基于PubMed数据库的传统医药治疗肝肿瘤文献计量分析
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摘要
目的:分析PubMed数据库里国际上传统医药治疗肝肿瘤研究文献的分布特点和研究现状,为中医药防治肝肿瘤提供参考信息。方法:检索自PubMed数据库建库以来至2017年10月31日收录的传统医药治疗肝肿瘤研究相关文献,运用书目共现分析系统(BICOMB2.0),对检索出的文献进行统计分析,使用CytoScape3.6.1绘制高频主题词及副主题词共现分析图,采用SPSS17软件对高频主题词进行聚类分析。结果:共检索出传统医药治疗肝肿瘤研究相关文献365篇,年发文量呈波动性上升趋势,文献语种以英文为主。在注明作者国家的文献中,发文量排名前10的国家和地区70%位于亚洲。其中,中国学者高居第1。高频主题词及副主题词前5名依次为Humans、Male、Animals、Liver Neoplasms/drug therapy和Carcinoma, Hepatocellular/drugtherapy。研究热点主要集中在9个方面:肝肿瘤细胞的新陈代谢、肝肿瘤病理、肝肿瘤的药物疗效、细胞增生和凋亡与药效之间的关系、老鼠异种移植肿瘤模型、抗肿瘤中草药或植物药的药理、药物剂量-反映关系以及细胞活性和信号传导对药效的影响、中医药和植物疗法的治疗用途、肝肿瘤的治疗结果及死亡率。结论:通过对传统医药治疗肝肿瘤研究相关文献进行文献计量学分析,可以了解该领域的主要研究方向及其发展现状,为中国中医药防治肝肿瘤提供参考。
In order to provide reference for treatment of liver tumors using traditional Chinese medicine, we analyzed the research status of liver tumor treatment with traditional Chinese Medicine based on PubMed. By the bibliography information concurrence mining system(BICOMB 2013), the literature were collected and analyzed from PubMed database from the day of establishment to 31 October 2017. CytoScape3.6.1 software was used to draw the Co-occurrence analysis chart of high-frequency subject headings and the subheadings, and SPSS17 statistical software was used to cluster the high frequency subject headings. 365 literatures were collected in total. The amount of published articles is increasing year by year. The literatures were mainly in English. From the literature indicating the author's country, we found that 70% of the top 10 countries and regions which published the most papers were from Asia. Among them,Chinese scholars ranked first. The top 5 of the high-frequency subject headings and the subheadings were Humans,Male, Animals, Liver Neoplasms/drug therapy and Carcinoma, and Hepatocellular/drug therapy. The research focused on the following 9 aspects: metabolism of liver cells, neoplasms, liver cancer pathology, pharmacological efficacy of liver cancer, relationship between cell proliferation and apoptosis and efficacy; xenograft model antitumor assays in mice,pharmacology of antitumor Chinese herbal medicine or phytogenic drugs, the effects of dose-response relationship,cellular activity and signal transduction on drug efficacy, therapeutic uses of traditional and phytotherapy and the outcome and mortality of liver tumor. By the bibliometric analysis in the field of traditional medicine for liver tumor, we can understand the research direction and development status of this field, which can be reference for prevention and treatment of liver cancer with TCM.
In order to provide reference for treatment of liver tumors using traditional Chinese medicine, we analyzed the research status of liver tumor treatment with traditional Chinese Medicine based on PubMed. By the bibliography information concurrence mining system(BICOMB 2013), the literature were collected and analyzed from PubMed database from the day of establishment to 31 October 2017. CytoScape3.6.1 software was used to draw the Co-occurrence analysis chart of high-frequency subject headings and the subheadings, and SPSS17 statistical software was used to cluster the high frequency subject headings. 365 literatures were collected in total. The amount of published articles is increasing year by year. The literatures were mainly in English. From the literature indicating the author's country, we found that 70% of the top 10 countries and regions which published the most papers were from Asia. Among them,Chinese scholars ranked first. The top 5 of the high-frequency subject headings and the subheadings were Humans,Male, Animals, Liver Neoplasms/drug therapy and Carcinoma, and Hepatocellular/drug therapy. The research focused on the following 9 aspects: metabolism of liver cells, neoplasms, liver cancer pathology, pharmacological efficacy of liver cancer, relationship between cell proliferation and apoptosis and efficacy; xenograft model antitumor assays in mice,pharmacology of antitumor Chinese herbal medicine or phytogenic drugs, the effects of dose-response relationship,cellular activity and signal transduction on drug efficacy, therapeutic uses of traditional and phytotherapy and the outcome and mortality of liver tumor. By the bibliometric analysis in the field of traditional medicine for liver tumor, we can understand the research direction and development status of this field, which can be reference for prevention and treatment of liver cancer with TCM.
引文
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2吕桂帅,陈磊,王红阳.我国肝癌研究的现状与前景.生命科学,2015,27(3):245.
3 Tang Z Y.Treatment of primary liver cancer-with special reference to the east part of China.Ann Acad Med Singapore,1980,9(2):251-255.
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5 Chay W Y,Tham C K,Toh H C,et al.Coriolus versicolor(Yunzhi)use as therapy in advanced hepatocellular carcinoma patients with poor liver function or who are unfit for standard therapy.Altern Complement Med,2017,23(8):648-652.
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7 Fei M,Lu M,Wang Y,et al.Arsenic trioxide-induced growth arrest of human hepatocellular carcinoma cells involving FOXO3a expression and localization.Med Oncol,2009,26(2):178-85.
8 Zhang Y,Lin Y,Zhao H,et al.Revealing the effects of the herbal pair of euphorbia kansui and glycyrrhiza on hepatocellular carcinoma ascites with integrating network target analysis and experimental validation.IntJ Biol Sci,2016,12(5):594-606.
9 Miao Q,Bi L L,Li X,et al.Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells:roles of apoptosis and autophagy.Int J Mol Sci,2013,14(1):1370-1382.
10 Lin L W,Lin X D,He Y M,et al.Experimental study on ultrasoundguidedintratumoral injection of"Star-99"in treatment of hepatocellular carcinoma of nude mice.World J Gastroenterol,2003,9(4):701-705.
11 Hu B,An H M,Shen K P,et al.Modified Yi Guan Jian,a Chinese herbal formula,induces anoikis in Bel-7402 human hepatocarcinoma cells in vitro.Oncol Rep,2011,26(6):1465-1470.
12 Mizukoshi E,Yamashita T,Arai K,et al.Myeloid-derived suppressor cells correlate with patientoutcomes in hepatic arterial infusion chemotherapy for hepatocellular carcinoma.Cancer Immunol Immunother,2016,65(6):715-725.
13 Kao S T,Yang S L,Hsieh C C,et al.Immunomodulation of Bu-ZhongYi-Qi-Tang on in vitro granulocyte colony-stimulating-factor and tumor necrosis factor-alpha production by peripheral blood mononuclear cells.Immunopharmacol Immunotoxicol,2000,22(4):711-720.
14 Hussin F,Eshkoor S A,Rahmat A,et al.The centellaasiatica juice effects on DNA damage,apoptosis and gene expression in hepatocellular carcinoma(HCC).BMC Complement Altern Med,2014,20(14):32.
15 Hsu Y L,Kuo Y C,Kuo P L,et al.Apoptotic effects of extract from Antrodiacamphorata fruiting bodies in human hepatocellular carcinoma cell lines.Cancer Lett,2005,221(1):77-89.
16 Chan J Y,Tang P M,Hon P M,et al.Pheophorbide a,a major antitumor component purified from Scutellariabarbata,induces apoptosis in human hepatocellular carcinoma cells.Planta Med,2006,72(1):28-33.
17 Hsu Y L,Kuo P L,Tzeng T F,et al.Huang-lian-jie-du-tang,a traditional Chinese medicine prescription,induces cell-cycle arrest and apoptosis in human liver cancer cells in vitro and in vivo.Gastroenterol Hepatol,2008,23(7 Pt 2):e290-299.
18 Wang G Y,Lv Q H,Dong Q,et al.Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice.Asian Nat Prod Res,2009,11(3):219-228.
19 Liu C,Gong K,Mao X,et al.Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma.Int J Cancer,2011,129(6):1519-1531.
20 Wu D,Bao W G,Ding Y H.Clinical and experimental study of xiaoshui decoction in the treatment of primary liver cancer caused ascites.Zhongguo Zhong Xi Yi Jie He Za Zhi,2005,25(12):1066-1069
21 Cui J,Nan K J,Tian T,et al.Chinese medicinal compound delisheng has satisfactory anti-tumor activity,and is associated with up-regulation of endostatin in human hepatocellular carcinoma cell line HepG2in three-dimensional culture.World J Gastroenterol,2007,13(41):5432-5439.
22 Chan E W,Cheng S C,Sin F W,et al.Triptolide induced cytotoxic effects on human promyelocytic leukemia,T cell lymphoma and human hepatocellular carcinoma cell lines.Toxicol Lett,2001,122(1):81-87.
23 Song X,Wang W,Zhang X,et al.Deglucose chikusetsusaponin IVa isolated from Rhizoma Panacis Majoris induces apoptosis in human HepG2hepatoma cells.Mol Med Rep,2015,12(4):5494-5500.
24 Li J,Tang H,Zhang Y,et al.Saponin 1 induces apoptosis and suppresses NF-κB-mediated survival signaling in glioblastoma multiforme(GBM).PLoS One,2013,8(11):e81258.
25 Li D T,Ling C Q,Lang Q B,et al.Construction of a therapeutic effect evaluation system for patients with primary liver cancer based on syndrome differentiation in traditional Chinese medicine.Zhong Xi Yi Jie He Xue Bao,2007,5(1):15-22.
26 Wang N,Feng Y,Tan H Y,et al.Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by an herbal formulation HuanglianJiedu decoction in human hepatocellular carcinoma.Ethnopharmacol,2015,164:309-318.
27.Zhong C,Li H D,Liu D Y,et al.Clinical study of hepatectomy combined with Jianpi Huayu Therapy for hepatocellular carcinoma.Asian Pac JCancer Prev,2014,15(14):5951-5957.
28 Zhou L,Rui J A,Wang S B,et al.Multi-modal serial therapy for primary liver cancer in senile patients:a report of 153 cases.Zhonghua Zhong Liu Za Zhi,2003,25(4):404-406.
29 Xu K,Luo H Y,Li L N.Clinical study on comprehensive treatment of primary liver cancer mainly with Chinese medicinal perfusion/embolization.Zhongguo Zhong Xi Yi Jie He Za Zhi,2005,25(4):299-302.
30 Kondo Y,Kimura O,Kogure T,et al.Radiation therapy is a reasonable option for improving the prognosis in hepatocellular carcinoma.Tohoku J Exp Med,2015,237(4):249-57.
2吕桂帅,陈磊,王红阳.我国肝癌研究的现状与前景.生命科学,2015,27(3):245.
3 Tang Z Y.Treatment of primary liver cancer-with special reference to the east part of China.Ann Acad Med Singapore,1980,9(2):251-255.
4魏矿荣,彭侠彪,梁智恒,等.全球肝癌流行情况.中国肿瘤,2015,24(8):621-622.
5 Chay W Y,Tham C K,Toh H C,et al.Coriolus versicolor(Yunzhi)use as therapy in advanced hepatocellular carcinoma patients with poor liver function or who are unfit for standard therapy.Altern Complement Med,2017,23(8):648-652.
6.刘晓英.图书馆评价研究.北京:知识产权出版社,2015:33.
7 Fei M,Lu M,Wang Y,et al.Arsenic trioxide-induced growth arrest of human hepatocellular carcinoma cells involving FOXO3a expression and localization.Med Oncol,2009,26(2):178-85.
8 Zhang Y,Lin Y,Zhao H,et al.Revealing the effects of the herbal pair of euphorbia kansui and glycyrrhiza on hepatocellular carcinoma ascites with integrating network target analysis and experimental validation.IntJ Biol Sci,2016,12(5):594-606.
9 Miao Q,Bi L L,Li X,et al.Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells:roles of apoptosis and autophagy.Int J Mol Sci,2013,14(1):1370-1382.
10 Lin L W,Lin X D,He Y M,et al.Experimental study on ultrasoundguidedintratumoral injection of"Star-99"in treatment of hepatocellular carcinoma of nude mice.World J Gastroenterol,2003,9(4):701-705.
11 Hu B,An H M,Shen K P,et al.Modified Yi Guan Jian,a Chinese herbal formula,induces anoikis in Bel-7402 human hepatocarcinoma cells in vitro.Oncol Rep,2011,26(6):1465-1470.
12 Mizukoshi E,Yamashita T,Arai K,et al.Myeloid-derived suppressor cells correlate with patientoutcomes in hepatic arterial infusion chemotherapy for hepatocellular carcinoma.Cancer Immunol Immunother,2016,65(6):715-725.
13 Kao S T,Yang S L,Hsieh C C,et al.Immunomodulation of Bu-ZhongYi-Qi-Tang on in vitro granulocyte colony-stimulating-factor and tumor necrosis factor-alpha production by peripheral blood mononuclear cells.Immunopharmacol Immunotoxicol,2000,22(4):711-720.
14 Hussin F,Eshkoor S A,Rahmat A,et al.The centellaasiatica juice effects on DNA damage,apoptosis and gene expression in hepatocellular carcinoma(HCC).BMC Complement Altern Med,2014,20(14):32.
15 Hsu Y L,Kuo Y C,Kuo P L,et al.Apoptotic effects of extract from Antrodiacamphorata fruiting bodies in human hepatocellular carcinoma cell lines.Cancer Lett,2005,221(1):77-89.
16 Chan J Y,Tang P M,Hon P M,et al.Pheophorbide a,a major antitumor component purified from Scutellariabarbata,induces apoptosis in human hepatocellular carcinoma cells.Planta Med,2006,72(1):28-33.
17 Hsu Y L,Kuo P L,Tzeng T F,et al.Huang-lian-jie-du-tang,a traditional Chinese medicine prescription,induces cell-cycle arrest and apoptosis in human liver cancer cells in vitro and in vivo.Gastroenterol Hepatol,2008,23(7 Pt 2):e290-299.
18 Wang G Y,Lv Q H,Dong Q,et al.Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice.Asian Nat Prod Res,2009,11(3):219-228.
19 Liu C,Gong K,Mao X,et al.Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma.Int J Cancer,2011,129(6):1519-1531.
20 Wu D,Bao W G,Ding Y H.Clinical and experimental study of xiaoshui decoction in the treatment of primary liver cancer caused ascites.Zhongguo Zhong Xi Yi Jie He Za Zhi,2005,25(12):1066-1069
21 Cui J,Nan K J,Tian T,et al.Chinese medicinal compound delisheng has satisfactory anti-tumor activity,and is associated with up-regulation of endostatin in human hepatocellular carcinoma cell line HepG2in three-dimensional culture.World J Gastroenterol,2007,13(41):5432-5439.
22 Chan E W,Cheng S C,Sin F W,et al.Triptolide induced cytotoxic effects on human promyelocytic leukemia,T cell lymphoma and human hepatocellular carcinoma cell lines.Toxicol Lett,2001,122(1):81-87.
23 Song X,Wang W,Zhang X,et al.Deglucose chikusetsusaponin IVa isolated from Rhizoma Panacis Majoris induces apoptosis in human HepG2hepatoma cells.Mol Med Rep,2015,12(4):5494-5500.
24 Li J,Tang H,Zhang Y,et al.Saponin 1 induces apoptosis and suppresses NF-κB-mediated survival signaling in glioblastoma multiforme(GBM).PLoS One,2013,8(11):e81258.
25 Li D T,Ling C Q,Lang Q B,et al.Construction of a therapeutic effect evaluation system for patients with primary liver cancer based on syndrome differentiation in traditional Chinese medicine.Zhong Xi Yi Jie He Xue Bao,2007,5(1):15-22.
26 Wang N,Feng Y,Tan H Y,et al.Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by an herbal formulation HuanglianJiedu decoction in human hepatocellular carcinoma.Ethnopharmacol,2015,164:309-318.
27.Zhong C,Li H D,Liu D Y,et al.Clinical study of hepatectomy combined with Jianpi Huayu Therapy for hepatocellular carcinoma.Asian Pac JCancer Prev,2014,15(14):5951-5957.
28 Zhou L,Rui J A,Wang S B,et al.Multi-modal serial therapy for primary liver cancer in senile patients:a report of 153 cases.Zhonghua Zhong Liu Za Zhi,2003,25(4):404-406.
29 Xu K,Luo H Y,Li L N.Clinical study on comprehensive treatment of primary liver cancer mainly with Chinese medicinal perfusion/embolization.Zhongguo Zhong Xi Yi Jie He Za Zhi,2005,25(4):299-302.
30 Kondo Y,Kimura O,Kogure T,et al.Radiation therapy is a reasonable option for improving the prognosis in hepatocellular carcinoma.Tohoku J Exp Med,2015,237(4):249-57.