郁金及其近缘药材的研究进展及质量标志物(Q-marker)的预测分析
|
摘要
郁金为多基原药材,与莪术、姜黄和片姜黄都来源于姜科姜黄属植物,并且基原之间各有交叉,但在入药部位、炮制方法上各有不同;在传统功效上同为辛、苦味,兼具活血和行气之功,但又有各自的特点和功效倾向。因此,对于这"一组"近缘中药,建立能够反映共同特点和差异性特征的质量评价方法和质量控制体系具有重要意义。在梳理传统文献及总结现代研究报道的基础上,根据中药质量标志物(Q-marker)的概念与核心理论,提出以"基原-炮制-药用部位"为基点的成分特有性、以"药效-药性-新临床用途"为基点的有效性的Q-marker研究思路和方法,对郁金类药材Q-marker进行预测分析。
Curcuma Radix is a kind of multi-base crude drug,which is originated from Curcuma genus same as Curcuma longa,Curcumae Rhizoma,and Wenyujin Rhizoma Concisum.There are original overlapping parts among them,but in the part of medicine and the processing method are different.In the traditional efficacy,the flavors of them are both spice and bitter,with the same effects of moving qi and activating blood flow,they also have their own characteristics and efficacy tendency.Therefore,it is of special significance to establish the quality evaluation method and quality control system which can reflect the common characteristics and the differences between Curcumae Radix and its near-source species.On the basis of combing the traditional literatures and summing up the modern research reports,according to the concept and core theory of quality marker of traditional Chinese medicine,this paper puts forward the research ideas and methods about characteristics of components based on "origin-processing-medicinal parts" and component validity based on "medicinal efficacy-medicinal property-new clinical use" to predict and analyze the quality marker of Curcumae Radix.
Curcuma Radix is a kind of multi-base crude drug,which is originated from Curcuma genus same as Curcuma longa,Curcumae Rhizoma,and Wenyujin Rhizoma Concisum.There are original overlapping parts among them,but in the part of medicine and the processing method are different.In the traditional efficacy,the flavors of them are both spice and bitter,with the same effects of moving qi and activating blood flow,they also have their own characteristics and efficacy tendency.Therefore,it is of special significance to establish the quality evaluation method and quality control system which can reflect the common characteristics and the differences between Curcumae Radix and its near-source species.On the basis of combing the traditional literatures and summing up the modern research reports,according to the concept and core theory of quality marker of traditional Chinese medicine,this paper puts forward the research ideas and methods about characteristics of components based on "origin-processing-medicinal parts" and component validity based on "medicinal efficacy-medicinal property-new clinical use" to predict and analyze the quality marker of Curcumae Radix.
引文
[1]中国药典[S].一部.2015.
[2]肖长坤.姜黄属植物的化学成分研究进展[J].中国实验方剂学杂志,2012,18(21):339-347.
[3]Qin X D,Zhao Y,Gao Y,et al.Curcumaromins A,B,and C,three novel curcuminoids from Curcuma aromatica[J].Helv Chim Acta,2015,98(9):1325-1331.
[4]王晓华,朱华,陈旭,等.郁金化学成分及其质量控制研究进展[J].安徽农业科学,2012,40(10):5873-5875.
[5]翁金月,张春椿,林君,等.HPLC分析比较不同产地郁金姜黄素的化学组分[J].中华中医药学刊,2015,33(6):1393-1395.
[6]翁金月,张春椿,陈茜茜,等.GC-MS分析比较不同产地温郁金挥发油的化学组分[J].中华中医药学刊,2015,33(4):981-985.
[7]蔡定多,苏孝共,郑冰珊.温郁金主根茎与侧根茎姜黄素及挥发油含量测定[J].中药材,2015,38(7):1447-1448.
[8]刘晶,王光函,庞敏,等.气相色谱法测定温郁金挥发油中5种成分含量[J].中华中医药学刊,2017,35(9):2415-2418.
[9]张军,王亮,石典花,等.4种不同药材来源郁金饮片中挥发油成分的GC-MS分析[J].中国实验方剂学杂志,2017,23(13):1-7.
[10]汤敏燕,汪洪武,孙凌峰.中药姜黄挥发油化学成分研究[J].江西师范大学学报:自然科学版,2000,24(3):274-276.
[11]刘喜华,赵应学,黄敏琪,等.不同形态桂郁金挥发性成分GC-MS分析[J].中药材,2014,37(5):819-822.
[12]张清哲,杨芳,朱晶晶,等.GC-MS比较温郁金、温莪术、片姜黄中挥发油的化学组成[J].中国中药杂志,2010,35(19):2590-2593.
[13]Yang F Q,Wang Y T,Li S P.Simultaneous determination of 11 characteristic components in three species of Curcuma rhizomes using pressurized liquid extraction and high-performance liquid chromatography[J].JChromatogr A,2006,1134(1):226-231.
[14]Lou Y,Zhao F,Wu Z H,et al.Germacrane-type sesquiterpenes from Curcuma wenyujin[J].Helv Chim Acta,2009,92(8):1665-1672.
[15]钮智刚,陈豪华,高成威,等.温莪术药渣化学成分的研究[J].广东化工,2014,41(16):22-23.
[16]刘红星,陈福北,黄初升,等.从姜黄及姜黄浸膏中提取的挥发油化学成分研究[J].分析测试学报,2007,26(9):146-148.
[17]Xie C Y,Wei Y,Ming L,et al.Cell apoptosis induced byδ-elemene in colorectal adenocarcinoma cells via a mitochondrial-mediated pathway[J].Chin Pharmacol Bull,2010,26(5):646-652.
[18]王利霞,邓志威,黄可新,等.温郁金茎叶化学成分研究[J].中国中药杂志,2008,33(7):785-786.
[19]徐玉平,钱海兵,王祥培.温郁金水煎剂中石油醚提取物的GC-MS分析[J].中国实验方剂学杂志,2012,18(1):139-141.
[20]赵秀玲.姜黄的化学成分、药理作用及其资源开发的研究进展[J].中国调味品,2012,37(5):9-12.
[21]刘娜,余德顺,代明权,等.蓬莪术挥发油提取技术的研究及其化学成分分析[J].西南师范大学学报:自然科学版,2002,27(3):430-434.
[22]Dang Y Y,Li X C,Zhang Q W,et al.Preparative isolation and purification of six volatile compounds from essential oil of Curcuma wenyujin using high performance centrifugal partition chromatography[J].J Sep Sci,2010,33(11):1658-1662.
[23]罗春兰,吴爱琴.不同品种莪术挥发油成分GC-MS分析[J].广东药学,2005,15(2):10-11.
[24]刘晓宇,楼燕,胡丹,等.温郁金挥发油的化学成分[J].沈阳药科大学学报,2007,24(11):682-684.
[25]陈佩东,陆兔林.莪术的化学成分研究[J].中药材,2006,29(7):675-678.
[26]周欣,李章万,王道平,等.姜科姜黄属植物有效成分的研究[J].分析测试学报,2004,23(6):53-56.
[27]Lou Y,Zhao F,He H,et al.Guaiane-type sesquiterpenes from Curcuma wenyujin and their inhibitory effects on nitric-oxide production[J].J Asian Nat Prod Res,2009,11(8):737.
[28]Gonda R,Tomoda M,Shimizu N,et al.Characterization of polysaccharides having activity on the reticuloendothelial system from the rhizome of Curcuma longa[J].Chem Pharm Bull,1990,38(2):482-486.
[29]王晓华,朱华,陈旭,等.不同基原的郁金类药材中郁金多糖的含量测定[J].安徽农业科学,2012,40(9):5173-5174.
[30]何飞龙,刘辉庭,黄巧燕,等.电感耦合等离子体法测定桂郁金中的微量元素[J].桂林理工大学学报,2012,32(2):250-252.
[31]吴新新,盛振华,吴巧凤.不同产地郁金中微量元素的测定及其主成分分析[J].中成药,2015,37(2):370-374.
[32]Wang L Y,Zhang M,Zhan C F,et al.Alkaloid and sesquiterpenes from the root tuber of Curcuma longa[J].Acta Pharm Sin,2008,43(7):724-727.
[33]黄伟.温郁金活性成分的研究[D].杭州:浙江大学,2008.
[34]Ma Z J,Meng Z K,Zhang P.Chemical constituentsfrom the radix of Curcuma wenyujin[J].Fitoterapia,2009,80(6):374-376.
[35]Huang J,Wang X,Ogihara Y.Novel biphenyl ether lignans from the rhizomers of Curcuma chuanyujin[J].Chem Pharm Bull,2000,48(8):1228-1229.
[36]韩婷,宓鹤鸣.姜黄的化学成分及药理活性研究进展[J].解放军药学学报,2001,17(2):40-42.
[37]易进海,陈燕,李伯刚,等.郁金化学成分的研究[J].天然产物研究与开发,2003,15(2):98-100.
[38]Xia Q,Wang X,Xu D J,et al.Inhibition of platelet aggregation by curdione from Curcuma wenyujin essential oil[J].Thromb Res,2012,130(3):409-414.
[39]王秀.莪术二酮抗血栓和抗血小板聚集作用研究[D].合肥:安徽医科大学,2012.
[40]庞雪芬.姜黄素在血管紧张素II致大鼠心机纤维化中的作用及机制研究[D].太原:山西医科大学,2016.
[41]黄宣,吕宾,赵敏,等.温郁金二萜类化合物C对幽门螺杆菌诱导人胃GES-1上皮细胞炎症的抑制作用及其对NF-κB信号通道的影响[J].中国药理学通报,2013,29(4):562-567.
[42]孙秀燕,郑艳萍,刘志峰,等.温莪术环状含氧倍半萜类化学成分的研究[J].分析测试学报,2006,25(6):27-30.
[43]Zhao C,He W,Wang Z,et al.Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents[J].Drug Des Devel Ther,2014,8:373-382.
[44]汤秀红,秦叔逵,谢恬.榄香烯注射液抗肿瘤作用基础研究的现状和进展[J].临床肿瘤学杂志,2010,15(3):266-273.
[45]张晔,曲秀娟,刘云鹏,等.β-榄香烯对人胃癌SGC7901/Adr细胞ERK通路的活化和GST-π表达的影响[J].世界华人消化杂志,2011,19(13):1394-1397.
[46]刘俊松.β-榄香烯对人胃癌细胞SGC7901作用的蛋白质组学研究[J].西安交通大学学报:医学版,2015,36(6):840-861.
[47]王超,张毅,何平.吉马酮对人肺癌A549细胞系增殖、凋亡的影响[J].实用药物与临床,2013,16(4):280-281.
[48]周勇,张毅,白雪,等.吉马酮对人肺鳞癌LK2细胞系增殖和凋亡的影响[J].中国医科大学学报,2013,42(6):508-510.
[49]金海峰,吕宾,陈喆,等.温郁金二萜类化合物C对人结肠癌细胞SW620增殖的影响[J].医药导报,2011,30(2):160-163.
[50]金海峰,吕宾,戴金锋,等.温郁金二萜类化合物C抗胃癌作用的实验研究[J].中国中西医结合杂志,2015,35(2):216-221.
[51]蒋浩,宋军,鄢良春,等.不同基原郁金的比较药理研究[J].中华中医药杂志,2015,30(12):4491-4494.
[52]张婉娴,朱彤彤,鲁育铭,等.郁金水煎剂对四氯化碳致急性肝损伤小鼠肝细胞p53和caspase-3表达的影响及其对肝损伤的保护作用[J].吉林大学学报,2014,40(1):82-86.
[53]刘昌孝,陈士林,肖小河,等.中药质量标志物(Q-Marker):中药产品质量控制的新概念[J].中草药,2016,47(9):1443-1457.
[54]刘昌孝.从中药资源-质量-质量标志物认识中药产业的健康发展[J].中草药,2016,47(18):3149-3154.
[55]张铁军,许浚,韩彦琪,等.中药质量标志物(Q-marker)研究:延胡索质量评价及质量标准研究[J].中草药,2016,47(9):1458-1467.
[56]熊亮,彭成.基于中药质量标志物(Q-Marker)的基本条件研究益母草和赶黄草的Q-Marker[J].中草药,2016,47(13):2212-2220.
[57]张铁军,许浚,申秀萍,等.基于中药质量标志物(Q-Marker)的元胡止痛滴丸的“性-效-物”三元关系和作用机制研究[J].中草药,2016,47(13):2199-2211.
[58]姜程曦,张铁军,陈常青,等.黄精的研究进展及其质量标志物的预测分析[J].中草药,2017,48(1):1-16.
[59]Liu C X.Biopotency assays,a model with integration feature for quality control research of CMM[J].Chin Herb Med,2014,6(4):255.
[60]Liu C X,Cheng Y Y,Guo D A,et al.A new concept on quality marker for quality assessment and process control of Chinese medicines[J].Chin Herb Med,2017,9(1):3-13.
[61]Guo D A.Quality marker concept inspires the quality research of traditional Chinese medicines[J].Chin Herb Med,2017,9(1):1-2.
[62]王颖.中药郁金姜黄莪术的化学成分比较研究[D].重庆:重庆大学,2014.
[63]Phrommintikul A,Chattipakorn N.Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death[J].Int J Cardiol,2006,112(2):142-152.
[64]Priyanka A,Anusree S S,Nisha V M,et al.Curcumin improves hypoxia induced dysfunctions in 3T3-L1adipocytes by protecting mitochondria and down regulating inflammation[J].Biofactors,2014,40(5):513-523.
[65]赖昌生,张蕙缨.苦味中药性能及功效特点分析[J].河南中医,2015,35(1):166-170.
[66]龙小琴,秦华珍,黄燕琼,等.姜科五属中药性效与亲缘关系相关性研究进展[J].中国药房,2016,27(23):3301-3304.
[67]安建军.有关郁金应用的探讨[J].实用医技杂志,2010,17(2):170.
[68]马行,库宝善,徐英,等.复方郁金胶囊抗抑郁抗焦虑的作用[J].中国临床康复,2006,10(15):56-58.
[69]冯学功,张立山,廉海红,等.开郁止咳颗粒治疗感冒后咳嗽临床研究[J].中华中医药杂志,2017,32(11):5240-5242.
[70]Chang Y C,Chang W C,Hung K H,et al.The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform:Identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress[J].Frontiers Aging Neurosci,2014,6:191-202.
[2]肖长坤.姜黄属植物的化学成分研究进展[J].中国实验方剂学杂志,2012,18(21):339-347.
[3]Qin X D,Zhao Y,Gao Y,et al.Curcumaromins A,B,and C,three novel curcuminoids from Curcuma aromatica[J].Helv Chim Acta,2015,98(9):1325-1331.
[4]王晓华,朱华,陈旭,等.郁金化学成分及其质量控制研究进展[J].安徽农业科学,2012,40(10):5873-5875.
[5]翁金月,张春椿,林君,等.HPLC分析比较不同产地郁金姜黄素的化学组分[J].中华中医药学刊,2015,33(6):1393-1395.
[6]翁金月,张春椿,陈茜茜,等.GC-MS分析比较不同产地温郁金挥发油的化学组分[J].中华中医药学刊,2015,33(4):981-985.
[7]蔡定多,苏孝共,郑冰珊.温郁金主根茎与侧根茎姜黄素及挥发油含量测定[J].中药材,2015,38(7):1447-1448.
[8]刘晶,王光函,庞敏,等.气相色谱法测定温郁金挥发油中5种成分含量[J].中华中医药学刊,2017,35(9):2415-2418.
[9]张军,王亮,石典花,等.4种不同药材来源郁金饮片中挥发油成分的GC-MS分析[J].中国实验方剂学杂志,2017,23(13):1-7.
[10]汤敏燕,汪洪武,孙凌峰.中药姜黄挥发油化学成分研究[J].江西师范大学学报:自然科学版,2000,24(3):274-276.
[11]刘喜华,赵应学,黄敏琪,等.不同形态桂郁金挥发性成分GC-MS分析[J].中药材,2014,37(5):819-822.
[12]张清哲,杨芳,朱晶晶,等.GC-MS比较温郁金、温莪术、片姜黄中挥发油的化学组成[J].中国中药杂志,2010,35(19):2590-2593.
[13]Yang F Q,Wang Y T,Li S P.Simultaneous determination of 11 characteristic components in three species of Curcuma rhizomes using pressurized liquid extraction and high-performance liquid chromatography[J].JChromatogr A,2006,1134(1):226-231.
[14]Lou Y,Zhao F,Wu Z H,et al.Germacrane-type sesquiterpenes from Curcuma wenyujin[J].Helv Chim Acta,2009,92(8):1665-1672.
[15]钮智刚,陈豪华,高成威,等.温莪术药渣化学成分的研究[J].广东化工,2014,41(16):22-23.
[16]刘红星,陈福北,黄初升,等.从姜黄及姜黄浸膏中提取的挥发油化学成分研究[J].分析测试学报,2007,26(9):146-148.
[17]Xie C Y,Wei Y,Ming L,et al.Cell apoptosis induced byδ-elemene in colorectal adenocarcinoma cells via a mitochondrial-mediated pathway[J].Chin Pharmacol Bull,2010,26(5):646-652.
[18]王利霞,邓志威,黄可新,等.温郁金茎叶化学成分研究[J].中国中药杂志,2008,33(7):785-786.
[19]徐玉平,钱海兵,王祥培.温郁金水煎剂中石油醚提取物的GC-MS分析[J].中国实验方剂学杂志,2012,18(1):139-141.
[20]赵秀玲.姜黄的化学成分、药理作用及其资源开发的研究进展[J].中国调味品,2012,37(5):9-12.
[21]刘娜,余德顺,代明权,等.蓬莪术挥发油提取技术的研究及其化学成分分析[J].西南师范大学学报:自然科学版,2002,27(3):430-434.
[22]Dang Y Y,Li X C,Zhang Q W,et al.Preparative isolation and purification of six volatile compounds from essential oil of Curcuma wenyujin using high performance centrifugal partition chromatography[J].J Sep Sci,2010,33(11):1658-1662.
[23]罗春兰,吴爱琴.不同品种莪术挥发油成分GC-MS分析[J].广东药学,2005,15(2):10-11.
[24]刘晓宇,楼燕,胡丹,等.温郁金挥发油的化学成分[J].沈阳药科大学学报,2007,24(11):682-684.
[25]陈佩东,陆兔林.莪术的化学成分研究[J].中药材,2006,29(7):675-678.
[26]周欣,李章万,王道平,等.姜科姜黄属植物有效成分的研究[J].分析测试学报,2004,23(6):53-56.
[27]Lou Y,Zhao F,He H,et al.Guaiane-type sesquiterpenes from Curcuma wenyujin and their inhibitory effects on nitric-oxide production[J].J Asian Nat Prod Res,2009,11(8):737.
[28]Gonda R,Tomoda M,Shimizu N,et al.Characterization of polysaccharides having activity on the reticuloendothelial system from the rhizome of Curcuma longa[J].Chem Pharm Bull,1990,38(2):482-486.
[29]王晓华,朱华,陈旭,等.不同基原的郁金类药材中郁金多糖的含量测定[J].安徽农业科学,2012,40(9):5173-5174.
[30]何飞龙,刘辉庭,黄巧燕,等.电感耦合等离子体法测定桂郁金中的微量元素[J].桂林理工大学学报,2012,32(2):250-252.
[31]吴新新,盛振华,吴巧凤.不同产地郁金中微量元素的测定及其主成分分析[J].中成药,2015,37(2):370-374.
[32]Wang L Y,Zhang M,Zhan C F,et al.Alkaloid and sesquiterpenes from the root tuber of Curcuma longa[J].Acta Pharm Sin,2008,43(7):724-727.
[33]黄伟.温郁金活性成分的研究[D].杭州:浙江大学,2008.
[34]Ma Z J,Meng Z K,Zhang P.Chemical constituentsfrom the radix of Curcuma wenyujin[J].Fitoterapia,2009,80(6):374-376.
[35]Huang J,Wang X,Ogihara Y.Novel biphenyl ether lignans from the rhizomers of Curcuma chuanyujin[J].Chem Pharm Bull,2000,48(8):1228-1229.
[36]韩婷,宓鹤鸣.姜黄的化学成分及药理活性研究进展[J].解放军药学学报,2001,17(2):40-42.
[37]易进海,陈燕,李伯刚,等.郁金化学成分的研究[J].天然产物研究与开发,2003,15(2):98-100.
[38]Xia Q,Wang X,Xu D J,et al.Inhibition of platelet aggregation by curdione from Curcuma wenyujin essential oil[J].Thromb Res,2012,130(3):409-414.
[39]王秀.莪术二酮抗血栓和抗血小板聚集作用研究[D].合肥:安徽医科大学,2012.
[40]庞雪芬.姜黄素在血管紧张素II致大鼠心机纤维化中的作用及机制研究[D].太原:山西医科大学,2016.
[41]黄宣,吕宾,赵敏,等.温郁金二萜类化合物C对幽门螺杆菌诱导人胃GES-1上皮细胞炎症的抑制作用及其对NF-κB信号通道的影响[J].中国药理学通报,2013,29(4):562-567.
[42]孙秀燕,郑艳萍,刘志峰,等.温莪术环状含氧倍半萜类化学成分的研究[J].分析测试学报,2006,25(6):27-30.
[43]Zhao C,He W,Wang Z,et al.Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents[J].Drug Des Devel Ther,2014,8:373-382.
[44]汤秀红,秦叔逵,谢恬.榄香烯注射液抗肿瘤作用基础研究的现状和进展[J].临床肿瘤学杂志,2010,15(3):266-273.
[45]张晔,曲秀娟,刘云鹏,等.β-榄香烯对人胃癌SGC7901/Adr细胞ERK通路的活化和GST-π表达的影响[J].世界华人消化杂志,2011,19(13):1394-1397.
[46]刘俊松.β-榄香烯对人胃癌细胞SGC7901作用的蛋白质组学研究[J].西安交通大学学报:医学版,2015,36(6):840-861.
[47]王超,张毅,何平.吉马酮对人肺癌A549细胞系增殖、凋亡的影响[J].实用药物与临床,2013,16(4):280-281.
[48]周勇,张毅,白雪,等.吉马酮对人肺鳞癌LK2细胞系增殖和凋亡的影响[J].中国医科大学学报,2013,42(6):508-510.
[49]金海峰,吕宾,陈喆,等.温郁金二萜类化合物C对人结肠癌细胞SW620增殖的影响[J].医药导报,2011,30(2):160-163.
[50]金海峰,吕宾,戴金锋,等.温郁金二萜类化合物C抗胃癌作用的实验研究[J].中国中西医结合杂志,2015,35(2):216-221.
[51]蒋浩,宋军,鄢良春,等.不同基原郁金的比较药理研究[J].中华中医药杂志,2015,30(12):4491-4494.
[52]张婉娴,朱彤彤,鲁育铭,等.郁金水煎剂对四氯化碳致急性肝损伤小鼠肝细胞p53和caspase-3表达的影响及其对肝损伤的保护作用[J].吉林大学学报,2014,40(1):82-86.
[53]刘昌孝,陈士林,肖小河,等.中药质量标志物(Q-Marker):中药产品质量控制的新概念[J].中草药,2016,47(9):1443-1457.
[54]刘昌孝.从中药资源-质量-质量标志物认识中药产业的健康发展[J].中草药,2016,47(18):3149-3154.
[55]张铁军,许浚,韩彦琪,等.中药质量标志物(Q-marker)研究:延胡索质量评价及质量标准研究[J].中草药,2016,47(9):1458-1467.
[56]熊亮,彭成.基于中药质量标志物(Q-Marker)的基本条件研究益母草和赶黄草的Q-Marker[J].中草药,2016,47(13):2212-2220.
[57]张铁军,许浚,申秀萍,等.基于中药质量标志物(Q-Marker)的元胡止痛滴丸的“性-效-物”三元关系和作用机制研究[J].中草药,2016,47(13):2199-2211.
[58]姜程曦,张铁军,陈常青,等.黄精的研究进展及其质量标志物的预测分析[J].中草药,2017,48(1):1-16.
[59]Liu C X.Biopotency assays,a model with integration feature for quality control research of CMM[J].Chin Herb Med,2014,6(4):255.
[60]Liu C X,Cheng Y Y,Guo D A,et al.A new concept on quality marker for quality assessment and process control of Chinese medicines[J].Chin Herb Med,2017,9(1):3-13.
[61]Guo D A.Quality marker concept inspires the quality research of traditional Chinese medicines[J].Chin Herb Med,2017,9(1):1-2.
[62]王颖.中药郁金姜黄莪术的化学成分比较研究[D].重庆:重庆大学,2014.
[63]Phrommintikul A,Chattipakorn N.Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death[J].Int J Cardiol,2006,112(2):142-152.
[64]Priyanka A,Anusree S S,Nisha V M,et al.Curcumin improves hypoxia induced dysfunctions in 3T3-L1adipocytes by protecting mitochondria and down regulating inflammation[J].Biofactors,2014,40(5):513-523.
[65]赖昌生,张蕙缨.苦味中药性能及功效特点分析[J].河南中医,2015,35(1):166-170.
[66]龙小琴,秦华珍,黄燕琼,等.姜科五属中药性效与亲缘关系相关性研究进展[J].中国药房,2016,27(23):3301-3304.
[67]安建军.有关郁金应用的探讨[J].实用医技杂志,2010,17(2):170.
[68]马行,库宝善,徐英,等.复方郁金胶囊抗抑郁抗焦虑的作用[J].中国临床康复,2006,10(15):56-58.
[69]冯学功,张立山,廉海红,等.开郁止咳颗粒治疗感冒后咳嗽临床研究[J].中华中医药杂志,2017,32(11):5240-5242.
[70]Chang Y C,Chang W C,Hung K H,et al.The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform:Identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress[J].Frontiers Aging Neurosci,2014,6:191-202.