前列通Ⅰ号保留灌肠治疗ⅢA型前列腺炎湿热瘀阻证
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摘要
目的:观察前列通Ⅰ号保留灌肠治疗ⅢA型前列腺炎湿热瘀阻证的临床疗效。方法:将ⅢA型前列腺炎湿热瘀阻证患者60例,随机均分成治疗组30例,对照组30例。治疗组予以前列通Ⅰ号150 m L保留灌肠,每日1次;对照组予前列闭尔通栓1粒塞肛,每日1次,疗程为4周。治疗前后记录美国国立卫生研究院制定的慢性前列腺炎症状评分(health chronic prostatitis symptom score,NIH-CPSI)、中医证候积分,并进行直肠前列腺触诊,取前列腺按摩液进行镜检。评价ⅢA型前列腺炎湿热瘀阻证的疗效。结果:治疗组NIH-CPSI、中医证候积分、前列腺按摩液中白细胞数目和卵磷脂小体数量改善均显著优于对照组(P值分别为0. 001,0. 000,0. 001,0. 010)。治疗组与对照组有效率分别为86. 7%和60. 0%,治疗组显著优于对照组(P=0. 041)。结论:前列通Ⅰ号保留灌肠治疗ⅢA型前列腺炎湿热瘀阻证在改善NIH-CPSI评分、中医证候积分、前列腺按摩液中白细胞数目和卵磷脂小体数量方面优于前列闭尔通栓,安全有效。
Objective: To observe the curative effect of Qianlietong I in treatment Treatment of Type ⅢA Prostatitis with Damp-heat Stasis Syndrome. Methods: 60 type IIIA prostatitis patients with Damp-heat stasis resistance syndrome were randomly divided into treatment group and control group,with 30 cases in each group. The treatment group was received Qianlietong Ⅰ( 150 m L,retention enema,qd) and dthe control group received Qianlie Bier Tongshuan( 2. 2 g,into the anus,qd). The treatment course was 4 weeks. Before and after treatment,the American National Institutes of Health chronic prostatitis symptom score( NIH-CPSI) and the chronic prostatitis( hot and damp stasis resistance syndrome) symptom scores were recorded. Perform a rectal prostate palpation and take a prostate massage solution for microscopic examination. The severity and efficacy of ⅢA prostatitis with Damp-heat stasis resistance syndrome were evaluad. Results: The treatment group NIH-CPSI,TCM syndrome scores,the number of white blood cells in the prostate massage fluid and the number of lecithin bodies were significantly better than the control group( P values were0. 001,0. 000,0. 001,0. 010,respectively). The effective rate of the treatment group and the control group were 86. 7% and60. 0%,respectively,and that of the treatment group was significantly better than that of the control group( P = 0. 041). Conclusion: Qianlietong Ⅰ retention enema in treatment of type ⅢA prostatitis Damp-heat syndrome is better in improving the NIH-CPSI score,TCM syndrome score,the number of white blood cells in the prostate massage fluid and the number of lecithin bodies than Qianlie Bier Tongshuan. The clinical efficacy is safe and effective.
Objective: To observe the curative effect of Qianlietong I in treatment Treatment of Type ⅢA Prostatitis with Damp-heat Stasis Syndrome. Methods: 60 type IIIA prostatitis patients with Damp-heat stasis resistance syndrome were randomly divided into treatment group and control group,with 30 cases in each group. The treatment group was received Qianlietong Ⅰ( 150 m L,retention enema,qd) and dthe control group received Qianlie Bier Tongshuan( 2. 2 g,into the anus,qd). The treatment course was 4 weeks. Before and after treatment,the American National Institutes of Health chronic prostatitis symptom score( NIH-CPSI) and the chronic prostatitis( hot and damp stasis resistance syndrome) symptom scores were recorded. Perform a rectal prostate palpation and take a prostate massage solution for microscopic examination. The severity and efficacy of ⅢA prostatitis with Damp-heat stasis resistance syndrome were evaluad. Results: The treatment group NIH-CPSI,TCM syndrome scores,the number of white blood cells in the prostate massage fluid and the number of lecithin bodies were significantly better than the control group( P values were0. 001,0. 000,0. 001,0. 010,respectively). The effective rate of the treatment group and the control group were 86. 7% and60. 0%,respectively,and that of the treatment group was significantly better than that of the control group( P = 0. 041). Conclusion: Qianlietong Ⅰ retention enema in treatment of type ⅢA prostatitis Damp-heat syndrome is better in improving the NIH-CPSI score,TCM syndrome score,the number of white blood cells in the prostate massage fluid and the number of lecithin bodies than Qianlie Bier Tongshuan. The clinical efficacy is safe and effective.
引文
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[10]任冬冬,罗思蜻,杨红.皂角刺气化爆鸣液体外抑菌作用及成分的初步研究[J].广东药学院学报,2010,26(6):579-582.
[11]MIN HY,LEE SK. Inhibition of inducible prostaglandin E-2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria[J]. Arch Pharm Res,2007,30(10):1236.
[12]赵春苗,李亮亮.白芷总香豆素对疮疡模型的影响[J].中药药理临床,2014,30(1):61-63.
[13]李培源,卢汝梅,苏炜,等.萆薢总黄酮含量测定及其抗氧化活性研究[J].时珍国医国药,2015,26(6):1303-1304.
[14]周清,江浩,高云涛,等.冬瓜籽水提物抗氧化作用研究[J].微量元素与健康研究,2010,27(5):22-23.
[2]LIANG C C,LI H J,WANG Z P,et al. The prevalence of prostatitislike symptoms in China[J]. J Urol,2009,182:558-563.
[3]梁朝朝,王克绍.男科临床关键技术[M].合肥:安徽科学技术出版社,2013:297-319.
[4]那彦群,叶章群,孙颖浩,等.中国泌尿外科疾病诊断治疗指南手册[M].北京:人民卫生出版社,2014:560-582.
[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:168-172.
[6]秦国政.中医男科学[M].北京:中国中医药出版社,2012:325-330.
[7]李兰群,王传航,刘春英.慢性前列腺炎中医证型分布频率研究[J].中华中医药杂志,2005,20(4):245-246.
[8]邸大琳,李法庆,陈蕾,等.苦参体外抑菌作用的研究[J].时珍国医国药,2006,17(10):1974.
[9]殷网虎. 3味中药对前列腺主要致病菌抑制作用的观察[J].实用中西医结合临床,2003,3(2):53-54.
[10]任冬冬,罗思蜻,杨红.皂角刺气化爆鸣液体外抑菌作用及成分的初步研究[J].广东药学院学报,2010,26(6):579-582.
[11]MIN HY,LEE SK. Inhibition of inducible prostaglandin E-2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria[J]. Arch Pharm Res,2007,30(10):1236.
[12]赵春苗,李亮亮.白芷总香豆素对疮疡模型的影响[J].中药药理临床,2014,30(1):61-63.
[13]李培源,卢汝梅,苏炜,等.萆薢总黄酮含量测定及其抗氧化活性研究[J].时珍国医国药,2015,26(6):1303-1304.
[14]周清,江浩,高云涛,等.冬瓜籽水提物抗氧化作用研究[J].微量元素与健康研究,2010,27(5):22-23.