胆碱酯酶复能剂冲击用法在重度有机磷中毒中的临床应用疗效观察
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摘要
目的探讨胆碱酯酶复能剂冲击用法在重度有机磷中毒中的临床应用疗效观察。方法前瞻性随机选取2015年2月至2018年2月收治的重度有机磷中毒患者58例,给予其胆碱酯酶复能剂冲击用法治疗。结果治疗后58例患者好转率为98.28%,10例出现并发症,均获得有效治疗,死亡1例,58例患者胆碱酯酶、指脉氧饱和度等明显优于治疗前,差异显著(P<0.05)。结论胆碱酯酶复能剂冲击用法治疗重度有机磷中毒可快速活化胆碱酯酶、对改善有机磷中毒症状等,具有临床推广应用价值。
Objective To investigate the clinical application of cholinesterase complex energy receptor in severe organophosphate poisoning. Methods A total of 58 patients with severe organophosphorus poisoning who were admitted to the hospital from February 2015 to February 2018 were prospectively randomized to receive cholinesterase regenerative therapy. Results After treatment, the improvement rate of 58 patients was 98.28%. Ten patients had complications and were treated effectively. One patient died. Fifty-eight patients had significantly better cholinesterase and finger oxygen saturation than before treatment. Significant(P<0.05). Conclusion The cholinesterase complexing agent has a clinical application value in the treatment of severe organophosphorus poisoning, which can rapidly activate cholinesterase and improve the symptoms of organophosphate poisoning.
Objective To investigate the clinical application of cholinesterase complex energy receptor in severe organophosphate poisoning. Methods A total of 58 patients with severe organophosphorus poisoning who were admitted to the hospital from February 2015 to February 2018 were prospectively randomized to receive cholinesterase regenerative therapy. Results After treatment, the improvement rate of 58 patients was 98.28%. Ten patients had complications and were treated effectively. One patient died. Fifty-eight patients had significantly better cholinesterase and finger oxygen saturation than before treatment. Significant(P<0.05). Conclusion The cholinesterase complexing agent has a clinical application value in the treatment of severe organophosphorus poisoning, which can rapidly activate cholinesterase and improve the symptoms of organophosphate poisoning.
引文
[1]陈大贵,程向红,翟樊,等.盐酸戊乙奎醚与阿托品交替使用抢救重度有机磷农药中毒的临床疗效观察[J].职业与健康,2016,32(22):3163-3166.
[2]杨胜,张冬惠,王绍谦,等.胃肠道毒物优化清除对重度急性有机磷农药中毒患者疗效的影响[J].中国中西医结合急救杂志,2016,23(2):164-167.
[3]高茹春,赵建娅,潘爱群,等.急性有机磷农药中毒患者血清及全血胆碱酯酶的相关性研究[J].重庆医学,2016,45(5):648-650.
[4]陈永忠,许志忠,朱再志,等.血液灌流对重度有机磷农药中毒疗效的临床观察[J].临床肾脏病杂志,2017,17(8):495-498.
[5]焦清海,王帅,王健,等.早期乌司他丁联合血液灌流序贯连续性血液滤过治疗急性重度有机磷中毒临床效果观察[J].疑难病杂志,2016,15(11):1159-1161.
[6]侯景玉,吴畏,陈希妍,等.序贯性血液净化治疗急性重度有机磷农药中毒并发多器官功能障碍综合征疗效观察[J].新乡医学院学报,2016,33(2):126-129.
[7]张晓敏,王晨.血液灌流对急性重度有机磷农药中毒患者SOFA评分与胆碱酯酶的影响[J].安徽医学,2017,38(9):1192-1194.
[8]鲁永和,周马,符艳松.参麦注射液治疗急性有机磷中毒性心肌损害的疗效观察[J].河北医药,2016,38(16):2495-2497.
[9]黄秀荣,吴燕,俞宁,等.全自动换血疗法在急性有机磷农药中毒中间综合征中的应用研究[J].重庆医学,2017,46(22):3121-3123.
[10]廖汉文,朱梦,孟东勇.血液灌流联合血液滤过对治疗急性重度有机磷农药中毒的临床研究[J].中国中西医结合肾病杂志,2016,17(2):137-138.
[2]杨胜,张冬惠,王绍谦,等.胃肠道毒物优化清除对重度急性有机磷农药中毒患者疗效的影响[J].中国中西医结合急救杂志,2016,23(2):164-167.
[3]高茹春,赵建娅,潘爱群,等.急性有机磷农药中毒患者血清及全血胆碱酯酶的相关性研究[J].重庆医学,2016,45(5):648-650.
[4]陈永忠,许志忠,朱再志,等.血液灌流对重度有机磷农药中毒疗效的临床观察[J].临床肾脏病杂志,2017,17(8):495-498.
[5]焦清海,王帅,王健,等.早期乌司他丁联合血液灌流序贯连续性血液滤过治疗急性重度有机磷中毒临床效果观察[J].疑难病杂志,2016,15(11):1159-1161.
[6]侯景玉,吴畏,陈希妍,等.序贯性血液净化治疗急性重度有机磷农药中毒并发多器官功能障碍综合征疗效观察[J].新乡医学院学报,2016,33(2):126-129.
[7]张晓敏,王晨.血液灌流对急性重度有机磷农药中毒患者SOFA评分与胆碱酯酶的影响[J].安徽医学,2017,38(9):1192-1194.
[8]鲁永和,周马,符艳松.参麦注射液治疗急性有机磷中毒性心肌损害的疗效观察[J].河北医药,2016,38(16):2495-2497.
[9]黄秀荣,吴燕,俞宁,等.全自动换血疗法在急性有机磷农药中毒中间综合征中的应用研究[J].重庆医学,2017,46(22):3121-3123.
[10]廖汉文,朱梦,孟东勇.血液灌流联合血液滤过对治疗急性重度有机磷农药中毒的临床研究[J].中国中西医结合肾病杂志,2016,17(2):137-138.