基于VOSviewer的富血小板血浆研究热点主题分析
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摘要
背景:富血小板血浆为自体全血经离心之后所得的血小板浓缩物,含有大量生长因子及蛋白质。血小板活化后能够释放多种生长因子,加快细胞增殖及分化,能有效促进组织修复,且富血小板血浆取材方便,制备简单,被广泛应用于临床各领域应用。国外对于富血小板血浆的研究开展已久,并取得一定的研究成果。目的:综述并分析国外关于富血小板血浆近5年的研究进展。方法:由第一作者用计算机检索PubMed数据库,检索词为"Plasma,Platelet-Rich,Platelet Rich Plasma,Platelet-RichPlasma",检索时限为2014至2018年。利用可视化工具VOSviewer对检索所得研究论文的题录信息进行深度挖掘,从年度发文量、国家发文量以及研究主题等方面对其展开讨论,利用软件生成的知识图谱直观展示国外富血小板血浆研究的热点主题。结果与结论:检索得到相关文献38篇。结果表明,国外近5年关于富血小板血浆的研究论文发表量逐年递增,美国发文量最多,通过进行共词聚类分析可知关于富血小板血浆的研究热点主要集中在以下5个方面:动物实验、骨关节科、细胞学实验、口腔科、慢性伤口。研究结果为中国富血小板血浆领域的研究方向及热点选择提供了参考。
BACKGROUND: Platelet-rich plasma is a platelet concentrate obtained from autologous whole blood after centrifugation, which contains a lot of growth factors and proteins. Activated platelets can release a variety of growth factors so as to accelerate cell proliferation and differentiation, and can effectively promote tissue repair.Platelet-rich plasma has been widely used in various clinical fields because of its convenient sampling and simple preparation. Overseas research on platelet-rich plasma has been carried out for a long time, and has achieved certain results.OBJECTIVE: To review the research advance of platelet-rich plasma at abroad in recent 5 years.METHODS: PubMed database was retrieved with the keywords of "plasma, platelet-rich, platelet rich plasma,platelet-rich plasma'' and the retrieval time was from 2014-2018. The visual tool VOSviewer was used to deeply search the title information of the papers retrieved. The annual and national published number, and research topics were discussed. The knowledge map generated by software is used to visually display the hotspot of platelet-rich plasma research at abroad.RESULTS AND CONCLUSION: Thirty-eight relevant articles were retrieved. The results show that in the past five years the number of papers published on platelet-rich plasma in foreign countries has increased year by year, and the United States has the largest number of publications. Through co-word clustering analysis, the hotspots of platelet-rich plasma are mainly concentrated on the following five aspects:animal experiments, orthopedics, cytology experiments, stomatology and chronic wounds. Research results provide reference for the direction and hotspot of research on platelet-rich plasma in China.
BACKGROUND: Platelet-rich plasma is a platelet concentrate obtained from autologous whole blood after centrifugation, which contains a lot of growth factors and proteins. Activated platelets can release a variety of growth factors so as to accelerate cell proliferation and differentiation, and can effectively promote tissue repair.Platelet-rich plasma has been widely used in various clinical fields because of its convenient sampling and simple preparation. Overseas research on platelet-rich plasma has been carried out for a long time, and has achieved certain results.OBJECTIVE: To review the research advance of platelet-rich plasma at abroad in recent 5 years.METHODS: PubMed database was retrieved with the keywords of "plasma, platelet-rich, platelet rich plasma,platelet-rich plasma'' and the retrieval time was from 2014-2018. The visual tool VOSviewer was used to deeply search the title information of the papers retrieved. The annual and national published number, and research topics were discussed. The knowledge map generated by software is used to visually display the hotspot of platelet-rich plasma research at abroad.RESULTS AND CONCLUSION: Thirty-eight relevant articles were retrieved. The results show that in the past five years the number of papers published on platelet-rich plasma in foreign countries has increased year by year, and the United States has the largest number of publications. Through co-word clustering analysis, the hotspots of platelet-rich plasma are mainly concentrated on the following five aspects:animal experiments, orthopedics, cytology experiments, stomatology and chronic wounds. Research results provide reference for the direction and hotspot of research on platelet-rich plasma in China.
引文
[1]Bennell KL,Hunter DJ.Platelet-rich plasma for the management of hip and knee osteoarthritis.Curr Rheumatol Rep.2017;19(5):24.
[2]Whitney KE,Liebowitz A,Bolia IK,et al.Current perspectives on biological approaches for osteoarthritis.Ann N Y Acad Sci U S A.2017;1410(1):26-43.
[3]魏志华,林亚清,吴育辉,等.家族企业研究:一个文献计量分析[J].经济学(季刊),2014,13(1):27-56.
[4]VOSviewer Visualizing scientific landscapes[EB/OL].(2015-10-12)[2017-01-08].http://www.vosviewer.com/.
[5]周超峰.文献计量常用软件比较研究[D].武汉:华中师范大学,2017.
[6]Szponder T,Wessely-Szponder J,Sobczyńska-Rak A,et al.Application of platelet-rich plasma and tricalcium phosphate in the treatment of comminuted fractures in animals.In vivo.2018;32(6):1449-1455.
[7]Badis D.The effectiveness of platelet-rich plasma on the skin wound healing process:a comparative experimental study in sheep.Vet World.2018;11(6):800-808.
[8]Yang JM,Yang KI,Lee KH,et al.Effects of platelet-rich plasma on tooth replantation in dogs:a histologic and histomorphometric analysis.JPeriodontal Implant Sci.2018;48(4):224-235.
[9]庞伟峰,李会军,李东利,等.富血小板血浆在骨折不愈合中的应用[J].中国矫形外科杂志,2015,23(16):1535-1536.
[10]Zhang XL,Shi KQ,Jia PT,et al.Effects of platelet-rich plasma on angiogenesis and osteogenesis-associated factors in rabbits with avascular necrosis of the femoral head.Eur Rev Med Pharmacol Sci.2018;22(7):2143-2152.
[11]姜良斌,肖伯莲,刘松,等.富血小板血浆联合高位股骨头颈开窗植骨支撑术治疗早期股骨头坏死的研究[J].中国临床解剖学杂志,2018,36(4):449-452.
[12]Andia I,Maffulli N.Platelet-rich plasma for muscle injury and tendinopathy.Sports Med Arthrosc.2013;21(4):191-198.
[13]Wetzel RJ,Patel RM,Terry MA.Platelet-rich plasma as an effective treatment for proximal hamstring injuries.Orthopedics.2013;36(1):64-70.
[14]Anitua E,Sánchez M.More on platelet-rich plasma injections in acute muscle injury.N Engl J Med.2014;371(13):1264.
[15]Vetrano M,Castorina A,Vulpiani MC,et al.Platelet-rich plasma versus focused shock waves in the treatment of jumper's knee in athletes.Am JSports Med.2013;41(4):795-803.
[16]Rha DW,Park GY,Kim YK,et al.Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease:a randomized controlled trial.Clin Rehabil.2013;27(2):113-122.
[17]Say F,Gürler D,Yener K,et al.Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis.Acta Chir Orthop Traumatol Cech.2013;80(4):278-283.
[18]Yu T,Pan H,Hu Y,et al.Autologous platelet-rich plasma induces bone formation of tissue-engineered bone with bone marrow mesenchymal stem cells on beta-tricalcium phosphate ceramics.J Orthop Surg Res.2017;12(1):178.
[19]Rubio-Azpeitia E,Bilbao AM,Sánchez P,et al.The properties of 3different plasma formulations and their effects on tendinopathic cells.Am J Sports Med.2016;44(8):1952-1961.
[20]Barlian A,Judawisastra H,Alfarafisa NM,et al.Chondrogenic differentiation of adipose-derived mesenchymal stem cells induced by L-ascorbic acid and platelet rich plasma on silk fibroin scaffold.Peer J.2018;6:e5809.
[21]Liou JJ,Rothrauff BB,Alexander PG.Effect of platelet-rich plasma on chondrogenic differentiation of adipose-and bone marrow-derived mesenchymal stem cells.Tissue Eng Part A.2018;24(19-20):1432-1443.
[22]Tsai WC,Yu TY,Chang GJ,et al.Platelet-rich plasma releasate promotes regeneration and decreases inflammation and apoptosis of injured skeletal muscle.Am J Sports Med.2018;46(8):1980-1986.
[23]Filardo G,Kon E,Di Martino A,et al.Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology:study design and preliminary results of a randomized controlled trial.BMC Musculo-skeletal Disord.2012;13:229.
[24]王悦,李玉梅,王淑艳,等.富血小板血浆对脂肪间充质干细胞生物学行为的影响[J].中国老年学杂志,2011,31(6):997-999.
[25]Wang K,Li Z,Li J,et al.Optimization of the platelet-rich plasma concentration for mesenchymal stem cell applications.Tissue Eng Part A.2018.doi:10.1089/ten.TEA.2018.0091.
[26]Marx RE,Carlson ER,Eichstaedt RM,et al.Platelet-rich plasma:growth factor enhancement for bone grafts.Oral Surg Oral Med Oral Pathol Oral Radiol Endod.1998;85(6):638-646.
[27]胡秋斌.富血小板血浆促进口腔种植骨再生的临床应用研究[J].当代医学,2014,20(10):80-81.
[28]钱文慧,徐艳,孙颖,等.富血小板血浆修复牙周骨缺损的临床疗效[J].牙体牙髓牙周病学杂志,2014,24(7):415-418.
[29]袁霆,张长青,李四波,等.自体富血小板血浆与难愈合伤口的修复[J].中华整形外科杂志,2006,22(5):391-393.
[30]董希杰.富血小板纤维蛋白在慢性伤口治疗中的应用研究进展[J].湖北民族学院学报(医学版),2018,35(1):60-62,66
[31]孙洁,张剑明,李彦秋.富血小板纤维蛋白超微结构的观察与探讨[J].口腔医学研究,2010,26(1):98-101.
[32]Herbst RS.Review of epidermal growth factor receptor biology.Int JRadiat Oncol Biol Phys.2014;59(S2):21-26.
[33]?etinkaya RA,Yenilmez E,Petrone P,et al.Platelet-rich plasma as an additional therapeutic option for infected wounds with multi-drug resistant bacteria:in vitro antibacterial activity study.Eur J Trauma Emerg Surg.2018.doi:10.1007/s00068-018-0957-0.
[34]Ehrenfest D.Three-dimension-alarchitecture and cell composition of a Choukroun'splatelet-rich fibrin clot and membrane.J Periodontol.2010;1(4):546-555.
[35]付德丰,郑晓菊.富血小板血浆修复慢性难愈合伤口的疗效[J].临床医学研究与实践,2018,3(22):35-37.
[36]Agrawal AA,Evolution,current status and advances in application of platelet concentrate in periodontics and implantology.World J Clin Cases.2017;5(5):159-171.
[37]Cieslik-Bielecka A,Choukroun J,Odin G.L-PRP/L-PRF in esthetic plastic surgery,regenerative medicine of the skin and chronic wounds.Curr Pharm Biotechnol.2012;13(7):1266-1277.
[38]Zhang N,Wu YP,Qian SJ,et al.Research progress in the mechanism of effect of PRP in bone deficiency healing.Scientific World Journal.2013;2013:134582.
[2]Whitney KE,Liebowitz A,Bolia IK,et al.Current perspectives on biological approaches for osteoarthritis.Ann N Y Acad Sci U S A.2017;1410(1):26-43.
[3]魏志华,林亚清,吴育辉,等.家族企业研究:一个文献计量分析[J].经济学(季刊),2014,13(1):27-56.
[4]VOSviewer Visualizing scientific landscapes[EB/OL].(2015-10-12)[2017-01-08].http://www.vosviewer.com/.
[5]周超峰.文献计量常用软件比较研究[D].武汉:华中师范大学,2017.
[6]Szponder T,Wessely-Szponder J,Sobczyńska-Rak A,et al.Application of platelet-rich plasma and tricalcium phosphate in the treatment of comminuted fractures in animals.In vivo.2018;32(6):1449-1455.
[7]Badis D.The effectiveness of platelet-rich plasma on the skin wound healing process:a comparative experimental study in sheep.Vet World.2018;11(6):800-808.
[8]Yang JM,Yang KI,Lee KH,et al.Effects of platelet-rich plasma on tooth replantation in dogs:a histologic and histomorphometric analysis.JPeriodontal Implant Sci.2018;48(4):224-235.
[9]庞伟峰,李会军,李东利,等.富血小板血浆在骨折不愈合中的应用[J].中国矫形外科杂志,2015,23(16):1535-1536.
[10]Zhang XL,Shi KQ,Jia PT,et al.Effects of platelet-rich plasma on angiogenesis and osteogenesis-associated factors in rabbits with avascular necrosis of the femoral head.Eur Rev Med Pharmacol Sci.2018;22(7):2143-2152.
[11]姜良斌,肖伯莲,刘松,等.富血小板血浆联合高位股骨头颈开窗植骨支撑术治疗早期股骨头坏死的研究[J].中国临床解剖学杂志,2018,36(4):449-452.
[12]Andia I,Maffulli N.Platelet-rich plasma for muscle injury and tendinopathy.Sports Med Arthrosc.2013;21(4):191-198.
[13]Wetzel RJ,Patel RM,Terry MA.Platelet-rich plasma as an effective treatment for proximal hamstring injuries.Orthopedics.2013;36(1):64-70.
[14]Anitua E,Sánchez M.More on platelet-rich plasma injections in acute muscle injury.N Engl J Med.2014;371(13):1264.
[15]Vetrano M,Castorina A,Vulpiani MC,et al.Platelet-rich plasma versus focused shock waves in the treatment of jumper's knee in athletes.Am JSports Med.2013;41(4):795-803.
[16]Rha DW,Park GY,Kim YK,et al.Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease:a randomized controlled trial.Clin Rehabil.2013;27(2):113-122.
[17]Say F,Gürler D,Yener K,et al.Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis.Acta Chir Orthop Traumatol Cech.2013;80(4):278-283.
[18]Yu T,Pan H,Hu Y,et al.Autologous platelet-rich plasma induces bone formation of tissue-engineered bone with bone marrow mesenchymal stem cells on beta-tricalcium phosphate ceramics.J Orthop Surg Res.2017;12(1):178.
[19]Rubio-Azpeitia E,Bilbao AM,Sánchez P,et al.The properties of 3different plasma formulations and their effects on tendinopathic cells.Am J Sports Med.2016;44(8):1952-1961.
[20]Barlian A,Judawisastra H,Alfarafisa NM,et al.Chondrogenic differentiation of adipose-derived mesenchymal stem cells induced by L-ascorbic acid and platelet rich plasma on silk fibroin scaffold.Peer J.2018;6:e5809.
[21]Liou JJ,Rothrauff BB,Alexander PG.Effect of platelet-rich plasma on chondrogenic differentiation of adipose-and bone marrow-derived mesenchymal stem cells.Tissue Eng Part A.2018;24(19-20):1432-1443.
[22]Tsai WC,Yu TY,Chang GJ,et al.Platelet-rich plasma releasate promotes regeneration and decreases inflammation and apoptosis of injured skeletal muscle.Am J Sports Med.2018;46(8):1980-1986.
[23]Filardo G,Kon E,Di Martino A,et al.Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology:study design and preliminary results of a randomized controlled trial.BMC Musculo-skeletal Disord.2012;13:229.
[24]王悦,李玉梅,王淑艳,等.富血小板血浆对脂肪间充质干细胞生物学行为的影响[J].中国老年学杂志,2011,31(6):997-999.
[25]Wang K,Li Z,Li J,et al.Optimization of the platelet-rich plasma concentration for mesenchymal stem cell applications.Tissue Eng Part A.2018.doi:10.1089/ten.TEA.2018.0091.
[26]Marx RE,Carlson ER,Eichstaedt RM,et al.Platelet-rich plasma:growth factor enhancement for bone grafts.Oral Surg Oral Med Oral Pathol Oral Radiol Endod.1998;85(6):638-646.
[27]胡秋斌.富血小板血浆促进口腔种植骨再生的临床应用研究[J].当代医学,2014,20(10):80-81.
[28]钱文慧,徐艳,孙颖,等.富血小板血浆修复牙周骨缺损的临床疗效[J].牙体牙髓牙周病学杂志,2014,24(7):415-418.
[29]袁霆,张长青,李四波,等.自体富血小板血浆与难愈合伤口的修复[J].中华整形外科杂志,2006,22(5):391-393.
[30]董希杰.富血小板纤维蛋白在慢性伤口治疗中的应用研究进展[J].湖北民族学院学报(医学版),2018,35(1):60-62,66
[31]孙洁,张剑明,李彦秋.富血小板纤维蛋白超微结构的观察与探讨[J].口腔医学研究,2010,26(1):98-101.
[32]Herbst RS.Review of epidermal growth factor receptor biology.Int JRadiat Oncol Biol Phys.2014;59(S2):21-26.
[33]?etinkaya RA,Yenilmez E,Petrone P,et al.Platelet-rich plasma as an additional therapeutic option for infected wounds with multi-drug resistant bacteria:in vitro antibacterial activity study.Eur J Trauma Emerg Surg.2018.doi:10.1007/s00068-018-0957-0.
[34]Ehrenfest D.Three-dimension-alarchitecture and cell composition of a Choukroun'splatelet-rich fibrin clot and membrane.J Periodontol.2010;1(4):546-555.
[35]付德丰,郑晓菊.富血小板血浆修复慢性难愈合伤口的疗效[J].临床医学研究与实践,2018,3(22):35-37.
[36]Agrawal AA,Evolution,current status and advances in application of platelet concentrate in periodontics and implantology.World J Clin Cases.2017;5(5):159-171.
[37]Cieslik-Bielecka A,Choukroun J,Odin G.L-PRP/L-PRF in esthetic plastic surgery,regenerative medicine of the skin and chronic wounds.Curr Pharm Biotechnol.2012;13(7):1266-1277.
[38]Zhang N,Wu YP,Qian SJ,et al.Research progress in the mechanism of effect of PRP in bone deficiency healing.Scientific World Journal.2013;2013:134582.