摘要
目的:观察促性腺激素释放激素激动剂(GnRH-a)对子宫内膜异位症腹腔镜手术患者复发率及妊娠率的影响。方法:选取2015年9月-2016年10月于本院进行子宫内膜异位症腹腔镜手术的98例患者作为研究对象,按照随机数字表法分为对照组和观察组,每组49例。对照组采用孕三烯酮治疗,观察组采用GnRH-a治疗。比较治疗前后两组雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)等生殖激素水平,和活性氧(ROS)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平,统计复查期间两组疼痛缓解率、复发率及妊娠率。结果:治疗后观察组生殖激素水平均低于对照组(P<0.05),治疗后观察组ROS、MDA水平均低于对照组(P<0.05),SOD水平高于对照组(P<0.05)。观察组疼痛缓解率为89.80%,大于对照组的51.02%(P<0.05);观察组复发率为8.16%,低于对照组的24.49%(P<0.05);观察组妊娠率为34.69%,高于对照组的12.24%(P<0.05)。结论:GnRH-a能降低子宫内膜异位症腹腔镜手术患者复发率,提高妊娠率,增强手术治疗效果。
Objective:To observe the effect of Gonadotropin Releasing Hormone Agonist(GnRH-a)on the recurrence rate and pregnancy rate of patients with endometriosis undergoing laparoscopic surgery.Method:A total of 98 patients with endometriosis who underwent laparoscopic surgery in our hospital from September2015 to October 2016 were selected as the study objects.The patients were divided into the control group and the observation group by random number table method,49 cases in each group.The control group was treated with Gestrinone and the observation group was treated with GnRH-a.The levels of reproductive hormones such as estradiol(E2),follicle-stimulating hormone(FSH),luteinizing hormone(LH),reactive oxygen species(ROS),malondialdehyde(MDA)and superoxide dismutase(SOD)were compared before and after treatment of two groups.The pain relief rate,recurrence rate and pregnancy rate of two groups were recorded during the review period.Result:The levels of reproductive hormones in the observation group after treatment were lower than those in the control group(P<0.05).The ROS and MDA levels in the observation group after treatment were lower than those in the control group,and SOD level was higher than that in the control group,there were statistical significances(P<0.05).The pain relief rate of the observation group was 89.80%,it was higher than 51.02% of the control group(P<0.05),the recurrence rate of the observation group was 8.16%,it was lower than 24.49%of the control group(P<0.05),and the pregnancy rate of the observation group was 34.69%,it was higher than12.24% of the control group(P<0.05).Conclusion:GnRH-a can reduce the recurrence rate of endometriosis and increase the pregnancy rate in laparoscopic surgery,and enhance the surgical treatment effect.
引文
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