基于数据挖掘的广东省名中医黄枫治疗膝骨关节炎用药规律分析
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摘要
目的:基于中医传承辅助平台(V2. 5)软件,分析黄枫教授治疗膝骨关节炎(KOA)的用药规律。方法:收集黄枫教授治疗KOA门诊处方,录入中医传承辅助平台,采用该软件集成的规则分析、改进互信息法、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法,对黄枫教授治疗KOA的处方进行分析。结果:对筛选出的429个处方进行分析,确定用药频次,药物之间的关联规则等,演化得到6个新方组合。结论:黄枫教授治疗KOA用药以益气健脾祛湿、行气活血止痛为主,常辅以补肾强骨、舒筋活络、滋阴养阴等药,体现其诊治KOA从脾肾两脏入手,兼顾先后天之本的临证经验和"刚柔并济,筋骨并重"的治疗原则。
Objective: In this study,we collected the prescriptions of professor HUANG Feng used for the out-patients with knee osteoarthritis and analyzed the composing principles of the prescriptions by using traditional Chinese medicine( TCM) inheritance support platform( V2. 5). Methods: We collected the prescriptions used for KOA cases,then the data was entered into the TCM inheritance support platform and analyzed based on principle analysis,revised mutual information,complex system entropy cluster and unsupervised hierarchical clustering composing principles. Results: Based on the analysis of prescriptions of 429 cases,the frequency of each Chinese medicinal herb and association rules among herbs included in the database were computed and 6 new prescriptions were explored from the database. Conclusion: The methods of replenishing Qi,invigorating spleen,dispelling dampness and promoting Qi and activating blood to arrest pain were the key processes of professor HUANG Feng in treating KOA,assisted by herbal medicines of invigorating the kidney and strong bone,relaxing tendons and activating collaterals and nourishing Yin,which suggests the diagnosis and treatment of KOA starting from the spleen and kidney,taking into account the congenital and acquired foundation and principles of emphasis on both sinews and bones.
Objective: In this study,we collected the prescriptions of professor HUANG Feng used for the out-patients with knee osteoarthritis and analyzed the composing principles of the prescriptions by using traditional Chinese medicine( TCM) inheritance support platform( V2. 5). Methods: We collected the prescriptions used for KOA cases,then the data was entered into the TCM inheritance support platform and analyzed based on principle analysis,revised mutual information,complex system entropy cluster and unsupervised hierarchical clustering composing principles. Results: Based on the analysis of prescriptions of 429 cases,the frequency of each Chinese medicinal herb and association rules among herbs included in the database were computed and 6 new prescriptions were explored from the database. Conclusion: The methods of replenishing Qi,invigorating spleen,dispelling dampness and promoting Qi and activating blood to arrest pain were the key processes of professor HUANG Feng in treating KOA,assisted by herbal medicines of invigorating the kidney and strong bone,relaxing tendons and activating collaterals and nourishing Yin,which suggests the diagnosis and treatment of KOA starting from the spleen and kidney,taking into account the congenital and acquired foundation and principles of emphasis on both sinews and bones.
引文
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[13]汤化琪.玄胡索散成分分析及其治疗骨关节炎作用机制的网络药理学研究[D].北京:北京中医药大学,2017.
[14]何钟德.延胡索甲、乙素对坐骨神经痛大鼠止痛作用及其抗TRPV-1机理的研究[D].广州:广州中医药大学,2012.
[15]林洁,范展彪,刘献祥.基于数据挖掘技术探讨陈可冀《清宫配方集成》中治疗骨关节炎组方的用药规律[J].中医正骨,2017,29(11):15-19,25.
[2]Dieppe PA,Lohmander LS. Pathogenesis and management of pain in osteoarthritis[J]. Lancet,2005,365(9463):965-973.
[3]Bhandari M,Bannuru RR,Babins EM,et al. Intra-articular hyaluronic acid in the treatment of knee osteoarthritis:a Canadian evidencebased perspective[J]. Therapeutic advances in musculoskeletal disease,2017,9(9):231-246.
[4]唐芳,马武开,姚血明. Wnt/β-catenin信号通路与骨关节炎[J].风湿病与关节炎,2014,3(2):70-77.
[5]田中凯,李笑豫.膝骨关节炎的临床非手术治疗进展[J].中国中医药现代远程教育,2017,14(13):140-142.
[6]樊粤光,詹红生.中医骨伤科学[M].北京:人民卫生出版社,2012.
[7]国家药典委员会.中华人民共和国药典:一部[S].北京:中国医药科技出版社,2010.
[8]唐仕欢,申丹,卢朋,等.中医传承辅助平台应用评述[J].中华中医药杂志,2015,30(2):329-331.
[9]唐仕欢,陈建新,杨洪军,等.证-熵-方——中医药研究的新领域[J].中国中医基础医学杂志,2010,16(4):267-270.
[10]刘映岐,杨松涛,陶程露.中医内治法治疗膝骨关节炎研究进展[J].现代临床医学,2017,43(2):158-160.
[11]林玉敏,江钢辉.《黄帝内经》四时养生理念在岭南地区的应用[J].中医杂志,2017,58(17):1469-1472.
[12]钟露斌,曹学伟,李俊,等.岭南骨伤名家黄宪章治疗膝骨关节炎经验总结[J].时珍国医国药,2017,28(4):946-948.
[13]汤化琪.玄胡索散成分分析及其治疗骨关节炎作用机制的网络药理学研究[D].北京:北京中医药大学,2017.
[14]何钟德.延胡索甲、乙素对坐骨神经痛大鼠止痛作用及其抗TRPV-1机理的研究[D].广州:广州中医药大学,2012.
[15]林洁,范展彪,刘献祥.基于数据挖掘技术探讨陈可冀《清宫配方集成》中治疗骨关节炎组方的用药规律[J].中医正骨,2017,29(11):15-19,25.