鸡马立克病毒的研究进展
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摘要
马立克病毒(Marek’s disease virus,MDV)是一类可感染鸡诱发急性或亚急性淋巴细胞肉瘤的疱疹病毒。本文在对MDV的经典病毒学及分子生物学研究的早期成果进行概述的基础上,对近十多年来感染性克隆技术用于探索MDV主要蛋白基因的功能、以病毒编码的全部蛋白质为对象的蛋白组学、病毒编码的有调控作用的RNA及基因工程疫苗等方面的研究进展进行综述,并展望MDV进一步的研究方向和内容。
Marek's disease viruses(MDV) is a group of important herpesviruses, which can induce acute or sub-acute immunosuppressive and neoplastic disease in chickens, namely Marek's disease(MD). Based on a brief overview of early studies on the classical and molecular virology of MDV, the progresses in the last decade are reviewed in different aspects, such as the application of the technique of infectious bacterial chromosome clone(BAC) to study viral gene functions, the studies on proteomics of MDV protein-coding genes, the regulatory functions of virus-encoded non-coding RNAs, and the recombinant MDV vaccines. Furthermore, the expected subjects or aspects for the further study on MDV are also discussed.
Marek's disease viruses(MDV) is a group of important herpesviruses, which can induce acute or sub-acute immunosuppressive and neoplastic disease in chickens, namely Marek's disease(MD). Based on a brief overview of early studies on the classical and molecular virology of MDV, the progresses in the last decade are reviewed in different aspects, such as the application of the technique of infectious bacterial chromosome clone(BAC) to study viral gene functions, the studies on proteomics of MDV protein-coding genes, the regulatory functions of virus-encoded non-coding RNAs, and the recombinant MDV vaccines. Furthermore, the expected subjects or aspects for the further study on MDV are also discussed.
引文
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[2]Cui ZZ,Lee LF,Liu JL,et al.Structural analysis and transcriptional mapping of the Marek’s disease virus gene encoding pp38,an antigen associated with transformed cells[J].Journal of Virology,1991,65(12):6509-6515
[3]Ding JB,Cui ZZ,Lee LF.Marek’s disease virus unique genes pp38 and pp24 are essential for transactivating the bi-directional promoters for the 1.8 kb m RNA transcripts[J].Virus Genes,2007,35(3):643-650
[4]Jones D,Lee L,Liu JL,et al.Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors[J].Proceedings of the National Academy of Sciences of the United States of America,1992,89(9):4042-4046
[5]Lupiani B,Lee LF,Cui XP,et al.Marek’s disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101(32):11815-11820
[6]Lee LF,Wu P,Sui DX,et al.The complete unique long sequence and the overall genomic organization of the GA strain of Marek?s disease virus[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(11):6091-6096
[7]Reddy SM,Lupiani B,Gimeno IM,et al.Rescue of a pathogenic Marek?s disease virus with overlapping cosmid DNAs:use of a pp38 mutant to validate the technology for the study of gene function[J].Proceedings of the National Academy of Sciences of the United States of America,2002,99(10):7054-7059
[8]Lee LF,Lupiani B,Silva RF,et al.Recombinant Marek’s disease virus(MDV)lacking the Meq oncogene confers protection against challenge with a very virulent plus strain of MDV[J].Vaccine,2008,26(15):1887-1892
[9]Lee LF,Kreager KS,Arango J,et al.Comparative evaluation of vaccine efficacy of recombinant Marek’s disease virus vaccine lacking Meq oncogene in commercial chickens[J].Vaccine,2010,28(5):1294-1299
[10]Schumacher D,Tischer BK,Fuchs W,et al.Reconstitution of Marek’s Disease virus serotype 1(MDV-1)from DNA cloned as a bacterial artificial chromosome and characterization of a glycoprotein B-negative MDV-1 mutant[J].Journal of Virology,2000,74(23):11088-11098
[11]Petherbridge L,Howes K,Baigent SJ,et al.Replication-competent bacterial artificial chromosomes of Marek’s disease virus:novel tools for generation of molecularly defined herpesvirus vaccines[J].Journal of Virology,2003,77(16):8712-8718
[12]Baigent SJ,Petherbridge LJ,Smith LP,et al.Herpesvirus of turkey reconstituted from bacterial artificial chromosome clones induces protection against Marek’s disease[J].Journal of General Virology,2006,87(4):769-776
[13]Cui HY.Cloning of marek’s disease virus genome as an infectious bacterial artificial chromosome[D].Harbin:Master’s Thesis of Chinese Academy of Agricultural Sciences,2007(in Chinese)崔红玉.鸡马立克氏病病毒细菌人工染色体的构建[D].哈尔滨:中国农业科学院硕士学位论文,2007
[14]Petherbridge L,Xu HT,Zhao YG,et al.Cloning of Gallid herpesvirus 3(Marek’s disease virus serotype-2)genome as infectious bacterial artificial chromosomes for analysis of viral gene functions[J].Journal of Virological Methods,2009,158(1/2):11-17
[15]Petherbridge L,Brown AC,Baigent SJ,et al.Oncogenicity of virulent Marek’s disease virus cloned as bacterial artificial chromosomes[J].Journal of Virology,2004,78(23):13376-13380
[16]Sun AJ,Lawrence P,Zhao YG,et al.A BAC clone of MDVstrain GX0101 with REV-LTR integration retained its pathogenicity[J].Chinese Science Bulletin,2009,54(15):2641-2647
[17]Sun AJ,Xu XY,Petherbridge L,et al.Functional evaluation of the role of reticuloendotheliosis virus long terminal repeat(LTR)integrated into the genome of a field strain of Marek’s disease virus[J].Virology,2010,397(2):270-276
[18]Reddy SM,Sun AJ,Khan OA,et al.Cloning of a very virulent plus,686 strain of Marek’s disease virus as a bacterial artificial chromosome[J].Avian Diseases,2013,57(2 Suppl):469-473
[19]Jarosinski KW,Margulis NG,Kamil JP,et al.Horizontal transmission of Marek’s disease virus requires US2,the UL13protein kinase,and gC[J].Journal of Virology,2007,81(19):10575-10587
[20]Spatz SJ,Petherbridge L,Zhao YG,et al.Comparative full-length sequence analysis of oncogenic and vaccine(Rispens)strains of Marek’s disease virus[J].Journal of General Virology,2007,88(4):1080-1096
[21]Spatz SJ,Smith LP,Baigent SJ,et al.Genotypic characterization of two bacterial artificial chromosome clones derived from a single DNA source of the very virulent gallid herpesvirus-2 strain C12/130[J].Journal of General Virology,2011,92(7):1500-1507
[22]Li YP,Sun AJ,Su S,et al.Deletion of the Meq gene significantly decreases immunosuppression in chickens caused by pathogenic Marek’s disease virus[J].Virology Journal,2011,8:2
[23]Su S,Cui N,Cui ZZ,et al.Complete genome sequence of a recombinant Marek’s disease virus field strain with one reticuloendotheliosis virus long terminal repeat insert[J].Journal of Virology,2012,86(24):13818-13819
[24]Su S,Cui N,Zhou Y,et al.A recombinant field strain of Marek’s disease(MD)virus with reticuloendotheliosis virus long terminal repeat insert lacking the meq gene as a vaccine against MD[J].Vaccine,2015,33(5):596-603
[25]Lupiani B,Lee LF,Kreager KS,et al.Insertion of reticuloendotheliosis virus long terminal repeat into the genome of CVI988 strain of Marek’s disease virus results in enhanced growth and protection[J].Avian Diseases,2013,57(2 Suppl):427-431
[26]Spatz SJ,Zhao YG,Petherbridge L,et al.Comparative sequence analysis of a highly oncogenic but horizontal spread-defective clone of Marek’s disease virus[J].Virus Genes,2007,35(3):753-766
[27]Spatz SJ,Rue C,Schumacher D,et al.Clustering of mutations within the inverted repeat regions of a serially passaged attenuated gallid herpesvirus type 2 strain[J].Virus Genes,2008,37(1):69-80
[28]Tahiri-Alaoui A,Smith LP,Kgosana L,et al.Identification of a neurovirulence factor from Marek’s disease virus[J].Avian Diseases,2013,57(2 Suppl):387-394
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