蜈蚣草全草石油醚部位的化学成分研究
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摘要
目的:研究蜈蚣草全草石油醚部位的化学成分。方法:采用硅胶柱色谱、凝胶柱色谱、重结晶和薄层色谱法对蜈蚣草全草石油醚部位的化学成分进行分离纯化,根据理化性质、氢谱和碳谱数据鉴定化合物结构。结果:从蜈蚣草全草石油醚部位分离、鉴定得到11个化合物,分别为(2R)-acetyl pterosin B(Ⅰ)、十六烷酸(Ⅱ)、何帕-22(29)-烯(Ⅲ)、表木栓醇(Ⅳ)、羽扇豆酮(Ⅴ)、齐墩果-18-烯-3-酮(Ⅵ)、豆甾醇(Ⅶ)、β-谷甾醇(Ⅷ)、22-羟基何帕烷(Ⅸ)、麦角甾醇(Ⅹ)、β-谷甾醇乙酸酯(Ⅺ)。结论:化合物Ⅰ～Ⅶ和Ⅸ～Ⅺ为首次从该植物中分离得到,可为深入研究蜈蚣草的生物活性药效物质基础、丰富其化学成分研究资料提供理论依据。
OBJECTIVE:To study the chemical constituents from the petroleum ether part from whole herbs of Pteris vittata.METHODS:The petroleum ether part from whole herbs of P. vittata was separated and isolated by silica gel column,gel column,recrystallization and TLC. The structures of the compounds were identified according to physicochemical properties and spectrum data(~1H-NMR and~(13)C-NMR). RESULTS:A total of 11 compounds were isolated and identified from the petroleum ether part from whole herbs of P. vittata,as(2 R)-acetyl pterosin B(Ⅰ),palmitic acid(Ⅱ),hop-22(29)-ene(Ⅲ),epifriedelanol(Ⅳ),lupenone(Ⅴ),olean-18-en-3-one(Ⅵ),stigmasterol(Ⅶ),β-sitosterol(Ⅷ),22-hydroxyhopane(Ⅸ),ergosterol(Ⅹ),β-sitosterol acetate(Ⅺ). CONCLUSIONS:Compounds Ⅰ-Ⅶ and Ⅸ-Ⅺ are isolated from this plant for the first time,and can provide theoretic reference for further studying bioactive pharmacodynamic substances in P. vittata and enriching chemical component data.
OBJECTIVE:To study the chemical constituents from the petroleum ether part from whole herbs of Pteris vittata.METHODS:The petroleum ether part from whole herbs of P. vittata was separated and isolated by silica gel column,gel column,recrystallization and TLC. The structures of the compounds were identified according to physicochemical properties and spectrum data(~1H-NMR and~(13)C-NMR). RESULTS:A total of 11 compounds were isolated and identified from the petroleum ether part from whole herbs of P. vittata,as(2 R)-acetyl pterosin B(Ⅰ),palmitic acid(Ⅱ),hop-22(29)-ene(Ⅲ),epifriedelanol(Ⅳ),lupenone(Ⅴ),olean-18-en-3-one(Ⅵ),stigmasterol(Ⅶ),β-sitosterol(Ⅷ),22-hydroxyhopane(Ⅸ),ergosterol(Ⅹ),β-sitosterol acetate(Ⅺ). CONCLUSIONS:Compounds Ⅰ-Ⅶ and Ⅸ-Ⅺ are isolated from this plant for the first time,and can provide theoretic reference for further studying bioactive pharmacodynamic substances in P. vittata and enriching chemical component data.
引文
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[2]殷帅文,胡文杰,叶飞飞,等.蜈蚣草化学成分及抑制乙酰胆碱酯酶生物活性研究[J].天然产物研究与开发,2018,30(8):1367-1370.
[3]侯远鑫,周昌园,侯淑芬,等.蜈蚣草乙酸乙酯部位化学成分分离鉴定[J].中国实验方剂学杂志,2018,24(19):52-55.
[4] WANG YS,LI FY,HUANG R,et al. Chemical constituents of Pteris multifida[J]. Chem Nat Compd,2013,49(4):629-631.
[5]高建华,杨婷,董玉.蒙药复方协日嘎四味汤散的化学成分研究[J].中国药房,2014,25(47):4470-4472.
[6]杨宝,范真,朱锦萍,等.金鸡脚化学成分研究[J].中草药,2014,45(21):3053-3056.
[7]张慧颖,付兴情,蔡义玲,等.大理卫矛乙醇提取物的化学成分研究[J].中国药房,2018,29(2):176-179.
[8]张扩,赵明,王美娇,等.细叶杜香叶中三萜类化学成分研究[J].中草药,2018,49(6):1250-1254.
[9]钱春香,孙丽娜,薛璇玑,等.乳苣全草石油醚部位化学成分的研究[J].中草药,2017,48(7):1302-1305.
[10]赵震宇,罗宁,陈晨,等.单针藻的化学成分及其体外抗菌、抗氧化活性研究[J].中国药房,2017,28(4):465-468.
[11]黄周锋,黄建猷,卢文杰,等.裸花水竹草化学成分[J].中国实验方剂学杂志,2016,22(21):73-76.
[12]郭志俊,杨竹雅,谭文红,等.制黄草乌化学成分研究[J].中药材,2015,38(5):988-991.