孤独谱系障碍患儿执行功能与功能磁共振关系的研究进展
|
摘要
孤独谱系障碍(ASD)是复杂的神经发育疾病,执行功能缺陷是其重要缺陷。功能磁共振是非侵入性且可视化的成像方法,数据采集简便易行,已成为探索ASD患者脑功能变化的主要成像手段。本文总结了ASD患者的执行功能特点,从任务态和静息态两个方面梳理了执行功能与功能磁共振的关系。
Autism spectrum disorder(ASD) is a complex neuro-developmental disease with executive function defect as its core.Functional magnetic resonance imaging is a non-invasive and visual imaging method while its data acquisition is simple and easy,thus becoming the main imaging method for exploring brain function changes in ASD patients.This article summarizes the characteristics of executive function in ASD patients,and combs the relationship between executive function and functional magnetic resonance from task state and resting state.
Autism spectrum disorder(ASD) is a complex neuro-developmental disease with executive function defect as its core.Functional magnetic resonance imaging is a non-invasive and visual imaging method while its data acquisition is simple and easy,thus becoming the main imaging method for exploring brain function changes in ASD patients.This article summarizes the characteristics of executive function in ASD patients,and combs the relationship between executive function and functional magnetic resonance from task state and resting state.
引文
[1] Xu G,Strathearn L,Liu B,et al.Prevalence of autism spectrum disorder among US children and adolescents,2014-2016 [J].JAMA,2018,319(1):81-82.
[2] Zhou H,Xu X,Yan W,et al.Prevalence of autism spectrum disorder in China:a nationwide multi-centre population-based study among children aged 6 to 12 years [J/OL].Social Science Electronic Publishing,2018.https://ssrn.com/abstract=3216225
[3] 侯婷婷,杨福义.学龄前自闭症儿童的执行功能研究[J].中国特殊教育,2016,23(3):10-16.
[4] Pastor-cerezuela G,Fern Ndez-andr SM-I,Feo-昣lvarez M,et al.Semantic verbal fluency in children with and without autism spectrum disorder:Relationship with chronological age and IQ [J].Front Psychol,2016,7:921.
[5] Merchan-naranjo J,Boada L,Del Rey-mej ASá,et al.Executive function is affected in autism spectrum disorder,but does not correlate with intelligence[J].Revista de Psiquiatríay Salud Mental(English Edition),2016,9(1):39-50.
[6] Craig F,margari F,legrottaglie AR,et al.A review of executive function deficits in autism spectrum disorder and attention-deficit/hyperactivity disorder [J].Neuro Psychiatric Dis Treat,2016,12(1):1191-1202.
[7] Garon N,Smith IM,Bryson SE.Early executive dysfunction in ASD:Simple versus complex skills [J].Autism Res,2018,11(2):318-330.
[8] Jones CRG,Simonoff E,baird G,et al.The association between theory of mind,executive function,and the symptoms of autism spectrum disorder [J].Autism Res,2018,11(1):95-109.
[9] Faja S,Dawson G,Sullivan K,et al.Executive function predicts the development of play skills for verbal preschoolers with autism spectrum disorders [J].Autism Res,2016,9(12):1274-1284.
[10] Hilton CL,Cumpata K,Klohr C,et al.Effects of exergaming on executive function and motor skills in children with autism spectrum disorder:a pilot study [J].Am J Occup Ther,2014,68(1):57-65.
[11] Pugliese CE,Anthony LG,Strang JF,et al.Longitudinal examination of adaptive behavior in autism spectrum disorders:influence of executive function[J].J Autism Dev Disord,2016,46(2):467-477.
[12] Torske T,Nrland T,?ie MG,et al.Metacognitive aspects of executive function are highly associated with social functioning on parent-rated measures in children with autism spectrum disorder [J].Front Behav Neurosci,2018,11:258.
[13] Kaushanskaya M,Park JS,Gangopadhyay I,et al.The relationship between executive functions and language abilities in children:a latent variables approach[J].J Speech Lang Hear Res,2017,60(4):1-12.
[14] Kaushanskaya M,Park JS,Gangopadhyay I,et al.The relationship between executive functions and language abilities in children:a latent variables approach[J].J Speech Lang Hear Res,2017,60(4):912-923.
[15] Brown HM,Oram-Cardy J,Johnson A.A meta-analysis of the reading comprehension skills of individuals on the autism spectrum [J].J Autism Dev Disord,2013,43(4):932-955.
[16] John TS,Dawson G,Estes A.Brief report:executive function as a predictor of academic achievement in school-aged children with ASD [J].J Autism Dev Disord,2018,48(1):276-283.
[17] De Vries M,Geurts H.Influence of autism traits and executive functioning on quality of life in children with an autism spectrum disorder [J].J Autism Dev Disord,2015,45(9):2734-2743.
[18] Brunsdon VE,Colvet E,Ames C,et al.Exploring the cognitive features in children with autism spectrum disorder,their co-twins,and typically developing children within a population-based sample [J].J Child Psychol Psychiatry,2015,56(8):893-902.
[19] Kimhi Y,Shoam-Kugelmas D,Ben-Artzi GA,et al.Theory of mind and executive function in preschoolers with typical development versus intellectually able preschoolers with autism spectrum disorder [J].J Autism Dev Disord,2014,44(9):2341-2354.
[20] Gilbert SJ,Bird G,Brindley R,et al.Atypical recruitment of medial prefrontal cortex in autism spectrum disorders:an fMRI study of two executive function tasks [J].Neuropsychologia,2008,46(9):2281-2291.
[21] Fan J,Bernardi S,Van Dam NT,et al.Functional deficits of the attentional networks in autism [J].Brain & Behav,2012,2(5):647-660.
[22] Just MA,Cherkassky VL,Keller TA,et al.Functional and anatomical cortical underconnectivity in autism:evidence from an FMRI study of an executive function task and corpus callosum morphometry [J].Cereb Cortex,2006,17(4):951-961.
[23] Solomon M,Ozonoff SJ,Ursu S,et al.The neural substrates of cognitive control deficits in autism spectrum disorders [J].Neuropsychologia,2009,47(12):2515-2526.
[24] Lynch CJ,Breeden AL,You X,et al.Executive dysfunction in autism spectrum disorder is associated with a failure to modulate frontoparietal-insular hub architecture [J].Biol Psychiatry:Cogn Neurosci Neuroimag,2017,2(6):537-545.
[25] 王龙伦,蔡金华.孤独症谱系障碍的 MRI 研究进展 [J].国际医学放射学杂志,2016,39(3):241-244.
[26] Mevel K,Fransson P.The functional brain connectome of the child and autism spectrum disorders [J].Acta Paediatrica,2016,105(9):1024-1035.
[27] 赵力聪,杜亚松.孤独谱系障碍患者脑网络研究进展 [J].中国儿童保健杂志,2016,24(9):940-942.
[28] 赵力聪,杜亚松.孤独谱系障碍患者大尺度脑网络功能连接改变的研究进展 [J].中国儿童保健杂志,2018,26(7):748-750.
[29] Shirer W,Ryali S,Rykhlevskaia E,et al.Decoding subject-driven cognitive states with whole-brain connectivity patterns [J].Cereb Cortex,2012,22(1):158-165.
[30] Abbott AE,Nair A,Keown CL,et al.Patterns of atypical functional connectivity and behavioral links in autism differ between default,salience,and executive networks [J].Cereb Cortex,2016,26(10):4034-4045.
[31] Elton A,Di Martino A,Hazlett HC,et al.Neural connectivity evidence for a categorical-dimensional hybrid model of autism spectrum disorder [J].Biol Psychiatry,2016,80(2):120-128.
[32] Di Martino A,Yan CG,Li Q,et al.The autism brain imaging data exchange:towards a large-scale evaluation of the intrinsic brain architecture in autism [J].Mol Psychiatry,2014,19(6):659-667.
[33] 鲁彬,陈骁,李乐,等.孤独症脑自发活动动态性及其整合的异常机制 [J].科学通报,2018,63(15):1452-1463.
[34] Supekar K,Uddin LQ,Khouzam A,et al.Brain hyperconnectivity in children with autism and its links to social deficits [J].Cell Rep,2013,5(3):738-747.
[35] Mueller S,Keeser D,Samson AC,et al.Convergent findings of altered functional and structural brain connectivity in individuals with high functioning autism:a multimodal MRI study [J].PLoS One,2013,8(6):e67329.
[36] 徐晓晓,蒋军.自闭症谱系障碍患者异常的大尺度脑网络研究[J].心理学进展 ,2017,7(12):1419-1429.
[37] Vogan VM,Francis KE,Morgan BR,et al.Load matters:neural correlates of verbal working memory in children with autism spectrum disorder [J].J Neurodev Disord,2018,10(1):19.
[38] Dvornek NC,Ventola P,Pelphrey KA ,et al.Identifying autism from resting-state fMRI using long short-term memory networks[J].Mach Learn Med Imaging,2017,10541:362-370.
[2] Zhou H,Xu X,Yan W,et al.Prevalence of autism spectrum disorder in China:a nationwide multi-centre population-based study among children aged 6 to 12 years [J/OL].Social Science Electronic Publishing,2018.https://ssrn.com/abstract=3216225
[3] 侯婷婷,杨福义.学龄前自闭症儿童的执行功能研究[J].中国特殊教育,2016,23(3):10-16.
[4] Pastor-cerezuela G,Fern Ndez-andr SM-I,Feo-昣lvarez M,et al.Semantic verbal fluency in children with and without autism spectrum disorder:Relationship with chronological age and IQ [J].Front Psychol,2016,7:921.
[5] Merchan-naranjo J,Boada L,Del Rey-mej ASá,et al.Executive function is affected in autism spectrum disorder,but does not correlate with intelligence[J].Revista de Psiquiatríay Salud Mental(English Edition),2016,9(1):39-50.
[6] Craig F,margari F,legrottaglie AR,et al.A review of executive function deficits in autism spectrum disorder and attention-deficit/hyperactivity disorder [J].Neuro Psychiatric Dis Treat,2016,12(1):1191-1202.
[7] Garon N,Smith IM,Bryson SE.Early executive dysfunction in ASD:Simple versus complex skills [J].Autism Res,2018,11(2):318-330.
[8] Jones CRG,Simonoff E,baird G,et al.The association between theory of mind,executive function,and the symptoms of autism spectrum disorder [J].Autism Res,2018,11(1):95-109.
[9] Faja S,Dawson G,Sullivan K,et al.Executive function predicts the development of play skills for verbal preschoolers with autism spectrum disorders [J].Autism Res,2016,9(12):1274-1284.
[10] Hilton CL,Cumpata K,Klohr C,et al.Effects of exergaming on executive function and motor skills in children with autism spectrum disorder:a pilot study [J].Am J Occup Ther,2014,68(1):57-65.
[11] Pugliese CE,Anthony LG,Strang JF,et al.Longitudinal examination of adaptive behavior in autism spectrum disorders:influence of executive function[J].J Autism Dev Disord,2016,46(2):467-477.
[12] Torske T,Nrland T,?ie MG,et al.Metacognitive aspects of executive function are highly associated with social functioning on parent-rated measures in children with autism spectrum disorder [J].Front Behav Neurosci,2018,11:258.
[13] Kaushanskaya M,Park JS,Gangopadhyay I,et al.The relationship between executive functions and language abilities in children:a latent variables approach[J].J Speech Lang Hear Res,2017,60(4):1-12.
[14] Kaushanskaya M,Park JS,Gangopadhyay I,et al.The relationship between executive functions and language abilities in children:a latent variables approach[J].J Speech Lang Hear Res,2017,60(4):912-923.
[15] Brown HM,Oram-Cardy J,Johnson A.A meta-analysis of the reading comprehension skills of individuals on the autism spectrum [J].J Autism Dev Disord,2013,43(4):932-955.
[16] John TS,Dawson G,Estes A.Brief report:executive function as a predictor of academic achievement in school-aged children with ASD [J].J Autism Dev Disord,2018,48(1):276-283.
[17] De Vries M,Geurts H.Influence of autism traits and executive functioning on quality of life in children with an autism spectrum disorder [J].J Autism Dev Disord,2015,45(9):2734-2743.
[18] Brunsdon VE,Colvet E,Ames C,et al.Exploring the cognitive features in children with autism spectrum disorder,their co-twins,and typically developing children within a population-based sample [J].J Child Psychol Psychiatry,2015,56(8):893-902.
[19] Kimhi Y,Shoam-Kugelmas D,Ben-Artzi GA,et al.Theory of mind and executive function in preschoolers with typical development versus intellectually able preschoolers with autism spectrum disorder [J].J Autism Dev Disord,2014,44(9):2341-2354.
[20] Gilbert SJ,Bird G,Brindley R,et al.Atypical recruitment of medial prefrontal cortex in autism spectrum disorders:an fMRI study of two executive function tasks [J].Neuropsychologia,2008,46(9):2281-2291.
[21] Fan J,Bernardi S,Van Dam NT,et al.Functional deficits of the attentional networks in autism [J].Brain & Behav,2012,2(5):647-660.
[22] Just MA,Cherkassky VL,Keller TA,et al.Functional and anatomical cortical underconnectivity in autism:evidence from an FMRI study of an executive function task and corpus callosum morphometry [J].Cereb Cortex,2006,17(4):951-961.
[23] Solomon M,Ozonoff SJ,Ursu S,et al.The neural substrates of cognitive control deficits in autism spectrum disorders [J].Neuropsychologia,2009,47(12):2515-2526.
[24] Lynch CJ,Breeden AL,You X,et al.Executive dysfunction in autism spectrum disorder is associated with a failure to modulate frontoparietal-insular hub architecture [J].Biol Psychiatry:Cogn Neurosci Neuroimag,2017,2(6):537-545.
[25] 王龙伦,蔡金华.孤独症谱系障碍的 MRI 研究进展 [J].国际医学放射学杂志,2016,39(3):241-244.
[26] Mevel K,Fransson P.The functional brain connectome of the child and autism spectrum disorders [J].Acta Paediatrica,2016,105(9):1024-1035.
[27] 赵力聪,杜亚松.孤独谱系障碍患者脑网络研究进展 [J].中国儿童保健杂志,2016,24(9):940-942.
[28] 赵力聪,杜亚松.孤独谱系障碍患者大尺度脑网络功能连接改变的研究进展 [J].中国儿童保健杂志,2018,26(7):748-750.
[29] Shirer W,Ryali S,Rykhlevskaia E,et al.Decoding subject-driven cognitive states with whole-brain connectivity patterns [J].Cereb Cortex,2012,22(1):158-165.
[30] Abbott AE,Nair A,Keown CL,et al.Patterns of atypical functional connectivity and behavioral links in autism differ between default,salience,and executive networks [J].Cereb Cortex,2016,26(10):4034-4045.
[31] Elton A,Di Martino A,Hazlett HC,et al.Neural connectivity evidence for a categorical-dimensional hybrid model of autism spectrum disorder [J].Biol Psychiatry,2016,80(2):120-128.
[32] Di Martino A,Yan CG,Li Q,et al.The autism brain imaging data exchange:towards a large-scale evaluation of the intrinsic brain architecture in autism [J].Mol Psychiatry,2014,19(6):659-667.
[33] 鲁彬,陈骁,李乐,等.孤独症脑自发活动动态性及其整合的异常机制 [J].科学通报,2018,63(15):1452-1463.
[34] Supekar K,Uddin LQ,Khouzam A,et al.Brain hyperconnectivity in children with autism and its links to social deficits [J].Cell Rep,2013,5(3):738-747.
[35] Mueller S,Keeser D,Samson AC,et al.Convergent findings of altered functional and structural brain connectivity in individuals with high functioning autism:a multimodal MRI study [J].PLoS One,2013,8(6):e67329.
[36] 徐晓晓,蒋军.自闭症谱系障碍患者异常的大尺度脑网络研究[J].心理学进展 ,2017,7(12):1419-1429.
[37] Vogan VM,Francis KE,Morgan BR,et al.Load matters:neural correlates of verbal working memory in children with autism spectrum disorder [J].J Neurodev Disord,2018,10(1):19.
[38] Dvornek NC,Ventola P,Pelphrey KA ,et al.Identifying autism from resting-state fMRI using long short-term memory networks[J].Mach Learn Med Imaging,2017,10541:362-370.