基于色度学原理的颜色分析方法在药物研究领域的应用概况
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摘要
颜色分析方法是一种基于色度学原理,可快速检测物体颜色的技术,其广泛地应用于各个领域,通过将颜色以数值的形式进行描述,并与产品性状质量建立相关性,从而实现对产品颜色及品质的有效管理。本文对颜色分析在药物研究领域的应用进行了概述,旨在为实现药物的深入研究提供参考。
The color difference analysis method is a technique based on the principle of chromaticity and it can quickly detect the color of the object. It is widely used in various fields. The color is described in numerical form and is related to the quality of the product trait. The color and quality of the product can be effectively managed. This paper mainly introduces the knowledge of chromaticity,and summarizes the application of color difference analysis in medicine research. It aims to provide reference for achieving in-depth study of medicine.
The color difference analysis method is a technique based on the principle of chromaticity and it can quickly detect the color of the object. It is widely used in various fields. The color is described in numerical form and is related to the quality of the product trait. The color and quality of the product can be effectively managed. This paper mainly introduces the knowledge of chromaticity,and summarizes the application of color difference analysis in medicine research. It aims to provide reference for achieving in-depth study of medicine.
引文
[1]秦一心,方亮,张龙,等.森林色彩三要素独立变化对观赏效应的影响[J].中国城市林业,2016,14(3):26QIN YX,FANG L,ZHANG L,et al.Aesthetic effects of individual variation of three forest color elements[J].J Chin Urban Forest,2016,14(3):26
[2]REINHARD E,ASHIKHMIN M,GOOCH B,et al.Color transfer between images[J].IEEE Comput Graph Appl,2001,21(5):34
[3]杨璟,朱雷.基于RGB颜色空间的彩色图像分割方法[J].计算机与现代化,2010(8):147YANG J,ZHU L.Color image segmentation method based on RGBcolor space[J].Comput Mod,2010(8):147,171
[4]SüSSTRUNK S,BUCKLEY R,SWEN S.Standard RGB Color Spaces[C].Color Imag Confer,1999,7:127
[5]BULAN O,SHARMA G.Improved Color Barcodes via Expectation Maximization Style Interference Cancellation[C].IEEEInternational Conference on Acoustics,2012,22(10):1509
[6]宋麦玲,李欢.一种基于HSV颜色空间的图像检索技术[J].电脑知识与技术,2007,1(1):200SONG ML,LI H.An image retrieval technologe based on HSV color space[J].Computer Knowledge Technol,2007,1(1):200
[7]朱正芳,汤顺青.色度学及其进展[J].物理,1996,25(6):342ZHU ZF,TANG SQ.Chromaticism and its progress[J].Physics,1996,25(6):342
[8]NIELSEN SS.Food Analysis[M].4th Ed.Springer US,2010:35
[9]徐海松.颜色技术原理及在印染中的应用(十四)第十一篇光电积分式测色仪器及荧光材料的颜色测量[J].印染,2006,32(7):40XU HS.Color technical principle and its application to dyeing and finishing(X IV)[J].Dye Finis,2006,32(7):40
[10]徐海松.颜色技术原理及在印染中的应用(十三)第九篇分光光度测色仪器[J].印染,2006,32(6):41XU HS.Color technical principle and its application to dyeing and finishing(X III)[J].Dye Finis,2006,32(6):41
[11]周怡.化学药品标准中杂质控制及其限度的建立[J].药物生物技术,2010,17(2):181ZHOU Y.Establishment of the criteria for impurities in drug standards[J].Chin J Pharm Biotechnol,2010,17(2):181
[12]李旻,陈美君,潘欢欢,等.基于颜色客观化的陈皮药材鉴别[J].中国实验方剂学杂志,2016,22(18):31LI M,CHEN MJ,PAN HH,et al.Discrimination of Citri Reticulatae Pericarpium based on color objectivization[J].Chin J Exp Tradit Med Form,2016,22(18):31
[13]陈梁,李丽,肖永庆,等.仿野生与人工栽培防风饮片的色彩色差分析[J].中国实验方剂学杂志,2013,19(12):92CHEN L,LI L,XIAO YQ,et al.Color analysis between imitatively wild and artificially cultivated pieces of Saposhnikoviae Radix by colorimeter[J].Chin J Exp Tradit Med Form,2013,19(12):92
[14]刘红亮,晏仁义,郭健,等.厚朴”发汗”前后药材颜色及气味差异的数值化研究[J].中国中药杂志,2013,38(1):45LIU HL,YAN RY,GUO J,et al.Study on digitalization in drug color and odor of Magnoliae Officinalis Cortex before and after perspiration[J].China J Chin Mater Med,2013,38(1):45
[15]邹慧琴,李硕,林相龙,等.基于色度学理论的甘草颜色数字化方法学研究[J].世界科学技术-中医药现代化,2014(12):2681ZOU HQ,LI S,LIN XL,et al.Methodological research on color digitalization of Glycyrrhize Radix et Rhizoma based on colorimetry theory[J].World Sci Technol Mod Tradit Chin Med Mater Med,2014,16:(12):2681
[16]杨小露,李水清,王淑美,等.基于主成分分析的不同产地茺蔚子质量评价研究[J].广东药学院学报,2017,33(4):461YANG XL,LI SQ,WANG SM,et al.Study on quality evaluaion of Leonur Fructus from different habitats based on principal components[J].J Guangdong Pharm Univ,2017,33(4):461
[17]胥敏,杨诗龙,李欣逸,等.基于性状客观化的五种芸香科中药鉴别研究[J].中药与临床,2015,6(6):1XU M,YANG SL,LI XY,et al.Research on discrimination of five Rutaceae herbs by objectifying its characters[J].Pharm Clin Chin Mater Med,2015,6(6):1
[18]何婉婉,张建逵,李云静,等.北豆根药材粉末色泽与有效成分的相关性[J].中国实验方剂学杂志,2017,23(5):57HE WW,ZHANG JK,LI YJ,et al.Correlation between color traits of Menispermi Rhizoma powder and its effective components[J].Chin J Exp Tradit Med Form,2017,23(5):57
[19]侯伟龙,窦德强.甘草的色泽与甘草苷、甘草酸含量的相关性研究[J].中国实验方剂学杂志,2013,19(15):130HOU WL,DOU DQ.Research on the correlation between color traits of licorice and its content of Glycyrrhizic acid and liquiritin[J].Chin J Exp Tradit Med Form,2013,19(15):130
[20]李春阳,许时婴,张红城,等.葡萄籽贮藏过程中色差变化的研究[J].食品工业科技,2007,28(10):208LI CY,XU SY,ZHANG HC,et al.Study on the variation of color difference during grape seed storage[J].Sci Technol Food Ind,2007,28(10):208
[21]XU M,DU C,ZHANG N,et al.Color spaces of safflower(Carthamus tinctorius L.)for quality assessment[J].J Tradit Chin Med Sci,2016,3(3):168
[22]李庆,张建逵,康廷国,等.莲须粉末颜色与总黄酮含量相关性研究[J].亚太传统医药,2016,12(14):32LI Q,ZHANG JK,KANG TG,et al.Study of correlation between the content of total flavonoids and powder color of Stamen Nelumbinis[J].Asia-Pacific Tradit Med,2016,12(14):32
[23]方小华,谢一辉,姚冬琴,等.不同发酵时间对樟帮枳壳饮片质量的影响[J].中国实验方剂学杂志,2012,18(9):17FANG XH,XIE YH,YAO DQ,et al.Quality control method Citrus anrantiun pices with different fermentation time[J].Chin J Exp Tradit Med Form,2012,18(9):17
[24]刘粤疆,李文敏,张慧慧,等.色彩色差计在槟榔炒焦加工中的应用[C]//中华中医药学会中药炮制分会2008年学术研讨会论文集,2008:254LIU YJ,LI WM,ZHANG HH,et al.Application of color difference meter in betel nut speculation processing[C]//Chinese Medicine Society of Chinese Medicine Processing Branch 2008 Symposium Proceedings,2008:254
[25]刘粤疆,张继良,吴纯洁,等.中药藕节现代炮制过程数据量化控制研究[J].中国医药导报,2009,36(6):9LIU YJ,ZHANG JL,WU CJ,et al.Research on quantitative control in modern processing of lotus rhizome node[J].Chin Med Her,2009,36(6):9
[26]殷放宙,吴晓燕,李林,等.炮制火候对饮片颜色的影响[J].中草药,2013,44(16):2252YIN FZ,WU XY,LI L,et al.Influence of different heating degrees on color of Chinese materia medica pieces[J].Chin Tradit Herb Drugs,2013,44(16):2252
[27]刘文琴,余无双,周丽姣,等.泽泻饮片质量控制方法研究[J].中国实验方剂学杂志,2011,17(7):87LIU WQ,YU WS,ZHOU LJ,et al.Study on quality control method of processed Alisma pieces[J].Chin J Exp Tradit Med Form,2011,17(7):87
[28]肖井雷,刘玉翠,刘媛媛,等.熟大黄炮制工艺优选及判定标准量化研究[J].中草药,2017,48(8):1571XIAO JL,LIU YC,LIU YY,et al.Study on process optimization and judgment standard of quantitative of cooked Rhei Radix et Rhizoma[J].Chin Tradit Herb Drugs,2017,48(8):1571
[29]李雪莲.白术麸炒过程中颜色与物质基础变化相关性研究[D].成都:成都中医药大学,2015LI XL.Study on the Correlation of Both Color and Material Basis of Atracylodes During the Process of Frying[D].Chengdu:Chengdu University of Tradituonal Chinese Medicine,2015
[30]吴衍风,李德坤,周大铮,等.色差计法测定注射用益气复脉(冻干)溶液的颜色[J].中华中医药学刊,2012,30(1):52WU YF,LI DK,ZHOU DZ,et al.Determination of Yiqi Fumai injection color by colorimeter[J].Chin Arch Tradit Chin Med,2012,30(1):52
[31]刘君动,叶正良,李德坤,等.色差计法测定注射用丹参多酚酸溶液的颜色[J].辽宁中医杂志,2013,40(1):143LIU JD,YE ZL,LI DK,et al.Color difference meters measuring the color of saivianolate lyophilized injection solution[J].Liaoning JTradit Chin Med,2013,40(1):143
[32]刘炜,潘卫松,张嘉莹,等.色差计法在注射剂溶液颜色检查法中的应用[J].药物分析杂志,2015,35(12):2131LIU W,PAN WS,ZHANG JY,et al.Application of colorimeter method for solution color inspection in injections[J].Chin J Pharm Anal,2015,35(12):2131
[33]黄春辉.灰黄霉素色泽的色差法测定[J].中国医药工业杂志,2001,32(4):169HUANG CH.Determination of etodolac sustained release tablets and its methyl derivatives by HPLC[J].Chin J Pharm,2001,32(4):169
[34]庞青云,柳飞,张洁萍,等.注射用头孢曲松钠溶液颜色与相关杂质的研究[J].中国药品标准,2009,10(2):101PANG QY,LIU F,ZHANG JP,et al.Study of the solutions colour and relative substance in ceftriaxone sodium for injection[J].Drug Stand China,2009,10(2):101
[35]北村智,周嘉秀.药物水溶液颜色变化的动力学[J].药学实践杂志,1987(1):35BEI CZ,ZHOU JX.Kinetics of color change of drug aqueous solution[J].J Pharm Pract,1987(1):35
[36]王国兰,寇晋萍,余立,等.注射用粉针溶液颜色限度的制订[J].中国药品标准,2004,5(4):23WANG GL,KOU JP,YU L,et al.Establishment of limit for the color of solution of power for injection[J].Drug Stand China,2004,5(4):23
[37]朱一玮.色差分析法测定治偏痛微丸圆整度的计算方法研究[J].江西中医学院学报,2011,23(4):53ZHU YW.An algorithm for pellet edge tracking based on color analysis[J].J Jiangxi Univ Tradit Chin Med,2011,23(4):53
[38]王小平.粒子设计改善中药粉体均一性与溶解性的工艺原理研究[D].成都:成都中医药大学,2015WANG XP.Study on the Principle of Particle Design to Improve the Uniformity and Solubility of Traditional Chinese Medicine Powder[D].Chengdu:Chengdu University of Tradintional Chinese Medicine,2015
[39]顾金林,沈鸿.用漫反射光谱法测定固体制剂的颜色变化[J].分析化学,1995,23(4):487GU JL,SHEN H.Determination of color change of solid preparation by diffusing reflectance spectroscopy[J].Chin J Anal Chem,1995,23(4):487
[40]佟宝光.色差法确定化学反应终点的研究[J].染料与染色,2007,44(2):52TONG BG.A study on the termination of chemical reaction by chroma stism[J].Dyestuffs Colorat,2007,44(2):52
[41]杨诗龙.基于智能感官分析技术的贝母及黄连饮片鉴别研究[D].成都:成都中医药大学,2015YANG SL.Discrimination of Bulbus of Fritillaria and Processed Products of Coptidis Rhizoma by Using Intelligent Sensory technologies[D].Chengdu:Chengdu University of Traditional Chinese Medicine,2015
[42]ANTONIELLA E.Counterfeit drugs detection by measurement of tablets and secondary packaging colour[J].J Pharm Biomed Anal,2010,53(2):215
[2]REINHARD E,ASHIKHMIN M,GOOCH B,et al.Color transfer between images[J].IEEE Comput Graph Appl,2001,21(5):34
[3]杨璟,朱雷.基于RGB颜色空间的彩色图像分割方法[J].计算机与现代化,2010(8):147YANG J,ZHU L.Color image segmentation method based on RGBcolor space[J].Comput Mod,2010(8):147,171
[4]SüSSTRUNK S,BUCKLEY R,SWEN S.Standard RGB Color Spaces[C].Color Imag Confer,1999,7:127
[5]BULAN O,SHARMA G.Improved Color Barcodes via Expectation Maximization Style Interference Cancellation[C].IEEEInternational Conference on Acoustics,2012,22(10):1509
[6]宋麦玲,李欢.一种基于HSV颜色空间的图像检索技术[J].电脑知识与技术,2007,1(1):200SONG ML,LI H.An image retrieval technologe based on HSV color space[J].Computer Knowledge Technol,2007,1(1):200
[7]朱正芳,汤顺青.色度学及其进展[J].物理,1996,25(6):342ZHU ZF,TANG SQ.Chromaticism and its progress[J].Physics,1996,25(6):342
[8]NIELSEN SS.Food Analysis[M].4th Ed.Springer US,2010:35
[9]徐海松.颜色技术原理及在印染中的应用(十四)第十一篇光电积分式测色仪器及荧光材料的颜色测量[J].印染,2006,32(7):40XU HS.Color technical principle and its application to dyeing and finishing(X IV)[J].Dye Finis,2006,32(7):40
[10]徐海松.颜色技术原理及在印染中的应用(十三)第九篇分光光度测色仪器[J].印染,2006,32(6):41XU HS.Color technical principle and its application to dyeing and finishing(X III)[J].Dye Finis,2006,32(6):41
[11]周怡.化学药品标准中杂质控制及其限度的建立[J].药物生物技术,2010,17(2):181ZHOU Y.Establishment of the criteria for impurities in drug standards[J].Chin J Pharm Biotechnol,2010,17(2):181
[12]李旻,陈美君,潘欢欢,等.基于颜色客观化的陈皮药材鉴别[J].中国实验方剂学杂志,2016,22(18):31LI M,CHEN MJ,PAN HH,et al.Discrimination of Citri Reticulatae Pericarpium based on color objectivization[J].Chin J Exp Tradit Med Form,2016,22(18):31
[13]陈梁,李丽,肖永庆,等.仿野生与人工栽培防风饮片的色彩色差分析[J].中国实验方剂学杂志,2013,19(12):92CHEN L,LI L,XIAO YQ,et al.Color analysis between imitatively wild and artificially cultivated pieces of Saposhnikoviae Radix by colorimeter[J].Chin J Exp Tradit Med Form,2013,19(12):92
[14]刘红亮,晏仁义,郭健,等.厚朴”发汗”前后药材颜色及气味差异的数值化研究[J].中国中药杂志,2013,38(1):45LIU HL,YAN RY,GUO J,et al.Study on digitalization in drug color and odor of Magnoliae Officinalis Cortex before and after perspiration[J].China J Chin Mater Med,2013,38(1):45
[15]邹慧琴,李硕,林相龙,等.基于色度学理论的甘草颜色数字化方法学研究[J].世界科学技术-中医药现代化,2014(12):2681ZOU HQ,LI S,LIN XL,et al.Methodological research on color digitalization of Glycyrrhize Radix et Rhizoma based on colorimetry theory[J].World Sci Technol Mod Tradit Chin Med Mater Med,2014,16:(12):2681
[16]杨小露,李水清,王淑美,等.基于主成分分析的不同产地茺蔚子质量评价研究[J].广东药学院学报,2017,33(4):461YANG XL,LI SQ,WANG SM,et al.Study on quality evaluaion of Leonur Fructus from different habitats based on principal components[J].J Guangdong Pharm Univ,2017,33(4):461
[17]胥敏,杨诗龙,李欣逸,等.基于性状客观化的五种芸香科中药鉴别研究[J].中药与临床,2015,6(6):1XU M,YANG SL,LI XY,et al.Research on discrimination of five Rutaceae herbs by objectifying its characters[J].Pharm Clin Chin Mater Med,2015,6(6):1
[18]何婉婉,张建逵,李云静,等.北豆根药材粉末色泽与有效成分的相关性[J].中国实验方剂学杂志,2017,23(5):57HE WW,ZHANG JK,LI YJ,et al.Correlation between color traits of Menispermi Rhizoma powder and its effective components[J].Chin J Exp Tradit Med Form,2017,23(5):57
[19]侯伟龙,窦德强.甘草的色泽与甘草苷、甘草酸含量的相关性研究[J].中国实验方剂学杂志,2013,19(15):130HOU WL,DOU DQ.Research on the correlation between color traits of licorice and its content of Glycyrrhizic acid and liquiritin[J].Chin J Exp Tradit Med Form,2013,19(15):130
[20]李春阳,许时婴,张红城,等.葡萄籽贮藏过程中色差变化的研究[J].食品工业科技,2007,28(10):208LI CY,XU SY,ZHANG HC,et al.Study on the variation of color difference during grape seed storage[J].Sci Technol Food Ind,2007,28(10):208
[21]XU M,DU C,ZHANG N,et al.Color spaces of safflower(Carthamus tinctorius L.)for quality assessment[J].J Tradit Chin Med Sci,2016,3(3):168
[22]李庆,张建逵,康廷国,等.莲须粉末颜色与总黄酮含量相关性研究[J].亚太传统医药,2016,12(14):32LI Q,ZHANG JK,KANG TG,et al.Study of correlation between the content of total flavonoids and powder color of Stamen Nelumbinis[J].Asia-Pacific Tradit Med,2016,12(14):32
[23]方小华,谢一辉,姚冬琴,等.不同发酵时间对樟帮枳壳饮片质量的影响[J].中国实验方剂学杂志,2012,18(9):17FANG XH,XIE YH,YAO DQ,et al.Quality control method Citrus anrantiun pices with different fermentation time[J].Chin J Exp Tradit Med Form,2012,18(9):17
[24]刘粤疆,李文敏,张慧慧,等.色彩色差计在槟榔炒焦加工中的应用[C]//中华中医药学会中药炮制分会2008年学术研讨会论文集,2008:254LIU YJ,LI WM,ZHANG HH,et al.Application of color difference meter in betel nut speculation processing[C]//Chinese Medicine Society of Chinese Medicine Processing Branch 2008 Symposium Proceedings,2008:254
[25]刘粤疆,张继良,吴纯洁,等.中药藕节现代炮制过程数据量化控制研究[J].中国医药导报,2009,36(6):9LIU YJ,ZHANG JL,WU CJ,et al.Research on quantitative control in modern processing of lotus rhizome node[J].Chin Med Her,2009,36(6):9
[26]殷放宙,吴晓燕,李林,等.炮制火候对饮片颜色的影响[J].中草药,2013,44(16):2252YIN FZ,WU XY,LI L,et al.Influence of different heating degrees on color of Chinese materia medica pieces[J].Chin Tradit Herb Drugs,2013,44(16):2252
[27]刘文琴,余无双,周丽姣,等.泽泻饮片质量控制方法研究[J].中国实验方剂学杂志,2011,17(7):87LIU WQ,YU WS,ZHOU LJ,et al.Study on quality control method of processed Alisma pieces[J].Chin J Exp Tradit Med Form,2011,17(7):87
[28]肖井雷,刘玉翠,刘媛媛,等.熟大黄炮制工艺优选及判定标准量化研究[J].中草药,2017,48(8):1571XIAO JL,LIU YC,LIU YY,et al.Study on process optimization and judgment standard of quantitative of cooked Rhei Radix et Rhizoma[J].Chin Tradit Herb Drugs,2017,48(8):1571
[29]李雪莲.白术麸炒过程中颜色与物质基础变化相关性研究[D].成都:成都中医药大学,2015LI XL.Study on the Correlation of Both Color and Material Basis of Atracylodes During the Process of Frying[D].Chengdu:Chengdu University of Tradituonal Chinese Medicine,2015
[30]吴衍风,李德坤,周大铮,等.色差计法测定注射用益气复脉(冻干)溶液的颜色[J].中华中医药学刊,2012,30(1):52WU YF,LI DK,ZHOU DZ,et al.Determination of Yiqi Fumai injection color by colorimeter[J].Chin Arch Tradit Chin Med,2012,30(1):52
[31]刘君动,叶正良,李德坤,等.色差计法测定注射用丹参多酚酸溶液的颜色[J].辽宁中医杂志,2013,40(1):143LIU JD,YE ZL,LI DK,et al.Color difference meters measuring the color of saivianolate lyophilized injection solution[J].Liaoning JTradit Chin Med,2013,40(1):143
[32]刘炜,潘卫松,张嘉莹,等.色差计法在注射剂溶液颜色检查法中的应用[J].药物分析杂志,2015,35(12):2131LIU W,PAN WS,ZHANG JY,et al.Application of colorimeter method for solution color inspection in injections[J].Chin J Pharm Anal,2015,35(12):2131
[33]黄春辉.灰黄霉素色泽的色差法测定[J].中国医药工业杂志,2001,32(4):169HUANG CH.Determination of etodolac sustained release tablets and its methyl derivatives by HPLC[J].Chin J Pharm,2001,32(4):169
[34]庞青云,柳飞,张洁萍,等.注射用头孢曲松钠溶液颜色与相关杂质的研究[J].中国药品标准,2009,10(2):101PANG QY,LIU F,ZHANG JP,et al.Study of the solutions colour and relative substance in ceftriaxone sodium for injection[J].Drug Stand China,2009,10(2):101
[35]北村智,周嘉秀.药物水溶液颜色变化的动力学[J].药学实践杂志,1987(1):35BEI CZ,ZHOU JX.Kinetics of color change of drug aqueous solution[J].J Pharm Pract,1987(1):35
[36]王国兰,寇晋萍,余立,等.注射用粉针溶液颜色限度的制订[J].中国药品标准,2004,5(4):23WANG GL,KOU JP,YU L,et al.Establishment of limit for the color of solution of power for injection[J].Drug Stand China,2004,5(4):23
[37]朱一玮.色差分析法测定治偏痛微丸圆整度的计算方法研究[J].江西中医学院学报,2011,23(4):53ZHU YW.An algorithm for pellet edge tracking based on color analysis[J].J Jiangxi Univ Tradit Chin Med,2011,23(4):53
[38]王小平.粒子设计改善中药粉体均一性与溶解性的工艺原理研究[D].成都:成都中医药大学,2015WANG XP.Study on the Principle of Particle Design to Improve the Uniformity and Solubility of Traditional Chinese Medicine Powder[D].Chengdu:Chengdu University of Tradintional Chinese Medicine,2015
[39]顾金林,沈鸿.用漫反射光谱法测定固体制剂的颜色变化[J].分析化学,1995,23(4):487GU JL,SHEN H.Determination of color change of solid preparation by diffusing reflectance spectroscopy[J].Chin J Anal Chem,1995,23(4):487
[40]佟宝光.色差法确定化学反应终点的研究[J].染料与染色,2007,44(2):52TONG BG.A study on the termination of chemical reaction by chroma stism[J].Dyestuffs Colorat,2007,44(2):52
[41]杨诗龙.基于智能感官分析技术的贝母及黄连饮片鉴别研究[D].成都:成都中医药大学,2015YANG SL.Discrimination of Bulbus of Fritillaria and Processed Products of Coptidis Rhizoma by Using Intelligent Sensory technologies[D].Chengdu:Chengdu University of Traditional Chinese Medicine,2015
[42]ANTONIELLA E.Counterfeit drugs detection by measurement of tablets and secondary packaging colour[J].J Pharm Biomed Anal,2010,53(2):215