益肾种子丸治疗肾虚精亏型弱精子症的临床研究
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摘要
目的观察益肾种子丸对肾虚精亏型弱精子症患者精子活力的影响。方法将144例患者按随机数字表法分为治疗组(71例)和对照组(73例),治疗过程中脱落10例,完成134例,每组67例。治疗组给予益肾种子丸,每次6 g,每日2次;对照组给予五子衍宗丸,每次6 g,每日2次,两组疗程均为1个月。观察两组患者治疗前后精子活力变化,临床疗效及中医症状评分的变化。结果与本组治疗前比较,治疗后两组a级精子和a+b级精子百分率均增高(P<0.01),且治疗组高于对照组(P<0.05)。治疗组治疗后总有效率为77.61%(52/67),对照组总有效率为58.21%(39/67),两组比较,治疗组优于对照组(Z=-2.914,P=O.004)。与本组治疗前比较,两组治疗后症状积分均降低(P<0.01),治疗组积分差值高于对照组(P<0.01)。结论益肾种子丸治疗肾虚精亏型弱精子症疗效良好,可有效提高精子活力。
Objective To observe the effect of Yishen Zhongzi Pill(YZP) on the sperm motility of Shen-essence deficiency syndrome(SEDS) patients.Methods Totally 144 patients were randomly assigned to the treatment group(71 cases) and the control group(73 cases).Ten cases dropped out during the therapeutic course.A total of 134 patients completed this clinical study,67 in each group.Patients in the treatment group took YZP(6 g each time,twice daily),while those in the control group took Wuzi Yanzong Pill(6 g each time,twice daily).The therapeutic course for all was one month.Changes of the sperm motility,clinical efficacy,and Chinese medical symptoms scores were observed between the two groups before and after treatment.Results Compared with before treatment in the same group,percentages of class a spermatozoa and class a + b spermatozoa were enhanced in the two groups after treatment(P <0.01).Besides,they were higher in treatment group than in the control group(P <0.05).The total effective rate of the treatment group was 77.61%(52/67 cases),while it was 58.21%(39/67cases) in the control group.It was better in the treatment group than in the control group(Z=-2.914,P =0.004).Compared with before treatment in the same group,scores for Chinese medical symptoms decreased in the two groups(P <0.01).The difference of pre-post integrals was higher in the treatment group than in the control group(P <0.01).Conclusion YZP showed favorable effect in treating asthenospermia patients with SEDS and could effectively elevate the motility of sperm.
Objective To observe the effect of Yishen Zhongzi Pill(YZP) on the sperm motility of Shen-essence deficiency syndrome(SEDS) patients.Methods Totally 144 patients were randomly assigned to the treatment group(71 cases) and the control group(73 cases).Ten cases dropped out during the therapeutic course.A total of 134 patients completed this clinical study,67 in each group.Patients in the treatment group took YZP(6 g each time,twice daily),while those in the control group took Wuzi Yanzong Pill(6 g each time,twice daily).The therapeutic course for all was one month.Changes of the sperm motility,clinical efficacy,and Chinese medical symptoms scores were observed between the two groups before and after treatment.Results Compared with before treatment in the same group,percentages of class a spermatozoa and class a + b spermatozoa were enhanced in the two groups after treatment(P <0.01).Besides,they were higher in treatment group than in the control group(P <0.05).The total effective rate of the treatment group was 77.61%(52/67 cases),while it was 58.21%(39/67cases) in the control group.It was better in the treatment group than in the control group(Z=-2.914,P =0.004).Compared with before treatment in the same group,scores for Chinese medical symptoms decreased in the two groups(P <0.01).The difference of pre-post integrals was higher in the treatment group than in the control group(P <0.01).Conclusion YZP showed favorable effect in treating asthenospermia patients with SEDS and could effectively elevate the motility of sperm.
引文
[1]郭军,常德贵主编.中西医结合男科治疗学[M].北京:人民军医出版社,2003:245—256.
[2]Kumar R,Gautam G,Gupta NP.Drug therapy for idiopathic male infertility:rationale versus evidence[J].Urology,2006,176(4Pt1):1307-1312.
[3]郭军,张春影.龟龄集胶囊治疗少弱精子症的疗效观察[J].中国男科学杂志,2009,48(7):50.
[4]世界卫生组织.世界卫生组织男性不育标准化检查与诊疗手册[M].北京:人民卫生出版社,2007:3—21.
[5]国家中医药管理局.中医临床诊疗术语证候部分[M].北京:中国标准出版社,1997:33—34.
[6]郑莜萸主编.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:129—134.
[7]Tang X,Zhang J.Cai Y,et al.Sperm membrane protein(hSMP-1)and RanBPM complex in the microtubule-organizing centre[J].Mol Med,2004,82(6):383-388.
[8]Bohring C,Krause W.Characterization of spermatozoa surface antigens by antisperm antibodies and its influence on acrosomal exocytosis[J].Am J Reprod Immunol,2003,50(5):411-419.
[9]王旭均,李海松.补肾法治疗男性不育症探析[J].中华中医药学刊,201 1,29(2):289—290.
[10]商学军,黄宇烽,李克,等.L-肉碱治疗附睾结节伴弱精子症初步观察[J].中华男科学杂志,2004,10(9):671—675.
[1 1]廖芝健,周建甫,殷振超,等.短程补肾疗法对肾虚型弱精子症患者近期精液质量的影响研究[J].中华男科学杂志,2013,19(2):159—162.
[12]王德俊,盛树青,梁虹.肉苁蓉对小鼠睾丸和附睾形态学及组织化学的影响[J].解剖学研究,2000,22(2):101—103.
[13]欧阳臻,陈钧.桑叶的化学成分及其药理作用研究进展[J].江苏大学学报(自然科学版),2003,24(6):39—44.
[14]王淑兰,王宜,李淑连,等.红景天素抗老化作用的实验研究[J].白求恩医科大学学报,1991,17(6):542.
[15]郭军,宋春生,耿强,等.六五生精汤治疗少、弱精子症不育的临床观察[J].中国中西医结合杂志,2007,27(11):986—988.
[2]Kumar R,Gautam G,Gupta NP.Drug therapy for idiopathic male infertility:rationale versus evidence[J].Urology,2006,176(4Pt1):1307-1312.
[3]郭军,张春影.龟龄集胶囊治疗少弱精子症的疗效观察[J].中国男科学杂志,2009,48(7):50.
[4]世界卫生组织.世界卫生组织男性不育标准化检查与诊疗手册[M].北京:人民卫生出版社,2007:3—21.
[5]国家中医药管理局.中医临床诊疗术语证候部分[M].北京:中国标准出版社,1997:33—34.
[6]郑莜萸主编.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:129—134.
[7]Tang X,Zhang J.Cai Y,et al.Sperm membrane protein(hSMP-1)and RanBPM complex in the microtubule-organizing centre[J].Mol Med,2004,82(6):383-388.
[8]Bohring C,Krause W.Characterization of spermatozoa surface antigens by antisperm antibodies and its influence on acrosomal exocytosis[J].Am J Reprod Immunol,2003,50(5):411-419.
[9]王旭均,李海松.补肾法治疗男性不育症探析[J].中华中医药学刊,201 1,29(2):289—290.
[10]商学军,黄宇烽,李克,等.L-肉碱治疗附睾结节伴弱精子症初步观察[J].中华男科学杂志,2004,10(9):671—675.
[1 1]廖芝健,周建甫,殷振超,等.短程补肾疗法对肾虚型弱精子症患者近期精液质量的影响研究[J].中华男科学杂志,2013,19(2):159—162.
[12]王德俊,盛树青,梁虹.肉苁蓉对小鼠睾丸和附睾形态学及组织化学的影响[J].解剖学研究,2000,22(2):101—103.
[13]欧阳臻,陈钧.桑叶的化学成分及其药理作用研究进展[J].江苏大学学报(自然科学版),2003,24(6):39—44.
[14]王淑兰,王宜,李淑连,等.红景天素抗老化作用的实验研究[J].白求恩医科大学学报,1991,17(6):542.
[15]郭军,宋春生,耿强,等.六五生精汤治疗少、弱精子症不育的临床观察[J].中国中西医结合杂志,2007,27(11):986—988.