SREBP-1c与妊娠期糖尿病的相关研究进展
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摘要
妊娠期糖尿病(GDM)是妊娠期常见并发症之一,可造成不良妊娠结局,且GDM孕妇和新生儿有远期发生2型糖尿病和代谢综合征的风险。GDM孕妇严重糖脂代谢紊乱的发生与脂肪因子、细胞因子、炎性因子以及内质网应激等密切相关。固醇调节元件结合蛋白1c(SREBP-1c)是一类分布于内质网和核膜上的膜连接蛋白,可通过干扰胰岛素信号通路,引起糖脂代谢紊乱,参与GDM的发生发展,且SREBP-1c与GDM发生的诸多相关因子存在关联。
Gestational diabetes mellitus( GDM) is one of the most common complications during pregnancy. It can not only cause adverse pregnancy outcomes,but also lead to the long-term risk of type 2 diabetes mellitus and metabolic syndrome in the mothers and newborns of GDM. There is a serious disorder of glycolipid metabolism in pregnant women with GDM,which is closely related to adipokines,cytokines,inflammatory factors and endoplasmic reticulum stress. Sterol regulatory primitive binding protein 1 c( SREBP-1 c) is a class of membrane-bound proteins distributed on endoplasmic reticulum and nuclear membrane,which can interfere with insulin signaling pathway,cause disorder of glycolipid metabolism and participate in the occurrence and development of GDM. It is found that SREBP-1 c is also associated with many related factors of GDM.
Gestational diabetes mellitus( GDM) is one of the most common complications during pregnancy. It can not only cause adverse pregnancy outcomes,but also lead to the long-term risk of type 2 diabetes mellitus and metabolic syndrome in the mothers and newborns of GDM. There is a serious disorder of glycolipid metabolism in pregnant women with GDM,which is closely related to adipokines,cytokines,inflammatory factors and endoplasmic reticulum stress. Sterol regulatory primitive binding protein 1 c( SREBP-1 c) is a class of membrane-bound proteins distributed on endoplasmic reticulum and nuclear membrane,which can interfere with insulin signaling pathway,cause disorder of glycolipid metabolism and participate in the occurrence and development of GDM. It is found that SREBP-1 c is also associated with many related factors of GDM.
引文
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[2] Retnakaran R,Qi Y,Conneliy PW,et al. Low adiponectin concentration during pregnancy predicts postpartum insulin resistance,beta cell dysfunction and fasting glycaemia[J]. Diabetologia,2010,53(2):268-276.
[3]赵改霞.固醇调节元件结合蛋白(SREBPs)的研究进展[D].济南:山东大学,2005.
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[6]袁智敏.SREBP4c基因多态性和血清RBP-4水平与妊娠期糖代谢异常的关系[D].广州:中山大学,2010.
[7]高燕翔,张勇,刘裕,等.SREBP-1c在白藜芦醇预防大鼠非酒精性脂肪肝发生中的作用[J].第三军医大学学报,2015,37(17):17044708.
[8]韩波,张桓虎.肝脂康胶囊对大鼠非酒精性脂肪性肝病SREBP-1表达的影响[J].中国医疗前沿,2011,6(19):39-40.
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[14]张凯,杨慧霞.脂联素与妊娠期糖尿病相关性的研究进展[J].中华围产医学杂志,2013,16(6):341-344.
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[16] Kunal S, Sanket KS, Neel P,et al. High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR-γ[J]. Cell Physiol Biochem,2018,48(3):13174331.
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[19]叶梓莹,黎晔,赵震,等.妊娠期糖尿病产妇胎盘组织内质网应激状态及其对胎盘组织形态学的影响[J].山东医药,2014,54(30):23-25.
[20]刘陶,房臻,杨冬,等.炎性及脂肪细胞因子与妊娠期糖尿病发病的相关性及在产褥期的变化[J].中华妇产科杂志,2012,47(6):436-439.
[21]杨林辉. TNF-α对肝细胞脂肪变性模型SCAP-SREBP-1c脂质合成通路的影响[D].重庆:第三军医大学,2006.
[22]孙楠,崔景秋,高志红,等.高脂饮食诱导的胰岛素抵抗大鼠肝脏固醇调节元件结合蛋白-1c mRNA的表达[J].中国糖尿病杂志,2010,2(3):216-218.
[23]李艾珍.孕中晚期TNF-α和8-iso-PGF2α与GDM发病机制相关性的研究[D].武汉:华中科技大学,2015.
[24]梁艳,徐先明.炎症因子与妊娠期糖尿病发病的关系[J].中华围产医学杂志,2007,10(5):354-356.
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[26] Jeon EJ,Hong SY,Ji HL. Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus[J]. Diabetes Metab,2017,41(6)457-465.
[27] Powe CE. Early Pregnancy Biochemical Predictors of Gestational Diabetes Mellitus[J]. Curr Diab Rep,2017,17(2):12.
[28] Tsiotra PC, Halvatsiotis P, Patsouras K. Circulating adipokines and mRNA expression in adipose tissue and the placenta inwomen with gestational diabetes mellitus[J]. Peptides,2018,101:157-466.
[29] Iciek R, Wender-Ozegowska E, Zawiejska A, et al. Placental leptin and its receptor genes expression in pregnancies complicated by type 1 diabetes[J]. J physiol pharmacol,2013,64(5):579-585.
[30] Kieffer TJ, Heller RS, Leech CA, et al. Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K~+Channels in Pancreaticβ-Cells[J]. Diabetes,1997,46(6):10874093.
[31] Marques-Oliveira GH,Da ST, Lima WG, et al. Insulin as a hormone regulator of the synthesis and release of leptin by white adipose tissue[J].Peptides,2018,106:49-58.
[32] Zhai X, Yan K,Fan J,et al. Theβ-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis[J]. Br J Phannacol,2013,169(1):197-212.
[33] MierzyaSki R, Poniedzialek-Czajkowska E, DIUski D, et al. The role of new adipokines in gestational diabetes mellitus pathogenesis[J].Ginekologia Polska,2018,103(1):222-227.
[34] Aye IL, Powell TL, Jansson T. Review:Adiponectin-the missing link between maternal adiposity, placental transport and fetal growth?[J]. Placenta,2013,34 Suppl:S40-45.
[35] Hedderson MM, Darbinian J, Havel PJ, et al. Low Prepregnancy Adiponectin Concentrations Are Associated With a Marked Increase in Risk for Development of Gestational Diabetes Mellitus[J]. Diabetes Care,2013,36(12):3930-3937.
[36] Yamauchi T,Kamon J,Minokoshi Y,et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMPactivated protein kinase[J]. Nat Med,2002,8(11):1288-1295.
[37]曹姝.胰岛素对骨骼肌细胞SREBP-1c的调节作用[D].南京:南京医科大学,2015.
[38]周萍,陈丹青.视黄醇结合蛋白4与妊娠期糖尿病的研究进展[J].国际妇产科学杂志,2013,40(6):496-499.
[39] Yang Q, Graham TE,Mody N,et al. Serum retinol binding protein 4contributes to insulin resistance in obesity and type 2 diabetes[J].Nature,2005,436(7049):356-362.
[40] Chen Y, Lv P, Du M, et al. Increased retinol-free RBP4 contributes to insulin resistance in gestational diabetes mellitus[J].Arch Gynecol Obstet,2017,296(1):1-9.
[41]薛丽丽,陈丹青.妊娠期糖尿病患者视黄醇结合蛋白4的变化及其与血糖和血脂的代谢关系[J].实用妇产科杂志,2013,29(6):450-453.
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[43] Xia M,Liu Y, Guo H,et al. Retinol binding protein 4 stimulates hepatic sterol regulatory element-binding protein 1 and increases lipogenesis through the peroxisome proliferator-activated receptor-I~3 coactivator 1I~2-dependent pathway[J]. Hepatology, 2013,58(2):564-575.
[44] Gemand AD, Simhan HN, Caritis S, et al. Maternal Vitamin D Status and Small-for-Gestational-Age Offspring in Women at High Risk for Preeclampsia[J]. Obstet Gynecol, 2014, 123(1):40-48.
[45] Bodnar LM,Klebanoff MA, Gernand AD,et al. Maternal Vitamin D Status and Spontaneous Preterm Birth by Placental Histology in the US Collaborative Perinatal Project[J]. Am J Epidemiol,2014,179(2):168476.
[46]宋鸿碧,杨慧霞.维生素D对妊娠期糖尿病发病的影响[J].中华妇产科杂志,2014, 49(1):59-60.
[47] Lacroix M, Battista MC, Doyon M, et al. Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus[J]. Acta Diabetol, 2014, 51(4):609-616.
[48] Yang Z,Liu F,Qu H,et al. 1,25(OH)_2D_3 protectsβcell againsthigh glucose-induced apoptosis through mTOR suppressing[J].Mol Cell Endocrinol,2015,414:111-119.
[49] Li G,Lin L, Wang YL, et al. 1,25(OH)_2D_3 Protects Trophoblasts Against Insulin Resistance and Inflammation Via Suppressing mTOR Signaling[J]. Reprod Sci, 2019,26(2):223-232.
[50]孙丽洲,马孝甜,葛志平,等.滋养细胞内质网应激特征性分子葡萄糖调节蛋白及内质网凋亡因子caspase-12与子痫前期发病的关系[J].中华妇产科杂志,2010,45(12):891-895.
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[52]闵敏.UPR联合SREBP-1c在内质网应激致大鼠NASH形成中的作用及意义[D].重庆:第三军医大学,2009.
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[2] Retnakaran R,Qi Y,Conneliy PW,et al. Low adiponectin concentration during pregnancy predicts postpartum insulin resistance,beta cell dysfunction and fasting glycaemia[J]. Diabetologia,2010,53(2):268-276.
[3]赵改霞.固醇调节元件结合蛋白(SREBPs)的研究进展[D].济南:山东大学,2005.
[4]缪雪钦.LXRa、SREBP-1c介导脂质代谢紊乱在子痫前期中的作用及机制[D].福州:福建医科大学,2013.
[5]孙卫平.胰岛素治疗通过减轻内质网应激改善2型糖尿病大鼠肝脏胰岛素敏感性和脂肪沉积[D].广州:中山大学,2008.
[6]袁智敏.SREBP4c基因多态性和血清RBP-4水平与妊娠期糖代谢异常的关系[D].广州:中山大学,2010.
[7]高燕翔,张勇,刘裕,等.SREBP-1c在白藜芦醇预防大鼠非酒精性脂肪肝发生中的作用[J].第三军医大学学报,2015,37(17):17044708.
[8]韩波,张桓虎.肝脂康胶囊对大鼠非酒精性脂肪性肝病SREBP-1表达的影响[J].中国医疗前沿,2011,6(19):39-40.
[9]周晓玲.补体关键成分及SREBP-1c在妊娠期急性脂肪肝患者肝组织中的表达及其意义[D].福州:福建医科大学.2016.
[10] Marseille-Tremblay C, Gravel A, Lafond J, et al. Effect of an enriched cholesterol diet during gestation on fatty acid synthase,HMG-CoA reductase and SREBP-1/2 expressions in rabbits[J].Life Sci,2007,81(9):772-778.
[11] Sweeney TR, Moser AH, Shigenaga JK, et al. Decreased nuclear hormone receptor expression in the livers of mice in late pregnancy[J]. Am J Physiol,2006,290(6):1313-1320.
[12]莫育霞,廖化梅,周燕.妊娠期糖尿病与脂肪因子参与的胰岛素抵抗的相关性研究进展[J].现代医药卫生,2017,33(18):2810-2812.
[13] Kautzky-Willer A, Pacini G,Tura A, et al. Increased plasma leptin in gestational diabetes[J]. Diabetologia, 2001,44(2):164-172.
[14]张凯,杨慧霞.脂联素与妊娠期糖尿病相关性的研究进展[J].中华围产医学杂志,2013,16(6):341-344.
[15]刘长江,王颜刚.孕中期妊娠期糖尿病患者胰岛素抵抗、胰岛素分泌功能变化及临床意义[J].山东医药,2012,52(17):54-55.
[16] Kunal S, Sanket KS, Neel P,et al. High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR-γ[J]. Cell Physiol Biochem,2018,48(3):13174331.
[17]阳琰,高琳,邓华聪,等.脂联素对糖尿病大鼠肝脏中PPARα、SREBP4C、载脂蛋白A5表达及甘油三酯含量的影响[J].中华内分泌代谢杂志,2013,29(8):696-599.
[18]赵祖英,李水莲,陆洁清.妊娠期糖尿病患者血清TNF-α的检测及意义[J/CD].实用妇科内分泌杂志(电子版),2017,4(15):132-132.
[19]叶梓莹,黎晔,赵震,等.妊娠期糖尿病产妇胎盘组织内质网应激状态及其对胎盘组织形态学的影响[J].山东医药,2014,54(30):23-25.
[20]刘陶,房臻,杨冬,等.炎性及脂肪细胞因子与妊娠期糖尿病发病的相关性及在产褥期的变化[J].中华妇产科杂志,2012,47(6):436-439.
[21]杨林辉. TNF-α对肝细胞脂肪变性模型SCAP-SREBP-1c脂质合成通路的影响[D].重庆:第三军医大学,2006.
[22]孙楠,崔景秋,高志红,等.高脂饮食诱导的胰岛素抵抗大鼠肝脏固醇调节元件结合蛋白-1c mRNA的表达[J].中国糖尿病杂志,2010,2(3):216-218.
[23]李艾珍.孕中晚期TNF-α和8-iso-PGF2α与GDM发病机制相关性的研究[D].武汉:华中科技大学,2015.
[24]梁艳,徐先明.炎症因子与妊娠期糖尿病发病的关系[J].中华围产医学杂志,2007,10(5):354-356.
[25] Mosavat M, Omar SZ, Tan PC, et al. Leptin and soluble leptin receptor in association with gestational diabetes:A prospective case-control study[J]. Arch Gynecol Obstetr, 2018,297(3):797-803.
[26] Jeon EJ,Hong SY,Ji HL. Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus[J]. Diabetes Metab,2017,41(6)457-465.
[27] Powe CE. Early Pregnancy Biochemical Predictors of Gestational Diabetes Mellitus[J]. Curr Diab Rep,2017,17(2):12.
[28] Tsiotra PC, Halvatsiotis P, Patsouras K. Circulating adipokines and mRNA expression in adipose tissue and the placenta inwomen with gestational diabetes mellitus[J]. Peptides,2018,101:157-466.
[29] Iciek R, Wender-Ozegowska E, Zawiejska A, et al. Placental leptin and its receptor genes expression in pregnancies complicated by type 1 diabetes[J]. J physiol pharmacol,2013,64(5):579-585.
[30] Kieffer TJ, Heller RS, Leech CA, et al. Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K~+Channels in Pancreaticβ-Cells[J]. Diabetes,1997,46(6):10874093.
[31] Marques-Oliveira GH,Da ST, Lima WG, et al. Insulin as a hormone regulator of the synthesis and release of leptin by white adipose tissue[J].Peptides,2018,106:49-58.
[32] Zhai X, Yan K,Fan J,et al. Theβ-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis[J]. Br J Phannacol,2013,169(1):197-212.
[33] MierzyaSki R, Poniedzialek-Czajkowska E, DIUski D, et al. The role of new adipokines in gestational diabetes mellitus pathogenesis[J].Ginekologia Polska,2018,103(1):222-227.
[34] Aye IL, Powell TL, Jansson T. Review:Adiponectin-the missing link between maternal adiposity, placental transport and fetal growth?[J]. Placenta,2013,34 Suppl:S40-45.
[35] Hedderson MM, Darbinian J, Havel PJ, et al. Low Prepregnancy Adiponectin Concentrations Are Associated With a Marked Increase in Risk for Development of Gestational Diabetes Mellitus[J]. Diabetes Care,2013,36(12):3930-3937.
[36] Yamauchi T,Kamon J,Minokoshi Y,et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMPactivated protein kinase[J]. Nat Med,2002,8(11):1288-1295.
[37]曹姝.胰岛素对骨骼肌细胞SREBP-1c的调节作用[D].南京:南京医科大学,2015.
[38]周萍,陈丹青.视黄醇结合蛋白4与妊娠期糖尿病的研究进展[J].国际妇产科学杂志,2013,40(6):496-499.
[39] Yang Q, Graham TE,Mody N,et al. Serum retinol binding protein 4contributes to insulin resistance in obesity and type 2 diabetes[J].Nature,2005,436(7049):356-362.
[40] Chen Y, Lv P, Du M, et al. Increased retinol-free RBP4 contributes to insulin resistance in gestational diabetes mellitus[J].Arch Gynecol Obstet,2017,296(1):1-9.
[41]薛丽丽,陈丹青.妊娠期糖尿病患者视黄醇结合蛋白4的变化及其与血糖和血脂的代谢关系[J].实用妇产科杂志,2013,29(6):450-453.
[42] Ost A, Danielsson A, Liden,et al. Retinol-binding protein-4attenuates insulin-induced phosphorylation of IRSI and ERK1/2in primary human adipocytes[J]. Faseb Journal, 2007,21(13):3696-3704.
[43] Xia M,Liu Y, Guo H,et al. Retinol binding protein 4 stimulates hepatic sterol regulatory element-binding protein 1 and increases lipogenesis through the peroxisome proliferator-activated receptor-I~3 coactivator 1I~2-dependent pathway[J]. Hepatology, 2013,58(2):564-575.
[44] Gemand AD, Simhan HN, Caritis S, et al. Maternal Vitamin D Status and Small-for-Gestational-Age Offspring in Women at High Risk for Preeclampsia[J]. Obstet Gynecol, 2014, 123(1):40-48.
[45] Bodnar LM,Klebanoff MA, Gernand AD,et al. Maternal Vitamin D Status and Spontaneous Preterm Birth by Placental Histology in the US Collaborative Perinatal Project[J]. Am J Epidemiol,2014,179(2):168476.
[46]宋鸿碧,杨慧霞.维生素D对妊娠期糖尿病发病的影响[J].中华妇产科杂志,2014, 49(1):59-60.
[47] Lacroix M, Battista MC, Doyon M, et al. Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus[J]. Acta Diabetol, 2014, 51(4):609-616.
[48] Yang Z,Liu F,Qu H,et al. 1,25(OH)_2D_3 protectsβcell againsthigh glucose-induced apoptosis through mTOR suppressing[J].Mol Cell Endocrinol,2015,414:111-119.
[49] Li G,Lin L, Wang YL, et al. 1,25(OH)_2D_3 Protects Trophoblasts Against Insulin Resistance and Inflammation Via Suppressing mTOR Signaling[J]. Reprod Sci, 2019,26(2):223-232.
[50]孙丽洲,马孝甜,葛志平,等.滋养细胞内质网应激特征性分子葡萄糖调节蛋白及内质网凋亡因子caspase-12与子痫前期发病的关系[J].中华妇产科杂志,2010,45(12):891-895.
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