启东市肝癌家系初检成员脂肪肝患病率及其关联因素研究
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摘要
目的了解江苏省启东市肝癌家系初检成员的脂肪肝患病情况并探讨其关联因素,为肝癌家系成员防治脂肪肝提供科学依据。方法选择2014年1月~2015年12月在启东市人民医院肝病家系备案的537例肝癌患者家族初检成员,收集其体检资料和个人基本信息,分析脂肪肝的患病情况,应用单因素分析和多因素Logistic回归分析探讨其关联因素。结果 537例调查对象经B超诊断脂肪肝112例,患病率为20.86%,男性患病率高于女性(22.75%>19.15%,X~2=5.292,P=0.021),脂肪肝患病率随年龄增长而升高;有烟酒嗜好者、超重与肥胖者、有高血压及高血糖者的脂肪肝患病率均高于无相应因素者,且差异都有统计学意义(均有P<0.05)。多因素Logistic模型分析结果显示超重与肥胖、高血压、有烟酒嗜好以及高血糖者脂肪肝患病危险性高。结论需要加强生活方式干预,戒烟限酒,将体重、血压及血糖维持在正常水平以降低脂肪肝患病率。
Objective To investigate the prevalence of fatty liver in primary examination members of Qidong hepatoma family in Jiangsu and analyze its associated factors in order to provide scientific basis for the prevention and treatment of fatty liver in members of hepatoma family. Methods A total of 537 participants in early detection of liver cancer family were selected from Qidong People's Hospital from January 2014 to December 2015 and their medical records and basic personal information were collected to analyze the prevalence of fatty liver. The related factors of fatty liver were explored by univariate analysis and Logistic regression analysis. Results Among the 537 participants,112 cases of fatty liver were diagnosed by B-ultrasonography and the prevalence rates of fatty liver was 20. 86%,which was higher in males than that in females.( 22. 75% >19. 15%,X~2= 5. 292,P = 0. 021). The prevalence of fatty liver was increased with age,which was higher in alcoholic drinks,overweight and obese,hypertension and hyperglycemia people,and the differences were statistically significant( all P<0. 05). Moreover,multivariate Logistic regression analysis showed that overweight and obesity,hypertension,tobacco and alcohol addiction,hyperglycemia were risk factors of fatty liver disease. Conclusions We need to strengthen the lifestyle intervention,have no smoking and limited amount of liquor,keep weight,blood pressure and blood sugar in normal levels in order to reduce the incidence of fatty liver.
Objective To investigate the prevalence of fatty liver in primary examination members of Qidong hepatoma family in Jiangsu and analyze its associated factors in order to provide scientific basis for the prevention and treatment of fatty liver in members of hepatoma family. Methods A total of 537 participants in early detection of liver cancer family were selected from Qidong People's Hospital from January 2014 to December 2015 and their medical records and basic personal information were collected to analyze the prevalence of fatty liver. The related factors of fatty liver were explored by univariate analysis and Logistic regression analysis. Results Among the 537 participants,112 cases of fatty liver were diagnosed by B-ultrasonography and the prevalence rates of fatty liver was 20. 86%,which was higher in males than that in females.( 22. 75% >19. 15%,X~2= 5. 292,P = 0. 021). The prevalence of fatty liver was increased with age,which was higher in alcoholic drinks,overweight and obese,hypertension and hyperglycemia people,and the differences were statistically significant( all P<0. 05). Moreover,multivariate Logistic regression analysis showed that overweight and obesity,hypertension,tobacco and alcohol addiction,hyperglycemia were risk factors of fatty liver disease. Conclusions We need to strengthen the lifestyle intervention,have no smoking and limited amount of liquor,keep weight,blood pressure and blood sugar in normal levels in order to reduce the incidence of fatty liver.
引文
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[6]乔丽娜,戴光荣,张锦,等.延安地区成人脂肪肝患病率及其危险因素的探讨[J].临床肝胆病杂志,2015,31(1):82-87.
[7]Sporea I.Ultrasound and liver elastography-tools for detection and quantification of severity in nonalcoholic fatty liver disease(NAFLD)in general population[J].Med Ultrason,2017,19(3):247-249.
[8]秦利,苏青,顾红霞,等.崇明地区脂肪肝患病率及其危险因素的流行病学调查[J].内科理论与实践,2012,7(4):280-283.
[9]余霞玲,傅迎春,文育锋.北京某化工企业职工脂肪肝患病情况及其影响因素分析[J].中华疾病控制杂志,2015,19(8):803-805.
[10]产松苗,欧希龙,孙为豪,等.南京市梅山社区老年人脂肪肝患病趋势及其相关危险因素[J].江苏医药,2016,42(2):193-195.
[11]潘燕芳,劳汝明,陈陶玲.社区人群脂肪肝患病率及相关因素的流行病学调查[J].中国医药导报,2014,11(7):108-110.
[12]陶凌红,傅春玲,邱晶.性别、年龄和体重指数与脂肪肝患病的相关性分析[J].职业与健康,2014,30(16):2261-2263.
[13]Chen CH,Huang MH,Yang JC,et al.Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of taiwan:metabolic significance of nonalcoholic fatty liver disease in nonobese adults[J].J Clin Gastroenterol,2006,40(8):745-752.
[14]Hannah WN Jr,Harrison SA.Lifestyle and dietary interventions in the management of nonalcoholic fatty liver disease[J].Dig Dis Sci,2016,61(5):1365-1374.
[15]薛学锋,尹燕慈,张启南,等.原发性肝癌患者与其一级亲属的血糖水平分析[J].中国肿瘤,2014,23(4):289-291.
[16]Yang Z,Zhang H,Niu Y,et al.Circulating periostin in relation to insulin resistance and nonalcoholic fatty liver disease among overweight and obese subjects[J].Sci Rep,2016,6:37886.
[17]Ballestri S,Zona S,Targher G,et al.Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome.Evidence from a systematic review and meta-analysis[J].J Gastroenterol Hepatol,2016,31(5):936-944.
[18]Fotbolcu H,Zorlu E.Nonalcoholic fatty liver disease as a multisystemic disease[J].World J Gastroenterol,2016,22(16):4079-4090.
[2]Fan JG.Epidemiology of alcoholic and nonalcoholic fatty liver disease in China[J].J Gastroenterol Hepatol,2013,28(Suppl 1):11-17.
[3]卫生部疾病控制司.中国成人超重和肥胖症预防控制指南[M].北京:人民卫生出版社,2006.
[4]卫生部疾病控制局高血压联盟国家心血管疾病中心.中国高血压防治指南[M].北京:人民卫生出版社,2010.
[5]中华医学会肝病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南(2010年修订版)[J].中华肝脏病杂志,2010,18(3):163-166.
[6]乔丽娜,戴光荣,张锦,等.延安地区成人脂肪肝患病率及其危险因素的探讨[J].临床肝胆病杂志,2015,31(1):82-87.
[7]Sporea I.Ultrasound and liver elastography-tools for detection and quantification of severity in nonalcoholic fatty liver disease(NAFLD)in general population[J].Med Ultrason,2017,19(3):247-249.
[8]秦利,苏青,顾红霞,等.崇明地区脂肪肝患病率及其危险因素的流行病学调查[J].内科理论与实践,2012,7(4):280-283.
[9]余霞玲,傅迎春,文育锋.北京某化工企业职工脂肪肝患病情况及其影响因素分析[J].中华疾病控制杂志,2015,19(8):803-805.
[10]产松苗,欧希龙,孙为豪,等.南京市梅山社区老年人脂肪肝患病趋势及其相关危险因素[J].江苏医药,2016,42(2):193-195.
[11]潘燕芳,劳汝明,陈陶玲.社区人群脂肪肝患病率及相关因素的流行病学调查[J].中国医药导报,2014,11(7):108-110.
[12]陶凌红,傅春玲,邱晶.性别、年龄和体重指数与脂肪肝患病的相关性分析[J].职业与健康,2014,30(16):2261-2263.
[13]Chen CH,Huang MH,Yang JC,et al.Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of taiwan:metabolic significance of nonalcoholic fatty liver disease in nonobese adults[J].J Clin Gastroenterol,2006,40(8):745-752.
[14]Hannah WN Jr,Harrison SA.Lifestyle and dietary interventions in the management of nonalcoholic fatty liver disease[J].Dig Dis Sci,2016,61(5):1365-1374.
[15]薛学锋,尹燕慈,张启南,等.原发性肝癌患者与其一级亲属的血糖水平分析[J].中国肿瘤,2014,23(4):289-291.
[16]Yang Z,Zhang H,Niu Y,et al.Circulating periostin in relation to insulin resistance and nonalcoholic fatty liver disease among overweight and obese subjects[J].Sci Rep,2016,6:37886.
[17]Ballestri S,Zona S,Targher G,et al.Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome.Evidence from a systematic review and meta-analysis[J].J Gastroenterol Hepatol,2016,31(5):936-944.
[18]Fotbolcu H,Zorlu E.Nonalcoholic fatty liver disease as a multisystemic disease[J].World J Gastroenterol,2016,22(16):4079-4090.