P.,Garty,M.,and Krause,I.(2016).Triglyceride levels and risk of type 2 diabetes mellitus:Alongitudinal large study.J Investig Med 64,383-387.
Chen,H.C.,Smith,S.J.,Ladha,Z.,Jensen,D.R.,Ferreira,L.D.,Pulawa,L.K.,McGuire,J.G.,Pitas,R.E.,Eckel,R.H.,and Farese Jr.,R.V.(2002).Increased insulin and leptin sensitivity in mice lacking acyl CoA:Diacylglycerol acyltransferase 1.J Clin Invest 109,1049-1055.
Chen,X.,Su,T.,Chen,Y.,He,Y.,Liu,Y.,Xu,Y.,Wei,Y.,Li,J.,and He,R.(2017).D-Ribose as a contributor to glycated haemoglobin.Ebiomedicine 25,143-153.
Kawano,Y.,and Cohen,D.E.(2013).Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease.J Gastroenterol 48,434-441.
Kazumi,T.,Kawaguchi,A.,Hirano,T.,and Yoshino,G.(2004).Serum adiponectin is associated with high-density lipoprotein cholesterol,triglycerides,and low-density lipoprotein particle size in young healthy men.Metabolism 53,589-593.
Sáinz,N.,Barrenetxe,J.,Moreno-Aliaga,M.J.,and Martínez,J.A.(2015).Leptin resistance and diet-induced obesity:Central and peripheral actions of leptin.Metabolism 64,35-46.
Seghieri,M.,Tricò,D.,and Natali,A.(2017).The impact of triglycerides on glucose tolerance:Lipotoxicity revisited.Diabetes Metab 43,314-322.
Su T.,and He R.Q.(2015)An insight of D-ribose metabolic imbalance in type 2 diabetes mellitus.Prog Biochem Biophys 42:390-392.
Su,T.,Xin,L.,He,Y.G.,Wei,Y.,Song,Y.X.,Li,W.W.,Wang,X.M.,and He,R.Q.(2013).The abnormally high level of uric D-ribose for type-2diabetics.Prog Biochem Biophys 40,816-825.
Yen,C.L.E.,Stone,S.J.,Koliwad,S.,Harris,C.,and Farese Jr.,R.V.(2008).Thematic review series:Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis.J Lipid Res 49,2283-2301.
Yin,K.,and Tang,C.K.(2011).Inflammation,lipid metabolism dysfunction,and hypertension:Active research fields in atherosclerosis-related cardiovascular disease in China.Sci China Life Sci 54,976-979.
Youngwanichsetha,S.(2018).Fatty liver:Risk factors and prevention.JNutr Food Sci 8,e145.
Yu,J.,and Li,P.(2017).The size matters:Regulation of lipid storage by lipid droplet dynamics.Sci China Life Sci 60,46-56.
Zhou,Y.,Wang,X.,Fan,S.,and He,R.(2018).A lumbrokinase isozyme targets hepatitis B e-antigen.Sci China Life Sci 61,1596-1598.