普芦卡必利与伊托必利在慢性便秘患者肠道准备中的效果比较
|
摘要
目的比较普芦卡必利与伊托必利联合复方聚乙二醇电解质散在结肠镜检查前肠道准备的效果。方法选取拟行结肠镜检查的慢性便秘患者160例,随机分为普芦卡必利组和伊托必利组,每组80例。普芦卡必利组检查前3d开始口服普芦卡必利2mg,1次/d,检查当日服用复方聚乙二醇电解质散;伊托必利组检查前3d开始口服伊托必利50mg,3次/d,检查当日服用复方聚乙二醇电解质散。比较2组肠道清洁程度、息肉检出率、到达回盲部时间及不良反应发生情况。结果普芦卡必利组波士顿肠道准备量表评分和息肉检出率高于伊托必利组,到达回盲部时间短于伊托必利组,差异均有统计学意义(P<0.05);2组不良反应发生率差异无统计学意义(P>0.05)。结论普芦卡必利联合复方聚乙二醇电解质散在便秘患者肠道准备中的效果优于伊托必利联合复方聚乙二醇电解质散。
Objective To compare the effect of prucalopride and itopride combined with polyethylene glycol electrolyte in bowel preparation before colonoscopy.Methods Totally 160 chronic constipation patients scheduled for colonoscopy were randomly divided into prucalopride and itopride groups,80 cases in each group.Patients in prucalopride group started taking prucalopride 2 mg per day three days before colonoscopy,and taking the polyethylene glycol electrolyte on the day of colonoscopy;patients in itopride group started taking itopride 50 mg 3 times per day three days before colonoscopy,and taking the polyethylene glycol electrolyte on the day of colonoscopy.The bowel preparation quality,polyp detection rate,time of reaching the ileocecal junction and adverse reactions were compared between the two groups.Results The Boston Bowel Preparation Scale score of the bowel preparation quality and the polyp detection rate of the prucaropride group were higher than that of the itopride group,and the time of reaching the ileocecal group was shorter than that of the itopride group,there was a statistical differences in the two groups(P<0.05).There was no significant difference in the incidence rate of adverse reaction between the two groups(P>0.05).Conclusion The effect of prucalopride combined with polyethylene glycol electrolyte for colonscopy preparation is better than itopride combined with polyethylene glycol electrolyte.
Objective To compare the effect of prucalopride and itopride combined with polyethylene glycol electrolyte in bowel preparation before colonoscopy.Methods Totally 160 chronic constipation patients scheduled for colonoscopy were randomly divided into prucalopride and itopride groups,80 cases in each group.Patients in prucalopride group started taking prucalopride 2 mg per day three days before colonoscopy,and taking the polyethylene glycol electrolyte on the day of colonoscopy;patients in itopride group started taking itopride 50 mg 3 times per day three days before colonoscopy,and taking the polyethylene glycol electrolyte on the day of colonoscopy.The bowel preparation quality,polyp detection rate,time of reaching the ileocecal junction and adverse reactions were compared between the two groups.Results The Boston Bowel Preparation Scale score of the bowel preparation quality and the polyp detection rate of the prucaropride group were higher than that of the itopride group,and the time of reaching the ileocecal group was shorter than that of the itopride group,there was a statistical differences in the two groups(P<0.05).There was no significant difference in the incidence rate of adverse reaction between the two groups(P>0.05).Conclusion The effect of prucalopride combined with polyethylene glycol electrolyte for colonscopy preparation is better than itopride combined with polyethylene glycol electrolyte.
引文
[1] Yi LJ,Tian X,Pi YP,et al.Comparative efficacy of lowvolume versus traditional standard volume PEG on bowelpreparation before colonoscopy:Protocol for an updated meta-analysis with trial sequential analysis[J]. Medicine(Baltimore),2018,97(17):e0599.
[2] 王晓武,盛桂仙,姚杏荣.快速肠道准备对结直肠术后肠道黏膜屏障功能的影响[J].河北医科大学学报,2012,33(2):157-160.
[3] 陈子洋,刘晓岗,胡晓,等.普芦卡必利在女性慢性便秘患者肠镜检查前肠道准备中的应用[J].四川医学,2016,37(3):281-283.
[4] 李彦,刘会永.伊托必利在便秘患者结肠镜前肠道准备中的应用价值[J].安徽医药,2014,18(4):753-754.
[5] Yiannakou Y,Piessevaux H,Bouchoucha M,et al.Arandomized,double-blind,placebo-controlled,phase 3trial toevaluate the efficacy,safety,and tolerability of prucalopride inmen with chronic constipation[J].Am J Gastroenterol,2015,110(5):741-748.
[6] 中华医学会消化病学分会胃肠动力学组,中华医学会外科学分会结直肠肛门外科学组.中国慢性便秘诊治指南(2013年,武汉)[J].中华消化杂志,2013,33(5):291-297.
[7] Calderwood AH,Schroy Pc 3rD,Lieberman DA,et al.Bostonbowel preparation scale scores provide a standardizeddefinition of adequate for describing bowel cleanliness[J].Gastrointest Endosc,2014,80(2):269-276.
[8] Anderson JC,Butterly LF,Robinson CM,et al.Impact of fairbowel preparation quality on adenoma and serrated polypdetection:data from the New Hampshire ColonoscopyRegistry by using a standardized preparation-quality rating[J].Gastrointest Endosc,2014,80(3):463-470.
[9] Martens P,Bisschops R.Bowel preparation for colonoscopy:efficacy,tolerability and safety[J].Acta Gastroenterol Belg,2014,77(2):249-255.
[10] Holt EW,Yimam KK,Ma H,et al.Patient tolerability ofbowel preparation is associated with polyp detection rateduring colonoscopy[J].J Gastrointestin Liver Dis,2014,23(2):135-140.
[11] Sbahi H,Cash BD.Chronic Constipation:a Review of CurrentLiterature[J].Curr Gastroenterol Rep,2015,17(12):47.
[12] Vazquez Roque M, Bouras EP. Epidemiology andmanagement of chronic constipation in elderly patients[J].Clin Interv Aging,2015,10:919-930.
[13] Black CJ,Burr NE,Quigley EMM,et al.Efficacy ofSecretagogues in Patients With Irritable Bowel SyndromeWith Constipation:Systematic Review and Network Meta-analysis[J].Gastroenterology,2018,155(6):1753-1763.
[14] Costilla VC,Foxx-Orenstein AE.Constipation:understandingmechanisms and management[J],2014,30(1):107-115.
[15] Parente F,Vailati C,Bargiggia S,et al.2-Litre polyethyleneglycol-citrate-simethicone plus bisacodyl versus 4-litrepolyethylene glycol as preparation for colonoscopy in chronicconstipation[J].Dig Liver Dis,2015,7(10):857-863.
[16] Basch CH,Hillyer GC,Basch CE,et al.Characteristicsassociated with suboptimal bowel preparation prior tocolonoscopy:results of a national survey[J].Int J Prev Med,2014,5(2):233-237.
[17] Lyons BL,Korsten MA,Spungen AM,et al.Comparisonbetween pulsed irrigation enhanced evacuation andpolyethylene glycol-electrolyte lavage solution for bowelpreparation prior to elective colonoscopy in veterans withspinal cord injury[J].J Spinal Cord Med,2015,38(6):805-811.
[18] Abid S,Jafri W,Zaman MU,et al.Itopride for gastricvolume,gastric emptying and drinking capacity in functionaldyspepsia[J].World J Gastrointest Pharmacol Ther,2017,8(1):74-80.
[19] Tack J,Camilleri M,Dubois D,et al.Association betweenhealth-related quality of life and symptoms in patients withchronic constipation:an integrated analysis of three phase 3trials of prucalopride[J].Neurogastroenterol Motil,2015,27(3):397-405.
[2] 王晓武,盛桂仙,姚杏荣.快速肠道准备对结直肠术后肠道黏膜屏障功能的影响[J].河北医科大学学报,2012,33(2):157-160.
[3] 陈子洋,刘晓岗,胡晓,等.普芦卡必利在女性慢性便秘患者肠镜检查前肠道准备中的应用[J].四川医学,2016,37(3):281-283.
[4] 李彦,刘会永.伊托必利在便秘患者结肠镜前肠道准备中的应用价值[J].安徽医药,2014,18(4):753-754.
[5] Yiannakou Y,Piessevaux H,Bouchoucha M,et al.Arandomized,double-blind,placebo-controlled,phase 3trial toevaluate the efficacy,safety,and tolerability of prucalopride inmen with chronic constipation[J].Am J Gastroenterol,2015,110(5):741-748.
[6] 中华医学会消化病学分会胃肠动力学组,中华医学会外科学分会结直肠肛门外科学组.中国慢性便秘诊治指南(2013年,武汉)[J].中华消化杂志,2013,33(5):291-297.
[7] Calderwood AH,Schroy Pc 3rD,Lieberman DA,et al.Bostonbowel preparation scale scores provide a standardizeddefinition of adequate for describing bowel cleanliness[J].Gastrointest Endosc,2014,80(2):269-276.
[8] Anderson JC,Butterly LF,Robinson CM,et al.Impact of fairbowel preparation quality on adenoma and serrated polypdetection:data from the New Hampshire ColonoscopyRegistry by using a standardized preparation-quality rating[J].Gastrointest Endosc,2014,80(3):463-470.
[9] Martens P,Bisschops R.Bowel preparation for colonoscopy:efficacy,tolerability and safety[J].Acta Gastroenterol Belg,2014,77(2):249-255.
[10] Holt EW,Yimam KK,Ma H,et al.Patient tolerability ofbowel preparation is associated with polyp detection rateduring colonoscopy[J].J Gastrointestin Liver Dis,2014,23(2):135-140.
[11] Sbahi H,Cash BD.Chronic Constipation:a Review of CurrentLiterature[J].Curr Gastroenterol Rep,2015,17(12):47.
[12] Vazquez Roque M, Bouras EP. Epidemiology andmanagement of chronic constipation in elderly patients[J].Clin Interv Aging,2015,10:919-930.
[13] Black CJ,Burr NE,Quigley EMM,et al.Efficacy ofSecretagogues in Patients With Irritable Bowel SyndromeWith Constipation:Systematic Review and Network Meta-analysis[J].Gastroenterology,2018,155(6):1753-1763.
[14] Costilla VC,Foxx-Orenstein AE.Constipation:understandingmechanisms and management[J],2014,30(1):107-115.
[15] Parente F,Vailati C,Bargiggia S,et al.2-Litre polyethyleneglycol-citrate-simethicone plus bisacodyl versus 4-litrepolyethylene glycol as preparation for colonoscopy in chronicconstipation[J].Dig Liver Dis,2015,7(10):857-863.
[16] Basch CH,Hillyer GC,Basch CE,et al.Characteristicsassociated with suboptimal bowel preparation prior tocolonoscopy:results of a national survey[J].Int J Prev Med,2014,5(2):233-237.
[17] Lyons BL,Korsten MA,Spungen AM,et al.Comparisonbetween pulsed irrigation enhanced evacuation andpolyethylene glycol-electrolyte lavage solution for bowelpreparation prior to elective colonoscopy in veterans withspinal cord injury[J].J Spinal Cord Med,2015,38(6):805-811.
[18] Abid S,Jafri W,Zaman MU,et al.Itopride for gastricvolume,gastric emptying and drinking capacity in functionaldyspepsia[J].World J Gastrointest Pharmacol Ther,2017,8(1):74-80.
[19] Tack J,Camilleri M,Dubois D,et al.Association betweenhealth-related quality of life and symptoms in patients withchronic constipation:an integrated analysis of three phase 3trials of prucalopride[J].Neurogastroenterol Motil,2015,27(3):397-405.