术前吸入抗胆碱能药物对慢性阻塞性肺疾病患者腹部手术后肺部并发症的影响
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摘要
目的:探讨术前吸入抗胆碱能药物对慢性阻塞性肺疾病(COPD)患者腹部手术后肺部并发症的影响。方法:回顾性分析COPD腹部手术患者,按照患者术前使用抗胆碱能药物吸入情况分为两组,比较肺部并发症发生情况。结果:术前吸入抗胆碱能药物组肺部并发症发生率12.7%,低于术前未吸入抗胆碱能组的29.0%,两组比较,差异有统计学意义(P<0.05)。结论:术前吸入抗胆碱能药物可降低COPD患者腹部手术后肺部并发症发生率。
Objective To investigate the influence of inhalation of anticholinergic drugs preoperatively on patients with Chronic Obstructive Pulmonary Disease(COPD) regarding pulmonary complications after abdominal surgery.Method All of the patients with COPD after abdominal were retrospectively analyzed and were divided randomly into two groups regarding to inhaling anticholinergic drugs preoperatively or not.The incidence rates of complications after abdominal surgery were compared between those two groups.Results The incidence rates of complications after abdominal surgeryof the group who had inhaled anticholinergic drugs preoperatively were significantly lower than who had not.Conclusion Inhaling anticholinergic drugs preoperatively may reduce the incidence of the pulmonary complications after abdominal surgery in COPD patients.
Objective To investigate the influence of inhalation of anticholinergic drugs preoperatively on patients with Chronic Obstructive Pulmonary Disease(COPD) regarding pulmonary complications after abdominal surgery.Method All of the patients with COPD after abdominal were retrospectively analyzed and were divided randomly into two groups regarding to inhaling anticholinergic drugs preoperatively or not.The incidence rates of complications after abdominal surgery were compared between those two groups.Results The incidence rates of complications after abdominal surgeryof the group who had inhaled anticholinergic drugs preoperatively were significantly lower than who had not.Conclusion Inhaling anticholinergic drugs preoperatively may reduce the incidence of the pulmonary complications after abdominal surgery in COPD patients.
引文
[1] GOLD Executive Committee.Guidelines:Global Strategy for Diag-nosis,Management and Prevention of COPD (Revised 2016)[EB/OL].http://www.gold.copd.com.
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[3] 毛学岩.慢性阻塞性肺疾病治疗研究进展[J].吉林医学,2014,35(32):7247.
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[5] 陈宝,范峰,傅柏涵,等.异丙托溴铵雾化治疗用于围手术期慢性阻塞性肺疾病中国患者Ⅳ期临床试验[J].中华胸心血管外科杂志,2017,(3):175.
[6] Numata T,Nakayama K,Fujii S,et al.Risk factors of postoperative pulmonary complications in patients with asthma and COPD[J].BMC pulmonary medicine,2018,18(1):4.
[7] Barnes P J.The role of anticholinergics in chronic obstructive pulmonary disease[J].American Journal of Medicine,1997,117(12):24.
[8] 中华医学会麻醉学分会老年人麻醉学组.慢性阻塞性肺疾病患者非肺部手术麻醉及围手术期管理专家共识[J].中华医学杂志,2017,(40):3128.
[9] 多学科围手术期气道管理专家共识(2016年版)专家组.多学科围手术期气道管理专家共识(2016年版)[J].中国胸心血管外科临床杂志,2016,23(7):641.
[10] 中华医学会呼吸病学分会《雾化吸入疗法在呼吸系统疾病中的应用专家共识》制定专家组.雾化吸入疗法在呼吸系统疾病中的应用专家共识[J].中华医学杂志,2016,96(34):2696.
[11] Smetana GW.Preoperative pulmonary evaluation:identifying andreducing risks for pulmonary complications[J].Cleve Clin J Med,2006,73(Suppl 1 ):36.
[2] Vogelmeier C F,Criner G J,Martinez F J,et al.Global Strategy for the Diagnosis,Management,and Prevention of Chronic Obstructive Lung Disease 2017 Report.GOLD Executive Summary[J].American Journal of Respiratory & Critical Care Medicine,2017,195(5):557.
[3] 毛学岩.慢性阻塞性肺疾病治疗研究进展[J].吉林医学,2014,35(32):7247.
[4] 王天佑.吸入型抗胆碱能药物在围手术期肺保护中的应用专家共识[J].中华胸心血管外科杂志,2011,27(9):513.
[5] 陈宝,范峰,傅柏涵,等.异丙托溴铵雾化治疗用于围手术期慢性阻塞性肺疾病中国患者Ⅳ期临床试验[J].中华胸心血管外科杂志,2017,(3):175.
[6] Numata T,Nakayama K,Fujii S,et al.Risk factors of postoperative pulmonary complications in patients with asthma and COPD[J].BMC pulmonary medicine,2018,18(1):4.
[7] Barnes P J.The role of anticholinergics in chronic obstructive pulmonary disease[J].American Journal of Medicine,1997,117(12):24.
[8] 中华医学会麻醉学分会老年人麻醉学组.慢性阻塞性肺疾病患者非肺部手术麻醉及围手术期管理专家共识[J].中华医学杂志,2017,(40):3128.
[9] 多学科围手术期气道管理专家共识(2016年版)专家组.多学科围手术期气道管理专家共识(2016年版)[J].中国胸心血管外科临床杂志,2016,23(7):641.
[10] 中华医学会呼吸病学分会《雾化吸入疗法在呼吸系统疾病中的应用专家共识》制定专家组.雾化吸入疗法在呼吸系统疾病中的应用专家共识[J].中华医学杂志,2016,96(34):2696.
[11] Smetana GW.Preoperative pulmonary evaluation:identifying andreducing risks for pulmonary complications[J].Cleve Clin J Med,2006,73(Suppl 1 ):36.