ABO血型不相合对异基因造血干细胞移植治疗HPS后急性移植物抗宿主病的影响
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摘要
目的回顾性分析ABO血型不相合对异基因造血干细胞移植治疗噬血细胞综合征(HPS)后急性移植物抗宿主病的影响。方法选取2013-2017年于该院血液科行异基因造血干细胞移植治疗HPS的患者32例,统计移植后急性移植物抗宿主病的发生率。结果 ABO血型相合组16例患者中11例在移植后出现急性移植物抗宿主病,ABO血型不相合组16例患者中13例在移植后出现急性移植物抗宿主病,差异无统计学意义(P>0.05)。ABO血型不相合组中主要不相合6例、次要不相合6例、主次要不相合1例,三者之间差异无统计学意义(P>0.05)。结论 ABO血型不相合对异基因造血干细胞移植治疗HPS后急性移植物抗宿主病的发生率并无影响。
Objective To retrospectively analyze the influence of ABO-incompatibility on acute graft-versus-host disease(aGVHD)after allogeneic hematopoietic stem cell transplantation for treating hemophagocytic syndrome(HPS).Methods Thirty-two patients with HPS treated by allogeneic hematopoietic stem cell transplantation in the hematology department of this hospital during 2013-2017 were selected.Then the occurrence rate of aGVHD was performed the statistics.Results Among 16 cases in the ABO-compatibility group,11 cases appeared aGVHD after transplantation,while among 16 cases in the ABO-incompatibility group,13 cases appeared aGVHD after transplantation,the difference was not statistically significant(P>0.05).In the ABO-incompatibility group,6 cases were major incompatible,6 cases appeared minor incompatible,1 case was major and minor incompatible,the difference among them had no statistical difference(P>0.05).Conclusion ABO-incompatibility has no influence on the occurrence rate of aGVHD after allogeneic hematopoietic stem cell transplantation for treating HPS.
Objective To retrospectively analyze the influence of ABO-incompatibility on acute graft-versus-host disease(aGVHD)after allogeneic hematopoietic stem cell transplantation for treating hemophagocytic syndrome(HPS).Methods Thirty-two patients with HPS treated by allogeneic hematopoietic stem cell transplantation in the hematology department of this hospital during 2013-2017 were selected.Then the occurrence rate of aGVHD was performed the statistics.Results Among 16 cases in the ABO-compatibility group,11 cases appeared aGVHD after transplantation,while among 16 cases in the ABO-incompatibility group,13 cases appeared aGVHD after transplantation,the difference was not statistically significant(P>0.05).In the ABO-incompatibility group,6 cases were major incompatible,6 cases appeared minor incompatible,1 case was major and minor incompatible,the difference among them had no statistical difference(P>0.05).Conclusion ABO-incompatibility has no influence on the occurrence rate of aGVHD after allogeneic hematopoietic stem cell transplantation for treating HPS.
引文
[1]曾祥宗,王旖旎,王昭.成人噬血细胞性淋巴组织细胞增生症[J].内科急危重症杂志,2015,21(2):81-85.
[2]JORDAN M B,ALLEN C E,WEITZMAN S A,et al.How I treat hemophagocytic lymphohistiocytosis[J].Blood,2011,118(15):4041-4052.
[3]HENTER J I,HORNE A,ARICM,et al.HLH-2004:diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis[J].Pediatr Blood Cancer,2007,48(2):124-131.
[4]PRZEPIORKA D,WEISDORF D,MARTIN P,et al.1994consensus conference on acute GVHD grading[J].Bone Marrow Transplant,1995,15(6):825-828.
[5]TEKGNDZ S A,ZBEK N.ABO blood group mismatched hematopoietic stem cell transplantation[J].Transfus Apher Sci,2016,54(1):24-29.
[6]VAEZI M,OULAD DAMESHGHI D,SOURI M,et al.ABO incompatibility and hematopoietic stem cell transplantation outcomes[J].Int J Hematol Oncolo Stem Cell Res,2017,11(2):139-147.
[7]陈瑶,陆道培,刘开彦,等.异基因造血干细胞移植后急性移植物抗宿主病151例危险因素分析[J].中华血液学杂志,2005,26(2):13-16.
[8]FLOWERS M E,INAMOTO Y,CARPENTER P A,et al.Comparative analysis of risk factors for acute graftversus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria[J].Blood,2011,117(11):3214-3219.
[9]CANANNI J,SAVANI B N,LABOPIN M,et al.Imapct of ABO incompatibility on patients outcome after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia-a report from the Acute Leukemia Working Party of the EBMT[J].Haematologica,2017,120(6):1066-1074.
[10]ZAIMOKU Y,TAKAMI A,SATO H,et al.IgM antirecipent ABO antibodies predict acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation[J].Int J Hematol,2013,98(1):96-101.
[11]KIM J G,SOHN S K,KIM D H,et al.Impact of ABO incompatibility on outcome after allogeneic peripheral blood stem cell transplantation[J].Bone Marrow Transplant,2005,35(5):489-495.
[12]GUTIRREZ-AGUIRRE C H,GMEZ-DE-LEN A,ALATORRE-RICARDO J,et al.Allogeneic peripheral blood stem cell transplantation using reduced-intensity conditioning in an outpatient setting in ABO-incompatible patients:are survival and graft-versus-host disease different[J].Transfusion,2014,54(5):1269-1277.
[2]JORDAN M B,ALLEN C E,WEITZMAN S A,et al.How I treat hemophagocytic lymphohistiocytosis[J].Blood,2011,118(15):4041-4052.
[3]HENTER J I,HORNE A,ARICM,et al.HLH-2004:diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis[J].Pediatr Blood Cancer,2007,48(2):124-131.
[4]PRZEPIORKA D,WEISDORF D,MARTIN P,et al.1994consensus conference on acute GVHD grading[J].Bone Marrow Transplant,1995,15(6):825-828.
[5]TEKGNDZ S A,ZBEK N.ABO blood group mismatched hematopoietic stem cell transplantation[J].Transfus Apher Sci,2016,54(1):24-29.
[6]VAEZI M,OULAD DAMESHGHI D,SOURI M,et al.ABO incompatibility and hematopoietic stem cell transplantation outcomes[J].Int J Hematol Oncolo Stem Cell Res,2017,11(2):139-147.
[7]陈瑶,陆道培,刘开彦,等.异基因造血干细胞移植后急性移植物抗宿主病151例危险因素分析[J].中华血液学杂志,2005,26(2):13-16.
[8]FLOWERS M E,INAMOTO Y,CARPENTER P A,et al.Comparative analysis of risk factors for acute graftversus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria[J].Blood,2011,117(11):3214-3219.
[9]CANANNI J,SAVANI B N,LABOPIN M,et al.Imapct of ABO incompatibility on patients outcome after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia-a report from the Acute Leukemia Working Party of the EBMT[J].Haematologica,2017,120(6):1066-1074.
[10]ZAIMOKU Y,TAKAMI A,SATO H,et al.IgM antirecipent ABO antibodies predict acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation[J].Int J Hematol,2013,98(1):96-101.
[11]KIM J G,SOHN S K,KIM D H,et al.Impact of ABO incompatibility on outcome after allogeneic peripheral blood stem cell transplantation[J].Bone Marrow Transplant,2005,35(5):489-495.
[12]GUTIRREZ-AGUIRRE C H,GMEZ-DE-LEN A,ALATORRE-RICARDO J,et al.Allogeneic peripheral blood stem cell transplantation using reduced-intensity conditioning in an outpatient setting in ABO-incompatible patients:are survival and graft-versus-host disease different[J].Transfusion,2014,54(5):1269-1277.