甲状腺自身免疫抗体与丙型肝炎病毒感染的关系研究
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摘要
目的研究甲状腺自身免疫抗体与丙型肝炎病毒感染的关系。方法选取2016年1月至2017年12月期间本校附院接收的甲状腺自身免疫抗体(thyroid autoimmune antibody,TAA)阳性患者150例(观察组)和甲状腺自身免疫抗体(TAA)阴性患者150例(对照组),对血清抗-HCV水平同TAA相关抗体的相关性进行分析。另外,再选择正常健康人群、丙型肝炎患者、慢性乙型肝炎患者各100例作为研究对象,对TpOAb水平与血清抗-HCV相关性进行分析。结果观察组和对照组的HCV感染率比较差异无统计学意义,观察组的抗-HCV水平明显更高(P<0.05);观察组高度阳性患者的血清抗-HCV水平高于中度、低度阳性患者(P<0.05);丙型肝炎组的TpOAb、TgAb阳性率比正常组、慢性乙型肝炎组高(P<0.05)。结论在临床中需对丙型肝炎患者加强甲状腺指标的监测,避免甲状腺自身免疫抗体的发生。
Objective To study the relationship between thyroid autoimmune antibodies and hepatitis C virus infection. Methods 150 patients with thyroid autoimmune antibody positive and 150 thyroid autoimmune antibody(TAA) negative patients received from the hospital from January2016 to December 2017 were selected. Serum anti-HCV levels were compared between the two groups. The correlation with TAA-related antibodies was analyzed. In addition, normal healthy people, hepatitis C patients, and chronic hepatitis B patients were selected as subjects, 100 in each group.The correlation between TpOAb levels and serum anti-HCV was analyzed. Results There was no significant difference in the HCV infection rate between the observation group and the control group. The anti-HCV level in the former group was significantly higher(P<0.05); serum anti-HCV was highly positive in the observation group. The positive rate of TpOAb and TgAb in hepatitis C group was higher than that in normal group and chronic hepatitis B group(P<0.05). Conclusion In the clinic, it is necessary to strengthen the monitoring of thyroid index in patients with hepatitis C and avoid the occurrence of thyroid autoimmune antibodies.
Objective To study the relationship between thyroid autoimmune antibodies and hepatitis C virus infection. Methods 150 patients with thyroid autoimmune antibody positive and 150 thyroid autoimmune antibody(TAA) negative patients received from the hospital from January2016 to December 2017 were selected. Serum anti-HCV levels were compared between the two groups. The correlation with TAA-related antibodies was analyzed. In addition, normal healthy people, hepatitis C patients, and chronic hepatitis B patients were selected as subjects, 100 in each group.The correlation between TpOAb levels and serum anti-HCV was analyzed. Results There was no significant difference in the HCV infection rate between the observation group and the control group. The anti-HCV level in the former group was significantly higher(P<0.05); serum anti-HCV was highly positive in the observation group. The positive rate of TpOAb and TgAb in hepatitis C group was higher than that in normal group and chronic hepatitis B group(P<0.05). Conclusion In the clinic, it is necessary to strengthen the monitoring of thyroid index in patients with hepatitis C and avoid the occurrence of thyroid autoimmune antibodies.
引文
[1]张振华,苏自杰,李红光,等.甲状腺自身免疫抗体与丙型肝炎病毒感染的相关性研究[J].中华医院感染学杂志,2016,26(18):4113-4115.
[2]鲁陈,朱颖.甲状腺自身免疫抗体与丙型肝炎病毒感染的关联性分析[J].实验与检验医学,2017,35(5):757-759.
[3]袁孟伟,苑文雯,戴亮,等.丙肝相关性自身免疫性甲状腺疾病患者甲状腺自身抗体变化特点研究[J].中国医药导报,2017,14(5):117-120.
[4]王晗,杨宁,于长明.HCV相关自身免疫性甲状腺疾病自身抗体研究进展[J].检验医学与临床,2017,14(5):742-745.
[5]刘淼,陈华锋,李梦华.丙肝患者的甲状腺激素及相关抗体水平的研究[J].中国冶金工业医学杂志,2016,33(2):242-243.
[6]李妍,黄加干,杨宁,等.丙肝患者干扰素治疗后并发AITD的自身抗体变化特点研究[J].检验医学与临床,2017,14(Z1):4-7.
[7]陈墨洋,李树臣.慢性丙型肝炎患者抗甲状腺抗体异常相关影响因素的研究[J].肝脏,2016,21(12):1035-1036.
[8]杨榕,单忠艳,李玉妹,等.甲状腺自身免疫性抗体与丙型肝炎病毒感染的相关性分析[J].中华传染病杂志,2009,27(3):138-141.
[9]陈倩,亓传旺,张会,等.慢性丙型肝炎患者抗病毒治疗后甲状腺功能动态变化和转归及其影响因素[J].吉林大学学报,2014,40(3):641-645.
[2]鲁陈,朱颖.甲状腺自身免疫抗体与丙型肝炎病毒感染的关联性分析[J].实验与检验医学,2017,35(5):757-759.
[3]袁孟伟,苑文雯,戴亮,等.丙肝相关性自身免疫性甲状腺疾病患者甲状腺自身抗体变化特点研究[J].中国医药导报,2017,14(5):117-120.
[4]王晗,杨宁,于长明.HCV相关自身免疫性甲状腺疾病自身抗体研究进展[J].检验医学与临床,2017,14(5):742-745.
[5]刘淼,陈华锋,李梦华.丙肝患者的甲状腺激素及相关抗体水平的研究[J].中国冶金工业医学杂志,2016,33(2):242-243.
[6]李妍,黄加干,杨宁,等.丙肝患者干扰素治疗后并发AITD的自身抗体变化特点研究[J].检验医学与临床,2017,14(Z1):4-7.
[7]陈墨洋,李树臣.慢性丙型肝炎患者抗甲状腺抗体异常相关影响因素的研究[J].肝脏,2016,21(12):1035-1036.
[8]杨榕,单忠艳,李玉妹,等.甲状腺自身免疫性抗体与丙型肝炎病毒感染的相关性分析[J].中华传染病杂志,2009,27(3):138-141.
[9]陈倩,亓传旺,张会,等.慢性丙型肝炎患者抗病毒治疗后甲状腺功能动态变化和转归及其影响因素[J].吉林大学学报,2014,40(3):641-645.