小柴胡汤加减方治疗上呼吸道感染发热临床研究
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摘要
目的:探讨小柴胡汤加减方治疗上呼吸道感染发热的治疗效果。方法:选择80例上呼吸道感染发热患者,按照随机数字表法分为观察组和对照组各40例,观察组给予小柴胡汤加减方治疗,对照组给予抗感染,退热治疗。观察比较两组的治疗总有效率,主要症状消失时间,血清反应蛋白(CRP)、β_2-微球蛋白(β_2-MG)、前白蛋白(PA)及血沉(ESR)、T淋巴细胞亚群、免疫球蛋白情况。结果:观察组总有效率为97.50%,明显高于对照组(75.00%),差异具有统计学意义(P<0.05);观察组发热反复次数(2.36±0.62)次,平均发热时间为(1.24±0.73)d,咽部充血消失时间(2.12±0.24)d,咳嗽消失时间(2.89±0.22)d,流涕停止时间(2.14±0.24)d,咳痰停止时间(2.65±0.59)d,均显著少于对照组各症状消失时间(P<0.05);治疗后观察组血清CRP、β_2-MG、ESR水平明显低于对照组,PA水平明显高于对照组(P<0.05);临床症状体征发热、咳嗽、咳痰、鼻塞、纳少等中医证候积分及总积分明显低于对照组(P<0.05);T淋巴细胞亚群CD_4~+、CD_3~+含量明显高于对照组,CD_4~+/CD_8~+值明显大于对照组,IgG、IgM、IgA明显低于对照组,差异具有统计学意义(P<0.05)。结论:小柴胡汤加减方治疗上呼吸道感染发热疗效显著,可在短时间内降低患者体温,改善患者症状,提高患者免疫功能。
Objective:To investigate the therapeutic effect of Xiaochaihu decoction in treating upper respiratory tract infection fever.Methods:The 80 patients with upper respiratory tract infections were selected and divided into observation group(n=40)and control group(n=40)according to the random number table method.The observation group was treated with Xiaochaihu decoction,the control group was given anti-infection,antipyretic therapy.the total effective rate of treatment,the disappearance time of main symptoms,serum reactive protein(CRP),β_2-microglobulin(β_2-MG),prealbumin(PA),ESR,and T lymphocyte subsets,immunoglobulin conditions were observed and compared.Results:The total effective rate in the observation group was 97.50%,which was significantly higher than that in the control group(75.00%),and the difference was statistically significant(P<0.05).The number of repeated episodes of fever(2.36±0.62)was observed in the observation group.The mean fever time was(1.24±0.73)days,the disappearance time of pharyngeal congestion(2.12±0.24)d,the time of disappearance of cough(2.89±0.22)days,and the time of flow cessation(2.14±0.24)d,cough stop time(2.65±0.59)d,both significantly less than the disappearance time of each symptom in the control group(P<0.05).After treatment,serum CRP,β_2-MG,and ESR levels in the observation group were significantly lower than those in the control group,the PA level was significantly higher than the control group(P<0.05).The TCM syndrome scores and total scores such as fever,cough,sputum,nasal congestion,and nausea were significantly lower than those in the control group(P<0.05).The content of CD_4~+and CD_3~+in T lymphocyte subsets was significantly higher than that in the control group,the CD_4~+/CD_8~+values were significantly higher than those in the control group,IgG,IgM,and IgA were significantly lower than those in the control group,with a significant difference(P<0.05).Conclusion:Xiaochaihu decoction is effective in treating upper respiratory tract infections and can reduce the body temperature of patients in a short period of time,improve the symptoms of patients,and improve the immune function of patients.It has certain application value.
Objective:To investigate the therapeutic effect of Xiaochaihu decoction in treating upper respiratory tract infection fever.Methods:The 80 patients with upper respiratory tract infections were selected and divided into observation group(n=40)and control group(n=40)according to the random number table method.The observation group was treated with Xiaochaihu decoction,the control group was given anti-infection,antipyretic therapy.the total effective rate of treatment,the disappearance time of main symptoms,serum reactive protein(CRP),β_2-microglobulin(β_2-MG),prealbumin(PA),ESR,and T lymphocyte subsets,immunoglobulin conditions were observed and compared.Results:The total effective rate in the observation group was 97.50%,which was significantly higher than that in the control group(75.00%),and the difference was statistically significant(P<0.05).The number of repeated episodes of fever(2.36±0.62)was observed in the observation group.The mean fever time was(1.24±0.73)days,the disappearance time of pharyngeal congestion(2.12±0.24)d,the time of disappearance of cough(2.89±0.22)days,and the time of flow cessation(2.14±0.24)d,cough stop time(2.65±0.59)d,both significantly less than the disappearance time of each symptom in the control group(P<0.05).After treatment,serum CRP,β_2-MG,and ESR levels in the observation group were significantly lower than those in the control group,the PA level was significantly higher than the control group(P<0.05).The TCM syndrome scores and total scores such as fever,cough,sputum,nasal congestion,and nausea were significantly lower than those in the control group(P<0.05).The content of CD_4~+and CD_3~+in T lymphocyte subsets was significantly higher than that in the control group,the CD_4~+/CD_8~+values were significantly higher than those in the control group,IgG,IgM,and IgA were significantly lower than those in the control group,with a significant difference(P<0.05).Conclusion:Xiaochaihu decoction is effective in treating upper respiratory tract infections and can reduce the body temperature of patients in a short period of time,improve the symptoms of patients,and improve the immune function of patients.It has certain application value.
引文
[1] Zhang X,Gu J,Cao L,et al.Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection[J].Molecular Biosystems,2014,10(10):2517-2525.
[2]刘艳敏,黄明志,罗俊彪,等.玉屏风散颗粒联合转移因子治疗儿童反复上呼吸道感染的疗效观察[J].中南医学科学杂志,2015,43(4):401-403.
[3]张晶.关于修订《中药新药临床研究指导原则》的建议[J].中药新药与临床药理,2000,11(2):67-79.
[4]陈瑜,王向东,杨林东.心胸外科术后并发上呼吸道感染近期心血管事件发生的危险因素分析[J].陕西医学杂志,2017,46(2):180.
[5] Santee C,Nagalingam N,Faruqi A,et al.Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis[J].Microbiome,2016,4(1):1-9.
[6]马欣波.热必清颗粒不同给药途径对小儿上呼吸道感染发热的临床观察[J].现代中医药,2017,37(3):24-25.
[7]马永剑,侯莉娟.丁象宸教授应用小柴胡汤合生化汤加减治疗产后发热体会[J].陕西中医,2015,36(9):1228-1229.
[8]马荣,杨秀捷,王颖辉,等.加减葛根汤治疗上呼吸道感染发热的疗效观察[J].北京中医药,2016,35(11):1055-1057.
[9]张洁,李建波,杨秀丽,等.小柴胡汤加减治疗癌性发热的临床研究[J].现代中西医结合杂志,2017,26(6):603-605.
[10]张莹,周小莉.小柴胡汤对机体免疫系统的影响及临床应用[J].中医药导报,2016,22(8):116-118,121.
[11]孟祖东,杜天平,王玉.小柴胡汤治疗系统性红斑狼疮临床疗效及对血清TIM-1、TIM-3水平的影响[J].陕西中医,2017,38(11):1544-1545.
[12]侯宝渊.小柴胡汤治疗急性上呼吸道感染的临床疗效分析[J].内蒙古中医药,2016,35(5):24-25.
[13]刘云琴,张智玲.小柴胡汤配伍保和丸加减治疗急性上呼吸道感染初期的临床观察[J].新疆医学,2016,46(6):643-645.
[14]张昆.全血CRP联合血常规在诊断儿科感染类型中的应用评价[J].陕西医学杂志,2015,44(12):1605-1606.
[2]刘艳敏,黄明志,罗俊彪,等.玉屏风散颗粒联合转移因子治疗儿童反复上呼吸道感染的疗效观察[J].中南医学科学杂志,2015,43(4):401-403.
[3]张晶.关于修订《中药新药临床研究指导原则》的建议[J].中药新药与临床药理,2000,11(2):67-79.
[4]陈瑜,王向东,杨林东.心胸外科术后并发上呼吸道感染近期心血管事件发生的危险因素分析[J].陕西医学杂志,2017,46(2):180.
[5] Santee C,Nagalingam N,Faruqi A,et al.Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis[J].Microbiome,2016,4(1):1-9.
[6]马欣波.热必清颗粒不同给药途径对小儿上呼吸道感染发热的临床观察[J].现代中医药,2017,37(3):24-25.
[7]马永剑,侯莉娟.丁象宸教授应用小柴胡汤合生化汤加减治疗产后发热体会[J].陕西中医,2015,36(9):1228-1229.
[8]马荣,杨秀捷,王颖辉,等.加减葛根汤治疗上呼吸道感染发热的疗效观察[J].北京中医药,2016,35(11):1055-1057.
[9]张洁,李建波,杨秀丽,等.小柴胡汤加减治疗癌性发热的临床研究[J].现代中西医结合杂志,2017,26(6):603-605.
[10]张莹,周小莉.小柴胡汤对机体免疫系统的影响及临床应用[J].中医药导报,2016,22(8):116-118,121.
[11]孟祖东,杜天平,王玉.小柴胡汤治疗系统性红斑狼疮临床疗效及对血清TIM-1、TIM-3水平的影响[J].陕西中医,2017,38(11):1544-1545.
[12]侯宝渊.小柴胡汤治疗急性上呼吸道感染的临床疗效分析[J].内蒙古中医药,2016,35(5):24-25.
[13]刘云琴,张智玲.小柴胡汤配伍保和丸加减治疗急性上呼吸道感染初期的临床观察[J].新疆医学,2016,46(6):643-645.
[14]张昆.全血CRP联合血常规在诊断儿科感染类型中的应用评价[J].陕西医学杂志,2015,44(12):1605-1606.