特应性皮炎动物模型与免疫学机制及中药治疗的研究进展
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摘要
特应性皮炎(atopic dermatitis,AD)是一种由遗传、环境、皮肤屏障功能及外界变应性等因素引起的慢性炎症性皮肤病,并且涉及不同类型细胞相关因子以及通路的相互作用,目前对该病病因尚待进一步研究。本文对AD的动物模型、免疫学机制以及近几年中药治疗及其研究现状进行综述。
Atopic dermatitis(AD) is a chronic relapsing disease caused by genetic, environmental, skin barrier function, and external allergic factors, ainvolving the interaction of different cell types and pathways. The etiology of this disease remains unclear. In this paper, the immune mechanism and the treatment with traditional Chinese medicine in recent years were reviewed.
Atopic dermatitis(AD) is a chronic relapsing disease caused by genetic, environmental, skin barrier function, and external allergic factors, ainvolving the interaction of different cell types and pathways. The etiology of this disease remains unclear. In this paper, the immune mechanism and the treatment with traditional Chinese medicine in recent years were reviewed.
引文
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[9]Novak N,Bieber T.The role of dendritic cell subtypes in the pathophysiology of atopic dermatitis[J].J Am Acad Dermatol,2005,53(2 Suppl 2):171-176.
[10]Zachariassen LF,Krych L,Engkilde K,et al.Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice[J].Sci Rep,2017,79(1):1-7.
[11]Choi EJ,Debnath T,Tang Y,et al.Topical application of Moringa oleifera leaf extract ameliorates experimentally induced atopic dermatitis by the regulation of Th1/Th2/Th17 balance[J].Biomed Pharmacother,2016,84:870-877.
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[15]Tyurin YA,Shamsutdinov AF,Kalinin NN,et al.Association of Toll-like cell receptors TLR2(p.Arg753GLN)and TLR4(p.Asp299GLY)polymorphisms with indicators of general and local immunity in patients with atopic dermatitis[J].J Immunol Res,2017,2017:1-6.
[16]Batista DIS,Perez L,Orfali RL,et al.Profile of skin barrier proteins(filaggrin,claudins 1 and 4)and Th1/Th2/Th17 cytokines in adults with atopic dermatitis[J].Eur Acad Dermatol Venereol,2014,29(6):1091-1095.
[17]Matsushita S,Takagi R,Hashimoto K,et al.Qualitative evaluation of adjuvant activities and its application to Th2/17 diseases[J].Int Arch Allergy Immunol,2011,155(Suppl.1):2-5.
[18]Lue H,Kleemann R,Calandra T,et al.Macrophage migration inhibitory factor(MIF):mechanisms of action and role in disease[J].Microbes Infect,2002,4(4):449-460.
[19]Suwanpradid J,Shih M,Pontius L,et al.Arginase1 Deficiency in monocytes/macrophages upregulates inducible nitric oxide synthase to promote cutaneous contact hypersensitivity[J].J Immunol,2017,199(5):1827-1834.
[20]Sung YY,Kim HK.Crocin Ameliorates atopic dermatitis symptoms by down regulation of Th2 response via blocking of NF-κB/STAT6 signaling pathways in mice[J].Nutrients,2018,10(11):1-11.
[21]Choi JK,Jang YH,Lee S,et al.Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes[J].Food Chem Toxicol,2017,110:142-150.
[22]Bao L,Shi VY,Chan LS.IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1,2/Stat6 signal transduction pathway:Implication for atopic dermatitis[J].Mol Immunol,2012,50(1-2):91-97.
[23]Jin W,Huang W,Chen L,et al.Topical application of JAK1/JAK2 inhibitor momelotinib exhibits significant anti-inflammatory responses in DNCB-Induced atopic dermatitis model mice[J].Int J Mol Sci,2018,19(12):1-12.
[24]Kanemaru K,Nakamura Y,Totoki K,et al.Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity[J].Cell Death Differ,2017,24(6):1079-1090.
[25]Bongjun S,Bombi L,Ye Y,et al.Extract of polygala tenuifolia alleviates stress-exacerbated atopy-like skin dermatitis through the modulation of protein kinase a and p38mitogen-activated protein kinase signaling pathway[J].Int JMol Sci,2017,18(1):190-206.
[26]Szymanski L,Cios A,Lewicki S,et al.Fas/FasL pathway and cytokines in keratinocytes in atopic dermatitis-Manipulation by the electromagnetic field[J].PLoS One,2018,13(10):1-12.
[27]Karolina B,Magdalena?,Piotr O,et al.Involvement of Fas/FasL pathway in the murine model of atopic dermatitis[J].Inflamm Res,2017,66(6):1-12.
[28]齐晓涟,曹阳.临床药师在卡马西平引起剥脱性皮炎不良反应处理中的作用[J].中南药学,2015,13(4):441-442.
[29]廖作庄,杨凤莲,王俊利.黑骨藤药理作用研究进展[J].右江医学,2014,42(3):361-363.
[30]Bao C,Liu Y,Sun X,et al.Periploca forrestii saponin ameliorates CIA via suppressing proinflammatory cytokines and nuclear factor kappa-B pathways[J].PLoS One,2017,12(5):1-15.
[31]鲍春梅,孙广臣.黑骨藤皂苷对特应性皮炎小鼠的治疗作用及对Th1型免疫反应的影响[J].山东医药,2017,57(13):38-41.
[32]浦跃武,熊冬生,黎慧瑜.樟芝的研究及其应用[J].中国医院药学杂志,2004,24(7):430-432.
[33]Kao ST,Kuo YH,Wang SD,et al.Analogous corticosteroids,9A and EK100,derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages[J].Cytokine,2018,108:136-144.
[34]Yang SC,Huang TH,Chiu CH,et al.The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorate[J].J Dermatol Sci,2018,92(2):188-196.
[35]赵平,张文治,王凯.旋覆花化学成分研究[J].齐齐哈尔大学学报(自然科学版),2012,28(2):12-14.
[36]Zarei M,Mohammadi S,Komaki A.Antinociceptive activity of inula britannica l.and patuletin:in vivo and possible mechanisms studies[J].J Ethnopharmacol,2018,219:351-358.
[37]Wang Q,Gao S,Wu GZ,et al.Total sesquiterpene lactones isolated from Inula helenium L.attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice[J].Phytomedicine,2018,46:78-84.
[38]段启,许冬谨,刘传祥,等.白术的研究进展[J].中草药,2008,39(5):800-802.
[39]Yang P,Zhu JY,Gong ZJ,et al.Transcriptome analysis of the Chinese white wax scale ericerus pela with focus on genes involved in wax biosynthesis[J].PLoS One,2012,7(4):e35719.
[40]Lin L,Zhou Y,Li H,et al.Polysaccharide extracted from Chinese white wax scale ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB/c mice[J].Saudi Pharm J,2017,25(4):625-632.
[41]朱江,蔡德海,芮菁.栀子的抗炎镇痛作用研究[J].中草药,2000,31(3):198-200.
[42]傅春升,娄红祥,张学顺.栀子的化学成分与药理作用[J].现代药物与临床,2004,19(4):152-156.
[43]Xiao W,Li S,Wang S,et al.Chemistry and bioactivity of Gardenia jasminoides[J].J Food Drug Anal,2017,25(1):43-61.
[44]李越峰,黄玉新,李廷利,等.四逆散拆方过程中成分变化的分析研究[J].中成药,2009,31(8):1308-1310.
[45]Wen J,Wang Y,Yang L,et al.Comparative pharmacokinetic study of four major components after oral administration of pure compounds,herbs and Si-Ni-San to rats[J]Xenobiotica,2014,44(9):855-860.
[46]Fan HJ,Xie ZP,Lu ZW,et al.Anti-inflammatory and immune response regulation of Si-Ni-San in 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin dysfunction[J].J Ethnopharmacol,2018,222:1-10.
[47]Wegner J,Saloga J,Grabbe S,et al.IgE-specific immunoadsorption:New treatment option for severe refractory atopic dermatitis[J].Allergy,2019,1(10):1-10.
[2]陈婕,曹伟,程泽能.与抗变态反应药物相关的药物相互作用[J].中南药学,2008,6(5):592-595.
[3]Cantani A.Pathogenesis of atopic dermatitis(AD)and the role of allergic factors[J].Eur Rev Med Pharmacol Sci,2001,5(5):95-117.
[4]Chan LS,Robinson N,Xu L.Expression of interleukin-4in the epidermis of transgenic mice results in a pruritic inflammatory skin disease:an experimental animal model to study atopic dermatitis[J].J Investig Dermatol Symp Proc,2001,117(4):977-983.
[5]Jin H,He R,Oyoshi M,et al.Animal models of atopic dermatitis[J].J Invest Dermatol,2009,129(1):31-40.
[6]Ohmura T,Konomi A,Satoh Y,et al.Suppression of atopic-like dermatitis by treatment with antibody to lymphocyte function-associated antigen-1 in NC/Nga mouse[J].Eur J Pharmacol,2004,504(1-2):113-117.
[7]Kawakami Y,Kawakami T.A mouse model of atopic dermatitis[J].Methods Mol Biol,2015,1220:497-502.
[8]Martel BC,Lovato P,B?umer W,et al.Focus:Comparative medicine:translational animal models of atopic dermatitis for preclinical studies[J].Yale J Biol Med,2017,90(3):389-402.
[9]Novak N,Bieber T.The role of dendritic cell subtypes in the pathophysiology of atopic dermatitis[J].J Am Acad Dermatol,2005,53(2 Suppl 2):171-176.
[10]Zachariassen LF,Krych L,Engkilde K,et al.Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice[J].Sci Rep,2017,79(1):1-7.
[11]Choi EJ,Debnath T,Tang Y,et al.Topical application of Moringa oleifera leaf extract ameliorates experimentally induced atopic dermatitis by the regulation of Th1/Th2/Th17 balance[J].Biomed Pharmacother,2016,84:870-877.
[12]Leung DYM,Soter NA.Cellular and immunologic mechanisms in atopic dermatitis[J].J Am Acad Dermatol,2001,44(1 Suppl):S1-S12.
[13]Toda M,Leung DYM,Molet S,et al.Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions[J].J Allergy Clin Immunol Pract,2003,111(4):875-881.
[14]Medzhitov R.TLR-mediated innate immune recognition[J].Semin Immuno,2007,19(1):1-2.
[15]Tyurin YA,Shamsutdinov AF,Kalinin NN,et al.Association of Toll-like cell receptors TLR2(p.Arg753GLN)and TLR4(p.Asp299GLY)polymorphisms with indicators of general and local immunity in patients with atopic dermatitis[J].J Immunol Res,2017,2017:1-6.
[16]Batista DIS,Perez L,Orfali RL,et al.Profile of skin barrier proteins(filaggrin,claudins 1 and 4)and Th1/Th2/Th17 cytokines in adults with atopic dermatitis[J].Eur Acad Dermatol Venereol,2014,29(6):1091-1095.
[17]Matsushita S,Takagi R,Hashimoto K,et al.Qualitative evaluation of adjuvant activities and its application to Th2/17 diseases[J].Int Arch Allergy Immunol,2011,155(Suppl.1):2-5.
[18]Lue H,Kleemann R,Calandra T,et al.Macrophage migration inhibitory factor(MIF):mechanisms of action and role in disease[J].Microbes Infect,2002,4(4):449-460.
[19]Suwanpradid J,Shih M,Pontius L,et al.Arginase1 Deficiency in monocytes/macrophages upregulates inducible nitric oxide synthase to promote cutaneous contact hypersensitivity[J].J Immunol,2017,199(5):1827-1834.
[20]Sung YY,Kim HK.Crocin Ameliorates atopic dermatitis symptoms by down regulation of Th2 response via blocking of NF-κB/STAT6 signaling pathways in mice[J].Nutrients,2018,10(11):1-11.
[21]Choi JK,Jang YH,Lee S,et al.Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes[J].Food Chem Toxicol,2017,110:142-150.
[22]Bao L,Shi VY,Chan LS.IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1,2/Stat6 signal transduction pathway:Implication for atopic dermatitis[J].Mol Immunol,2012,50(1-2):91-97.
[23]Jin W,Huang W,Chen L,et al.Topical application of JAK1/JAK2 inhibitor momelotinib exhibits significant anti-inflammatory responses in DNCB-Induced atopic dermatitis model mice[J].Int J Mol Sci,2018,19(12):1-12.
[24]Kanemaru K,Nakamura Y,Totoki K,et al.Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity[J].Cell Death Differ,2017,24(6):1079-1090.
[25]Bongjun S,Bombi L,Ye Y,et al.Extract of polygala tenuifolia alleviates stress-exacerbated atopy-like skin dermatitis through the modulation of protein kinase a and p38mitogen-activated protein kinase signaling pathway[J].Int JMol Sci,2017,18(1):190-206.
[26]Szymanski L,Cios A,Lewicki S,et al.Fas/FasL pathway and cytokines in keratinocytes in atopic dermatitis-Manipulation by the electromagnetic field[J].PLoS One,2018,13(10):1-12.
[27]Karolina B,Magdalena?,Piotr O,et al.Involvement of Fas/FasL pathway in the murine model of atopic dermatitis[J].Inflamm Res,2017,66(6):1-12.
[28]齐晓涟,曹阳.临床药师在卡马西平引起剥脱性皮炎不良反应处理中的作用[J].中南药学,2015,13(4):441-442.
[29]廖作庄,杨凤莲,王俊利.黑骨藤药理作用研究进展[J].右江医学,2014,42(3):361-363.
[30]Bao C,Liu Y,Sun X,et al.Periploca forrestii saponin ameliorates CIA via suppressing proinflammatory cytokines and nuclear factor kappa-B pathways[J].PLoS One,2017,12(5):1-15.
[31]鲍春梅,孙广臣.黑骨藤皂苷对特应性皮炎小鼠的治疗作用及对Th1型免疫反应的影响[J].山东医药,2017,57(13):38-41.
[32]浦跃武,熊冬生,黎慧瑜.樟芝的研究及其应用[J].中国医院药学杂志,2004,24(7):430-432.
[33]Kao ST,Kuo YH,Wang SD,et al.Analogous corticosteroids,9A and EK100,derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages[J].Cytokine,2018,108:136-144.
[34]Yang SC,Huang TH,Chiu CH,et al.The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorate[J].J Dermatol Sci,2018,92(2):188-196.
[35]赵平,张文治,王凯.旋覆花化学成分研究[J].齐齐哈尔大学学报(自然科学版),2012,28(2):12-14.
[36]Zarei M,Mohammadi S,Komaki A.Antinociceptive activity of inula britannica l.and patuletin:in vivo and possible mechanisms studies[J].J Ethnopharmacol,2018,219:351-358.
[37]Wang Q,Gao S,Wu GZ,et al.Total sesquiterpene lactones isolated from Inula helenium L.attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice[J].Phytomedicine,2018,46:78-84.
[38]段启,许冬谨,刘传祥,等.白术的研究进展[J].中草药,2008,39(5):800-802.
[39]Yang P,Zhu JY,Gong ZJ,et al.Transcriptome analysis of the Chinese white wax scale ericerus pela with focus on genes involved in wax biosynthesis[J].PLoS One,2012,7(4):e35719.
[40]Lin L,Zhou Y,Li H,et al.Polysaccharide extracted from Chinese white wax scale ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB/c mice[J].Saudi Pharm J,2017,25(4):625-632.
[41]朱江,蔡德海,芮菁.栀子的抗炎镇痛作用研究[J].中草药,2000,31(3):198-200.
[42]傅春升,娄红祥,张学顺.栀子的化学成分与药理作用[J].现代药物与临床,2004,19(4):152-156.
[43]Xiao W,Li S,Wang S,et al.Chemistry and bioactivity of Gardenia jasminoides[J].J Food Drug Anal,2017,25(1):43-61.
[44]李越峰,黄玉新,李廷利,等.四逆散拆方过程中成分变化的分析研究[J].中成药,2009,31(8):1308-1310.
[45]Wen J,Wang Y,Yang L,et al.Comparative pharmacokinetic study of four major components after oral administration of pure compounds,herbs and Si-Ni-San to rats[J]Xenobiotica,2014,44(9):855-860.
[46]Fan HJ,Xie ZP,Lu ZW,et al.Anti-inflammatory and immune response regulation of Si-Ni-San in 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin dysfunction[J].J Ethnopharmacol,2018,222:1-10.
[47]Wegner J,Saloga J,Grabbe S,et al.IgE-specific immunoadsorption:New treatment option for severe refractory atopic dermatitis[J].Allergy,2019,1(10):1-10.