宣肺通便方治疗功能性便秘疗效观察及对胃肠激素、结肠传输功能的影响
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摘要
目的观察宣肺通便方治疗功能性便秘的临床疗效及对胃肠激素、结肠传输功能的影响。方法将100例功能性便秘患者按照随机数字表法分为2组。对照组50例予麻仁丸治疗;治疗组50例予宣肺通便方治疗。2组均连续治疗4周,比较2组治疗前后血清胃肠激素[胃动素(MTL)、胃泌素(GAS)、血管活性肠肽(VIP)]、结肠传输功能,并统计临床疗效及不良反应发生情况。结果治疗组总有效率92.00%,对照组总有效率75.00%,治疗组疗效优于对照组(P<0.05)。治疗后2组血清MTL、GAS、VIP水平均明显升高(P<0.05,P<0.01),治疗组血清MTL、GAS、VIP水平均高于对照组(P<0.05)。治疗后2组右半结肠、左半结肠、乙状结肠直肠、全结肠传输时间均明显缩短(P<0.05,P<0.01),且治疗组均明显短于对照组(P<0.05,P<0.01)。2组不良反应比较差异无统计学意义(P>0.05)。结论宣肺通便方能提高功能性便秘患者胃肠激素水平,改善结肠传输功能,提高临床疗效,且用药安全。
引文
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[19] 郑晨辉,徐小宏,孙秋华,等.参黄散外敷对术后肠功能障碍大鼠结肠传输时间及血浆胃肠激素水平的影响[J].浙江临床医学,2018,20(3):400-402.
[20] 段永强,程卫东,成映霞,等.四君子汤和理中汤干预腹泻型IBS大鼠胃肠转运功能和P物质、胆囊收缩素的比较研究[J].中成药,2015,37(2):405-408.
[21] 张晓旭,陈云,王晓超.厚朴排气合剂对瘢痕子宫产妇二次剖宫产后胃肠功能及泌乳的影响[J].河北中医,2018,40(3):358-362,366.
[22] 费春娟.结肠传输功能试验对慢性功能性便秘的诊断作用分析[J].基层医学论坛,2016,20(1):155-156.
[23] Shin A,Acosta A,Camilleri M,et al.A randomized trial of 5-hydroxytryptamine4-receptor agonist,YKP10811,on colonic transit and bowel function in functional constipation[J].Clin Gastroenterol Hepatol,2015,13(4):701-708.
[2] Jarmuz A,Zielinska M,Storr M,et al.Emerging treatments in Neurogastroenterology:Perspectives of guanylyl cyclase C agonists use in functional gastrointestinal disorders and inflammatory bowel diseases[J].Neurogastroenerol Motil,2015,27(8):1057-1068.
[3] 彭随风,时昭红,石拓,等.黄芪当归汤联合莫沙比利治疗功能性便秘的疗效及对血清胃肠激素水平的影响[J].现代生物医学进展,2018,18(2):321-325.
[4] Koppen IJN,van Wassenaer EA,Barendsen RW,et al.Adherence to Polyethylene Glycol Treatment in Children with Functional Constipation Is Associated with Parental Illness Perceptions,Satisfaction with Treatment,and Perceived Treatment Convenience[J].J Pediatr,2018,199:132-139.
[5] 王北辰,康斐.通乐颗粒治疗慢性功能性便秘阴虚肠燥证临床研究[J].中医学报,2015,30(9):1354-1356.
[6] 中华医学会消化病学分会胃肠动力学组,中华医学会外科学分会结直肠肛门外科学组.中国慢性便秘诊治指南(2013年,武汉)[J].胃肠病学,2013,18(10):605-612.
[7] 中华中医药学会脾胃病分会.慢性便秘中医诊疗共识意见(2009,深圳)[J].中国中西医结合消化杂志,2010,18(2):136-139.
[8] 周仲瑛.中医内科学[M].北京:中国中医药出版社,2007:249-253.
[9] Reck-Burneo CA,Vilanova-Sanchez A,Gasior AC,et al.A structured bowel management program for patients with severe functional constipation can help decrease emergency department visits,hospital admissions,and healthcare costs[J].J Pediatr Surg,2018,53(9):1737-1741.
[10] 周峰,张旗,张永安,等.益气养阴方治疗慢性功能性便秘(气阴两虚证)的临床研究[J].河北中医,2017,39(11):1646-1649.
[11] 徐年年,熊秀萍.功能性便秘从肺论治[J].吉林中医药,2016,36(3):240-243.
[12] 唐容川.血证论[M].北京:人民卫生出版社,2005:22-23.
[13] 宁月季,张蔚,林琳.功能性便秘与胃肠激素的关系[J].国际内科学杂志,2009,36(7):399-404.
[14] Ge Z,Duan Z,Yang H,et al.Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids[J].Evid Based Complement Alternat Med,2018,2018:2086163.
[15] 向薇.艾灸腹部穴位治疗慢性肾脏病合并功能性便秘的临床研究[J].现代中西医结合杂志,2018,27(17):1906-1909.
[16] Jia R,Xing HJ,Zhang XP,et al.Effects of Different Acupuncture and Moxibustion Methods on Plasma NO,NOS and VIP Contents and the Expression of Colonic VIP Protein in Functional Constipation Rats[J].Zhen Ci Yan Jiu,2017,42(1):50-55.
[17] 常东,汪栋材,李健,等.中医辨证治疗功能性便秘对患者胃肠激素和NO含量的影响[J].中国中西医结合消化杂志,2015,23(11):756-759.
[18] 王毅,李宇航,郑丰杰,等.宣肺中药对小鼠肠道传输功能减缓的调节作用[J].中华中医药学刊,2011,29(4):731-733.
[19] 郑晨辉,徐小宏,孙秋华,等.参黄散外敷对术后肠功能障碍大鼠结肠传输时间及血浆胃肠激素水平的影响[J].浙江临床医学,2018,20(3):400-402.
[20] 段永强,程卫东,成映霞,等.四君子汤和理中汤干预腹泻型IBS大鼠胃肠转运功能和P物质、胆囊收缩素的比较研究[J].中成药,2015,37(2):405-408.
[21] 张晓旭,陈云,王晓超.厚朴排气合剂对瘢痕子宫产妇二次剖宫产后胃肠功能及泌乳的影响[J].河北中医,2018,40(3):358-362,366.
[22] 费春娟.结肠传输功能试验对慢性功能性便秘的诊断作用分析[J].基层医学论坛,2016,20(1):155-156.
[23] Shin A,Acosta A,Camilleri M,et al.A randomized trial of 5-hydroxytryptamine4-receptor agonist,YKP10811,on colonic transit and bowel function in functional constipation[J].Clin Gastroenterol Hepatol,2015,13(4):701-708.