牛传染性鼻气管炎研究现状
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摘要
牛传染性鼻气管炎(IBR)是由牛疱疹病毒1型(BoHV-1)引起牛的一种接触性传染病,表现为上呼吸道感染及气管黏膜炎症、呼吸困难等症状,还可引起生殖道感染、脑膜炎、结膜炎、流产等多种病型。该病呈世界性流行,我国部分地区也有发生。BoHV-1感染造成的免疫抑制,容易使其他病原体侵入引发继发感染,从而导致牛呼吸道疾病综合征(BRDC)的发生,给世界养牛业造成了巨大经济损失。论文围绕IBR病原学、流行病学、诊断、防控等方面阐述了近年来牛传染性鼻气管炎的研究进展,以期为牛传染性鼻气管炎的诊断及防控提供参考。
Infectious bovine rhinotrachealitis is a contagious disease of cattle caused by bovine herpesvirus-1,which manifests as respiratory symptoms,such as upper respiratory tract infections,tracheal mucosal inflammation and dyspnea.It prevails in the worldwide,and also found in some areas in China.BoHV-1can also cause genital tract infections,meningitis,conjunctival inflammation,abortion and other diseases.BoHV-1infection can lead to the secondary infection by other pathogens,and bovine respiratory disease complex because of the immunosuppression.The high mortality of IBR has caused great economic losses to the cattle raising industry in the world.This article elaborated the recent research progress of IBR in four aspects including its etiology,epidemiology,diagnosis,prevention and control in order to provide some reference for IBR diagnosis,prevention and control.
Infectious bovine rhinotrachealitis is a contagious disease of cattle caused by bovine herpesvirus-1,which manifests as respiratory symptoms,such as upper respiratory tract infections,tracheal mucosal inflammation and dyspnea.It prevails in the worldwide,and also found in some areas in China.BoHV-1can also cause genital tract infections,meningitis,conjunctival inflammation,abortion and other diseases.BoHV-1infection can lead to the secondary infection by other pathogens,and bovine respiratory disease complex because of the immunosuppression.The high mortality of IBR has caused great economic losses to the cattle raising industry in the world.This article elaborated the recent research progress of IBR in four aspects including its etiology,epidemiology,diagnosis,prevention and control in order to provide some reference for IBR diagnosis,prevention and control.
引文
[1]窦树龙,季新成,康伟,等.从进口动物检疫角度推进奶业供给侧结构性改革[J].中国动物检疫,2017,34(9):41-45.
[2]王永艳,王仲兵,郑明学,等.牛传染性鼻气管炎的流行与防控[J].动物医学进展,2010,31(1):112-115.
[3] Biswas S,Bandyopadhyay S,Dimri U,et al.Bovine herpesvirus-1(BHV-1)-a reemerging concern in livestock:a revisit to its biology,epidemiology,diagnosis,and prophylaxis[J].Vet Quar,2013,33(2):68-81.
[4] d'Offay J M,Fulton R W,Eberle R.Complete genome sequence of the NVSL BoHV-1.1 Cooper reference strain.[J].Arch Virol,2013,158(5):1109-1113.
[5] Fulton R W,d'Offay J M,Eberle R,et al.Bovine herpesvirus-1:Evaluation of genetic diversity of subtypes derived from field strains of varied clinical syndromes and their relationship to vaccine strains.[J].Vaccine,2015,33(4):549-558.
[6] Fulton R W,d'Offay J M,Dubovi E J,et al.Bovine herpesvirus-1:Genetic diversity of field strains from cattle with respiratory disease,genital,fetal disease and systemic neonatal disease and their relationship to vaccine strains[J].Virus Res,2016,223:115-121.
[7] Muylkens B,Thiry J,Kirten P,et al.Bovine herpesvirus 1infection and infectious bovine rhinotracheitis[J].Vet Res,2007,38(2):181-209.
[8] Sibhat B,Ayelet G,Skjerve E,et al.Bovine herpesvirus-1in three major milk sheds of Ethiopia:Serostatus and association with reproductive disorders in dairy cattle[J].Prev Vet Med,2018,150:126-132.
[9] Marin M S,Leunda M R,Verna A E,et al.Distribution of bovine herpesvirus type 1in the nervous system of experimentally infected calves[J].Vet J,2016,209:82-86.
[10] van Oirschot J T.Bovine herpesvirus 1in semen of bulls and the risk of transmission:a brief review[J].Vet Quart,1995,17(1):29-33.
[11]季新成.牛传染性鼻气管炎病毒和牛病毒性腹泻病毒分子生物学检测技术研究[D].陕西杨凌:西北农林科技大学,2010.
[12] Tignon M,De B M,Hanon J B,et al.Characterization of three commercial ELISA kits for detection of BOHV-1gE specific antibodies in serum and milk samples and applicability of bulk milk for determination of herd status.[J].J Virol Meth,2017,245:66-72.
[13] Raaperi K,Orro T,Viltrop A.Epidemiology and control of bovine herpesvirus 1infection in Europe[J].Vet J,2014,201(3):249-256.
[14] Madin S H,Mckercher D G,York C J.Isolation of the infectious bovine rhinotracheitis virus[J].Science,1956,124(3225):721-722.
[15]周泰冲,叶章明,蔡少权,等.从新西兰进口奶牛中分离传染性牛鼻道气管炎病毒[J].中国兽医科技,1981(1):6-9.
[16]颜邦芬.牛传染性鼻气管炎病毒抗体间接ELISA的建立及其在流行病学研究中的应用[D].湖北武汉:华中农业大学,2007.
[17]希尼尼根,云涛,党娟,等.内蒙古地区牛传染性鼻气管炎血清学调查[J].内蒙古农业大学学报:自然科学版,2012,33(3):13-15.
[18]韩照清,高建峰,贡科,等.青海省部分地区牦牛传染性鼻气管炎血清学调查[J].畜牧与兽医,2015,47(8):153.
[19]郭亚男,曹思婷,何生虎,等.宁夏部分地区规模化奶牛场4种疫病的血清学调查分析[J].动物医学进展,2017,38(5):123-126.
[20] Ackermann M,Engels M.Pro and contra IBR-eradication.[J].Vet Microbiol,2006,113(3-4):293-302.
[21]张志飞.BHV-1在MDBK细胞中的增殖规律及其对牛单核巨噬细胞TLR2和TLR9表达的影响[D].内蒙古呼和浩特:内蒙古农业大学,2016.
[22] Marin M S,Quintana S,Leunda M R,et al.A new method for simultaneous detection and discrimination of bovine herpesvirus types 1(BoHV-1)and 5(BoHV-5)using real time PCR with high resolution melting(HRM)analysis[J].J Virol Meth,2016,227:14-22.
[23] Malla J A,Chakravarti S,Gupta V,et al.Novel polymerase spiral reaction(PSR)for rapid visual detection of bovine herpesvirus 1genomic DNA from aborted bovine fetus and semen[J].Gene,2018,644:107-112.
[24]乔波,陈楠楠,赵静虎,等.牛传染性鼻气管炎病毒TaqManMGB荧光定量PCR方法的建立[J].中国预防兽医学报,2015,37(4):282-285.
[25] Fan Q,Xie Z X,Xie Z Q,et al.Development of a GeXP-multiplex PCR assay for the simultaneous detection and differentiation of six cattle viruses[J].PLoS One,2017,12(2):e0171287.
[26]徐娜,杨帆,雷宇,等.牛传染性鼻气管炎病毒gB和gE基因双重荧光定量PCR检测方法的建立[J].中国预防兽医学报,2017,39(7):556-559.
[27] Wernike K,Hoffmann B,Kalthoff D,et al.Development and validation of a triplex real-time PCR assay for the rapid detection and differentiation of wild-type and glycoprotein E-deleted vaccine strains of bovine herpesvirus type 1.[J].J Virol Meth,2011,174(1-2):77-84.
[28]胡成.Ⅰ型鸭肝炎病毒环介导等温扩增检测方法的建立及其在临床上的初步应用[D].江苏扬州:扬州大学,2016.
[29]冯蒙.可视化检测牛传染性鼻气管炎病毒LAMP法的建立及其对流行状况的初步调查[D].江苏南京:南京农业大学,2016.
[30] Dummer L A,Araujo I L,Campos F S,et al.Development of an indirect ELISA for serological diagnosis of bovine herpesvirus 5[J].PLoS One,2016,11(2):e0149134.
[31] Tignon M,De B M,Hanon J B,et al.Characterization of three commercial ELISA kits for detection of BOHV-1gE specific antibodies in serum and milk samples and applicability of bulk milk for determination of herd status[J].J Virol Meth,2017,245:66-72.
[32]宋林.牛传染性鼻气管炎病毒gB基因的截短表达与间接ELISA诊断方法的建立[D].黑龙江哈尔滨:东北农业大学,2015.
[33]周跃辉.牛传染性鼻气管炎病毒糖蛋白gD单抗制备及其抗原表位鉴定与双抗夹心ELISA的建立[D].北京:中国农业科学院,2015.
[34] Pawar S S,Meshram C D,Singh N K,et al.Development of a SYBR Green I based duplex real-time PCR for detection of bovine herpesvirus-1in semen[J].J Virol Meth,2014,208:6-10.
[35] Raaperi K,Orro T,Viltrop A.Effect of vaccination against bovine herpesvirus 1with inactivated gE-negative marker vaccines on the health of dairy cattle herds.[J].Prev Vet Med,2015,118(4):467-476.
[2]王永艳,王仲兵,郑明学,等.牛传染性鼻气管炎的流行与防控[J].动物医学进展,2010,31(1):112-115.
[3] Biswas S,Bandyopadhyay S,Dimri U,et al.Bovine herpesvirus-1(BHV-1)-a reemerging concern in livestock:a revisit to its biology,epidemiology,diagnosis,and prophylaxis[J].Vet Quar,2013,33(2):68-81.
[4] d'Offay J M,Fulton R W,Eberle R.Complete genome sequence of the NVSL BoHV-1.1 Cooper reference strain.[J].Arch Virol,2013,158(5):1109-1113.
[5] Fulton R W,d'Offay J M,Eberle R,et al.Bovine herpesvirus-1:Evaluation of genetic diversity of subtypes derived from field strains of varied clinical syndromes and their relationship to vaccine strains.[J].Vaccine,2015,33(4):549-558.
[6] Fulton R W,d'Offay J M,Dubovi E J,et al.Bovine herpesvirus-1:Genetic diversity of field strains from cattle with respiratory disease,genital,fetal disease and systemic neonatal disease and their relationship to vaccine strains[J].Virus Res,2016,223:115-121.
[7] Muylkens B,Thiry J,Kirten P,et al.Bovine herpesvirus 1infection and infectious bovine rhinotracheitis[J].Vet Res,2007,38(2):181-209.
[8] Sibhat B,Ayelet G,Skjerve E,et al.Bovine herpesvirus-1in three major milk sheds of Ethiopia:Serostatus and association with reproductive disorders in dairy cattle[J].Prev Vet Med,2018,150:126-132.
[9] Marin M S,Leunda M R,Verna A E,et al.Distribution of bovine herpesvirus type 1in the nervous system of experimentally infected calves[J].Vet J,2016,209:82-86.
[10] van Oirschot J T.Bovine herpesvirus 1in semen of bulls and the risk of transmission:a brief review[J].Vet Quart,1995,17(1):29-33.
[11]季新成.牛传染性鼻气管炎病毒和牛病毒性腹泻病毒分子生物学检测技术研究[D].陕西杨凌:西北农林科技大学,2010.
[12] Tignon M,De B M,Hanon J B,et al.Characterization of three commercial ELISA kits for detection of BOHV-1gE specific antibodies in serum and milk samples and applicability of bulk milk for determination of herd status.[J].J Virol Meth,2017,245:66-72.
[13] Raaperi K,Orro T,Viltrop A.Epidemiology and control of bovine herpesvirus 1infection in Europe[J].Vet J,2014,201(3):249-256.
[14] Madin S H,Mckercher D G,York C J.Isolation of the infectious bovine rhinotracheitis virus[J].Science,1956,124(3225):721-722.
[15]周泰冲,叶章明,蔡少权,等.从新西兰进口奶牛中分离传染性牛鼻道气管炎病毒[J].中国兽医科技,1981(1):6-9.
[16]颜邦芬.牛传染性鼻气管炎病毒抗体间接ELISA的建立及其在流行病学研究中的应用[D].湖北武汉:华中农业大学,2007.
[17]希尼尼根,云涛,党娟,等.内蒙古地区牛传染性鼻气管炎血清学调查[J].内蒙古农业大学学报:自然科学版,2012,33(3):13-15.
[18]韩照清,高建峰,贡科,等.青海省部分地区牦牛传染性鼻气管炎血清学调查[J].畜牧与兽医,2015,47(8):153.
[19]郭亚男,曹思婷,何生虎,等.宁夏部分地区规模化奶牛场4种疫病的血清学调查分析[J].动物医学进展,2017,38(5):123-126.
[20] Ackermann M,Engels M.Pro and contra IBR-eradication.[J].Vet Microbiol,2006,113(3-4):293-302.
[21]张志飞.BHV-1在MDBK细胞中的增殖规律及其对牛单核巨噬细胞TLR2和TLR9表达的影响[D].内蒙古呼和浩特:内蒙古农业大学,2016.
[22] Marin M S,Quintana S,Leunda M R,et al.A new method for simultaneous detection and discrimination of bovine herpesvirus types 1(BoHV-1)and 5(BoHV-5)using real time PCR with high resolution melting(HRM)analysis[J].J Virol Meth,2016,227:14-22.
[23] Malla J A,Chakravarti S,Gupta V,et al.Novel polymerase spiral reaction(PSR)for rapid visual detection of bovine herpesvirus 1genomic DNA from aborted bovine fetus and semen[J].Gene,2018,644:107-112.
[24]乔波,陈楠楠,赵静虎,等.牛传染性鼻气管炎病毒TaqManMGB荧光定量PCR方法的建立[J].中国预防兽医学报,2015,37(4):282-285.
[25] Fan Q,Xie Z X,Xie Z Q,et al.Development of a GeXP-multiplex PCR assay for the simultaneous detection and differentiation of six cattle viruses[J].PLoS One,2017,12(2):e0171287.
[26]徐娜,杨帆,雷宇,等.牛传染性鼻气管炎病毒gB和gE基因双重荧光定量PCR检测方法的建立[J].中国预防兽医学报,2017,39(7):556-559.
[27] Wernike K,Hoffmann B,Kalthoff D,et al.Development and validation of a triplex real-time PCR assay for the rapid detection and differentiation of wild-type and glycoprotein E-deleted vaccine strains of bovine herpesvirus type 1.[J].J Virol Meth,2011,174(1-2):77-84.
[28]胡成.Ⅰ型鸭肝炎病毒环介导等温扩增检测方法的建立及其在临床上的初步应用[D].江苏扬州:扬州大学,2016.
[29]冯蒙.可视化检测牛传染性鼻气管炎病毒LAMP法的建立及其对流行状况的初步调查[D].江苏南京:南京农业大学,2016.
[30] Dummer L A,Araujo I L,Campos F S,et al.Development of an indirect ELISA for serological diagnosis of bovine herpesvirus 5[J].PLoS One,2016,11(2):e0149134.
[31] Tignon M,De B M,Hanon J B,et al.Characterization of three commercial ELISA kits for detection of BOHV-1gE specific antibodies in serum and milk samples and applicability of bulk milk for determination of herd status[J].J Virol Meth,2017,245:66-72.
[32]宋林.牛传染性鼻气管炎病毒gB基因的截短表达与间接ELISA诊断方法的建立[D].黑龙江哈尔滨:东北农业大学,2015.
[33]周跃辉.牛传染性鼻气管炎病毒糖蛋白gD单抗制备及其抗原表位鉴定与双抗夹心ELISA的建立[D].北京:中国农业科学院,2015.
[34] Pawar S S,Meshram C D,Singh N K,et al.Development of a SYBR Green I based duplex real-time PCR for detection of bovine herpesvirus-1in semen[J].J Virol Meth,2014,208:6-10.
[35] Raaperi K,Orro T,Viltrop A.Effect of vaccination against bovine herpesvirus 1with inactivated gE-negative marker vaccines on the health of dairy cattle herds.[J].Prev Vet Med,2015,118(4):467-476.