植物识别脂多糖的分子机制研究进展
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摘要
脂多糖(LPS)是革兰氏阴性细菌外膜的主要成分,它作为一种典型的微生物相关分子模式,被动植物识别后可以诱导产生免疫反应。相对于LPS在动物中的研究, LPS引起的植物免疫反应以及植物识别LPS的分子机制还很不清楚,但近几年也取得了一些重要进展。因此,本文将从LPS的复杂结构和LPS引起的独特的植物免疫反应等方面出发,综述研究植物识别LPS分子机制的复杂性以及取得的研究进展。
Lipopolysaccharide(LPS) is a major component of gram-negative bacterial outer membrane. As a typical microbe-associated molecular pattern(MAMP), LPS induces host immune responses in both mammals and plants. Compared to that in mammals, the study of LPS perception and signaling in plant immunity is still in its infancy, but some important progress has been made in recent years. Therefore, in this review, we discuss the complexity of LPS recognition and signaling in terms of the complicated LPS structure and the noncanonical immune responses in plants.
Lipopolysaccharide(LPS) is a major component of gram-negative bacterial outer membrane. As a typical microbe-associated molecular pattern(MAMP), LPS induces host immune responses in both mammals and plants. Compared to that in mammals, the study of LPS perception and signaling in plant immunity is still in its infancy, but some important progress has been made in recent years. Therefore, in this review, we discuss the complexity of LPS recognition and signaling in terms of the complicated LPS structure and the noncanonical immune responses in plants.
引文
Baloyi NM,Dubery IA,Piater LA(2017).Proteomic analysis of Arabidopsis plasma membranes reveals lipopolysaccharide-responsive changes.Biochem Biophys Res Commun,486(4):1137-1142
Boller T,Felix G(2009).A renaissance of elicitors:perception of microbe-associated molecular patterns and danger signals by pattern-recognition receptors.Annu Rev Plant Biol,60:379-406
Braun SG,Meyer A,Holst O,et al(2005).Characterization of the Xanthomonas campestris pv.campestris lipopolysaccharide substructures essential for elicitation of an oxidative burst in tobacco cells.Mol Plant Microbe Interact,18(7):674-681
Chinchilla D,Zipfel C,Robatzek S,et al(2007).A flagellin-induced complex of the receptor FLS2 and BAK1initiates plant defence.Nature,448(7152):497-501
Desaki Y,Kouzai Y,Ninomiya Y,et al(2018).OsCERK1plays a crucial role in the lipopolysaccharide-induced immune response of rice.New Phytol,217(3):1042-1049
Desaki Y,Miya A,Venkatesh B,et al(2006).Bacterial lipopolysaccharides induce defense responses associated with programmed cell death in rice cells.Plant Cell Physiol,47(11):1530-1540
Dodds PN,Rathjen JP(2010).Plant immunity:towards an integrated view of plant-pathogen interactions.Nat Rev Genet,11(8):539-548
Doerrler WT(2006).Lipid trafficking to the outer membrane of gram-negative bacteria.Mol Microbiol,60(3):542-552
Erridge C,Bennett-Guerrero E,Poxton IR(2002).Structure and function of lipopolysaccharides.Microbes Infect,4(8):837-851
Gobbato E(2015).Recent developments in arbuscular mycorrhizal signaling.Curr Opin Plant Biol,26:1-7
Gust AA,Willmann R,Desaki Y,et al(2012).Plant LysMproteins:modules mediating symbiosis and immunity.Trends Plant Sci,17(8):495-502
Iizasa S,Iizasa E,Matsuzaki S,et al(2016).Arabidopsis LBP/BPI related-1 and-2 bind to LPS directly and regulate PR1 expression.Sci Rep,6:27527
Iizasa S,Iizasa E,Watanabe K,et al(2017).Transcriptome analysis reveals key roles of AtLBR-2 in LPS-induced defense responses in plants.BMC Genomics,18:995
Lamb C,Dixon RA(1997).The oxidative burst in plant disease resistance.Annu Rev Plant Biol,48:251-275
Liu B,Li JF,AO Y,et al(2012).Lysin motif-containing proteins LYP4 and LYP6 play dual roles in peptidoglycan and chitin perception in rice innate immunity.Plant Cell,24(8):3406-3419
Lu D,Wu S,Gao X,et al(2010).A receptor-like cytoplasmic kinase,BIK1,associates with a flagellin receptor complex to initiate plant innate immunity.Proc Natl Acad Sci USA,107(1):496-501
Macho AP,Zipfel C(2014).Plant PRRs and the activation of innate immune signaling.Mol Cell,54(2):263-272
Madala NE,Molinaro A,Dubery IA(2011).Distinct carbohydrate and lipid-based molecular patterns within lipopolysaccharides from Burkholderia cepacia contribute to defense-associated differential gene expression in Arabidopsis thaliana.Innate Immun,18(1):140-154
Mathison JC,Tobias PS,Wolfson E,et al(1992).Plasma lipopolysaccharide(LPS)-binding protein.A key component in macrophage recognition of gram-negative LPS.J Immunol,149(1):200-206
Meyer A,Pühler A,Niehaus K(2001).The lipopolysaccharides of the phytopathogen Xanthomonas campestris pv.campestris induce an oxidative burst reaction in cell cultures of Nicotiana tabacum.Planta,213(2):214-222
Mohamed KH,Daniel T,Aurélien D,et al(2015).Deciphering the dual effect of lipopolysaccharides from plant pathogenic Pectobacterium.Plant Signal Behav,10(3):e1000160
Needham BD,Trent MS(2013).Fortifying the barrier:the impact of lipid A remodelling on bacterial pathogenesis.Nat Rev Microbiol,11(7):467-481
Newman MA,Sundelin T,Nielsen JT,et al(2013).MAMP(microbe-associated molecular pattern)triggered immunity in plants.Front Plant Sci,4:139
Oikawa M,Shintaku T,Fukuda N,et al(2004).NMR conformational analysis of biosynthetic precursor-type lipid A:monomolecular state and supramolecular assembly.Org Biomol Chem,2(24):3557-3565
Raetz CRH,Garrett TA,Reynolds CM,et al(2006).Kdo2-Lipid A of Escherichia coli,a defined endotoxin that activates macrophages via TLR-4.J Lipid Res,47(5):1097-1111
Raetz CRH,Reynolds CM,Trent MS,et al(2007).Lipid Amodification systems in gram-negative bacteria.Annu Rev Biochem 76:295-329
Ranf S,Gisch N,Sch?ffer M,et al(2015).A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana.Nat Immunol,16(4):426-433
Schreiber KJ,Baudin M,Hassan JA,et al(2016).Die another day:molecular mechanisms of effector-triggered immunity elicited by type ⅡI secreted effector proteins.Semin Cell Dev Biol,56:124-133
Seydel U,Schromm AB,Blunck R,et al(2000).Chemical structure,molecular conformation,and bioactivity of endotoxins.Chem Immunol,74:5-24
Shang-Guan K,Wang M,Htwe,NMPS,et al(2018).Lipopolysaccharides trigger two successive bursts of reactive oxygen species at distinct cellular locations.Plant Physiol,176(3):2543-2556
Shinya T,Nakagawa T,Kaku H,et al(2015).Chitin-mediated plant-fungal interactions:catching,hiding and handshaking.Curr Opin Plant Biol,26:64-71
Storek KM,Monack DM(2015).Bacterial recognition pathways that lead to inflammasome activation.Immunol Rev,265:112-129
Sun Y,Li L,Macho AP,et al(2013).Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1immune complex.Science,342(6158):624-628
Torres MA(2010).ROS in biotic interactions.Physiol Plantarum,138(4):414-429
Vilakazi CS,Dubery IA,Piater LA(2017).Identification of lipopolysaccharide-interacting plasma membrane-type proteins in Arabidopsis thaliana.Plant Physiol Biochem,111:155-165
Yang J,Zhao Y,Shao F(2015).Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity.Curr Opin Immunol,32:78-83
Yuan X,Li DY,Song FM(2017).Rice broad-spectrum resistance against blast disease:molecular mechanism and applications.Plant Physiol J,53(8):1348-1358(in Chinese with English abstract)[袁熹,李大勇,宋凤鸣(2017).水稻对稻瘟病的广谱抗性:分子机制及其育种应用.植物生理学报,53(8):1348-1358]
Zhang J,Li W,Xiang T,et al(2010).Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector.Cell Host Microbe,7(4):290-301
Zheng Y,Chen ZJ(2015).Organellar calcium signaling in plants.Plant Physiol J,51(8):1195-1203(in Chinese with English abstract)[郑远,陈兆进(2015).植物细胞器钙信号研究进展.植物生理学报,51(8):1195-1203]
Zipfel C,Kunze G,Chinchilla D,et al(2006).Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation.Cell,125(4):749-760
Boller T,Felix G(2009).A renaissance of elicitors:perception of microbe-associated molecular patterns and danger signals by pattern-recognition receptors.Annu Rev Plant Biol,60:379-406
Braun SG,Meyer A,Holst O,et al(2005).Characterization of the Xanthomonas campestris pv.campestris lipopolysaccharide substructures essential for elicitation of an oxidative burst in tobacco cells.Mol Plant Microbe Interact,18(7):674-681
Chinchilla D,Zipfel C,Robatzek S,et al(2007).A flagellin-induced complex of the receptor FLS2 and BAK1initiates plant defence.Nature,448(7152):497-501
Desaki Y,Kouzai Y,Ninomiya Y,et al(2018).OsCERK1plays a crucial role in the lipopolysaccharide-induced immune response of rice.New Phytol,217(3):1042-1049
Desaki Y,Miya A,Venkatesh B,et al(2006).Bacterial lipopolysaccharides induce defense responses associated with programmed cell death in rice cells.Plant Cell Physiol,47(11):1530-1540
Dodds PN,Rathjen JP(2010).Plant immunity:towards an integrated view of plant-pathogen interactions.Nat Rev Genet,11(8):539-548
Doerrler WT(2006).Lipid trafficking to the outer membrane of gram-negative bacteria.Mol Microbiol,60(3):542-552
Erridge C,Bennett-Guerrero E,Poxton IR(2002).Structure and function of lipopolysaccharides.Microbes Infect,4(8):837-851
Gobbato E(2015).Recent developments in arbuscular mycorrhizal signaling.Curr Opin Plant Biol,26:1-7
Gust AA,Willmann R,Desaki Y,et al(2012).Plant LysMproteins:modules mediating symbiosis and immunity.Trends Plant Sci,17(8):495-502
Iizasa S,Iizasa E,Matsuzaki S,et al(2016).Arabidopsis LBP/BPI related-1 and-2 bind to LPS directly and regulate PR1 expression.Sci Rep,6:27527
Iizasa S,Iizasa E,Watanabe K,et al(2017).Transcriptome analysis reveals key roles of AtLBR-2 in LPS-induced defense responses in plants.BMC Genomics,18:995
Lamb C,Dixon RA(1997).The oxidative burst in plant disease resistance.Annu Rev Plant Biol,48:251-275
Liu B,Li JF,AO Y,et al(2012).Lysin motif-containing proteins LYP4 and LYP6 play dual roles in peptidoglycan and chitin perception in rice innate immunity.Plant Cell,24(8):3406-3419
Lu D,Wu S,Gao X,et al(2010).A receptor-like cytoplasmic kinase,BIK1,associates with a flagellin receptor complex to initiate plant innate immunity.Proc Natl Acad Sci USA,107(1):496-501
Macho AP,Zipfel C(2014).Plant PRRs and the activation of innate immune signaling.Mol Cell,54(2):263-272
Madala NE,Molinaro A,Dubery IA(2011).Distinct carbohydrate and lipid-based molecular patterns within lipopolysaccharides from Burkholderia cepacia contribute to defense-associated differential gene expression in Arabidopsis thaliana.Innate Immun,18(1):140-154
Mathison JC,Tobias PS,Wolfson E,et al(1992).Plasma lipopolysaccharide(LPS)-binding protein.A key component in macrophage recognition of gram-negative LPS.J Immunol,149(1):200-206
Meyer A,Pühler A,Niehaus K(2001).The lipopolysaccharides of the phytopathogen Xanthomonas campestris pv.campestris induce an oxidative burst reaction in cell cultures of Nicotiana tabacum.Planta,213(2):214-222
Mohamed KH,Daniel T,Aurélien D,et al(2015).Deciphering the dual effect of lipopolysaccharides from plant pathogenic Pectobacterium.Plant Signal Behav,10(3):e1000160
Needham BD,Trent MS(2013).Fortifying the barrier:the impact of lipid A remodelling on bacterial pathogenesis.Nat Rev Microbiol,11(7):467-481
Newman MA,Sundelin T,Nielsen JT,et al(2013).MAMP(microbe-associated molecular pattern)triggered immunity in plants.Front Plant Sci,4:139
Oikawa M,Shintaku T,Fukuda N,et al(2004).NMR conformational analysis of biosynthetic precursor-type lipid A:monomolecular state and supramolecular assembly.Org Biomol Chem,2(24):3557-3565
Raetz CRH,Garrett TA,Reynolds CM,et al(2006).Kdo2-Lipid A of Escherichia coli,a defined endotoxin that activates macrophages via TLR-4.J Lipid Res,47(5):1097-1111
Raetz CRH,Reynolds CM,Trent MS,et al(2007).Lipid Amodification systems in gram-negative bacteria.Annu Rev Biochem 76:295-329
Ranf S,Gisch N,Sch?ffer M,et al(2015).A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana.Nat Immunol,16(4):426-433
Schreiber KJ,Baudin M,Hassan JA,et al(2016).Die another day:molecular mechanisms of effector-triggered immunity elicited by type ⅡI secreted effector proteins.Semin Cell Dev Biol,56:124-133
Seydel U,Schromm AB,Blunck R,et al(2000).Chemical structure,molecular conformation,and bioactivity of endotoxins.Chem Immunol,74:5-24
Shang-Guan K,Wang M,Htwe,NMPS,et al(2018).Lipopolysaccharides trigger two successive bursts of reactive oxygen species at distinct cellular locations.Plant Physiol,176(3):2543-2556
Shinya T,Nakagawa T,Kaku H,et al(2015).Chitin-mediated plant-fungal interactions:catching,hiding and handshaking.Curr Opin Plant Biol,26:64-71
Storek KM,Monack DM(2015).Bacterial recognition pathways that lead to inflammasome activation.Immunol Rev,265:112-129
Sun Y,Li L,Macho AP,et al(2013).Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1immune complex.Science,342(6158):624-628
Torres MA(2010).ROS in biotic interactions.Physiol Plantarum,138(4):414-429
Vilakazi CS,Dubery IA,Piater LA(2017).Identification of lipopolysaccharide-interacting plasma membrane-type proteins in Arabidopsis thaliana.Plant Physiol Biochem,111:155-165
Yang J,Zhao Y,Shao F(2015).Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity.Curr Opin Immunol,32:78-83
Yuan X,Li DY,Song FM(2017).Rice broad-spectrum resistance against blast disease:molecular mechanism and applications.Plant Physiol J,53(8):1348-1358(in Chinese with English abstract)[袁熹,李大勇,宋凤鸣(2017).水稻对稻瘟病的广谱抗性:分子机制及其育种应用.植物生理学报,53(8):1348-1358]
Zhang J,Li W,Xiang T,et al(2010).Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector.Cell Host Microbe,7(4):290-301
Zheng Y,Chen ZJ(2015).Organellar calcium signaling in plants.Plant Physiol J,51(8):1195-1203(in Chinese with English abstract)[郑远,陈兆进(2015).植物细胞器钙信号研究进展.植物生理学报,51(8):1195-1203]
Zipfel C,Kunze G,Chinchilla D,et al(2006).Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation.Cell,125(4):749-760