摘要
目的分析结直肠癌与其癌旁组织中端锚聚合酶2(TNKS2)的表达差异情况,探讨TNKS2在结肠癌中发生发展的作用。方法收集30例结直肠癌患者肿瘤组织及其癌旁组织,常规抽提组织中的总RNA,应用实时荧光定量PCR方法检测样本中TNKS2的表达情况。结果结直肠癌组织中TNKS2 mRNA表达高于癌旁组织(<0.05);与癌旁组织相比,肿瘤组织中TNKS2的表达量上升(<0.05)。结论结直肠癌中TNKS2在分子水平和蛋白水平都高表达,猜测TNKS2表达上升使TRF1与端粒之间的表达失衡从而引发细胞永生化。
引文
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