357例手足口病患儿心肌酶谱检测的临床意义
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摘要
目的探讨手足口病(HMFD)患儿血清心肌酶谱的变化及临床意义。方法通过收集我院2008年3月—2013年10月收治的357例手足口病住院患儿详细数据,其中普通病例249例,重症病例108例,检测α-丁酸脱氮酶(α-HBDH),激酸激酶(CK),激酸激酶同工酶(CK-MB),乳酸脱氮酶(LDH),谷草转氨酶(AST)。结果重症手足口病组α-HBDH、CK、CK-MB、LDH、AST水平高于普通组(P值均<0.05)。结论心肌酶谱对判断手足口病病情、心肌损伤程度及重症病例的早期识别具有一定的参考价值。
Objective To study the hand,foot and mouth disease(HMFD) changes in serum myocardial enzyme and its clinical significance.Methods We collected our hospital's data in March 2008-October 2013 treated about 357 cases of hand,foot and mouth disease in children hospitalized detailed,including ordinary cases 249 cases,108 cases of severe cases,testing α-acid dehydrogenase(α-HBDH),stimulated kinase(CK),stimulated kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),aspartate aminotransferase(AST).Results The test results comparing myocardial enzymesin severe HFMD group α-HBDH,CK,CK-MB,LDH,and AST levels were significantly higher than normal group.Conclusion Myocardial enzymes in judging the severity of hand,foot and mouth disease,early identification of severe cases have a certain reference value.
Objective To study the hand,foot and mouth disease(HMFD) changes in serum myocardial enzyme and its clinical significance.Methods We collected our hospital's data in March 2008-October 2013 treated about 357 cases of hand,foot and mouth disease in children hospitalized detailed,including ordinary cases 249 cases,108 cases of severe cases,testing α-acid dehydrogenase(α-HBDH),stimulated kinase(CK),stimulated kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),aspartate aminotransferase(AST).Results The test results comparing myocardial enzymesin severe HFMD group α-HBDH,CK,CK-MB,LDH,and AST levels were significantly higher than normal group.Conclusion Myocardial enzymes in judging the severity of hand,foot and mouth disease,early identification of severe cases have a certain reference value.
引文
[1]Shao QM,Lou GQ,Yan JJ.The clinical epidemiology characteristics of HFMD in 2010 of Hangzhou[J].Chinese Journal of Experimental and Clinical Virology,2011,25(4):289-291.
[2]Sun LM,Zheng HY,Zheng HZ,et al.An enterovirus71 epidemic in Guangdong Province of China,2008:epidemiological,clinical,and virogenic manilestations[J].Jpn J Infect Dis,2011,64(1):13-18.
[3]Chang LJ,chang LY,Huang LM.Besides increasing surveillance and waiting for an effective vaccine to emerge in the future,what else can he done to save the lives of HFMD victims?[J].J Formos Med Assoc,2008,107(8):589-590.
[4]Zhu Z,Xu WB,Xu AQ,et al.Molecular epidemiological analysis of echovirus 19 isolated from an outbreak associated with hand,foot,and mouth disease(HFMD)in Shandong Province of China[J].Biomed Environ Sci,2007,20(4):321-328.
[5]手足口病诊疗指南[S].2012版.
[6]唐晓燕,田春.轮状病毒性肠炎患儿血清心肌酶谱测定的临床意义[J].临床合理用药,2012,5(7B):30-31.
[7]Kavsak PA,Worster A.For a rapid diagnosis of acute myocardial infarction,a sensitive troponin assay is needed in the near-patient testing setting[J].Expert Rev Cardiovasc Ther,2012,10(3):309-312.
[2]Sun LM,Zheng HY,Zheng HZ,et al.An enterovirus71 epidemic in Guangdong Province of China,2008:epidemiological,clinical,and virogenic manilestations[J].Jpn J Infect Dis,2011,64(1):13-18.
[3]Chang LJ,chang LY,Huang LM.Besides increasing surveillance and waiting for an effective vaccine to emerge in the future,what else can he done to save the lives of HFMD victims?[J].J Formos Med Assoc,2008,107(8):589-590.
[4]Zhu Z,Xu WB,Xu AQ,et al.Molecular epidemiological analysis of echovirus 19 isolated from an outbreak associated with hand,foot,and mouth disease(HFMD)in Shandong Province of China[J].Biomed Environ Sci,2007,20(4):321-328.
[5]手足口病诊疗指南[S].2012版.
[6]唐晓燕,田春.轮状病毒性肠炎患儿血清心肌酶谱测定的临床意义[J].临床合理用药,2012,5(7B):30-31.
[7]Kavsak PA,Worster A.For a rapid diagnosis of acute myocardial infarction,a sensitive troponin assay is needed in the near-patient testing setting[J].Expert Rev Cardiovasc Ther,2012,10(3):309-312.