尤瑞克林联合丁苯酞对72例急性脑梗死患者血管内皮功能及神经功能的影响
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摘要
目的:研究尤瑞克林联合丁苯酞治疗急性脑梗死的疗效及其对患者血管内皮功能及神经功能的影响。方法:选取144例急性脑梗死患者并随机均分为实验组和对照组。所有患者均接受常规支持治疗,对照组在此基础上予以尤瑞克林治疗,实验组予以尤瑞克林联合丁苯酞治疗。比较分析两组的临床疗效,患者治疗前后的血浆一氧化氮(NO)、内皮素-1(ET-1)含量及神经功能缺损评分。结果 :治疗后,实验组的临床疗效优于对照组(P<0.05);两组患者的血浆NO均明显升高,而血浆ET-1明显降低,并且实验组的NO含量高于对照组,ET-1含量低于对照组(P<0.05);两组患者的NIHSS、CNFDS评分均明显下降,且实验组下降程度优于对照组(P<0.05)。两组安全性差异不显著。结论:尤瑞克林联合丁苯酞治疗急性脑梗死,能够有效改善患者血管内皮功能及神经功能,疗效显著。
Objective:To explore the effect of urinary kallikrein plus butylphthalide on endothelial and neurological functions in the treatment of patients with acute cerebral infarction.Methods:One hundred and forty-four cases with acute cerebral infarction were randomly divided into a research group and a control group.Besides the conventional therapy,the control group was treated with urinary kallikrein and the research group with urinary kallikrein plus butylphthalide.The clinical effects,plasma nitric oxide,content of ET-1 and neurological deficit score were compared between the two groups.Results:The clinical effects were better in the research group than in the control group after treatment(P<0.05).The content of plasma nitric oxide was improved and the content of ET-1 was decreased in the two groups.The content of plasma nitric oxide was higher while the content of ET-1 was significantly lower in the research group than in the control group(P<0.05).The NIHSS and CNFDS scores were all decreased in both groups and the decrease was more significant in the research group(P<0.05).There were no differences between the two groups in the incidence of adverse reactions.Conclusion:Urinary kallikrein plus butylphthalide for the treatment of patients with acute cerebral infarction can improve the endothelial and neurological functions with remarkable curative effect.
Objective:To explore the effect of urinary kallikrein plus butylphthalide on endothelial and neurological functions in the treatment of patients with acute cerebral infarction.Methods:One hundred and forty-four cases with acute cerebral infarction were randomly divided into a research group and a control group.Besides the conventional therapy,the control group was treated with urinary kallikrein and the research group with urinary kallikrein plus butylphthalide.The clinical effects,plasma nitric oxide,content of ET-1 and neurological deficit score were compared between the two groups.Results:The clinical effects were better in the research group than in the control group after treatment(P<0.05).The content of plasma nitric oxide was improved and the content of ET-1 was decreased in the two groups.The content of plasma nitric oxide was higher while the content of ET-1 was significantly lower in the research group than in the control group(P<0.05).The NIHSS and CNFDS scores were all decreased in both groups and the decrease was more significant in the research group(P<0.05).There were no differences between the two groups in the incidence of adverse reactions.Conclusion:Urinary kallikrein plus butylphthalide for the treatment of patients with acute cerebral infarction can improve the endothelial and neurological functions with remarkable curative effect.
引文
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[2]王杰,陈璟,熊小檍,等.影响急性脑梗死短期预后因素的临床研究[J].重庆医学,2014,43(9):1075-1077.
[3]全国第四届脑血管病学术会议.脑卒中患者临床神经功能缺损程度评分标准[J].中华神经外科杂志,1996,29(6):381-383.
[4]Wang YX,Chen Y,Zhang CH,et al.Study on the effect of urinary kallidinogenase after thrombolytic treatment for acute cerebral infarction[J].Eur Rev Med Pharmacol Sci,2015,19(6):1009-1012.
[5]李艾帆,崔传举,袁树华,等.尤瑞克林治疗急性进展性脑梗死60例疗效分析[J].重庆医学,2014,43(15):1931-1933.
[6]潘君枝,程超禅,陈瑞炳.丁苯酞治疗对急性脑梗死患者血管内皮功能与血栓形成的影响[J].中国老年学,2015,35(13):3580-3582.
[7]王新,王默力,杨盛.丁苯酞软胶囊(恩必普)联用尤瑞克林注射液治疗大面积脑梗死的临床疗效研究[J].中国医科大学学报,2014,43(12):1136-1138.
[8]王建,董力,贾晨红.丁苯酞注射液对急性脑梗死患者神经功能及脑血管储备功能的影响[J].实用临床医药杂志,2015,19(11):117-118.
[9]Zhao JH,Xu YM,Xing HX,et al.Associations between matrix metalloproteinase gene polymorphisms and the development of cerebral infarction[J].Genet Mol Res,2016,14(4):19418-19424.
[10]李强,田文艳,陈立英,等.丁苯酞对急性脑梗死患者血管内皮生长因子、肿瘤坏死因子a及神经功能的影响[J].医学综述,2017,23(5):1001-1005.