福建省南平地区妇科人乳头瘤病毒分型检测及结果分析
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摘要
目的探讨人乳头瘤病毒(HPV)分型检测在福建省南平地区宫颈癌筛查中的价值。方法回顾性分析2015—2017年南平地区9 000例农村户口妇女免费宫颈癌筛查HPV分型检测资料,研究不同HPV分型感染与宫颈疾病之间的关系。结果福建省南平地区9 000例体检妇女HPV病毒感染率为15.07%,以52(32.23%)、58(13.72%)、16(12.09%)亚型感染率最高;HPV感染者年龄分布主要在40～54岁之间,占总感染者人数的78.24%;随着宫颈病变级别的升高,HR-HPV的感染阳性率也增高(χ2=3 400.431,P<0.05);宫颈病变级别越高的患者中,HR-HPV多种亚型感染阳性率亦越高(χ2=15.708,P<0.05)。结论 HPV分型检测在宫颈疾病的诊断与治疗中具有重要意义。
Objective To investigate the value of human papillomavirus(HPV)typing in cervical cancer screening in Nanping Area,Fujian Province.Methods A retrospective analysis of the HPV typing data of 9 000 women under rural household registration inNanping Area from 2015 to 2017 was conducted to investigate the relationship between different HPV genotype infections and cervicaldiseases.Results The HPV virus infection rate of 9 000 medical examination women in Nanping Area,Fujian Province was 15.07%,and the highest infection rate was 52(32.23%),58(13.72%)and 16(12.09%)subtypes. The distribution of the age of HPV infectedpersons was mainly between 40～54 years old,accounting for 78.24% of the total infected persons. With the increase of cervical le-sions,the positive rate of HR-HPV infection was also increased(χ2=3 400.431,P<0.05). Among patients of the higher the level of cervical lesions,the positive rate of multiple subtypes of HR-HPV infection was also higher(χ2=15.708,P<0.05).Conclusion HPV typing is of great significance in the diagnosis and treatment of cervical diseases.
Objective To investigate the value of human papillomavirus(HPV)typing in cervical cancer screening in Nanping Area,Fujian Province.Methods A retrospective analysis of the HPV typing data of 9 000 women under rural household registration inNanping Area from 2015 to 2017 was conducted to investigate the relationship between different HPV genotype infections and cervicaldiseases.Results The HPV virus infection rate of 9 000 medical examination women in Nanping Area,Fujian Province was 15.07%,and the highest infection rate was 52(32.23%),58(13.72%)and 16(12.09%)subtypes. The distribution of the age of HPV infectedpersons was mainly between 40～54 years old,accounting for 78.24% of the total infected persons. With the increase of cervical le-sions,the positive rate of HR-HPV infection was also increased(χ2=3 400.431,P<0.05). Among patients of the higher the level of cervical lesions,the positive rate of multiple subtypes of HR-HPV infection was also higher(χ2=15.708,P<0.05).Conclusion HPV typing is of great significance in the diagnosis and treatment of cervical diseases.
引文
[1]张漩,肖兰华.宫颈液基细胞学联合HPV分型检测及宫颈活检对宫颈病变筛查的研究[J].赣南医学院学报,2010,30(2):279-280.
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[4]朱莉,曹萍,葛松梅.宫颈鳞癌人乳头状瘤病毒16/18E6感染与脆性组氨酸三联体表达状态的研究[J].中国临床保健杂志,2011,14(2):182-184.
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[7]焦凤娟,韩洁.液基细胞学及HPV分型检测在宫颈病变筛查中的应用[J].按摩与康复医学,2013,4(4):89-90.
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[9]杜茜,邓永丽,张全,等.人乳头瘤病毒在宫颈癌前病变诊断中的意义[J].解放军医学杂志,2006,31(5):462-464.
[10] CIAPPONI A,BARDACH A,GLUJOVSKY D,et al. Type-specific HPV prevalence in cervical cancer and high-grade le-sions in Lation America amd the Caribbean:systematic reviewand meta-analysis[J]. PloS One,2011,6(10):e25493.
[11]刘冬,叶敏娟,杨越波. HPV基因型与宫颈病变的关系探讨[J].中国肿瘤临床,2013,40(24):1531-1534.
[12]李霓,代敏.中国妇女人乳头状瘤病毒感染的多中心横断面研究[J].中华疾病控制杂志,2008,12(5):411-415.
[13]王晓莉.北京市HPV分子流行病学调查项目初步结果分析[A].中华医学会妇产科学分会感染协作组.中华医学会第一次全国女性生殖道感染研究进展学术会议论文汇编[C].中华医学会妇产科学分会感染协作组:2008:4.
[2]余琦,李宁,杨江辉,等.TCT技术与HPV分型技术在子宫颈病变筛查中的应用价值[J].标记免疫分析与临床,2010,17(3):171-175.
[3]朱园园,程志祥,李兵,等.人乳头瘤病毒分型联合液基细胞学检测在宫颈病变筛查中的意义[J].中国临床保健杂志,2014,17(3):243-246.
[4]朱莉,曹萍,葛松梅.宫颈鳞癌人乳头状瘤病毒16/18E6感染与脆性组氨酸三联体表达状态的研究[J].中国临床保健杂志,2011,14(2):182-184.
[5]侯萌,李娜,朱广霞,等.妇科门诊患者宫颈人乳头瘤病毒的感染情况分析[J].西安交通大学学报(医学版),2013,34(2):229-232,262.
[6]胡庆兰,刘永珠,朱伟艳,等. 5000例宫颈细胞人乳头状瘤病毒感染筛查结果分析[J].现代医院,2012,12(2):136-138.
[7]焦凤娟,韩洁.液基细胞学及HPV分型检测在宫颈病变筛查中的应用[J].按摩与康复医学,2013,4(4):89-90.
[8]于鹃鹏,王一荃,童华.HPV分型检测对宫颈高度病变的筛查作用[J].中国现代医学杂志,2011,21(12):1491-1495.
[9]杜茜,邓永丽,张全,等.人乳头瘤病毒在宫颈癌前病变诊断中的意义[J].解放军医学杂志,2006,31(5):462-464.
[10] CIAPPONI A,BARDACH A,GLUJOVSKY D,et al. Type-specific HPV prevalence in cervical cancer and high-grade le-sions in Lation America amd the Caribbean:systematic reviewand meta-analysis[J]. PloS One,2011,6(10):e25493.
[11]刘冬,叶敏娟,杨越波. HPV基因型与宫颈病变的关系探讨[J].中国肿瘤临床,2013,40(24):1531-1534.
[12]李霓,代敏.中国妇女人乳头状瘤病毒感染的多中心横断面研究[J].中华疾病控制杂志,2008,12(5):411-415.
[13]王晓莉.北京市HPV分子流行病学调查项目初步结果分析[A].中华医学会妇产科学分会感染协作组.中华医学会第一次全国女性生殖道感染研究进展学术会议论文汇编[C].中华医学会妇产科学分会感染协作组:2008:4.