长期低剂量克拉霉素联合鼻用激素治疗慢性鼻-鼻窦炎的临床总有效率探讨
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摘要
目的对长期低剂量克拉霉素联合鼻用激素治疗慢性鼻-鼻窦炎的疗效进行分析探讨。方法将2016年1月—2018年4月在该院接受治疗的153例慢性鼻-鼻窦炎患者随机分为3组,I组51例患者以克拉霉素片进行治疗,Ⅱ组51例患者以布地奈德喷雾剂治疗,Ⅲ组51例患者以克拉霉素片联合布地奈德喷雾剂治疗,对比三组患者的治疗效果。结果Ⅲ组治疗有效率为90.20%,明显高于Ⅰ组的74.51%、II组的76.47%,差异有统计学意义(P<0.05)。3组患者治疗后VAS评分、Lund-Mackay评分均得到明显降低(P<0.05),且Ⅲ组低于Ⅰ组、Ⅱ组,差异有统计学意义(P<0.05)。结论对慢性鼻-鼻窦炎患者采用小剂量克拉霉素联合布地奈德喷雾剂治疗,能够有效缓解患者鼻部症状,提高治疗效果,改善患者预后,临床应用价值较高。
Objective To analyze the curative effect of long-term low-dose clarithromycin combined with nasal hormone in the treatment of chronic rhinosinusitis. Methods A total of 153 patients with chronic rhinosinusitis who were treated in our hospital from January 2016 to April 2018 were randomly divided into three groups. 51 patients in group Ⅰ were treated with clarithromycin tablets, and 51 patients in group Ⅱ were treated with budesonide spray, 51 patients in group Ⅲ were treated with clarithromycin tablets and budesonide spray, and the therapeutic effects of the three groups were compared. Results The effective rate of treatment in group Ⅲ was 90.20%, which was significantly higher than74.51% in group Ⅰ and 76.47% in group Ⅱ. The difference was statistically significant(P<0.05). The VAS score and Lund-Mackay score of the three groups were significantly lower after treatment(P<0.05), and the group Ⅲ was lower than the group Ⅰ and the group Ⅱ, the difference was statistically significant(P <0.05). Conclusion Low-dose clarithromycin combined with budesonide spray in patients with chronic rhinosinusitis can effectively alleviate nasal symptoms, improve treatment and improve patient prognosis.
Objective To analyze the curative effect of long-term low-dose clarithromycin combined with nasal hormone in the treatment of chronic rhinosinusitis. Methods A total of 153 patients with chronic rhinosinusitis who were treated in our hospital from January 2016 to April 2018 were randomly divided into three groups. 51 patients in group Ⅰ were treated with clarithromycin tablets, and 51 patients in group Ⅱ were treated with budesonide spray, 51 patients in group Ⅲ were treated with clarithromycin tablets and budesonide spray, and the therapeutic effects of the three groups were compared. Results The effective rate of treatment in group Ⅲ was 90.20%, which was significantly higher than74.51% in group Ⅰ and 76.47% in group Ⅱ. The difference was statistically significant(P<0.05). The VAS score and Lund-Mackay score of the three groups were significantly lower after treatment(P<0.05), and the group Ⅲ was lower than the group Ⅰ and the group Ⅱ, the difference was statistically significant(P <0.05). Conclusion Low-dose clarithromycin combined with budesonide spray in patients with chronic rhinosinusitis can effectively alleviate nasal symptoms, improve treatment and improve patient prognosis.
引文
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[10]吴昕.三种大环内酯类药物治疗支气管扩张症的疗效分析[J].临床肺科杂志,2017,22(5):904-907.
[11]张悦.地红霉素和克拉霉素及阿奇霉素的药物不良反应分析[J].中国处方药,2017,15(2):59-60.
[12]李富民.慢性鼻-鼻窦炎行长期小剂量克拉霉素联合鼻用激素治疗的疗效[J].中国实用医药,2016,11(22):144-145.
[13]刘艳,丁锋,李波蓬,等.长期小剂量克拉霉素治疗慢性鼻-鼻窦炎的疗效观察[J].中国中西医结合耳鼻咽喉科杂志,2016,24(6):424-427.
[14]戴润芝,李谨,张群,等.长期低剂量克拉霉素联合鼻用激素治疗慢性鼻-鼻窦炎的疗效分析[J].医学研究杂志,2015,44(5):137-140.
[15]龚剑卿.克拉霉素联合鼻用激素及鼻腔冲洗在慢性鼻-鼻窦炎中的应用[J].中外医学研究,2015,13(33):43-44.
[16]Ragab SM,Lund VJ,Scadding G.Evaluation of the medical and surgical treatment of chronic rhinosinusitis:a prospective,randomized,ctrial[J].Laryngoscope,2015,114(5):923-930.
[17]邱荣敏,邓碧凡,廖敏,等.大环内酯类并糖皮质激素治疗慢性鼻-鼻窦炎效果分析[J].浙江临床医学,2014,16(7):1082-1083.
[2]卢佳佳,方玲,张玉玲.抗生素联合鼻腔冲洗在慢性鼻窦炎中的治疗效果观察[J].医学信息,2015,12(45):99-100.
[3]劳国光,黄碧文,田文浩,等.激素联合低剂量克拉霉素及鼻腔冲洗治疗复发性鼻窦炎临床效果分析[J].齐齐哈尔医学院学报,2015,20(25):3788-3789.
[4]宋伟伟,龚志云.小剂量克拉霉素联合鼻用激素对慢性鼻-鼻窦炎的疗效观察[J].当代医学,2016,22(28):152-153.
[5]叶卫东,刘兴华,钟凤如,等.小剂量克拉霉素联合鼻用激素治疗慢性鼻-鼻窦炎的疗效[J].实用临床医学,2017,18(5):75-77.
[6]刘艳,丁锋,李波蓬,等.长期小剂量克拉霉素治疗慢性鼻-鼻窦炎的疗效观察[J].中国中西医结合耳鼻咽喉科杂志,2016,24(6):424-427
[7]Desrosiers M,Evans GA,Keith PK,et al.Canadian clinical practice guidelines for acute and chronic rhinosinusitis[J].J Otolaryngol Head Neck Surg,2016,40(2):99-193.
[8]邵鑫,吴涛,陈瑶,等.鼻用激素联合克拉霉素治疗慢性鼻-鼻窦炎疗效观察[J].中华临床医师杂志:电子版,2014,8(8):1455-1458.
[9]Fokkens W,Lnnd V,Mullol J,et al.European position paper on rhinosinusitis and nasal polyps 2007[J].Rhinol Suppl,2015(20):1-13.
[10]吴昕.三种大环内酯类药物治疗支气管扩张症的疗效分析[J].临床肺科杂志,2017,22(5):904-907.
[11]张悦.地红霉素和克拉霉素及阿奇霉素的药物不良反应分析[J].中国处方药,2017,15(2):59-60.
[12]李富民.慢性鼻-鼻窦炎行长期小剂量克拉霉素联合鼻用激素治疗的疗效[J].中国实用医药,2016,11(22):144-145.
[13]刘艳,丁锋,李波蓬,等.长期小剂量克拉霉素治疗慢性鼻-鼻窦炎的疗效观察[J].中国中西医结合耳鼻咽喉科杂志,2016,24(6):424-427.
[14]戴润芝,李谨,张群,等.长期低剂量克拉霉素联合鼻用激素治疗慢性鼻-鼻窦炎的疗效分析[J].医学研究杂志,2015,44(5):137-140.
[15]龚剑卿.克拉霉素联合鼻用激素及鼻腔冲洗在慢性鼻-鼻窦炎中的应用[J].中外医学研究,2015,13(33):43-44.
[16]Ragab SM,Lund VJ,Scadding G.Evaluation of the medical and surgical treatment of chronic rhinosinusitis:a prospective,randomized,ctrial[J].Laryngoscope,2015,114(5):923-930.
[17]邱荣敏,邓碧凡,廖敏,等.大环内酯类并糖皮质激素治疗慢性鼻-鼻窦炎效果分析[J].浙江临床医学,2014,16(7):1082-1083.