乳腺浸润性导管癌钼靶X线表现与ER和PR的相关性研究
|
摘要
目的通过对乳腺浸润性导管癌钼靶X线征象:肿块大小、恶性钙化、毛刺征以及淋巴结转移情况与ER、PR的表达进行相关性研究,进一步探讨乳腺癌影像学价值。方法回顾性分析72例病理证实的乳腺浸润性导管癌患者的影像学资料,所有患者均为女性,年龄36岁～76岁,平均年龄(46.4±7.5)岁。统计乳腺肿块的大小、有无钙化、毛刺及淋巴结转移,病理标本观察免疫组织化学指标ER及PR,统计学分析二者之间有无相关性。结果肿块≥3 cm,ER阳性31例(57.41%),PR阳性24例(44.44%),<3 cm ER阳性13(72.22%),PR阳性12例(66.67%),ER、PR的表达在肿瘤的大小中差异无统计学意义(P>0.05);有毛刺的ER阳性29例(69.05%),PR阳性24例(57.41%),无毛刺的ER阳性15例(50%),PR阳性12例(40%),ER、PR的表达在有无毛刺中差异无统计学意义(P>0.05);有恶性钙化ER阳性15例(75%),PR阳性11例(55%),无恶性钙化ER阳性29(55.77%),PR阳性25例(48.08%),ER、PR的表达在有无恶性钙化中差异无统计学意义(P>0.05);有淋巴结转移ER阳性23例(63.89%),PR阳性17例(47.22%),无淋巴结转移ER阳性21(58.33%),PR阳性19例(52.78%),ER、PR的表达在有无淋巴结转移中差异无统计学意义(P>0.05)。结论乳腺癌典型X线恶性征象与ER、PR表达无明显相关性,乳腺癌影像学特征尚不能做为肿瘤标记物ER、PR预测的指标。
Objective To investigate the X-ray characteristics of mammary gland invasive ductal carcinomaand its correlation with the expressions of ER and PR in order to explore further the application value of iconography in diagnosis of breast cancer.Methods The imaging data of 72 women patients aged 36～76 years,with an average age being(46.4±7.5)years,who were pathologically diagnosed as breast cancer,were retrospectively analyzed.The size,spiculate boundary and malignant calcification of tumor,the status of lymph node metastasis,and the immunohistochemical indexes including ER and PR were statistically analyzed.Moreover the correlation between the immunohistochemical indexes and the imaging features of tumor was analyzed.Results There were 31 cases(57.41%) of ER-positive with tumour size ≥ 3 cm,and 24 cases(44.44%) of PR-positive with tumour size ≥ 3 cm. In the situation of tumour size ≤3 cm,there were 13 cases(72.22%) of ER-positive,and 12 cases(66.67%) of PR-positive.There was no significant difference between the expression of ER,PR and the size of tumor(P>0.05).For the breast cancer with spiculate boundary,there were 29 cases(69.05%) of ER-positive,and 24 cases(57.41%) of PR-positive.For the breast cancer without spiculate boundary,there were 15 cases(50%) of ER-positive,and 12 cases(40%) of PR-positive.There was no significant difference between the expression of ER, PR and the status of spiculate boundary(P>0.05).For the tumor with malignant calcification,there were 15 cases(75%) of ER-positive,and 11 cases(55%) of PR-positive.For the tumor without malignant calcification,there were 29 cases(55.77%) of ER-positive,and 25 cases(48.08%) of PR-positive.There was no significant difference between the expression of ER,PR and the status of malignant calcification(P>0.05).For the tumor with lymph node metastasis,there were 23 cases(63.89%) of ER-positive,and 17 cases(47.22%) of PR-positive.For the tumor without lymph node metastasis,there were 21 cases(58.33%) of ER-positive,and 19 cases(52.78%) of PR-positive.There was no significant difference between the expression of ER,PR and the status of lymph node metastasis(P>0.05).Conclusion There is no significant correlation between the expressions of ER as well as PR and the mammogram features in women patients with breast cancer,therefor, the imaging features of breast cancer can not be used yet as the predictive indexes for the tumor markers of ER and PR.
Objective To investigate the X-ray characteristics of mammary gland invasive ductal carcinomaand its correlation with the expressions of ER and PR in order to explore further the application value of iconography in diagnosis of breast cancer.Methods The imaging data of 72 women patients aged 36～76 years,with an average age being(46.4±7.5)years,who were pathologically diagnosed as breast cancer,were retrospectively analyzed.The size,spiculate boundary and malignant calcification of tumor,the status of lymph node metastasis,and the immunohistochemical indexes including ER and PR were statistically analyzed.Moreover the correlation between the immunohistochemical indexes and the imaging features of tumor was analyzed.Results There were 31 cases(57.41%) of ER-positive with tumour size ≥ 3 cm,and 24 cases(44.44%) of PR-positive with tumour size ≥ 3 cm. In the situation of tumour size ≤3 cm,there were 13 cases(72.22%) of ER-positive,and 12 cases(66.67%) of PR-positive.There was no significant difference between the expression of ER,PR and the size of tumor(P>0.05).For the breast cancer with spiculate boundary,there were 29 cases(69.05%) of ER-positive,and 24 cases(57.41%) of PR-positive.For the breast cancer without spiculate boundary,there were 15 cases(50%) of ER-positive,and 12 cases(40%) of PR-positive.There was no significant difference between the expression of ER, PR and the status of spiculate boundary(P>0.05).For the tumor with malignant calcification,there were 15 cases(75%) of ER-positive,and 11 cases(55%) of PR-positive.For the tumor without malignant calcification,there were 29 cases(55.77%) of ER-positive,and 25 cases(48.08%) of PR-positive.There was no significant difference between the expression of ER,PR and the status of malignant calcification(P>0.05).For the tumor with lymph node metastasis,there were 23 cases(63.89%) of ER-positive,and 17 cases(47.22%) of PR-positive.For the tumor without lymph node metastasis,there were 21 cases(58.33%) of ER-positive,and 19 cases(52.78%) of PR-positive.There was no significant difference between the expression of ER,PR and the status of lymph node metastasis(P>0.05).Conclusion There is no significant correlation between the expressions of ER as well as PR and the mammogram features in women patients with breast cancer,therefor, the imaging features of breast cancer can not be used yet as the predictive indexes for the tumor markers of ER and PR.
引文
1 Song F,He M,Li H,et al.A cancer incidence survey in Tianjin:the third largest city in China-between 1981 and 2000.Cancer Causes Control,2008,19:443-450.
2 American college of Radiology(ACR).Breast imaning reporting and data system (BI-RADS).4th ed.Reston:Amcollege Radiol,2003.1-259.
3 Fernandez OA,Jolis L,Villaro G,et al.Individualization of treatment strategies.Adv Ther,2011,28:19-38.
4 Zunzunegui RG,Chung MA,Oruwari J,et al.Casting-type calcifications with invasion and high-grade ductal carcinoma in situ:a more aggressive disease.Arch Surg,2013,138:537-540.
5 Gu YG,Zhou KR,Chen TZ,et al.Mammographic features of breast carcinoma:mammographic-pathplpgic correlation.Chin Jradiol,2003,5:439-443.
6 刘小庆,林青,崔春晓,等.ER和PR同一表达状态下HER-2与乳腺癌X线表现的相关性分析.临床放射学杂志,2015,34:31-35.
7 陈青,孟刚,黄雯.乳腺癌中ERα、PR的表达与预后关系及其影响阳性率的相关因素.临床与实验病理学杂志,2016,32:13-18.
8 廉馨,史丹,李洪艳.新型雌激素受体ER-α36与乳腺癌.中国生物化学与分子生物学报,2015,31:34-37.
9 Joyce CL,Valerie CL.The activity of progesterone receptor isoform A and B are differentially modulated by their ligands in a gene-selsctive manner.International Journal of Cancer,2008,122:230-243.
10 余辉,杨云振,崔振,等.宁夏回汉856例女性乳腺癌受体Her-2与肿瘤相关性研究.宁夏医学杂志,2010,32:310.
11 李金环,张婧婧,陆璐,等.三阴性乳腺癌的钼靶X线及MRI表现.临床放射学杂志,2015,21:894-897.
12 杨光,张详宏,赵俊京,等.乳腺癌钼靶X线微钙化与癌细胞ER、PR表达关系的研究.实用放射学杂志.2006,22:587-591.
13 Jiang L,Ma T.Mammography and morphobiologic characteristics of human breasr cancer.Anticancer Res,2011,31:2327-2334.
14 朱大玲,周怀琪.乳腺浸润性导管癌钼靶X线表现与ER、PR及CerbB-2 表达的相关性研究.中国妇幼保健杂志,2009,24:5209-5211.
15 Jiang L,Ma T.Manmmographic features are associated with clinicopatho-logical characteristics in invasive breast cancer.Anticancer Res,2011,31:2327-2334.
16 Lassetn C,Bonadona V.Medical Management of Women with Inherited Predisposition to Breast Cancer:Indicationsand Proce2 dures for Mammo-graphic Screening.Bull Cancer,2001,88:677-686.
2 American college of Radiology(ACR).Breast imaning reporting and data system (BI-RADS).4th ed.Reston:Amcollege Radiol,2003.1-259.
3 Fernandez OA,Jolis L,Villaro G,et al.Individualization of treatment strategies.Adv Ther,2011,28:19-38.
4 Zunzunegui RG,Chung MA,Oruwari J,et al.Casting-type calcifications with invasion and high-grade ductal carcinoma in situ:a more aggressive disease.Arch Surg,2013,138:537-540.
5 Gu YG,Zhou KR,Chen TZ,et al.Mammographic features of breast carcinoma:mammographic-pathplpgic correlation.Chin Jradiol,2003,5:439-443.
6 刘小庆,林青,崔春晓,等.ER和PR同一表达状态下HER-2与乳腺癌X线表现的相关性分析.临床放射学杂志,2015,34:31-35.
7 陈青,孟刚,黄雯.乳腺癌中ERα、PR的表达与预后关系及其影响阳性率的相关因素.临床与实验病理学杂志,2016,32:13-18.
8 廉馨,史丹,李洪艳.新型雌激素受体ER-α36与乳腺癌.中国生物化学与分子生物学报,2015,31:34-37.
9 Joyce CL,Valerie CL.The activity of progesterone receptor isoform A and B are differentially modulated by their ligands in a gene-selsctive manner.International Journal of Cancer,2008,122:230-243.
10 余辉,杨云振,崔振,等.宁夏回汉856例女性乳腺癌受体Her-2与肿瘤相关性研究.宁夏医学杂志,2010,32:310.
11 李金环,张婧婧,陆璐,等.三阴性乳腺癌的钼靶X线及MRI表现.临床放射学杂志,2015,21:894-897.
12 杨光,张详宏,赵俊京,等.乳腺癌钼靶X线微钙化与癌细胞ER、PR表达关系的研究.实用放射学杂志.2006,22:587-591.
13 Jiang L,Ma T.Mammography and morphobiologic characteristics of human breasr cancer.Anticancer Res,2011,31:2327-2334.
14 朱大玲,周怀琪.乳腺浸润性导管癌钼靶X线表现与ER、PR及CerbB-2 表达的相关性研究.中国妇幼保健杂志,2009,24:5209-5211.
15 Jiang L,Ma T.Manmmographic features are associated with clinicopatho-logical characteristics in invasive breast cancer.Anticancer Res,2011,31:2327-2334.
16 Lassetn C,Bonadona V.Medical Management of Women with Inherited Predisposition to Breast Cancer:Indicationsand Proce2 dures for Mammo-graphic Screening.Bull Cancer,2001,88:677-686.