CSE1L在恶性肿瘤中的表达及治疗应用研究进展
摘要
<正>恶性肿瘤是危害人类健康的全球公共卫生问题之一。有研究表明,染色体分离样蛋白1(CSE1L,也称为CSE1、CAS)的异常表达与肿瘤的细胞凋亡诱导、细胞周期阻滞、侵袭转移调控和肿瘤化疗耐药有关。CSE1L在细胞周期中参与有丝分裂和协助细胞凋亡;同时CSE1L被证实参与细胞侵袭转移和增殖,
引文
[1]PEIRAG,DIEBOLD J,LAHRSU.CAS(cellular apoptosis susceptibility)gene expression in ovarian carcinoma:correlation with20q13.2copy number and cyclin D1,p53,and Rb protein expression[J].Am J Clin Pathol,2002,118(6):922-929.
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[10]WELLMANN A,KRENACS L,FEST T,et al.Localization of the cell proliferation and apoptosis-associated CAS protein in lymphoid neoplasms[J].Am J Pathol,1997,150(1):25-30.
[11]SILLARS-HARDEBOL AH,CARVALHO B,BELIANJA,et al.CSE1L,DIDO1and RBM39in colorectal adenoma to carcinoma progression[J].Cell Oncol,2012,35(4):293-300.
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[14]SEIDENLONG IM,BROWN KR,SHIH W,et al.Transcriptional targets of hepatocyte growth factor signaling and Ki-ras oncogene activation in colorectal cancer[J].Oncogene,2006,25(1):91.
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[16]YUKSEL UM,DILEK G,DOGAN L,et al.The relationship between CSE1Lexpression and axillary lymph node metastasis in breast cancer[J].2015,101(2):217-219.
[17]YUKSEL UM,TURKER I,DILEK G,et al.Does CSE1Loverexpression affect distant metastasis development in breast cancer?[J].Oncol Res Treat,2015,38(9):778-779.
[18]HOLZER K,DRUCKER E,OLIVER S,et al.Cellular apoptosis susceptibility(CAS)is overexpressed in thyroid carcinoma and maintains tumor cell growth:apotential link to the BRAFV600Emutation[J].Int J Oncol,2016,48(4):1679-1687.
[19]PAPAY J,KRENACS T,MOLDVAY J,et al.Immunophenotypic profiling of nonsmall cell lung cancer progression using the tissue microarray approach[J].Appl Immun Mol Morphol,2007,15(1):19-30.
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[21]LIAO CF,LUO SF,LI LT,et al.CSE1L/CAS,the cellular apoptosis susceptibility protein,enhances invasion and metastasis but not proliferation of cancer cells[J].J Exp Clin Cancer Res,2008,27(1):15.
[22]LIAO CF,LIN SH,CHEN HC,et al.CSE1L,a novel microvesicle membrane protein,mediates Ras-triggered microvesicle generation and metastasis of tumor cells[J].Molecul Med,2015,18(9):1269.
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[24]TUNG JN,TSAO TY,CHEN SL,et al.Presence of secretory cellular apoptosis susceptibility protein in cerebrospinal fluids of patients with intracerebral hemorrhage caused by stroke and neurotrauma[J].Neuro Endocrinol Lett,2010,31(3):390-398.
[25]CAIVANO A,LAURENZANA I,DE LL,et al.High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders[J].Tumor Biology,2015,36(12):9739-9752.
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[27]YOUNES A,BARTLETT NL,LEONARD JP,et al.Brentuximab vedotin(SGN-35)for relapsed CD30-positive lymphomas[J].N Engl JMed,2010,363(19):1812-1821.
[28]NICULESCUDUVAZ I.Trastuzumab emtansine,an antibodydrug conjugate for the treatment of HER2+metastatic breast cancer[J].Curr Opin Molecul Therapeut,2010,12(3):350.
[29]HANAHAN D,ROBERT AW.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):1145-1147.
[30]CHANG WW,LEE CH,LEE P,et al.Expression of Globo H and SSEA3in breast cancer stem cells and the involvement of fucosyl transferases 1and 2in Globo H synthesis[J].Proc Natl Acad Sci USA,2008,105(33):11667-11672.
[2]STAWERSKI P,WAGROWSKA-DANILEWICZ M,STASIKOWS-KA O,et al.Immunoexpression of CAS protein is augmented in high grade serous ovarian tumors[J].Pol J Pathol Offic J,2010,61(4):219.
[3]BRUSTMANN H.Expression of cellular apoptosis susceptibility protein in serous ovarian carcinoma:a clinicopathologic and immunohistochemical study[J].Gynecol Oncol,2004,92(1):268-276.
[4]PEIRAG,DIEBOLD J,BARETTON GB,et al.Cellular apoptosis susceptibility gene expression in endometrial carcinoma:correlation with Bcl-2,Bax,and caspase-3expression and outcome[J].Int J Gynecol Pathol,2001,20(4):359-367.
[5]SHIRAKI K,FUJIKAWA K,SUGIMOTO K,et al.Cellular apoptosis susceptibility protein and proliferation in human hepatocellular carcinoma[J].Int J Mol Med,2006,18(18):77-81.
[6]臧红,赵景民,纪冬,等.CAS基因在原发性肝癌组织中的表达及其与HBV感染的关系[J].中华实验和临床病毒学杂志,2012,26(4):285-287.
[7]QIN L.The prognosis molecular markers in hepatocellular carcinoma[J].World J Gastroenterol,2002,8:228-233.
[8]WELLMANN A,FLEMMING P,BEHRENS P,et al.High expression of the proliferation and apoptosis associated CSE1L/CASgene in hepatitis and liver neoplasms:correlation with tumor progression[J].Int J Mol Med,2001,7(5):489.
[9]SOLDINI D,MONTAGNA C,SCHAFFLER P,et al.A new diagnostic algorithm for Burkitt and diffuse large B-cell lymphomas based on the expression of CSE1Land STAT3and on MYC rearrangement predicts outcome[J].Ann Oncol,2013,24(1):193-201.
[10]WELLMANN A,KRENACS L,FEST T,et al.Localization of the cell proliferation and apoptosis-associated CAS protein in lymphoid neoplasms[J].Am J Pathol,1997,150(1):25-30.
[11]SILLARS-HARDEBOL AH,CARVALHO B,BELIANJA,et al.CSE1L,DIDO1and RBM39in colorectal adenoma to carcinoma progression[J].Cell Oncol,2012,35(4):293-300.
[12]ALNABULSI A,AGOUNI A,MITRA S,et al.Cellular apoptosis susceptibility(chromosome segregation 1-like,CSE1L)gene is a key regulator of apoptosis,migration and invasion in colorectal cancer[J].J Pathol,2012,228(4):471-481.
[13]TAI CJ,SU TC,JIANG MC,et al.Correlations between cytoplasmic CSE1Lin neoplastic colorectal glands and depth of tumor penetration and cancer stage[J].J Trans Med,2013,11(1):29.
[14]SEIDENLONG IM,BROWN KR,SHIH W,et al.Transcriptional targets of hepatocyte growth factor signaling and Ki-ras oncogene activation in colorectal cancer[J].Oncogene,2006,25(1):91.
[15]BEHRENS P,BRINKMANN U,FOGT F,et al.Implication of the proliferation and apoptosis associated CSE1L/CAS gene for breast cancer development[J].Anticancer Res,2001,21(4A):2413-2417.
[16]YUKSEL UM,DILEK G,DOGAN L,et al.The relationship between CSE1Lexpression and axillary lymph node metastasis in breast cancer[J].2015,101(2):217-219.
[17]YUKSEL UM,TURKER I,DILEK G,et al.Does CSE1Loverexpression affect distant metastasis development in breast cancer?[J].Oncol Res Treat,2015,38(9):778-779.
[18]HOLZER K,DRUCKER E,OLIVER S,et al.Cellular apoptosis susceptibility(CAS)is overexpressed in thyroid carcinoma and maintains tumor cell growth:apotential link to the BRAFV600Emutation[J].Int J Oncol,2016,48(4):1679-1687.
[19]PAPAY J,KRENACS T,MOLDVAY J,et al.Immunophenotypic profiling of nonsmall cell lung cancer progression using the tissue microarray approach[J].Appl Immun Mol Morphol,2007,15(1):19-30.
[20]ZHU JH,HONG DF,SONG YM,et al.Suppression of cellular apoptosis susceptibility(CSE1L)inhibits proliferation and induces apoptosis in colorectal cancer cells[J].Asian Pacific J Cancer Prevent Apjcp,2013,14(2):1017-1021.
[21]LIAO CF,LUO SF,LI LT,et al.CSE1L/CAS,the cellular apoptosis susceptibility protein,enhances invasion and metastasis but not proliferation of cancer cells[J].J Exp Clin Cancer Res,2008,27(1):15.
[22]LIAO CF,LIN SH,CHEN HC,et al.CSE1L,a novel microvesicle membrane protein,mediates Ras-triggered microvesicle generation and metastasis of tumor cells[J].Molecul Med,2015,18(9):1269.
[23]COCUCCI E,RACCHETTI G,MELDOLESI J.Shedding microvesicles:artefacts no more[J].Trends Cell Biol,2009,19(2):43-51.
[24]TUNG JN,TSAO TY,CHEN SL,et al.Presence of secretory cellular apoptosis susceptibility protein in cerebrospinal fluids of patients with intracerebral hemorrhage caused by stroke and neurotrauma[J].Neuro Endocrinol Lett,2010,31(3):390-398.
[25]CAIVANO A,LAURENZANA I,DE LL,et al.High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders[J].Tumor Biology,2015,36(12):9739-9752.
[26]XU R,GREENING DW,RAI A,et al.Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct[J].Methods,2015,87:11-25.
[27]YOUNES A,BARTLETT NL,LEONARD JP,et al.Brentuximab vedotin(SGN-35)for relapsed CD30-positive lymphomas[J].N Engl JMed,2010,363(19):1812-1821.
[28]NICULESCUDUVAZ I.Trastuzumab emtansine,an antibodydrug conjugate for the treatment of HER2+metastatic breast cancer[J].Curr Opin Molecul Therapeut,2010,12(3):350.
[29]HANAHAN D,ROBERT AW.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):1145-1147.
[30]CHANG WW,LEE CH,LEE P,et al.Expression of Globo H and SSEA3in breast cancer stem cells and the involvement of fucosyl transferases 1and 2in Globo H synthesis[J].Proc Natl Acad Sci USA,2008,105(33):11667-11672.