自噬吞噬对miR-155调控结肠癌细胞存活和凋亡的影响
摘要
<正>全球平均每年有100万人被诊断出患有结直肠癌~([12]),结直肠癌存在的类型多样,约40%的病例携带KRAS突变,10%为BRAF突变~([3])。与野生型KRAS患者相比,突变的KRAS预示着不良的预后和生存,同时耐受抗表皮生长因子受体(EGFR)治疗~([4-6])。成熟的microRNAs(miRNAs)是内源性转录调节RNA分子,长度仅有18-25bp,与目标mRNA 3’UTR相结合,负向调节其翻译~([7])。miRNAs已被广泛证实可以调控基础细胞过程,如增殖,分
引文
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[2]Engelhardt EG,Révész,D,Tamminga HJ,et al.Clinical usefulness of tools to support decision-making for palliative treatment of metastatic colorectal cancer:A systematic review[J].Clin Colorectal Cancer,2017,17:e1.
[3]Sebolt-Leopold JS,Herrera R.Targeting the mitogen-activated protein kinase cascade to treat cancer[J].Nat Rev Cancer,2004,4:937.
[4]Bürzle M,Suzuki Y,Ackermann D,et al.The sodium-dependent ascorbic acid transporter family slc23[J].Mol Asp Med,2013,34:436.
[5]Tan C,Du X.Kras mutation testing in metastatic colorectal cancer[J].World J Gastroenterol,2012,18:5171.
[6]Lievre A,Bachet JB,Le Corre D,et al.Kras mutation status is predictive of response to cetuximab therapy in colorectal cancer[J].Cancer Res,2006,66:3992.
[7]Bartel DP.MicroRNAs.genomics,biogenesis,mechanism,and function[J].Cell,2004,116:281.
[8]Singh T,Jauhari A,Pandey A,et al.Regulatory triangle of neurodegeneration,adult neurogenesis and microRNAs[J].CNS Neurol Disord Drug Targets,2014,13:96.
[9]Papamichael D,Audisio RA,Glimelius B,et al.Treatment of colorectal cancer in older patients:International Society of Geriatric Oncology(SIOG)consensus recommendations 2013[J].Ann Oncol,2015,26:463.
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[11]Sontheimer EJ,Carthew RW.Silence from within:Endogenous siRNAs and miRNAs[J].Cell,2005,122:9.
[12]Faraoni I,Antonetti FR,Cardone J,et al.miR-155gene:A typical multifunctional microRNA[J].Biochim Biophys Acta,2009,1792:497.
[13]Suzuki K,Ohsumi Y.Molecular machinery of autophagosome formation in yeast,Saccharomyces cerevisiae[J].FEBS Lett,2007,581(11):2156.
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[15]Kroemer G,Mari1o G,Levine B.Autophagy and the integrated stress response[J].Mol Cell,2012,40(2):280.