中药莪术几种活性成分对肝脏疾病防治作用的机制
|
摘要
中药莪术几种主要活性成分如姜黄素、榄香烯、莪术醇、吉马酮对治疗肝脏疾病具有确定的疗效.研究发现姜黄素有抗肿瘤、抗炎、抗纤维化等作用,临床用于治疗慢性肝病、肿瘤等疾病;榄香烯能诱发肿瘤细胞凋亡,抑制肿瘤细胞的生长,提高机体免疫反应,降低放化疗不良反应;莪术醇可以通过抑制细胞因子表达发挥抗肝纤维化作用,并可以通过抑制基因表达诱导瘤细胞的凋亡,发挥抗肿瘤作用;吉马酮则在肝癌细胞的增殖、细胞周期及细胞凋亡等方面均有干预影响,从而呈现抗肝癌作用.
The main active ingredients of Rhizoma curcumae, such as curcumin, elemene, curcumol, and germacrone, have certain curative effect on liver diseases. Studies have found that curcumin has anti-tumor, anti-inflammatory, anti-fibrosis, and other properties and can be used for treatment of chronic liver disease, tumors and other diseases. Elemene can induce tumor apoptosis, inhibit the growth of tumor cells, improve the immune response, and reduce the toxic and side effects of chemotherapy. Zedoary alcohol can exert anti-fibrosis effects by inhibiting the expression of cytokines, and exert anti-tumor effects by inhibiting the apoptosis of tumor cells. Germacrone can intervene hepatocellular cancer cell proliferation, cell cycle, apoptosis, and other aspects, showing anti-hepatocarcinoma effects.
The main active ingredients of Rhizoma curcumae, such as curcumin, elemene, curcumol, and germacrone, have certain curative effect on liver diseases. Studies have found that curcumin has anti-tumor, anti-inflammatory, anti-fibrosis, and other properties and can be used for treatment of chronic liver disease, tumors and other diseases. Elemene can induce tumor apoptosis, inhibit the growth of tumor cells, improve the immune response, and reduce the toxic and side effects of chemotherapy. Zedoary alcohol can exert anti-fibrosis effects by inhibiting the expression of cytokines, and exert anti-tumor effects by inhibiting the apoptosis of tumor cells. Germacrone can intervene hepatocellular cancer cell proliferation, cell cycle, apoptosis, and other aspects, showing anti-hepatocarcinoma effects.
引文
1国家药典委员会.中华人民共和国药典:一部.2015年版.北京:中国医药科技出版社,2015:274-275
2陈旭,曾建红.广西莪术挥发油化学成分的研究.药物生物技术2008;15:324
3张红玉,张丽莎,张杰,张永勇,潘家荣.温郁金化学成分的研究.中药2016;38:1534-1537
4李金慈,陆兔林,毛春芹,季德,李林,肖永庆.莪术醋制前后抗复合因素致大鼠肝纤维化作用的比较研究.中草药2013;44:2710-2716
5邵敬伟,董海燕,王涛,郭养浩.中药莪术激活PXR及对大鼠肝细胞色素P4503A的影响.中国药理学通报2008;24:504-509
6张伟霞,李娟,陈禾凤,陈冰.姜黄素对雷公藤甲素肝损伤的保护作用.药学与临床研究2016;24:357-360
7 Manibusan MK,Odin M,Eastmond DA.Postulated carbon tetrachloride mode of action:a review.J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2007;25:185-209[PMID:17763046DOI:10.1080/10590500701569398]
8韩冰.姜黄素保护ConA诱导小鼠免疫性肝炎的作用机制.上海:复旦大学,2010:1-69
9李晶菁,张霞,陈瑜,蔡丹磊,黄中伟.Nrf2在脓毒症大鼠肝组织中的表达及姜黄素的干预作用.重庆医学2013;42:2873-2876
10 Wong VW,Wong GL,Choi PC,Chan AW,Li MK,Chan HY,Chim AM,Yu J,Sung JJ,Chan HL.Disease progression of non-alcoholic fatty liver disease:a prospective study with paired liver biopsies at 3 years.Gut 2010;59:969-974[PMID:20581244 DOI:10.1136/gut.2009.205088]
11王子超,赵丽娟,黄婷婷,朱明飞.姜黄素对大鼠非酒精性脂肪性肝病的治疗作用及其对肝脏瘦素表达的影响.解放军医学杂志2016;41:909-914
12周玲玲,林琼琼,周伶俐,祁旦巳,赵志光.姜黄素对非酒精性脂肪肝家兔血脂及肝组织PPAR-γ水平的影响.浙江中西医结合杂志2012;22:7-10
13 Lin J,Chen A.Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells.Lab Invest2008;88:529-540[PMID:18332871 DOI:10.1038/labinvest.2008.20]
14 Zhang F,Kong D,Chen L,Zhang X,Lian N,Zhu X,Lu Y,Zheng S.Peroxisome proliferatoractivated receptor-γinterrupts angiogenic signal transduction by transrepression of plateletderived growth factor-βreceptor in hepatic stellate cells.J Cell Sci 2014;127:305-314[PMID:24259663 DOI:10.1242/jcs.128306]
15狄建彬,顾振纶,赵笑东,钱培刚,蒋小岗,郭次仪.姜黄素防治大鼠高脂性脂肪肝的研究.中草药2010;41:1322-1326
16滕耀红,祝骥,庞珍珍,王萍儿,卢德赵.姜黄素对非酒精性脂肪肝细胞胆固醇代谢的影响.中医药大学学报2014;38:115-120
17麦静愔,刘玉莉,成扬,陈高峰,平键,汪美凤.姜黄素对大鼠非酒精性脂肪肝的干预作用.中国中西医结合消化杂志2011;19:239-242
18诸葛丽,苏冬梅,李健,杨美娟,刘云霞,李军祥.姜黄素对小鼠非酒精性脂肪性肝炎炎症信号传导通路的调控作用.中西医结合肝病杂志2011;21:352-355
19唐丹,周永健,李瑜元,杜艳蕾,聂玉强.姜黄素对脂肪变性肝细胞过氧化物酶体增殖物活化受体-α的去甲基化作用.广东医学2014;35:175-179
20曾瑜,刘婧,黄真真,潘兴昌,张立实.姜黄素对急性酒精性肝损伤小鼠抗氧化功能的影响.卫生研究2014;43:282-285
21胡静,陈新祥,胡剑峰,王洪武.姜黄素对乙醇诱导的人L-02肝细胞氧化损伤的保护作用研究.医学理论与实践2013;26:3-4
22 Bao W,Li K,Rong S,Yao P,Hao L,Ying C,Zhang X,Nussler A,Liu L.Curcumin alleviates ethanolinduced hepatocytes oxidative damage involving heme oxygenase-1 induction.J Ethnopharmacol2010;128:549-553[PMID:20080166 DOI:10.1016/j.jep.2010.01.029]
23吴雄健,朱海燕.姜黄素对大鼠肝纤维化防治作用.上海医药2015;36:72-75
24钟越,钟秀宏,孙艳美,杨淑燕.姜黄素拮抗四氯化碳致肝纤维化作用.中国公共卫生2015;31:447-449
25任新凤.姜黄素mPEG-PLGA纳米粒逆转二甲基亚硝胺大鼠肝纤维化作用研究.中华中医药学刊2011;29:2567-2569
26 Rajagopalan R,Sridharana S,Menon VP.Hepatoprotective role of bis-demethoxy curcumin analog on the expression of matrix metalloproteinase induced by alcohol and polyunsaturated fatty acid in rats.Toxicol Mech Methods 2010;20:252-259[PMID:20465419 DOI:10.3109/15376516.2010.482961]
27 Yao Q,Lin Y,Li X,Shen X,Wang J,Tu C.Curcumin ameliorates intrahepatic angiogenesis and capillarization of the sinusoids in carbon tetrachloride-induced rat liver fibrosis.Toxicol Lett2013;222:72-82[PMID:23845850 DOI:10.1016/j.toxlet.2013.06.240]
28赵岩,周毕军.姜黄素对大鼠肝癌诱发初期肝脏氧化应激的影响.中药药理与临床2014;30:43-45
29江敏华,谢莹,胡凤霞,甘建和.姜黄素对人肝癌细胞SMMC7721侵袭转移的影响.江苏医药2010;36:2780-2782
30李帅帅,孙军.PI3K/AKT/mTOR信号传导通路在姜黄素抑制人肝癌细胞Cox-2表达中的作用.解放军医学杂志2014;39:30-33
31 Huang AC,Lin SY,Su CC,Lin SS,Ho CC,Hsia TC,Chiu TH,Yu CS,Ip SW,Lin TP,Chung JG.Effects of curcumin on N-bis(2-hydroxypropyl)nitrosamine(DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo.In Vivo2008;22:781-785[PMID:19181006]
32 Chuang SE,Kuo ML,Hsu CH,Chen CR,Lin JK,Lai GM,Hsieh CY,Cheng AL.Curcumincontaining diet inhibits diethylnitrosamineinduced murine hepatocarcinogenesis.Carcinogenesis 2000;21:331-335[PMID:10657978DOI:10.1093/carcin/21.2.331]
33 Yoysungnoen P,Wirachwong P,Changtam C,Suksamrarn A,Patumraj S.Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice.World J Gastroenterol2008;14:2003-2009[PMID:18395899 DOI:10.3748/wjg.14.2003]
34 Sreepriya M,Bali G.Effects of administration of Embelin and Curcumin on lipid peroxidation,hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats.Mol Cell Biochem2006;284:49-55[PMID:16477385 DOI:10.1007/s11010-005-9012-7]
35张会存,塔娜,杨美娟.姜黄素对肿瘤坏死因子-α诱导后人肝癌细胞核转录因子表达的影响.中国中医药信息杂志2013;20:25-27
36焦艺博,刘晓婷,毛文超,张健,冯丽莉,田民强,张东星,蔡大勇,王玥琦.姜黄素对二乙胺基亚硝胺诱发小鼠肝癌前病变的预防作用.中国药师2012;15:1218-1222
37李勇,肖雅玲,陈朝晖,黎明,李青玲,邹欣,周海燕.姜黄素对人肝母细胞瘤细胞株HepG2增殖和转移的影响.中国普通外科杂志2014;23:117-120
38胡盛军,杨玲,朱清静,彭汉光.β-榄香烯对实验性肝纤维化大鼠TGF-β1、α-SMA、Col-1表达的影响.世界华人消化杂志2007;15:1324-1330
39朱锐,沈霖,杨玲,但丹,杨建国.β-榄香烯对肝星状细胞分泌ANG及表达AT1RmRNA的影响.山东医药2008;44:18-21
40方卓,陈洪胜,陈宏勃,刘跃明.榄香烯对PLA801D细胞株诱导分化研究.中国老年学杂志2008;28:768-769
41龚敏,梁鑫淼,崔晓楠.榄香烯对人肝癌HepG-2细胞增殖及拓扑异构酶Ⅰ的影响.中国癌症杂志2011;21:321-325
42 Chen W,Lu Y,Wu J,Gao M,Wang A,Xu B.Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis.Cancer Chemother Pharmacol 2011;67:799-808[PMID:20563582 DOI:10.1007/s00280-010-1378-x]
43胡军,金伟,杨佩满.β-榄香烯逆转人乳腺癌MCF-7/ADM细胞对阿霉素耐药性的研究.中华肿瘤杂志2004;26:268-270
44金梅,白雪,胡景慧.榄香烯复合抗肿瘤疫苗免疫的效应机制.中国农业科学2010;37:1379-1384
45林琳,沈洪,王立新,周晓波,吴静.黄芪甲苷、β-榄香烯对小鼠树突状细胞免疫功能的体外实验研究.临床检验杂志2011;29:129-131
46郑瑾,刘强,任凯夕,史恒军,丁井永.β-榄香烯对肝癌细胞SK-hep-1的迁移和侵袭力的影响.现代肿瘤医学2009;17:2054-2058
47郭霞,秦岩,谭婧,张红.榄香烯对肝癌H22细胞荷瘤小鼠的抑瘤作用及其可能机制.中国临床药学杂志2013;22:155-159
48彭齐荣,肖必,马珑,程涛,谭永才.榄香烯治疗中晚期原发性肝癌的临床疗效观察.中西医结合肝病杂志2010;20:274-276
49赵成,张蕴超,孙一予,贾英杰.榄香烯注射液联合介入化疗治疗原发性肝癌的临床研究.疑难病杂志2012;11:882-883
50唐渊,李晓辉.莪术提取物对肝癌细胞系HepG2的抗癌作用及机制研究.中国药理学通报2007;23:790-794
51黄岚珍,王娟,卢菲婷,杨飞城,陈旭.莪术醇抑制人肝癌细胞HepG2增殖的机制.中国中药杂志2013;38:1812-1815
52徐立春,陈海燕,文洁,陶亚玲.莪术醇对人胃癌细胞凋亡、MMP2、NO影响的初步探讨.中国医药导报2012;9:18-21
53龚玲,夏小芳,叶晓平,吴建,景钊.莪术醇β-环糊精包合物对Bel-7404肝癌细胞体外抑瘤作用和细胞周期影响的研究.中国现代医生2015;53:11-13
54 Sadia Roshan,柳昀熠,郑倩.吉马酮抑制肝癌BEL7402细胞增殖机制初步研究.时珍国医国药2014;25:2875-2877
55 Liu YY,Zheng Q,Fang B,Wang W,Ma FY,Roshan S,Banafa A,Chen MJ,Chang JL,Deng XM,Li KX,Yang GX,He GY.Germacrone induces apoptosis in human hepatoma HepG2cells through inhibition of the JAK2/STAT3signalling pathway.J Huazhong Univ Sci Technolog Med Sci 2013;33:339-345[PMID:23771657 DOI:10.1007/s11596-013-1121-z]
2陈旭,曾建红.广西莪术挥发油化学成分的研究.药物生物技术2008;15:324
3张红玉,张丽莎,张杰,张永勇,潘家荣.温郁金化学成分的研究.中药2016;38:1534-1537
4李金慈,陆兔林,毛春芹,季德,李林,肖永庆.莪术醋制前后抗复合因素致大鼠肝纤维化作用的比较研究.中草药2013;44:2710-2716
5邵敬伟,董海燕,王涛,郭养浩.中药莪术激活PXR及对大鼠肝细胞色素P4503A的影响.中国药理学通报2008;24:504-509
6张伟霞,李娟,陈禾凤,陈冰.姜黄素对雷公藤甲素肝损伤的保护作用.药学与临床研究2016;24:357-360
7 Manibusan MK,Odin M,Eastmond DA.Postulated carbon tetrachloride mode of action:a review.J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2007;25:185-209[PMID:17763046DOI:10.1080/10590500701569398]
8韩冰.姜黄素保护ConA诱导小鼠免疫性肝炎的作用机制.上海:复旦大学,2010:1-69
9李晶菁,张霞,陈瑜,蔡丹磊,黄中伟.Nrf2在脓毒症大鼠肝组织中的表达及姜黄素的干预作用.重庆医学2013;42:2873-2876
10 Wong VW,Wong GL,Choi PC,Chan AW,Li MK,Chan HY,Chim AM,Yu J,Sung JJ,Chan HL.Disease progression of non-alcoholic fatty liver disease:a prospective study with paired liver biopsies at 3 years.Gut 2010;59:969-974[PMID:20581244 DOI:10.1136/gut.2009.205088]
11王子超,赵丽娟,黄婷婷,朱明飞.姜黄素对大鼠非酒精性脂肪性肝病的治疗作用及其对肝脏瘦素表达的影响.解放军医学杂志2016;41:909-914
12周玲玲,林琼琼,周伶俐,祁旦巳,赵志光.姜黄素对非酒精性脂肪肝家兔血脂及肝组织PPAR-γ水平的影响.浙江中西医结合杂志2012;22:7-10
13 Lin J,Chen A.Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells.Lab Invest2008;88:529-540[PMID:18332871 DOI:10.1038/labinvest.2008.20]
14 Zhang F,Kong D,Chen L,Zhang X,Lian N,Zhu X,Lu Y,Zheng S.Peroxisome proliferatoractivated receptor-γinterrupts angiogenic signal transduction by transrepression of plateletderived growth factor-βreceptor in hepatic stellate cells.J Cell Sci 2014;127:305-314[PMID:24259663 DOI:10.1242/jcs.128306]
15狄建彬,顾振纶,赵笑东,钱培刚,蒋小岗,郭次仪.姜黄素防治大鼠高脂性脂肪肝的研究.中草药2010;41:1322-1326
16滕耀红,祝骥,庞珍珍,王萍儿,卢德赵.姜黄素对非酒精性脂肪肝细胞胆固醇代谢的影响.中医药大学学报2014;38:115-120
17麦静愔,刘玉莉,成扬,陈高峰,平键,汪美凤.姜黄素对大鼠非酒精性脂肪肝的干预作用.中国中西医结合消化杂志2011;19:239-242
18诸葛丽,苏冬梅,李健,杨美娟,刘云霞,李军祥.姜黄素对小鼠非酒精性脂肪性肝炎炎症信号传导通路的调控作用.中西医结合肝病杂志2011;21:352-355
19唐丹,周永健,李瑜元,杜艳蕾,聂玉强.姜黄素对脂肪变性肝细胞过氧化物酶体增殖物活化受体-α的去甲基化作用.广东医学2014;35:175-179
20曾瑜,刘婧,黄真真,潘兴昌,张立实.姜黄素对急性酒精性肝损伤小鼠抗氧化功能的影响.卫生研究2014;43:282-285
21胡静,陈新祥,胡剑峰,王洪武.姜黄素对乙醇诱导的人L-02肝细胞氧化损伤的保护作用研究.医学理论与实践2013;26:3-4
22 Bao W,Li K,Rong S,Yao P,Hao L,Ying C,Zhang X,Nussler A,Liu L.Curcumin alleviates ethanolinduced hepatocytes oxidative damage involving heme oxygenase-1 induction.J Ethnopharmacol2010;128:549-553[PMID:20080166 DOI:10.1016/j.jep.2010.01.029]
23吴雄健,朱海燕.姜黄素对大鼠肝纤维化防治作用.上海医药2015;36:72-75
24钟越,钟秀宏,孙艳美,杨淑燕.姜黄素拮抗四氯化碳致肝纤维化作用.中国公共卫生2015;31:447-449
25任新凤.姜黄素mPEG-PLGA纳米粒逆转二甲基亚硝胺大鼠肝纤维化作用研究.中华中医药学刊2011;29:2567-2569
26 Rajagopalan R,Sridharana S,Menon VP.Hepatoprotective role of bis-demethoxy curcumin analog on the expression of matrix metalloproteinase induced by alcohol and polyunsaturated fatty acid in rats.Toxicol Mech Methods 2010;20:252-259[PMID:20465419 DOI:10.3109/15376516.2010.482961]
27 Yao Q,Lin Y,Li X,Shen X,Wang J,Tu C.Curcumin ameliorates intrahepatic angiogenesis and capillarization of the sinusoids in carbon tetrachloride-induced rat liver fibrosis.Toxicol Lett2013;222:72-82[PMID:23845850 DOI:10.1016/j.toxlet.2013.06.240]
28赵岩,周毕军.姜黄素对大鼠肝癌诱发初期肝脏氧化应激的影响.中药药理与临床2014;30:43-45
29江敏华,谢莹,胡凤霞,甘建和.姜黄素对人肝癌细胞SMMC7721侵袭转移的影响.江苏医药2010;36:2780-2782
30李帅帅,孙军.PI3K/AKT/mTOR信号传导通路在姜黄素抑制人肝癌细胞Cox-2表达中的作用.解放军医学杂志2014;39:30-33
31 Huang AC,Lin SY,Su CC,Lin SS,Ho CC,Hsia TC,Chiu TH,Yu CS,Ip SW,Lin TP,Chung JG.Effects of curcumin on N-bis(2-hydroxypropyl)nitrosamine(DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo.In Vivo2008;22:781-785[PMID:19181006]
32 Chuang SE,Kuo ML,Hsu CH,Chen CR,Lin JK,Lai GM,Hsieh CY,Cheng AL.Curcumincontaining diet inhibits diethylnitrosamineinduced murine hepatocarcinogenesis.Carcinogenesis 2000;21:331-335[PMID:10657978DOI:10.1093/carcin/21.2.331]
33 Yoysungnoen P,Wirachwong P,Changtam C,Suksamrarn A,Patumraj S.Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice.World J Gastroenterol2008;14:2003-2009[PMID:18395899 DOI:10.3748/wjg.14.2003]
34 Sreepriya M,Bali G.Effects of administration of Embelin and Curcumin on lipid peroxidation,hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats.Mol Cell Biochem2006;284:49-55[PMID:16477385 DOI:10.1007/s11010-005-9012-7]
35张会存,塔娜,杨美娟.姜黄素对肿瘤坏死因子-α诱导后人肝癌细胞核转录因子表达的影响.中国中医药信息杂志2013;20:25-27
36焦艺博,刘晓婷,毛文超,张健,冯丽莉,田民强,张东星,蔡大勇,王玥琦.姜黄素对二乙胺基亚硝胺诱发小鼠肝癌前病变的预防作用.中国药师2012;15:1218-1222
37李勇,肖雅玲,陈朝晖,黎明,李青玲,邹欣,周海燕.姜黄素对人肝母细胞瘤细胞株HepG2增殖和转移的影响.中国普通外科杂志2014;23:117-120
38胡盛军,杨玲,朱清静,彭汉光.β-榄香烯对实验性肝纤维化大鼠TGF-β1、α-SMA、Col-1表达的影响.世界华人消化杂志2007;15:1324-1330
39朱锐,沈霖,杨玲,但丹,杨建国.β-榄香烯对肝星状细胞分泌ANG及表达AT1RmRNA的影响.山东医药2008;44:18-21
40方卓,陈洪胜,陈宏勃,刘跃明.榄香烯对PLA801D细胞株诱导分化研究.中国老年学杂志2008;28:768-769
41龚敏,梁鑫淼,崔晓楠.榄香烯对人肝癌HepG-2细胞增殖及拓扑异构酶Ⅰ的影响.中国癌症杂志2011;21:321-325
42 Chen W,Lu Y,Wu J,Gao M,Wang A,Xu B.Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis.Cancer Chemother Pharmacol 2011;67:799-808[PMID:20563582 DOI:10.1007/s00280-010-1378-x]
43胡军,金伟,杨佩满.β-榄香烯逆转人乳腺癌MCF-7/ADM细胞对阿霉素耐药性的研究.中华肿瘤杂志2004;26:268-270
44金梅,白雪,胡景慧.榄香烯复合抗肿瘤疫苗免疫的效应机制.中国农业科学2010;37:1379-1384
45林琳,沈洪,王立新,周晓波,吴静.黄芪甲苷、β-榄香烯对小鼠树突状细胞免疫功能的体外实验研究.临床检验杂志2011;29:129-131
46郑瑾,刘强,任凯夕,史恒军,丁井永.β-榄香烯对肝癌细胞SK-hep-1的迁移和侵袭力的影响.现代肿瘤医学2009;17:2054-2058
47郭霞,秦岩,谭婧,张红.榄香烯对肝癌H22细胞荷瘤小鼠的抑瘤作用及其可能机制.中国临床药学杂志2013;22:155-159
48彭齐荣,肖必,马珑,程涛,谭永才.榄香烯治疗中晚期原发性肝癌的临床疗效观察.中西医结合肝病杂志2010;20:274-276
49赵成,张蕴超,孙一予,贾英杰.榄香烯注射液联合介入化疗治疗原发性肝癌的临床研究.疑难病杂志2012;11:882-883
50唐渊,李晓辉.莪术提取物对肝癌细胞系HepG2的抗癌作用及机制研究.中国药理学通报2007;23:790-794
51黄岚珍,王娟,卢菲婷,杨飞城,陈旭.莪术醇抑制人肝癌细胞HepG2增殖的机制.中国中药杂志2013;38:1812-1815
52徐立春,陈海燕,文洁,陶亚玲.莪术醇对人胃癌细胞凋亡、MMP2、NO影响的初步探讨.中国医药导报2012;9:18-21
53龚玲,夏小芳,叶晓平,吴建,景钊.莪术醇β-环糊精包合物对Bel-7404肝癌细胞体外抑瘤作用和细胞周期影响的研究.中国现代医生2015;53:11-13
54 Sadia Roshan,柳昀熠,郑倩.吉马酮抑制肝癌BEL7402细胞增殖机制初步研究.时珍国医国药2014;25:2875-2877
55 Liu YY,Zheng Q,Fang B,Wang W,Ma FY,Roshan S,Banafa A,Chen MJ,Chang JL,Deng XM,Li KX,Yang GX,He GY.Germacrone induces apoptosis in human hepatoma HepG2cells through inhibition of the JAK2/STAT3signalling pathway.J Huazhong Univ Sci Technolog Med Sci 2013;33:339-345[PMID:23771657 DOI:10.1007/s11596-013-1121-z]