在药剂学中微球制剂制备方法研究
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摘要
本文通过从微球的优点、制备方法、质量控制三个方面进行综述,阐述了微球制剂与普通制剂的优点,举例说明每种制备方法,为微球制剂的进一步发展提供参考。
In this paper, the characteristics, preparation methods and quality control of sustained-release microspheres were reviewed. The difficulties in preparation process and technology of microspheres were summarized.The advantages of microspheres and ordinary preparations were described. The preparation methods were illustrated with examples, which could provide reference for the further development of microspheres.
In this paper, the characteristics, preparation methods and quality control of sustained-release microspheres were reviewed. The difficulties in preparation process and technology of microspheres were summarized.The advantages of microspheres and ordinary preparations were described. The preparation methods were illustrated with examples, which could provide reference for the further development of microspheres.
引文
[1]李勋,韦祎,马光辉,等.缓释微球制剂的研究进展[J].北京化工大学学报(自然科学版),44(6):1-9.
[2]韦祎,巩方玲,崔一民,等.微孔膜乳化技术制备缓释微球的研究进展[J].中国医药工业杂志,2018(10):1341-1352.
[3]魏显峰,王海华,单俊伟,等.海洋多糖BTH缓释微球的制备及释放特性研究[J].中国海洋药物,2018(2):52-56.
[4]张敏,张丽叶.洛伐他汀聚乳酸缓释微球的制备及其体外释药[J].北京化工大学学报(自然科学版),2011(2):94-98.
[5]张丽花,郝文艳,朱思庆,等.雌三醇微球的制备及体外缓释效果评价[J].中南药学,2018(12):1709-1712.
[6]张丽梅,黎迎,张运,等.喷雾干燥法制备异烟肼PLA缓释微球[J].中国科学:生命科学,2016(6):763-770.
[7]简宇凡,卜伟,李韦韦,等.复乳法制备盐酸多柔比星固体脂质纳米粒及其体外稳定性研究[J].中国药师,2018(12):2096-2100.
[8]郁晓,任杰,任天斌,等.两性霉素B缓释微球的制备及缓释性能研究[J].中国生物医学工程学报, 2007, 26(3):445-451.
[9]陈鸿雁,周永传,邓修,等.超临界溶液快速膨胀法制灰黄霉素微粒的预膨胀[J〕.华东理工大学学报(自然科学版),2000,26(l):18.
[10]李林,安富容,王琰.热熔挤出法增加布洛芬溶出度并改善磺丁基醚-β-环糊精吸湿性的研究[J].中国药房,2012,23(33):3117-3119.
[2]韦祎,巩方玲,崔一民,等.微孔膜乳化技术制备缓释微球的研究进展[J].中国医药工业杂志,2018(10):1341-1352.
[3]魏显峰,王海华,单俊伟,等.海洋多糖BTH缓释微球的制备及释放特性研究[J].中国海洋药物,2018(2):52-56.
[4]张敏,张丽叶.洛伐他汀聚乳酸缓释微球的制备及其体外释药[J].北京化工大学学报(自然科学版),2011(2):94-98.
[5]张丽花,郝文艳,朱思庆,等.雌三醇微球的制备及体外缓释效果评价[J].中南药学,2018(12):1709-1712.
[6]张丽梅,黎迎,张运,等.喷雾干燥法制备异烟肼PLA缓释微球[J].中国科学:生命科学,2016(6):763-770.
[7]简宇凡,卜伟,李韦韦,等.复乳法制备盐酸多柔比星固体脂质纳米粒及其体外稳定性研究[J].中国药师,2018(12):2096-2100.
[8]郁晓,任杰,任天斌,等.两性霉素B缓释微球的制备及缓释性能研究[J].中国生物医学工程学报, 2007, 26(3):445-451.
[9]陈鸿雁,周永传,邓修,等.超临界溶液快速膨胀法制灰黄霉素微粒的预膨胀[J〕.华东理工大学学报(自然科学版),2000,26(l):18.
[10]李林,安富容,王琰.热熔挤出法增加布洛芬溶出度并改善磺丁基醚-β-环糊精吸湿性的研究[J].中国药房,2012,23(33):3117-3119.