循环miRNA-21在急性冠脉综合征早期诊断中的表达水平及其临床意义研究
摘要
目的探讨循环miRNA-21在急性冠脉综合征(ACS)病人急性起病状态时的表达水平及其临床意义。方法入选2016年11月—2017年3月就诊于山西医科大学第一医院胸痛中心的ACS病人90例,其中,急性心肌梗死(AMI)组、不稳定型心绞痛(UA)组和非心源性胸痛组(对照组)各30例。受试者皆于入院后抽取肘静脉血,检测血浆miRNA-21水平。结合试验对象一般资料和心肌肌钙蛋白(cTnI)、N末端脑钠肽前体(NT-proBNP)等临床资料阐述其临床意义。结果与UA组、对照组相比,AMI组miRNA-21的表达水平差异有统计学意义(P<0.001);UA组和对照组相比较两组间miRNA-21表达水平差异有统计学意义(P<0.05)。AMI组中血浆miRNA-21表达水平和cTnI、NT-proBNP呈正相关。结论 ACS病人急性起病时,其循环miRNA-21的表达水平是上升的,miRNA-21在ACS的早期诊断具有一定价值。
引文
[1] QUIATD,OLSON E N.MicroRNAs in cardiovascular disease:from pathogenesis to prevention and treatment[J].J Clin Invest,2015,123(1):11-18.
[2] HU S J,HUANG M,PATRICIA K,et al.Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation[J].Circulation,2011,124(11 Suppl):27-34.
[3] THUM T L,GROSS C,FIEDLER J,et al.MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts[J].Nature,2008,456(7224):980-984.
[4] DONG S M,CHENG Y H,YANG J,et al.MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction[J].Journal of Biological Chemistry,2009:284.
[5] KRISTIAN T,JOSEPH S,ALPERT A S,et al.White and the writing group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the universal definition of myocardial infarction.Third universal definition of myocardial infarction[J].Eur Heart J,2012,33:2551-2567.
[6] 中华心血管病杂志编辑委员会.中华医学会心血管病学分会.急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志,2015,45(5):380-393.
[7] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会.非ST段抬高型急性冠状动脉综合征诊断和治疗指南(2016)[J].中华心血管病杂志,2017,45(5):359-376.
[8] DGC D E,JVSANCHEZ,D VILADES,et al.Atherosclerosis-ralated circulating miRNAs asnvoel and sensitive predictors foracute myocardial infarction[J].Biomed Res Int,2014,2014:418628.
[9] LIEBETRAU C L,NEF H,SZARDIEN S,et al.Release kinetics of circulating muscle-enriched microRNAs in patients undergoing transcoronary ablation of septal hypertrophy[J].J Am Coll Cardiol,2013,62(11):992-998.
[10] JINGYI R,JING Z,NING X,et al.Signature of circulating microRNAs as potients biomarkers invulnerable coronary artery disease[J].PLoS One,2013,8(12):e80738.
[2] HU S J,HUANG M,PATRICIA K,et al.Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation[J].Circulation,2011,124(11 Suppl):27-34.
[3] THUM T L,GROSS C,FIEDLER J,et al.MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts[J].Nature,2008,456(7224):980-984.
[4] DONG S M,CHENG Y H,YANG J,et al.MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction[J].Journal of Biological Chemistry,2009:284.
[5] KRISTIAN T,JOSEPH S,ALPERT A S,et al.White and the writing group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the universal definition of myocardial infarction.Third universal definition of myocardial infarction[J].Eur Heart J,2012,33:2551-2567.
[6] 中华心血管病杂志编辑委员会.中华医学会心血管病学分会.急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志,2015,45(5):380-393.
[7] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会.非ST段抬高型急性冠状动脉综合征诊断和治疗指南(2016)[J].中华心血管病杂志,2017,45(5):359-376.
[8] DGC D E,JVSANCHEZ,D VILADES,et al.Atherosclerosis-ralated circulating miRNAs asnvoel and sensitive predictors foracute myocardial infarction[J].Biomed Res Int,2014,2014:418628.
[9] LIEBETRAU C L,NEF H,SZARDIEN S,et al.Release kinetics of circulating muscle-enriched microRNAs in patients undergoing transcoronary ablation of septal hypertrophy[J].J Am Coll Cardiol,2013,62(11):992-998.
[10] JINGYI R,JING Z,NING X,et al.Signature of circulating microRNAs as potients biomarkers invulnerable coronary artery disease[J].PLoS One,2013,8(12):e80738.