养心汤治疗冠心病心绞痛的系统回顾与Meta分析
|
摘要
目的系统评价养心汤治疗冠心病心绞痛的疗效与安全性。方法计算机检索Pubmed、EMbase、Cochrane、中国知网、中国生物医学文献数据库、万方数据库、维普数据库,检索养心汤治疗冠心病心绞痛的随机对照试验,通过纳入与排除标准来选择文献、用Cochrane手册临床试验质量评价标准评价文献质量,提取有效数据,采用RevMan5.3进行数据的统计与分析。结果共纳入9项研究,包括692例患者。Meta分析结果显示:缓解心绞痛疗效分析结果显示[OR=1.92,95%CI(1.15,3.22)],观察组心绞痛疗效优于对照组。心电图疗效分析结果显示[OR=1.88,95%CI(1.18,2.99)],观察组心电图疗效优于对照组。中医证候分析结果显示[OR=3.20,95%CI(1.89,5.44)],观察组中医证候改善优于对照组。安全性评价:纳入的9篇文献中,观察过程中未报道不良反应的发生。结论养心汤能有效缓解冠心病心绞痛患者的心绞痛症状,改善心电图疗效及中医证候疗效。
Objective: To systematically evaluate the efficacy and safety of Yangxin Decoction on angina pectoris of coronary heart disease. Methods: Computer was used to search Pubmed,EMbase,Cochrane,China Knowledge Network,VIP database,China Biomedical Literature Database and Wanfang Database for randomized controlled trials of coronary heart disease and angina treated with Yangxin Decoction The inclusion and exclusion criteria were used to select the inclusion literature;the Cochrane Manual clinical trial quality evaluation criteria were used to evaluate the literature quality,and the effective data were extracted. RevMan 5.3 was used for data statistics and analysis. Results: 9 studies were included,including 692 patients. The results of meta-analysis showed that the results of the analysis of the effect of relieving angina showed that [OR =1.92,95% CI(1.15,3.22)]. The observation group was superior to the control group in the treatment of angina pectoris. The results of ECG analysis showed that [OR=1. 88,95%CI(1.18,2.99)]. The observation group was superior to the control group in the treatment of electrocardiogram. The results of TCM syndrome analysis showed that [OR =3.20,95%CI(1.89,5.44)]. The observation group had better TCM syndromes than the control group. Safety evaluation: in the 9 articles included,no adverse reactions were reported during the observation. Conclusions: Yangxin Decoction can effectively relieve the symptoms of angina pectoris in patients with coronary heart disease and angina pectoris,improve the efficacy of ECG and TCM syndrome,with high safety.
Objective: To systematically evaluate the efficacy and safety of Yangxin Decoction on angina pectoris of coronary heart disease. Methods: Computer was used to search Pubmed,EMbase,Cochrane,China Knowledge Network,VIP database,China Biomedical Literature Database and Wanfang Database for randomized controlled trials of coronary heart disease and angina treated with Yangxin Decoction The inclusion and exclusion criteria were used to select the inclusion literature;the Cochrane Manual clinical trial quality evaluation criteria were used to evaluate the literature quality,and the effective data were extracted. RevMan 5.3 was used for data statistics and analysis. Results: 9 studies were included,including 692 patients. The results of meta-analysis showed that the results of the analysis of the effect of relieving angina showed that [OR =1.92,95% CI(1.15,3.22)]. The observation group was superior to the control group in the treatment of angina pectoris. The results of ECG analysis showed that [OR=1. 88,95%CI(1.18,2.99)]. The observation group was superior to the control group in the treatment of electrocardiogram. The results of TCM syndrome analysis showed that [OR =3.20,95%CI(1.89,5.44)]. The observation group had better TCM syndromes than the control group. Safety evaluation: in the 9 articles included,no adverse reactions were reported during the observation. Conclusions: Yangxin Decoction can effectively relieve the symptoms of angina pectoris in patients with coronary heart disease and angina pectoris,improve the efficacy of ECG and TCM syndrome,with high safety.
引文
[1]Yoshiyama T,Sugioka K,Naruko T.Neopterin and cardiovascular events following coronary stent implantation in patients with stable angina pectoris[J].J Atheroscler Thromb,2018,28.
[2]Luo P,Dong G,Liu L.The long-term consumption of ginseng extract reduces the susceptibility of intermediate-aged hearts to acute ischemia reperfusion injury[J].PLoS One,2015,10(12):e0144733.
[3]Pan X,Bao H,Si Y.Spinal cord stimulation for refractory angina pectoris:a systematic review and Meta-analysis[J].Clin J Pain,2017,33(6):543-551.
[4]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.慢性稳定性心绞痛诊断与治疗指南[J].中华心血管病杂志,2007,35(3):195-206.
[5]柯元南,陈纪林.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2007,35(4):295-304.
[6]中国中西医结合学会心血管学会.冠心病中医辨证标准[J]中西医结合杂志,1991,11(5):257.
[7]全国冠心病座谈会.冠心病心绞痛及心电图疗效评定标准[J].人民军医,1974,25(5):62.
[8]梁茂新,高天舒.《中药新药临床研究指导原则》脏腑诸证考察与分析[J].中国中医基础医学杂志,2008,14(5):330-331,342.
[9]刘影哲,周亚滨,孙静,等.养心汤治疗冠心病不稳定性心绞痛临床观察[J].中医药学报,2009,37(4):40-41.
[10]李玉芳,吴维平.养心汤加减治疗冠心病心绞痛(胸痹-气阴两虚型)临床观察[J].牡丹江医学院学报,2009,30(6):34-36.
[11]于晓红.养心汤干预不稳定型心绞痛患者的临床研究及代谢组学影响[D].哈尔滨:黑龙江中医药大学,2011.
[12]于夕雯.养心汤干预UA患者疗效观察及对TNF-α、血浆代谢组学的影响[D].哈尔滨:黑龙江中医药大学,2012.
[13]高旭阳,遇昕.养心汤治疗胸痹心痛病气血亏虚型临床观察[J].黑龙江中医药,2013,42(2):13-14.
[14]朱衡.养心汤治疗不稳定型心绞痛34例疗效观察[J].福建中医药大学学报,2013,23(3):58-59.
[15]陈松柏,周亚滨,孙静,等.养心汤治疗冠心病不稳定性心绞痛临床观察[J].黑龙江医学,2014,38(8):904-905.
[16]李海龙.养心汤加减治疗冠心病合并心理障碍(气血虚滞证)的临床观察[D].长春:长春中医药大学,2015.
[17]曹罗文.冠心病不稳定性心绞痛应用养心汤治疗的效果分析[J].内蒙古中医药,2017,36(17):2-3.
[18]王阶,陈光.冠心病稳定型心绞痛中医诊疗专家共识[J]中医杂志,2018,59(5):447-450.
[19]范增光,杨建飞.中药养心汤的应用研究进展[J].中国中医急症,2016,25(12):2301-2303.
[2]Luo P,Dong G,Liu L.The long-term consumption of ginseng extract reduces the susceptibility of intermediate-aged hearts to acute ischemia reperfusion injury[J].PLoS One,2015,10(12):e0144733.
[3]Pan X,Bao H,Si Y.Spinal cord stimulation for refractory angina pectoris:a systematic review and Meta-analysis[J].Clin J Pain,2017,33(6):543-551.
[4]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.慢性稳定性心绞痛诊断与治疗指南[J].中华心血管病杂志,2007,35(3):195-206.
[5]柯元南,陈纪林.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2007,35(4):295-304.
[6]中国中西医结合学会心血管学会.冠心病中医辨证标准[J]中西医结合杂志,1991,11(5):257.
[7]全国冠心病座谈会.冠心病心绞痛及心电图疗效评定标准[J].人民军医,1974,25(5):62.
[8]梁茂新,高天舒.《中药新药临床研究指导原则》脏腑诸证考察与分析[J].中国中医基础医学杂志,2008,14(5):330-331,342.
[9]刘影哲,周亚滨,孙静,等.养心汤治疗冠心病不稳定性心绞痛临床观察[J].中医药学报,2009,37(4):40-41.
[10]李玉芳,吴维平.养心汤加减治疗冠心病心绞痛(胸痹-气阴两虚型)临床观察[J].牡丹江医学院学报,2009,30(6):34-36.
[11]于晓红.养心汤干预不稳定型心绞痛患者的临床研究及代谢组学影响[D].哈尔滨:黑龙江中医药大学,2011.
[12]于夕雯.养心汤干预UA患者疗效观察及对TNF-α、血浆代谢组学的影响[D].哈尔滨:黑龙江中医药大学,2012.
[13]高旭阳,遇昕.养心汤治疗胸痹心痛病气血亏虚型临床观察[J].黑龙江中医药,2013,42(2):13-14.
[14]朱衡.养心汤治疗不稳定型心绞痛34例疗效观察[J].福建中医药大学学报,2013,23(3):58-59.
[15]陈松柏,周亚滨,孙静,等.养心汤治疗冠心病不稳定性心绞痛临床观察[J].黑龙江医学,2014,38(8):904-905.
[16]李海龙.养心汤加减治疗冠心病合并心理障碍(气血虚滞证)的临床观察[D].长春:长春中医药大学,2015.
[17]曹罗文.冠心病不稳定性心绞痛应用养心汤治疗的效果分析[J].内蒙古中医药,2017,36(17):2-3.
[18]王阶,陈光.冠心病稳定型心绞痛中医诊疗专家共识[J]中医杂志,2018,59(5):447-450.
[19]范增光,杨建飞.中药养心汤的应用研究进展[J].中国中医急症,2016,25(12):2301-2303.