维生素C的作用及常见不良反应
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摘要
维生素C是人体所必需的一种微量营养元素,具有多种生物学功能,大剂量摄入维生素C可能引起血栓、结石、草酸盐肾病等不良反应,且过量服用维生素C的病例时有发生。本文总结了维生素C在抗肿瘤、抗氧化、抗衰老和眼病治疗等方面的功能、作用分子机制及临床应用做一综述,并总结维生素C过量引起的泌尿结石和肾脏损伤的常见不良反应,为临床上合理应用维生素C提供参考。
Vitamin C is an essential micronutrient element in the human body and has a variety of biological functions. In this paper, the function of vitamin C in antitumor, anti-oxidation, anti-senility and eye disease treatment, as well as the molecular mechanism and the clinical applications are summarized. However, in taking large doses of vitamin C causes blood clots, kidney stones, oxalate kidney disease and other adverse reactions, which are sometime observed in clinic. The side-effects of overtaking vitamin C including blood clot, urinary system stone and oxalate nephropathy are also discussed to provide certain reference for rational use of vitamin C in clinic.
Vitamin C is an essential micronutrient element in the human body and has a variety of biological functions. In this paper, the function of vitamin C in antitumor, anti-oxidation, anti-senility and eye disease treatment, as well as the molecular mechanism and the clinical applications are summarized. However, in taking large doses of vitamin C causes blood clots, kidney stones, oxalate kidney disease and other adverse reactions, which are sometime observed in clinic. The side-effects of overtaking vitamin C including blood clot, urinary system stone and oxalate nephropathy are also discussed to provide certain reference for rational use of vitamin C in clinic.
引文
[1]Kim S M, Lim S M, Yoo J A, et al. Consumption of high-dose vitamin C(1250mg per day)enhances functional and structural properties of serum lipoprotein to improve anti-oxidant, anti-atherosclerotic, and anti-aging effects via regulation of anti-inflammatory microRNA[J]. Food&function, 2015,6(11):3604-3612.
[2]Chen P, Stone J, Sullivan G, et al. Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models[J]. Free Radical Biology and Medicine, 2011, 51(3):681-687.Olsen SC. Recent developments in livestock and wildlife brucellosis vaccination[J].Rev Sci Tech, 2013, 32(1):207-217.
[3]Yun J, Mullarky E, Lu C, et al. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH[J]. Science, 2015,350(6266):1391-1396.
[4]张琳刚,刘静.维生素C对奥沙利铂诱导胃癌BGC-823细胞的增殖抑制和诱导凋亡作用研究[J].中国全科医学,2016,19(B12):80-82.
[5]Park S, Ahn S, Shin Y, et al. Vitamin C in cancer:A metabolomics perspective[J]. Frontiers in physiology,2018,9:762.
[6]金增霜,李积德.Ki67, P53, Her-2在乳腺癌中的表达及其相关性[J].医学信息, 2010, 23(1):278-230.
[7]Cho S, Chae J S, Shin H, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2expression[J]. Scientific reports,2018, 8(1):11372.
[8]Wei W, Li L, Zhang Y, et al. Vitamin C protected human retinal pigmented epithelium from oxidant injury depending on regulating SIRT1[J]. The Scientific World Journal,2014,2014.
[9]徐丽超,许静.维生素C注射液治疗高锰酸钾眼部烧伤的的疗效观察[J].河北医药,2011,33(24):3761-3762.
[10]Domith I, Socodato R, Portugal C C, et al. Vitamin C modulates glutamate transport and NMDA receptor function in the retina[J].Journal of neuroche mistry,2018,144(4):408-420.
[11]郭刚.维生素C治疗角膜炎、角膜溃疡患者的效果观察[J].中国实用医药, 2018, 13(16):139-141.
[12]Wei L, Liang G, Cai C, et al. Association of vitamin C with the risk of age-related cataract:a meta-analysis[J].Acta ophthalmologica,2016, 94(3):e170-e176.
[13]Kwak J Y, Park S, Seok J K, et al. Ascorbyl coumarates as multifunctional cosmeceutical agents that inhibit melanogenesis and enhance collagen synthesis[J]. Archives of dermatological research, 2015, 307(7):635-643.
[14]张兰芳,雷英,刘鸿雁.光子嫩肤合并左旋维生素C导入治疗面部黄褐斑的临床观察[J].华西医学,2011,26(4):544-546.
[15]Barbosa NS, Kalaaji AN. CAM use in dermatology. Is there a potential role for honey, green tea, and vitamin C Complementary. Therapies inclinicalPrac tice,2014,20(1):11-15.
[16]Crisan D, Roman I, Crisan M, et al. The role of vitamin C in pushing back the boundaries of skin aging:an ultrasonographic approach[J]. Clinical,cosmetic and investigational dermatology, 2015, 8:463.
[17]张立新,高志星.大剂量维生素C对肠易激综合征细胞免疫功能的影响[J].山东医药, 2012, 52(1):90-91.
[18]Vollbracht C, Raithel M, Raithel M, Krick B, et al. Intravenous vitamin C in the treatment of allergies:an interim subgroup analysis of a longterm observational study[J].Journal of InternationalMedicalResear ch,2018:46(9):3640-3655.
[19]杨青峰.联用小柴胡汤和维生素C治疗免疫性血小板减少症的效果分析[J].当代医药论丛, 2015(22):36-37.
[20]Huijskens M, Walczak M, Koller N, et al. Technical Advance:Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells[J].Journal of leukocyte biology,2014, 96(6):1165-1175.
[21]Manning J, Mitchell B, Appadurai D A, et al. Vitamin C promotes maturation of T-cells[J].Antioxidants&redox signaling,2013, 19(17):2054-2067.
[22]Van Gorkom G, Klein Wolterink R, Van Elssen C, et al. Influence of vitamin C on lymphocytes:An overview[J].Antioxidants, 2018, 7(3):41.
[23]王晓玉,李伟.肾病综合征患者免疫功能紊乱研究进展[J].医学信息:上旬刊, 2010, 23(19):3714-3715.
[24]Ozkanlar S, Akcay F. Antioxidant vitamins in atherosclerosis-animal experiments and clinical studies[J].Adv Clin Exp Med, 2012, 21(1):115-123.
[25]王廷海,付研.维生素C在2型糖尿病合并尿路感染治疗中的疗效观察[J].中国医药导刊,2015(3):280-281.
[26]旷焱平,王林静,钟淑婷,等. 2型糖尿病并发感染者血清维生素和免疫水平分析及临床护理研究[J].护士进修杂志,2012, 27(4):299-301.
[27]易莲,张松筠.维生素C对老年2型糖尿病患者记忆功能障碍的影响[J].疑难病杂志,2011, 10(2):104-106.
[28]Kim K, Bae O N, Koh S H, et al. High-dose vitamin C injection to cancer patients may promote thrombosis through procoagulant activation of erythrocytes[J]. Toxicological Sciences, 2015, 147(2):350-359.
[29]Ferraro P M, Curhan G C, Gambaro G, Gambaro G, et al. Total, dietary,and supplemental vitamin C intake and risk of incident kidney stones[J].American Journal of Kidney Diseases, 2016, 67(3):400-407.
[30]Chen X, Shen L, Gu X, et al. High-dose supplementation with vitamin C-induced pediatric urolithiasis:the first case report in a child and literature review[J]. Urology, 2014, 84(4):922-924.
[31]Lamarche J, Nair R, Peguero A, et al. Vitamin C-induced oxalate nephropathy[J]. International journal of nephrology, 2011, 2(2):78-88.
[32]Yaich S, Chaabouni Y, Charfeddine K, et al. Secondary oxalosis due toexcess vitamin C intake:a cause of graft loss in a renal transplant recipient[J]. Saudi Journal of Kidney Diseases and Transplantation, 2014, 25(1):113.
[2]Chen P, Stone J, Sullivan G, et al. Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models[J]. Free Radical Biology and Medicine, 2011, 51(3):681-687.Olsen SC. Recent developments in livestock and wildlife brucellosis vaccination[J].Rev Sci Tech, 2013, 32(1):207-217.
[3]Yun J, Mullarky E, Lu C, et al. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH[J]. Science, 2015,350(6266):1391-1396.
[4]张琳刚,刘静.维生素C对奥沙利铂诱导胃癌BGC-823细胞的增殖抑制和诱导凋亡作用研究[J].中国全科医学,2016,19(B12):80-82.
[5]Park S, Ahn S, Shin Y, et al. Vitamin C in cancer:A metabolomics perspective[J]. Frontiers in physiology,2018,9:762.
[6]金增霜,李积德.Ki67, P53, Her-2在乳腺癌中的表达及其相关性[J].医学信息, 2010, 23(1):278-230.
[7]Cho S, Chae J S, Shin H, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2expression[J]. Scientific reports,2018, 8(1):11372.
[8]Wei W, Li L, Zhang Y, et al. Vitamin C protected human retinal pigmented epithelium from oxidant injury depending on regulating SIRT1[J]. The Scientific World Journal,2014,2014.
[9]徐丽超,许静.维生素C注射液治疗高锰酸钾眼部烧伤的的疗效观察[J].河北医药,2011,33(24):3761-3762.
[10]Domith I, Socodato R, Portugal C C, et al. Vitamin C modulates glutamate transport and NMDA receptor function in the retina[J].Journal of neuroche mistry,2018,144(4):408-420.
[11]郭刚.维生素C治疗角膜炎、角膜溃疡患者的效果观察[J].中国实用医药, 2018, 13(16):139-141.
[12]Wei L, Liang G, Cai C, et al. Association of vitamin C with the risk of age-related cataract:a meta-analysis[J].Acta ophthalmologica,2016, 94(3):e170-e176.
[13]Kwak J Y, Park S, Seok J K, et al. Ascorbyl coumarates as multifunctional cosmeceutical agents that inhibit melanogenesis and enhance collagen synthesis[J]. Archives of dermatological research, 2015, 307(7):635-643.
[14]张兰芳,雷英,刘鸿雁.光子嫩肤合并左旋维生素C导入治疗面部黄褐斑的临床观察[J].华西医学,2011,26(4):544-546.
[15]Barbosa NS, Kalaaji AN. CAM use in dermatology. Is there a potential role for honey, green tea, and vitamin C Complementary. Therapies inclinicalPrac tice,2014,20(1):11-15.
[16]Crisan D, Roman I, Crisan M, et al. The role of vitamin C in pushing back the boundaries of skin aging:an ultrasonographic approach[J]. Clinical,cosmetic and investigational dermatology, 2015, 8:463.
[17]张立新,高志星.大剂量维生素C对肠易激综合征细胞免疫功能的影响[J].山东医药, 2012, 52(1):90-91.
[18]Vollbracht C, Raithel M, Raithel M, Krick B, et al. Intravenous vitamin C in the treatment of allergies:an interim subgroup analysis of a longterm observational study[J].Journal of InternationalMedicalResear ch,2018:46(9):3640-3655.
[19]杨青峰.联用小柴胡汤和维生素C治疗免疫性血小板减少症的效果分析[J].当代医药论丛, 2015(22):36-37.
[20]Huijskens M, Walczak M, Koller N, et al. Technical Advance:Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells[J].Journal of leukocyte biology,2014, 96(6):1165-1175.
[21]Manning J, Mitchell B, Appadurai D A, et al. Vitamin C promotes maturation of T-cells[J].Antioxidants&redox signaling,2013, 19(17):2054-2067.
[22]Van Gorkom G, Klein Wolterink R, Van Elssen C, et al. Influence of vitamin C on lymphocytes:An overview[J].Antioxidants, 2018, 7(3):41.
[23]王晓玉,李伟.肾病综合征患者免疫功能紊乱研究进展[J].医学信息:上旬刊, 2010, 23(19):3714-3715.
[24]Ozkanlar S, Akcay F. Antioxidant vitamins in atherosclerosis-animal experiments and clinical studies[J].Adv Clin Exp Med, 2012, 21(1):115-123.
[25]王廷海,付研.维生素C在2型糖尿病合并尿路感染治疗中的疗效观察[J].中国医药导刊,2015(3):280-281.
[26]旷焱平,王林静,钟淑婷,等. 2型糖尿病并发感染者血清维生素和免疫水平分析及临床护理研究[J].护士进修杂志,2012, 27(4):299-301.
[27]易莲,张松筠.维生素C对老年2型糖尿病患者记忆功能障碍的影响[J].疑难病杂志,2011, 10(2):104-106.
[28]Kim K, Bae O N, Koh S H, et al. High-dose vitamin C injection to cancer patients may promote thrombosis through procoagulant activation of erythrocytes[J]. Toxicological Sciences, 2015, 147(2):350-359.
[29]Ferraro P M, Curhan G C, Gambaro G, Gambaro G, et al. Total, dietary,and supplemental vitamin C intake and risk of incident kidney stones[J].American Journal of Kidney Diseases, 2016, 67(3):400-407.
[30]Chen X, Shen L, Gu X, et al. High-dose supplementation with vitamin C-induced pediatric urolithiasis:the first case report in a child and literature review[J]. Urology, 2014, 84(4):922-924.
[31]Lamarche J, Nair R, Peguero A, et al. Vitamin C-induced oxalate nephropathy[J]. International journal of nephrology, 2011, 2(2):78-88.
[32]Yaich S, Chaabouni Y, Charfeddine K, et al. Secondary oxalosis due toexcess vitamin C intake:a cause of graft loss in a renal transplant recipient[J]. Saudi Journal of Kidney Diseases and Transplantation, 2014, 25(1):113.