拟孢囊菌属放线菌的研究进展
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摘要
拟孢囊菌属(Kibdelosporangium)是一个经典的丝状放线菌类群。自Shearer等于1986年建立该属以来,不断有新的菌株从不同生境中被纯培养分离得到,目前已有效发表8个种、2个亚种。拟孢囊菌属作为稀有放线菌属,是获得新型抗生素类次生代谢产物的重要资源。本文结合我们分离到的一株该属菌株的功能研究、基因组分析和相关文献资料,系统综述了拟孢囊菌属放线菌的建立、分类学特征、属内种的分布、活性次级代谢产物的发现以及其他功能应用和开发前景,以期为该属其他新分离菌株的分类鉴定、新颖次级代谢产物的发现、功能基因资源的挖掘与开发提供借鉴。
The genus Kibdelosporangium is a classical group of actinomycetes. Since the establishment of this genus in 1986 by Shearer et al., new strains have been isolated from different habitats by pure culture methods, and8 species and 2 subspecies have been published. Kibdelosporangium is a rare actinomycete genus and an important resource for obtaining new secondary metabolites. Based on the function and genome analysis of a newly isolated strain and the related literature of the genus Kibdelosporangium, we systematically summarize the research advances of the genus Kibdelosporangium, including the genus establishment, taxonomic characteristics,distribution of the species, the discovery of active secondary metabolites and other functional applications and development prospects. This review provides references for the classification and identification of other new isolates, the discovery of novel secondary metabolites, and the exploitation of functional gene resources from the genus Kibdelosporangium in the future.
The genus Kibdelosporangium is a classical group of actinomycetes. Since the establishment of this genus in 1986 by Shearer et al., new strains have been isolated from different habitats by pure culture methods, and8 species and 2 subspecies have been published. Kibdelosporangium is a rare actinomycete genus and an important resource for obtaining new secondary metabolites. Based on the function and genome analysis of a newly isolated strain and the related literature of the genus Kibdelosporangium, we systematically summarize the research advances of the genus Kibdelosporangium, including the genus establishment, taxonomic characteristics,distribution of the species, the discovery of active secondary metabolites and other functional applications and development prospects. This review provides references for the classification and identification of other new isolates, the discovery of novel secondary metabolites, and the exploitation of functional gene resources from the genus Kibdelosporangium in the future.
引文
[1]Lazzarini A,Cavaletti L,Toppo G,Marinelli F.Rare genera of actinomycetes as potential producers of new antibiotics.Antonie van Leeuwenhoek,2000,78(3/4):399-405.
[2]Qin S,Xing K,Jiang JH,Xu LH,Li WJ.Biodiversity,bioactive natural products and biotechnological potential of plant-associated endophytic actinobacteria.Applied Microbiology and Biotechnology,2011,89(3):457-473.
[3]Tiwari K,Gupta RK.Rare actinomycetes:a potential storehouse for novel antibiotics.Critical Reviews in Biotechnology,2012,32(2):108-132.
[4]Dhakal D,Pokhrel AR,Shrestha B,Sohng JK.Marine rare actinobacteria:isolation,characterization,and strategies for harnessing bioactive compounds.Frontiers in Microbiology,2017,8:1106.
[5]Tian J,Chen HY,Guo ZY,Liu N,Li J,Huang Y,Xiang WS,Chen YH.Discovery of pentangular polyphenols hexaricins A-C from marine Streptosporangium sp.CGMCC 4.7309 by genome mining.Applied Microbiology and Biotechnology,2016,100(9):4189-4199.
[6]Shearer MC,Colman PM,Ferrin RM,Nisbet LJ,Nash IIICH.New genus of the Actinomycetales:Kibdelosporangium aridum gen.nov.,sp.nov..International Journal of Systematic Bacteriology,1986,36(1):47-54.
[7]Shearer MC,Actor P,Bowie BA,Grappel SF,Nash CH,Newman DJ,Oh YK,Pan CH,Nisbet LJ.Aridicins,novel glycopeptide antibiotics.I.taxonomy,production and biological activity.The Journal of Antibiotics,1985,38(5):555-560.
[8]Folena-Wasserman G,Poehland BL,Yeung EW,Staiger D,Killmer LB,Snader K,Dingerdissen JJ,Jeffs PW.Kibdelins(AAD-609),novel glycopeptide antibiotics.II.Isolation,purification and structure.The Journal of Antibiotics,1986,39(10):1395-1406.
[9]Tokiwa Y,Jarerat A.Biodegradation of poly(L-lactide).Biotechnology Letters,2004,26(10):771-777.
[10]Mertz FP,Yao RC.Kibdelosporangium philippinense sp.nov.isolated from soil.International Journal of Systematic Bacteriology,1988,38(3):282-286.
[11]Pascual J,González I,Estévez M,Benito P,Trujillo ME,Genilloud O.Description of Kibdelosporangium banguiense sp.nov.,a novel actinomycete isolated from soil of the forest of Pama,on the plateau of Bangui,Central African Republic.Antonie van Leeuwenhoek,2016,109(5):685-695.
[12]Xing K,Bian GK,Qin S,Klenk HP,Yuan B,Zhang YJ,Li WJ,Jiang JH.Kibdelosporangium phytohabitans sp.nov.,a novel endophytic actinomycete isolated from oil-seed plant Jatropha curcas L.containing1-aminocyclopropane-1-carboxylic acid deaminase.Antonie van Leeuwenhoek,2012,101(2):433-441.
[13]Li D,Huang YJ,Song SY,Xue C,Wu YY,Deng XM.Kibdelosporangium lantanae sp.nov.,isolated from the rhizosphere soil of an ornamental plant,Lantana camara L.International Journal of Systematic and Evolutionary Microbiology,2015,65(8):2581-2585.
[14]Cao YR,Yang WQ,Dao Y,Hu B,He ZK,Liang LM.Kibdelosporangium metalli sp.nov.,isolated from a rare earth mine.International Journal of Systematic and Evolutionary Microbiology,2017,67(1):101-107.
[15]Mingma R,Duangmal K,ōmura S,Takahashi Y,Matsumoto A.Three novel species of the genus Kibdelosporangium;Kibdelosporangium kanagawaense sp.nov.,Kibdelosporangium rhizosphaerae sp.nov.and Kibdelosporangium rhizovicinum sp.nov..International Journal of Systematic and Evolutionary Microbiology,2017,67(6):1758-1765.
[16]Zhi XY,Li WJ,Stackebrandt E.An update of the structure and 16S r RNA gene sequence-based definition of higher ranks of the class Actinobacteria,with the proposal of two new suborders and four new families and emended descriptions of the existing higher taxa.International Journal of Systematic and Evolutionary Microbiology,2009,59(3):589-608.
[17]Hatano M,Kinoshita N,Igarashi M,Nomoto A.Actinocrispum wychmicini gen.nov.,sp.nov.,a novel member of the family Pseudonocardiaceae,isolated from soil.International Journal of Systematic and Evolutionary Microbiology,2016,66(11):4779-4784.
[18]Lee SD.Labedaea rhizosphaerae gen.nov.,sp.nov.,isolated from rhizosphere soil.International Journal of Systematic and Evolutionary Microbiology,2012,62(8):1772-1778.
[19]Xia ZF,Guan TW,Ruan JS,Huang Y,Zhang LL.Longimycelium tulufanense gen.nov.,sp.nov.,a filamentous actinomycete of the family Pseudonocardiaceae.International Journal of Systematic and Evolutionary Microbiology,2013,63(8):2813-2818.
[20]Huang Y,Wang LM,Lu ZT,Hong L,Liu ZH,Tan GYA,Goodfellow M.Proposal to combine the genera Actinobispora and Pseudonocardia in an emended genus Pseudonocardia,and description of Pseudonocardia zijingensis sp.nov..International Journal of Systematic and Evolutionary Microbiology,2002,52(3):977-982.
[21]Shearer MC,Giovenella AJ,Grappel SF,Hedde RD,Mehta RJ,Oh YK,Pan CH,Pitkin DH,Nisbet LJ.Kibdelins,novel glycopeptide antibiotics.I.Discovery,production and biological evaluation.The Journal of Antibiotics,1986,39(10):1386-1394.
[22]Labeda DP,Kroppenstedt RM.Proposal for the new genus Allokutzneria gen.nov.within the suborder Pseudonocardineae and transfer of Kibdelosporangium albatum Tomita et al.1993 as Allokutzneria albata comb.nov..International Journal of Systematic and Evolutionary Microbiology,2008,58(Pt 6):1472-1475.
[23]Ranjani A,Gopinath PM,Rajesh K,Dhanasekaran D,Priyadharsini P.Diversity of silver nanoparticle synthesizing actinobacteria isolated from marine soil,Tamil Nadu,India.Arabian Journal for Science and Engineering,2016,41(1):25-32.
[24]Liu CB,Jiang Y,Wang XY,Chen DB,Chen X,Wang LS,Han L,Huang XH,Jiang CL.Diversity,antimicrobial activity,and biosynthetic potential of cultivable actinomycetes associated with lichen symbiosis.Microbial Ecology,2017,74(3):570-584.
[25]Qin S,Feng WW,Zhang YJ,Wang TT,Xiong YW,Xing K.Diversity of bacterial microbiota of coastal halophyte Limonium sinense and amelioration of salinity stress damage by symbiotic plant growth-promoting actinobacterium Glutamicibacter halophytocola KLBMP 5180.Applied and Environmental Microbiology,2018,84(19):e01533-18.
[26]Chung SK,Oh YK,Taylor P,Gerber R,Nisbet LJ.Biosynthetic studies of aridicin antibiotics.II.Microbial transformations and glycosylations by protoplasts.The Journal of Antibiotics,1986,39(5):652-659.
[27]Tsunakawa M,Komiyama N,Tenmyo O,Tomita K,Kawano K,Kotake C,Konishi M,Oki T.New antiviral antibiotics,cycloviracins B1 and B2.I.Production,isolation,physico-chemical properties and biological activity.The Journal of Antibiotics,1992,45(9):1467-1471.
[28]Ratnayake R,Lacey E,Tennant S,Gill JH,Capon RJ.Isokibdelones:novel heterocyclic polyketides from a Kibdelosporangium sp..Organic Letters,2006,8(23):5267-5270.
[29]Ratnayake R,Lacey E,Tennant S,Gill JH,Capon RJ.Kibdelones:novel anticancer polyketides from a rare Australian actinomycete.Chemistry,2007,13(5):1610-1619.
[30]Ogasawara Y,Liu HW.Biosynthetic studies of aziridine formation in azicemicins.Journal of the American Chemical Society,2009,131(50):18066-18068.
[31]Izumikawa M,Takagi M,Shin-Ya K.JBIR-78 and JBIR-95:phenylacetylated peptides isolated from Kibdelosporangium sp.AK-AA56.Journal of Natural Products,2012,75(2):280-284.
[32]Phillips JW,Goetz MA,Smith SK,Zink DL,Polishook J,Onishi R,Salowe S,Wiltsie J,Allocco J,Sigmund J,Dorso K,Lee S,Skwish S,de la Cruz M,Martín J,Vicente F,Genilloud O,Lu J,Painter RE,Young K,Overbye K,Donald RGK,Singh SB.Discovery of kibdelomycin,a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus.Chemistry&Biology,2011,18(8):955-965.
[33]Singh SB.Discovery and development of kibdelomycin,a new class of broad-spectrum antibiotics targeting the clinically proven bacterial type II topoisomerase.Bioorganic&Medicinal Chemistry,2016,24(24):6291-6297.
[34]Lin J,Zhou JW,Kang Z,Du GC,Chen J.Isolation,identification of poly lactic acid degrading microorganisms and optimization of the degradation process.Microbiology China,2013,40(9):1560-1569.(in Chinese)林娟,周景文,康振,堵国成,陈坚.聚乳酸降解菌株筛选鉴定及降解过程优化.微生物学通报,2013,40(9):1560-1569.
[35]Jarerat A,Tokiwa Y,Tanaka H.Poly(L-lactide)degradation by Kibdelosporangium aridum.Biotechnology Letters,2003,25(23):2035-2038.
[36]Abdulla HM,El-Shatoury SA.Actinomycetes in rice straw decomposition.Waste Management,2007,27(6):850-853.
[37]Qin S,Feng WW,Wang TT,Ding P,Xing K,Jiang JH.Plant growth-promoting effect and genomic analysis of the beneficial endophyte Streptomyces sp.KLBMP 5084isolated from halophyte Limonium sinense.Plant and Soil,2017,416(1/2):117-132.
[38]Qin S,Miao Q,Feng WW,Wang Y,Zhu X,Xing K,Jiang JH.Biodiversity and plant growth promoting traits of culturable endophytic actinobacteria associated with Jatropha curcas L.growing in Panxi dry-hot valley soil.Applied Soil Ecology,2015,93:47-55.
[39]Ali S,Kim WC.Plant growth promotion under water:decrease of waterlogging-induced ACC and ethylene levels by ACC deaminase-producing bacteria.Frontiers in Microbiology,2018,9:1096.
[40]Qin S,Feng WW,Xing K,Bai JL,Yuan B,Liu WJ,Jiang JH.Complete genome sequence of Kibdelosporangium phytohabitans KLBMP 1111T,a plant growth promoting endophytic actinomycete isolated from oil-seed plant Jatropha curcas L..Journal of Biotechnology,2015,216:129-130.
[41]Ogasawara Y,Torrez-Martinez N,Aragon AD,Yackley BJ,Weber JA,Sundararajan A,Ramaraj T,Edwards JS,Melan?on III CE.High-quality draft genome sequence of actinobacterium Kibdelosporangium sp.MJ126-NF4,producer of type II polyketide azicemicins,using Illumina and Pac Bio technologies.Genome Announcements,2015,3(2):e00114-15.
[42]Ma L,Kim J,Hatzenpichler R,Karymov MA,Hubert N,Hanan IM,Chang EB,Ismagilov RF.Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project’s Most Wanted taxa.Proceedings of the National Academy of Sciences of the United States of America,2014,111(27):9768-9773.
[43]Dong L,Chen DW,Liu SJ,Du W.Automated chemotactic sorting and single-cell cultivation of microbes using droplet microfluidics.Scientific Reports,2016,6:24192.
[44]Du C,van Wezel GP.Mining for microbial gems:integrating proteomics in the postgenomic natural product discovery pipeline.Proteomics,2018,18(18):e1700332.
[45]Choi SS,Katsuyama Y,Bai L,Deng ZX,Ohnishi Y,Kim ES.Genome engineering for microbial natural product discovery.Current Opinion in Microbiology,2018,45:53-60.
[2]Qin S,Xing K,Jiang JH,Xu LH,Li WJ.Biodiversity,bioactive natural products and biotechnological potential of plant-associated endophytic actinobacteria.Applied Microbiology and Biotechnology,2011,89(3):457-473.
[3]Tiwari K,Gupta RK.Rare actinomycetes:a potential storehouse for novel antibiotics.Critical Reviews in Biotechnology,2012,32(2):108-132.
[4]Dhakal D,Pokhrel AR,Shrestha B,Sohng JK.Marine rare actinobacteria:isolation,characterization,and strategies for harnessing bioactive compounds.Frontiers in Microbiology,2017,8:1106.
[5]Tian J,Chen HY,Guo ZY,Liu N,Li J,Huang Y,Xiang WS,Chen YH.Discovery of pentangular polyphenols hexaricins A-C from marine Streptosporangium sp.CGMCC 4.7309 by genome mining.Applied Microbiology and Biotechnology,2016,100(9):4189-4199.
[6]Shearer MC,Colman PM,Ferrin RM,Nisbet LJ,Nash IIICH.New genus of the Actinomycetales:Kibdelosporangium aridum gen.nov.,sp.nov..International Journal of Systematic Bacteriology,1986,36(1):47-54.
[7]Shearer MC,Actor P,Bowie BA,Grappel SF,Nash CH,Newman DJ,Oh YK,Pan CH,Nisbet LJ.Aridicins,novel glycopeptide antibiotics.I.taxonomy,production and biological activity.The Journal of Antibiotics,1985,38(5):555-560.
[8]Folena-Wasserman G,Poehland BL,Yeung EW,Staiger D,Killmer LB,Snader K,Dingerdissen JJ,Jeffs PW.Kibdelins(AAD-609),novel glycopeptide antibiotics.II.Isolation,purification and structure.The Journal of Antibiotics,1986,39(10):1395-1406.
[9]Tokiwa Y,Jarerat A.Biodegradation of poly(L-lactide).Biotechnology Letters,2004,26(10):771-777.
[10]Mertz FP,Yao RC.Kibdelosporangium philippinense sp.nov.isolated from soil.International Journal of Systematic Bacteriology,1988,38(3):282-286.
[11]Pascual J,González I,Estévez M,Benito P,Trujillo ME,Genilloud O.Description of Kibdelosporangium banguiense sp.nov.,a novel actinomycete isolated from soil of the forest of Pama,on the plateau of Bangui,Central African Republic.Antonie van Leeuwenhoek,2016,109(5):685-695.
[12]Xing K,Bian GK,Qin S,Klenk HP,Yuan B,Zhang YJ,Li WJ,Jiang JH.Kibdelosporangium phytohabitans sp.nov.,a novel endophytic actinomycete isolated from oil-seed plant Jatropha curcas L.containing1-aminocyclopropane-1-carboxylic acid deaminase.Antonie van Leeuwenhoek,2012,101(2):433-441.
[13]Li D,Huang YJ,Song SY,Xue C,Wu YY,Deng XM.Kibdelosporangium lantanae sp.nov.,isolated from the rhizosphere soil of an ornamental plant,Lantana camara L.International Journal of Systematic and Evolutionary Microbiology,2015,65(8):2581-2585.
[14]Cao YR,Yang WQ,Dao Y,Hu B,He ZK,Liang LM.Kibdelosporangium metalli sp.nov.,isolated from a rare earth mine.International Journal of Systematic and Evolutionary Microbiology,2017,67(1):101-107.
[15]Mingma R,Duangmal K,ōmura S,Takahashi Y,Matsumoto A.Three novel species of the genus Kibdelosporangium;Kibdelosporangium kanagawaense sp.nov.,Kibdelosporangium rhizosphaerae sp.nov.and Kibdelosporangium rhizovicinum sp.nov..International Journal of Systematic and Evolutionary Microbiology,2017,67(6):1758-1765.
[16]Zhi XY,Li WJ,Stackebrandt E.An update of the structure and 16S r RNA gene sequence-based definition of higher ranks of the class Actinobacteria,with the proposal of two new suborders and four new families and emended descriptions of the existing higher taxa.International Journal of Systematic and Evolutionary Microbiology,2009,59(3):589-608.
[17]Hatano M,Kinoshita N,Igarashi M,Nomoto A.Actinocrispum wychmicini gen.nov.,sp.nov.,a novel member of the family Pseudonocardiaceae,isolated from soil.International Journal of Systematic and Evolutionary Microbiology,2016,66(11):4779-4784.
[18]Lee SD.Labedaea rhizosphaerae gen.nov.,sp.nov.,isolated from rhizosphere soil.International Journal of Systematic and Evolutionary Microbiology,2012,62(8):1772-1778.
[19]Xia ZF,Guan TW,Ruan JS,Huang Y,Zhang LL.Longimycelium tulufanense gen.nov.,sp.nov.,a filamentous actinomycete of the family Pseudonocardiaceae.International Journal of Systematic and Evolutionary Microbiology,2013,63(8):2813-2818.
[20]Huang Y,Wang LM,Lu ZT,Hong L,Liu ZH,Tan GYA,Goodfellow M.Proposal to combine the genera Actinobispora and Pseudonocardia in an emended genus Pseudonocardia,and description of Pseudonocardia zijingensis sp.nov..International Journal of Systematic and Evolutionary Microbiology,2002,52(3):977-982.
[21]Shearer MC,Giovenella AJ,Grappel SF,Hedde RD,Mehta RJ,Oh YK,Pan CH,Pitkin DH,Nisbet LJ.Kibdelins,novel glycopeptide antibiotics.I.Discovery,production and biological evaluation.The Journal of Antibiotics,1986,39(10):1386-1394.
[22]Labeda DP,Kroppenstedt RM.Proposal for the new genus Allokutzneria gen.nov.within the suborder Pseudonocardineae and transfer of Kibdelosporangium albatum Tomita et al.1993 as Allokutzneria albata comb.nov..International Journal of Systematic and Evolutionary Microbiology,2008,58(Pt 6):1472-1475.
[23]Ranjani A,Gopinath PM,Rajesh K,Dhanasekaran D,Priyadharsini P.Diversity of silver nanoparticle synthesizing actinobacteria isolated from marine soil,Tamil Nadu,India.Arabian Journal for Science and Engineering,2016,41(1):25-32.
[24]Liu CB,Jiang Y,Wang XY,Chen DB,Chen X,Wang LS,Han L,Huang XH,Jiang CL.Diversity,antimicrobial activity,and biosynthetic potential of cultivable actinomycetes associated with lichen symbiosis.Microbial Ecology,2017,74(3):570-584.
[25]Qin S,Feng WW,Zhang YJ,Wang TT,Xiong YW,Xing K.Diversity of bacterial microbiota of coastal halophyte Limonium sinense and amelioration of salinity stress damage by symbiotic plant growth-promoting actinobacterium Glutamicibacter halophytocola KLBMP 5180.Applied and Environmental Microbiology,2018,84(19):e01533-18.
[26]Chung SK,Oh YK,Taylor P,Gerber R,Nisbet LJ.Biosynthetic studies of aridicin antibiotics.II.Microbial transformations and glycosylations by protoplasts.The Journal of Antibiotics,1986,39(5):652-659.
[27]Tsunakawa M,Komiyama N,Tenmyo O,Tomita K,Kawano K,Kotake C,Konishi M,Oki T.New antiviral antibiotics,cycloviracins B1 and B2.I.Production,isolation,physico-chemical properties and biological activity.The Journal of Antibiotics,1992,45(9):1467-1471.
[28]Ratnayake R,Lacey E,Tennant S,Gill JH,Capon RJ.Isokibdelones:novel heterocyclic polyketides from a Kibdelosporangium sp..Organic Letters,2006,8(23):5267-5270.
[29]Ratnayake R,Lacey E,Tennant S,Gill JH,Capon RJ.Kibdelones:novel anticancer polyketides from a rare Australian actinomycete.Chemistry,2007,13(5):1610-1619.
[30]Ogasawara Y,Liu HW.Biosynthetic studies of aziridine formation in azicemicins.Journal of the American Chemical Society,2009,131(50):18066-18068.
[31]Izumikawa M,Takagi M,Shin-Ya K.JBIR-78 and JBIR-95:phenylacetylated peptides isolated from Kibdelosporangium sp.AK-AA56.Journal of Natural Products,2012,75(2):280-284.
[32]Phillips JW,Goetz MA,Smith SK,Zink DL,Polishook J,Onishi R,Salowe S,Wiltsie J,Allocco J,Sigmund J,Dorso K,Lee S,Skwish S,de la Cruz M,Martín J,Vicente F,Genilloud O,Lu J,Painter RE,Young K,Overbye K,Donald RGK,Singh SB.Discovery of kibdelomycin,a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus.Chemistry&Biology,2011,18(8):955-965.
[33]Singh SB.Discovery and development of kibdelomycin,a new class of broad-spectrum antibiotics targeting the clinically proven bacterial type II topoisomerase.Bioorganic&Medicinal Chemistry,2016,24(24):6291-6297.
[34]Lin J,Zhou JW,Kang Z,Du GC,Chen J.Isolation,identification of poly lactic acid degrading microorganisms and optimization of the degradation process.Microbiology China,2013,40(9):1560-1569.(in Chinese)林娟,周景文,康振,堵国成,陈坚.聚乳酸降解菌株筛选鉴定及降解过程优化.微生物学通报,2013,40(9):1560-1569.
[35]Jarerat A,Tokiwa Y,Tanaka H.Poly(L-lactide)degradation by Kibdelosporangium aridum.Biotechnology Letters,2003,25(23):2035-2038.
[36]Abdulla HM,El-Shatoury SA.Actinomycetes in rice straw decomposition.Waste Management,2007,27(6):850-853.
[37]Qin S,Feng WW,Wang TT,Ding P,Xing K,Jiang JH.Plant growth-promoting effect and genomic analysis of the beneficial endophyte Streptomyces sp.KLBMP 5084isolated from halophyte Limonium sinense.Plant and Soil,2017,416(1/2):117-132.
[38]Qin S,Miao Q,Feng WW,Wang Y,Zhu X,Xing K,Jiang JH.Biodiversity and plant growth promoting traits of culturable endophytic actinobacteria associated with Jatropha curcas L.growing in Panxi dry-hot valley soil.Applied Soil Ecology,2015,93:47-55.
[39]Ali S,Kim WC.Plant growth promotion under water:decrease of waterlogging-induced ACC and ethylene levels by ACC deaminase-producing bacteria.Frontiers in Microbiology,2018,9:1096.
[40]Qin S,Feng WW,Xing K,Bai JL,Yuan B,Liu WJ,Jiang JH.Complete genome sequence of Kibdelosporangium phytohabitans KLBMP 1111T,a plant growth promoting endophytic actinomycete isolated from oil-seed plant Jatropha curcas L..Journal of Biotechnology,2015,216:129-130.
[41]Ogasawara Y,Torrez-Martinez N,Aragon AD,Yackley BJ,Weber JA,Sundararajan A,Ramaraj T,Edwards JS,Melan?on III CE.High-quality draft genome sequence of actinobacterium Kibdelosporangium sp.MJ126-NF4,producer of type II polyketide azicemicins,using Illumina and Pac Bio technologies.Genome Announcements,2015,3(2):e00114-15.
[42]Ma L,Kim J,Hatzenpichler R,Karymov MA,Hubert N,Hanan IM,Chang EB,Ismagilov RF.Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project’s Most Wanted taxa.Proceedings of the National Academy of Sciences of the United States of America,2014,111(27):9768-9773.
[43]Dong L,Chen DW,Liu SJ,Du W.Automated chemotactic sorting and single-cell cultivation of microbes using droplet microfluidics.Scientific Reports,2016,6:24192.
[44]Du C,van Wezel GP.Mining for microbial gems:integrating proteomics in the postgenomic natural product discovery pipeline.Proteomics,2018,18(18):e1700332.
[45]Choi SS,Katsuyama Y,Bai L,Deng ZX,Ohnishi Y,Kim ES.Genome engineering for microbial natural product discovery.Current Opinion in Microbiology,2018,45:53-60.