调节性B细胞在寄生虫感染中的免疫调节作用
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摘要
调节性B细胞(Regulatory B cells, Bregs)是存在于B细胞中的一类细胞亚群,该类细胞可以通过分泌细胞因子(IL-10、TGF-β和IL-35等)来抑制免疫反应。研究发现,寄生虫感染能诱导Bregs的产生,由Bregs分泌的IL-10是其发挥作用的关键因子。该类细胞可抑制由寄生虫引起的过度炎症,有助于寄生虫慢性感染的建立、维持宿主和寄生虫逃避免疫反应之间的平衡,降低寄生虫感染对机体造成的病理损伤。
Regulatory B cells(Bregs) are a subset of B cells that can inhibit immune responses by secreting cytokines(IL-10, TGF-β, IL-35, etc.). Research has indicated that production of Bregs can be induced by a parasitic infection. IL-10 secreted by Bregs is a key cytokine that plays an important role. Bregs can inhibit excessive inflammation caused by a parasite. This action helps lead to chronic infection by a parasite and it maintains a balance between the host and a parasite's evasion of the immune response. This reduces the pathological damage to the body caused by a parasitic infection.
Regulatory B cells(Bregs) are a subset of B cells that can inhibit immune responses by secreting cytokines(IL-10, TGF-β, IL-35, etc.). Research has indicated that production of Bregs can be induced by a parasitic infection. IL-10 secreted by Bregs is a key cytokine that plays an important role. Bregs can inhibit excessive inflammation caused by a parasite. This action helps lead to chronic infection by a parasite and it maintains a balance between the host and a parasite's evasion of the immune response. This reduces the pathological damage to the body caused by a parasitic infection.
引文
[1] 姜晶.旋毛虫感染对树突状细胞分化成熟的影响及其免疫机制研究[D].吉林农业大学,2015.
[2] 咸康文.日本血吸虫感染C57BL/6小鼠后B10细胞的免疫学特性研究[D].扬州大学,2016.
[3] Dai Y,Zhong J,Xu J.Regulatory B cells in infectious disease (Review)[J].Mol Med Rep,2017;16(1):3-10.
[4] Jeong YI,Hong SH,Cho SH,et al.Induction of IL-10-Producing CD1dhighCD5+ Regulatory B Cells following Babesia microti-Infection[J].PLoS ONE,2012,7(10):e46553.
[5] Moshkani S,Kuzin II,Adewale F,et al.CD23+CD21highCD1dhigh B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential[J].The Journal of Immunology,2012,188(12):5944-53.
[6] Meng X,Bettina G,Luo Y,et al.Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease[J].Nat Commun,2018,9(1):251.
[7] Sun J,Wang J,Pefanis E,et al.Transcriptomics identify CD9 as a marker of murine IL-10-competent regulatory B cells[J].Cell Rep,2015,13(6):1110-7.
[8] Bouaziz JD,Yanaba K,Tedder TF.Regulatory B cells as inhibitors of immune responses and inflammation.[J].Immun Rev,2010,224(1):201-14.
[9] 刘云峰.调节性B细胞在控制小鼠疟疾免疫病理中的作用及机制研究[D].中国科学技术大学,2013.
[10] Rosser EC,Mauri C.Regulatory B cells:Origin,phenotype,and function.[J].Immunity,2015,42(4):607-12.
[11] Guzman-Genuino RM,Diener KR.Regulatory B cells[M]// eLS.John Wiley & Sons,Ltd,2018.
[12] Noh G,Lee JH.Regulatory B cells and allergic diseases[J].Allergy Asthma Immunol Res,2011,3(3):168-77.
[13] Mauri C,Bosma A.Immune regulatory function of B cells.[J].Ann Rev Immunol,2012,30(30):221.
[14] Wilson MS,Taylor MD,O"Gorman MT,et al.Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation[J].European Journal of Immunology,2010,40(6):1682-1696.
[15] Hussaarts L,van der Vlugt,Yazdanbakhsh M,et al.Regulatory B-cell induction by helminths:Implications for allergic disease[J].Journal of Allergy and Clinical Immunology,2011,128(4):733-9.
[16] 胡雪莉.日本血吸虫虫卵抗原诱导产生调节性B细胞的特性研究[D].扬州大学,2014.
[17] Rodgers DT,Pineda MA,Mcgrath MA,et al.Protection against collagen-induced arthritis in mice afforded by the parasitic worm product,ES-62,is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints[J].Immunology,2014,141(3):457-66.
[18] Pineda MA,Mcgrath MA,Smith PC,et al.The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites[J].Arthritis & Rheumatism,2012,64(10):3168-78.
[19] Jeong YI,Hong SH,Cho SH,et al.Induction of IL-10-Producing CD1dhighCD5+ Regulatory B Cells following,Babesia microti-Infection[J].Plos One,2012,7(10):e46553.
[20] Tang H,Ming Z,Liu R,et al.Development of adult worms and granulomatous pathology are collectively regulated by T- and B-cells in mice infected with Schistosoma japonicum.[J].Plos One,2013,8(1):e54432.
[21] Matsushita T,Yanaba K,Bouaziz J D,et al.Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression[J].Journal of Clinical Investigation,2008,118(10):3420-30.
[22] Andreani G,Ouellet M,Menasria R,et al.Leishmania infantum Amastigotes Trigger a Subpopulation of Human B Cells with an Immunoregulatory Phenotype[J].PLOS Neglected Tropical Diseases,2015,9(2):e0003543.
[23] Ronet C,Hauyonla TY,Revazbreton M,et al.Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production.[J].Journal of Immunology,2010,184(2):886-94.
[24] Tian F,Hu X,Xian K,et al.B10 cells induced by Schistosoma japonicum,soluble egg antigens modulated regulatory T cells and cytokine production of T cells[J].Parasitology Research,2015,114(10):3827-34.
[25] Dilillo DJ ,Matsushita T,Tedder TF,et al.B10 cells and regulatory B cells balance immune responses during inflammation,autoimmunity,and cancer[J].Annals of the New York Academy of Sciences,2010,1183(1):38-57.
[26] Iwata Y,Matsushita T,Horikawa M,et al.Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.[J].Blood,2011,117(2):530-41.
[27] D.Bouaziz J,Le Buanec H,Saussine A,et al.IL-10 Producing Regulatory B Cells in Mice and Humans:State of the Art[J].Current Molecular Medicine,2012,12(5):519-27.
[28] Jin G,Hamaguchi Y,Matsushita T,et al.B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells[J].Journal of Allergy and Clinical Immunology,2013,131(6):1674-82.e9.
[29] Singh A,Iv W F C,Secor E R,et al.Regulatory role of B cells in a murine model of allergic airway disease[J].Journal of Immunology,2008,180(11):7318.
[30] Rincón-Arévalo,Héctor,Sanchez-Parra CC,et al.Regulatory B Cells and Mechanisms[J].International Reviews of Immunology,2016,35(2):156-76.
[31] Wang RX,Yu CR,Dambuza IM,et al.Interleukin-35 induces regulatory B cells that suppress autoimmune disease[J].Nature Medicine,2014,20(6):633-41.
[2] 咸康文.日本血吸虫感染C57BL/6小鼠后B10细胞的免疫学特性研究[D].扬州大学,2016.
[3] Dai Y,Zhong J,Xu J.Regulatory B cells in infectious disease (Review)[J].Mol Med Rep,2017;16(1):3-10.
[4] Jeong YI,Hong SH,Cho SH,et al.Induction of IL-10-Producing CD1dhighCD5+ Regulatory B Cells following Babesia microti-Infection[J].PLoS ONE,2012,7(10):e46553.
[5] Moshkani S,Kuzin II,Adewale F,et al.CD23+CD21highCD1dhigh B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential[J].The Journal of Immunology,2012,188(12):5944-53.
[6] Meng X,Bettina G,Luo Y,et al.Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease[J].Nat Commun,2018,9(1):251.
[7] Sun J,Wang J,Pefanis E,et al.Transcriptomics identify CD9 as a marker of murine IL-10-competent regulatory B cells[J].Cell Rep,2015,13(6):1110-7.
[8] Bouaziz JD,Yanaba K,Tedder TF.Regulatory B cells as inhibitors of immune responses and inflammation.[J].Immun Rev,2010,224(1):201-14.
[9] 刘云峰.调节性B细胞在控制小鼠疟疾免疫病理中的作用及机制研究[D].中国科学技术大学,2013.
[10] Rosser EC,Mauri C.Regulatory B cells:Origin,phenotype,and function.[J].Immunity,2015,42(4):607-12.
[11] Guzman-Genuino RM,Diener KR.Regulatory B cells[M]// eLS.John Wiley & Sons,Ltd,2018.
[12] Noh G,Lee JH.Regulatory B cells and allergic diseases[J].Allergy Asthma Immunol Res,2011,3(3):168-77.
[13] Mauri C,Bosma A.Immune regulatory function of B cells.[J].Ann Rev Immunol,2012,30(30):221.
[14] Wilson MS,Taylor MD,O"Gorman MT,et al.Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation[J].European Journal of Immunology,2010,40(6):1682-1696.
[15] Hussaarts L,van der Vlugt,Yazdanbakhsh M,et al.Regulatory B-cell induction by helminths:Implications for allergic disease[J].Journal of Allergy and Clinical Immunology,2011,128(4):733-9.
[16] 胡雪莉.日本血吸虫虫卵抗原诱导产生调节性B细胞的特性研究[D].扬州大学,2014.
[17] Rodgers DT,Pineda MA,Mcgrath MA,et al.Protection against collagen-induced arthritis in mice afforded by the parasitic worm product,ES-62,is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints[J].Immunology,2014,141(3):457-66.
[18] Pineda MA,Mcgrath MA,Smith PC,et al.The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites[J].Arthritis & Rheumatism,2012,64(10):3168-78.
[19] Jeong YI,Hong SH,Cho SH,et al.Induction of IL-10-Producing CD1dhighCD5+ Regulatory B Cells following,Babesia microti-Infection[J].Plos One,2012,7(10):e46553.
[20] Tang H,Ming Z,Liu R,et al.Development of adult worms and granulomatous pathology are collectively regulated by T- and B-cells in mice infected with Schistosoma japonicum.[J].Plos One,2013,8(1):e54432.
[21] Matsushita T,Yanaba K,Bouaziz J D,et al.Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression[J].Journal of Clinical Investigation,2008,118(10):3420-30.
[22] Andreani G,Ouellet M,Menasria R,et al.Leishmania infantum Amastigotes Trigger a Subpopulation of Human B Cells with an Immunoregulatory Phenotype[J].PLOS Neglected Tropical Diseases,2015,9(2):e0003543.
[23] Ronet C,Hauyonla TY,Revazbreton M,et al.Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production.[J].Journal of Immunology,2010,184(2):886-94.
[24] Tian F,Hu X,Xian K,et al.B10 cells induced by Schistosoma japonicum,soluble egg antigens modulated regulatory T cells and cytokine production of T cells[J].Parasitology Research,2015,114(10):3827-34.
[25] Dilillo DJ ,Matsushita T,Tedder TF,et al.B10 cells and regulatory B cells balance immune responses during inflammation,autoimmunity,and cancer[J].Annals of the New York Academy of Sciences,2010,1183(1):38-57.
[26] Iwata Y,Matsushita T,Horikawa M,et al.Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.[J].Blood,2011,117(2):530-41.
[27] D.Bouaziz J,Le Buanec H,Saussine A,et al.IL-10 Producing Regulatory B Cells in Mice and Humans:State of the Art[J].Current Molecular Medicine,2012,12(5):519-27.
[28] Jin G,Hamaguchi Y,Matsushita T,et al.B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells[J].Journal of Allergy and Clinical Immunology,2013,131(6):1674-82.e9.
[29] Singh A,Iv W F C,Secor E R,et al.Regulatory role of B cells in a murine model of allergic airway disease[J].Journal of Immunology,2008,180(11):7318.
[30] Rincón-Arévalo,Héctor,Sanchez-Parra CC,et al.Regulatory B Cells and Mechanisms[J].International Reviews of Immunology,2016,35(2):156-76.
[31] Wang RX,Yu CR,Dambuza IM,et al.Interleukin-35 induces regulatory B cells that suppress autoimmune disease[J].Nature Medicine,2014,20(6):633-41.